TNF-alpha NF-kB signaling pathway (Pan troglodytes)

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PMCYAccession Number: NetPath 9; cellmap:9ExtracellularProteolytic cleavageMTEnzyme complexENDeacetylationSumoylationActivationGlycosylationECPlasma membranePhosphorylationCY ->NUInhibitionEndosomeDemethylationCY ->NUDesumoylationPalmitoylationProteins in a complex interactionCytoplasmControlLigandEndoplasmic reticulumGolgi apparatusTranslocationNUDMolecular associationNucleusCY ->NUDephosphorylationReceptorUbiquitinationCY ->NUER(Protein-protein interaction)AutophosphorylationMolecule in the pathwayMethylationReaction through unknown mechanisms/moleculesDeubiquitinationMitochondrionAcetylationCY ->NURecruitmentGOBIRC2PSMD3YWHAQIKBKEPEG3IKBKBIKBKAPPSMC2TNFRSF1BTNFGTF2IFAF1PTK2NLRP4KPNA2FLNAPMLCASP2TNFRSF11ARPS13AKT2AKAP8CDC34SMARCA4MCM7NFKB1NFKBIZRELBGLG1PAPOLARPL30RPS11PSMD6MTIF2TRAIPMAP3K14COPS3PIAS3DDX3CDC37PSMD13BAG4WDR68NR2C2LOC464259TRAF1AKT1PKN1MAP3K1GSK3BUSP2NFKB2NKIRAS2PPP1R13LPSMB5PRKCZMAP2K5UNC5CLSMARCB1RELCSNK2A2POLR2HCHUKNFKBIBYWHAEPRKACASTAT1RASAL2RPL8PFDN2TANKPTPN11CREBBPBCL3TRADDTBK1GeneRIPK2TRAF2SMARCC2TXLNATNIP2TRAF4NFKB1CYLDGeneFADDNSMAFTAB3CUL1POLR2LKCNQ1NFKBIATNIP1TNFRSF1BPPP2CASKP1RELAPDCD2HDAC6PSMC1CFLARCASP8UBE2IRNF25PEBP1IKBKGTRAF4RPL6MAP3K7IP2FANCD2TNFRSF1APOLR1CNR2C2TIFAPOLR1BFKBP5POLR1ARIPK3NFKBIAUSP11PSMC3YWHAGIQGAP2PSMD7MAP3K8ACTL6ARELPOLR1ESMARCC1HSPB1RPL4TRAF2RELACASP7BTRCDPF2TNFGene SymbolTRADDTRAF1RPS6KB1TNFAIP3TNFRSF1AFBLRIPK1PSMD1CRADDYWHAHGeneTNFCD3EAPTNFRSF1AFBXW11MCM5RNF216TRAF6MCCTNFRSF1BRELBTNFKTN1LRPPRCMAP3K3SMARCE1POLR1DCOMMD1BIRC3TRAF5NFKBIECASP10CHUKMAP3K2UBE2D2TNFHIST3H3G3BP2BIRC2PSMD12NFKB1MARK2GeneCSNK2A1CAPN3MAP3K3BCL7AYWHAZEIF4A3UBE2D3PRIPK1TNFRSF8CSNK2BCASP8AP2NFKBIAYWHABTRAF3KPNA6HSP90AA1MAP3K7IP1SRCZFAND5LOC462950IKBKGALPLLOC464047RELACASP3BIRC3SUMO1GNB2L1NKIRAS1DAPRPS6KA5TRAF2TBK1CAV1RELAKPNA3LOC737497TRPC4APTNFAZI2GAB1


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 81% conversion rate.

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History

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CompareRevisionActionTimeUserComment
118010view11:31, 23 May 2021EweitzModified title
108150view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87790view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87789view11:14, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69230view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
41534view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
34270view21:54, 9 December 2009MaintBotAutomatic update of empty xrefs
33581view09:49, 1 December 2009MaintBotRemoved group label
31605view22:10, 13 August 2009MaintBotFixed text labels
30498view21:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

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Annotated Interactions

No annotated interactions
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