Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)

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BrainLiverKidney injuryCell deathImpaired proteostasisDecreased proximal tubule vectorial transportKidneyDecreased Na/K ATPase activityNeuroinflammationChemical induced Fanconi syndromeBrain injuryLiver injuryMitochondrial dysfunctionUnfolded protein response?Apoptosis[Autophagy]FerroptosisNecrosisIncreased ROSParkinsonian motor deficits[Degeneration of DA neurons of nigrostratial pathway]RotenoneDecreased mitochondrial oxidative phosphorylationInhibition of mitochondrial Complex IDeguelin


Description

AOP for C1 inhibition

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
116532view11:59, 7 May 2021EweitzModified title
115242view17:13, 7 February 2021EgonwReplaced a link to a deleted pathway to another pathway about necrosis
111416view10:33, 7 August 2020Marvin M2Modified description
111407view16:10, 6 August 2020EveloModified description
111406view16:09, 6 August 2020EveloModified description
111405view16:05, 6 August 2020EveloModified description
111404view16:04, 6 August 2020EveloModified description
111403view15:51, 6 August 2020EveloOntology Term : 'Parkinson's disease' added !
111402view15:43, 6 August 2020EveloModified description
111401view15:43, 6 August 2020EveloOntology Term : 'Fanconi-like syndrome' added !
111400view15:42, 6 August 2020EveloOntology Term : 'altered energy metabolic pathway' added !
111399view15:39, 6 August 2020EveloModified title
110993view17:50, 25 June 2020Marvin M2Modified title
110831view12:58, 11 June 2020AnnabayaEdit pathway node shapes
110381view15:34, 8 May 2020AnnabayaOntology Term : 'immune response pathway' added !
110378view15:29, 8 May 2020AnnabayaAdd pathway identifiers
110314view22:12, 3 May 2020Marvin M2Connected unconnected lines
110303view06:37, 3 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110271view13:53, 1 May 2020AnnabayaModified title
110270view13:51, 1 May 2020AnnabayaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ApoptosisPathwayWP1772 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
DeguelinMetaboliteCHEBI:4357 (ChEBI)
FerroptosisPathwayWP4313 (WikiPathways)
Increased ROSPathwayWP3941 (WikiPathways)
Inhibition of mitochondrial Complex IPathwayWP4324 (WikiPathways)
NecrosisPathwayWP3383 (WikiPathways)
Parkinsonian motor deficitsPathwayWP2371 (WikiPathways)
RotenoneMetaboliteCHEBI:8897 (ChEBI)
[Autophagy]Pathway
[Degeneration of DA neurons of nigrostratial pathway]PathwayWP2855 (WikiPathways)

Annotated Interactions

No annotated interactions

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