Peroxiredoxin 2 induced ovarian failure (Mus musculus)

From WikiPathways

Revision as of 08:43, 16 April 2020 by Fehrhart (Talk | contribs)
Jump to: navigation, search
1ApoptosisOvarian failureThe number of follicles and Corpora lutea declinesOvarian functional degenerationSize of ovaries declineAgingOvarian structural degeneration3Beta-HSDEstradiol-17betaPARPCytochrome cCaspase-3CYP11A1Reactive oxygen species BaxPeroxiredoxin-2StAR ProgesteroneJNK


Description

This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134351view05:38, 21 July 2024EgonwRemoved a template comment
110293view14:20, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110230view14:26, 27 April 2020EgonwUpdated the data source.
110070view08:45, 16 April 2020FehrhartOntology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110069view08:45, 16 April 2020FehrhartAdded reference and some graphical adjustments
110068view08:43, 16 April 2020FehrhartModified description
109438view12:54, 17 March 2020FehrhartOntology Term : 'ovarian dysfunction' added !
109437view12:54, 17 March 2020FehrhartOntology Term : 'signaling pathway' added !
109250view11:56, 2 March 2020LaurentModified title
109233view12:10, 1 March 2020Bas LahaijeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3Beta-HSDProteinE9PXG7 (Uniprot-TrEMBL)
BaxGeneProductENSMUSG00000003873 (Ensembl)
CYP11A1ProteinQ9QZ82 (Uniprot-TrEMBL) Mitochondrial
Caspase-3ProteinA0A1B0GRX1 (Uniprot-TrEMBL)
Cytochrome cProteinP62897 (Uniprot-TrEMBL) Somatic
Estradiol-17betaMetaboliteCHEBI:4864 (ChEBI)
JNKProteinENSMUSP00000023291 (Ensembl Mouse)
PARPMetaboliteCHEBI:62913 (ChEBI)
Peroxiredoxin-2ProteinQ61171 (Uniprot-TrEMBL)
ProgesteroneMetaboliteCHEBI:45786 (ChEBI)
Reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)
StAR ProteinP51557 (Uniprot-TrEMBL)
  • Mitichondrial
  • Type your comment here

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4835"
Personal tools