Endothelin pathways (Homo sapiens)
From WikiPathways
Description
Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
No bibliography
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AC | GeneProduct | ENSG00000143199 (Ensembl) | adenylate cyclase |
ATP | Metabolite | HMDB0001532 (HMDB) | |
Arachidonic acid | Metabolite | HMDB0001043 (HMDB) | |
Big ET1 | Protein | ||
CAD | GeneProduct | ENSG00000084774 (Ensembl) |
|
CGRP | GeneProduct | ENSG00000110680 (Ensembl) | |
COX2 | GeneProduct | 4513 (Entrez Gene) | |
CRLR | GeneProduct | ENSG00000064989 (Ensembl) | |
Ca2+ channel | GeneProduct | ||
Ca2+ | Metabolite | HMDB0000464 (HMDB) | |
CaM | GeneProduct | ENSG00000198668 (Ensembl) | |
Cap | GeneProduct | ENSG00000130176 (Ensembl) |
|
Citrulline | Metabolite | HMDB0000904 (HMDB) | |
DAG | Metabolite | HMDB0007008 (HMDB) | |
ECE | GeneProduct | ENSG00000117298 (Ensembl) | |
EDHF | Protein | ||
EDNRA | GeneProduct | ENSG00000151617 (Ensembl) | |
EDNRB | GeneProduct | ENSG00000136160 (Ensembl) | |
ERK1/2 | GeneProduct | ENSG00000100030 (Ensembl) | |
Endothelin 1 | GeneProduct | ENSG00000078401 (Ensembl) | |
Furin-like protease | Protein | ||
GTP | Metabolite | HMDB0001440 (HMDB) | |
GaI | GeneProduct | ENSG00000127955 (Ensembl) | |
GaQ | GeneProduct | ENSG00000060558 (Ensembl) | |
GaS | GeneProduct | ENSG00000087460 (Ensembl) | |
GbI | GeneProduct | ENSG00000069966 (Ensembl) | |
GbQ | GeneProduct | ENSG00000069966 (Ensembl) | |
GbS | GeneProduct | ENSG00000069966 (Ensembl) | |
GgI | GeneProduct | ENSG00000127588 (Ensembl) | |
GgQ | GeneProduct | ENSG00000127588 (Ensembl) | |
GgS | GeneProduct | ENSG00000127588 (Ensembl) | |
IP1 | GeneProduct | ENSG00000160013 (Ensembl) | Prostaglandin I2 Receptor |
IP3 | Metabolite | HMDB0001059 (HMDB) | |
IP3R | Protein | ||
K+ channel | Protein | ||
K+ | Metabolite | HMDB0000586 (HMDB) | |
L-Arginine | Metabolite | HMDB0000517 (HMDB) | |
MEK | GeneProduct | ENSG00000169032 (Ensembl) | |
MLC | GeneProduct | ENSG00000168530 (Ensembl) | myosine light chain |
MLCK | GeneProduct | ENSG00000065534 (Ensembl) | |
NO | Metabolite | HMDB0003378 (HMDB) | |
NPY | GeneProduct | ENSG00000122585 (Ensembl) | |
PGI2 | Metabolite | Q412050 (Wikidata) | |
PIP2 | Metabolite | HMDB0010032 (HMDB) | |
PKA | GeneProduct | ENSG00000178796 (Ensembl) | |
PKC | GeneProduct | ENSG00000154229 (Ensembl) | |
PLCb | GeneProduct | ENSG00000182621 (Ensembl) | |
PMCA | Protein | ||
Pre-pro ET1 | Protein | ||
RAF | GeneProduct | ENSG00000132155 (Ensembl) | |
RAMP1 | GeneProduct | ENSG00000132329 (Ensembl) | |
SERCA | GeneProduct | ENSG00000174437 (Ensembl) | |
Y1 | GeneProduct | ENSG00000164128 (Ensembl) | |
a adrenergic receptor | GeneProduct | ENSG00000120907 (Ensembl) | |
b adrenergic receptor | GeneProduct | ENSG00000043591 (Ensembl) | |
cAMP | Metabolite | HMDB0000058 (HMDB) | |
cGMP | Metabolite | HMDB0001314 (HMDB) | |
eNOS | GeneProduct | ENSG00000164867 (Ensembl) | |
sGC | GeneProduct | ENSG00000123201 (Ensembl) |
Annotated Interactions
No annotated interactions