DNA repair pathways, full network (Homo sapiens)

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2, 5DNA Repair PathwaysMismatch Repair (MMR)Nucleotide Excision Repair (NER)Base Excision Repair (BER)Homologous Recombination Repair (HR)Non-Homologous End Joining (NHEJ)Methyl-Guanine DNA Methyltransferase (MGMT)Fanconi Anemia Pathway (FA)3Trans-Lesion Synthesis (TLS)1ATMATRAlternative End-Joining (Alt-EJ)4RPA1RPA2RPA3RFC1MSH2MSH3MSH6RFC2RFC3RFC4RFC5EXO1PCNAMLH1PMS2POLEPOLE2POLE3POLE4POLD1POLD2POLD3POLD4LIG1RBX1DDB1DDB2CUL4ACUL4BXPCXPARAD23ARAD23BCETN2ERCC1ERCC2ERCC3ERCC4ERCC5ERCC6ERCC8CDK7MNAT1CCNHGTF2H5GTF2H2GTF2H1GTF2H3GTF2H4RPA1RPA2RPA3POLEPOLE2POLE3POLE4POLD1POLD2POLD3POLD4PCNARFC1RFC2RFC3RFC4RFC5LIG1XRCC4XRCC5XRCC6WRNPRKDCDCLRE1CPOLMPOLLLIG4NHEJ1OGG1NTHL1NEIL2NEIL3APEX1APEX2PNKPXRCC1POLBPOLLPARP1PARP2HMGB1LIG1LIG3UNGSMUG1MUTYHMPGMBD4TDGPOLD1POLD2POLD3POLD4PCNAPOLEPOLE2POLE3POLE4FEN1NBNMRE11ARPA1BRCA2RAD50RAD51RAD52RAD54BPOLD1POLD2POLD3POLD4FANCAFANCD2FANCCFANCNFANCMFANCLFANCJFANCIFANCGFANCFFANCEFANCBFAAP24FAAP100MHF1MHF2FAN1USP1UAF1ATRCHEK1H2AXBRCA1BRCA2RAD51CLIG4LIG1XRCC4XRCC5XRCC6PRKDCMRE11RAD50XRS2TERF2RAP1AATMATRREV3LREV1POLHPOLIPOLKPCNAMGMT


Description

DNA Repair Pathways (Full Network)

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Quality Tags

Ontology Terms

 

Bibliography

  1. Decottignies A; ''Alternative end-joining mechanisms: a historical perspective.''; Front Genet, 2013 PubMed Europe PMC Scholia
  2. Kee Y, D'Andrea AD; ''Expanded roles of the Fanconi anemia pathway in preserving genomic stability.''; Genes Dev, 2010 PubMed Europe PMC Scholia
  3. Kciuk M, Bukowski K, Marciniak B, Kontek R; ''Advances in DNA Repair-Emerging Players in the Arena of Eukaryotic DNA Repair.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  4. Goodman MF, Woodgate R; ''Translesion DNA polymerases.''; Cold Spring Harb Perspect Biol, 2013 PubMed Europe PMC Scholia
  5. Klinakis A, Karagiannis D, Rampias T; ''Targeting DNA repair in cancer: current state and novel approaches.''; Cell Mol Life Sci, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117703view12:23, 22 May 2021EweitzModified title
112230view17:38, 5 October 2020Khanspersupdated one more literature reference
112229view17:36, 5 October 2020Khanspersupdated literature reference format
112077view14:35, 18 September 2020DeSlAdded PW IDs, changed Unknown Nodes to PWs if ID was given in comment.
112076view14:24, 18 September 2020DeSlChanged arrows to graphical lines.
111386view12:22, 5 August 2020Marvin M2Ontology Term : 'DNA repair pathway' added !
111171view13:43, 21 July 2020EgonwAdded the alternative gene name as comment, as it is not an Ensembl identifier.
111170view13:41, 21 July 2020EgonwReplaced with a human gene: http://www.ensembl.org/Mus_musculus/Gene/Compara_Ortholog/Alignment?db=core;g=ENSMUSG00000031928;g1=ENSG00000020922;hom_id=466173121;r=9:14784654-14837123
111106view20:41, 10 July 2020DiazfloreseModified title
111088view22:36, 7 July 2020DaisydxNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APEX1GeneProductENSG00000100823 (Ensembl)
APEX2GeneProductENSG00000169188 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
Alternative End-Joining (Alt-EJ)
BRCA1GeneProductENSG00000012048 (Ensembl)
BRCA2GeneProductENSG00000139618 (Ensembl)
Base Excision Repair (BER)Wikipathway reference: WP4752
CCNHGeneProductENSG00000134480 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CETN2GeneProductENSG00000147400 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
CUL4AGeneProductENSG00000139842 (Ensembl)
CUL4BGeneProductENSG00000158290 (Ensembl)
DCLRE1CGeneProductENSG00000152457 (Ensembl)
DDB1GeneProductENSG00000167986 (Ensembl)
DDB2GeneProductENSG00000134574 (Ensembl)
DNA Repair PathwaysPathway
ERCC1GeneProductENSG00000012061 (Ensembl)
ERCC2GeneProductENSG00000104884 (Ensembl)
ERCC3GeneProductENSG00000163161 (Ensembl)
ERCC4GeneProductENSG00000175595 (Ensembl)
ERCC5 GeneProductENSG00000134899 (Ensembl)
ERCC6GeneProductENSG00000225830 (Ensembl)
ERCC8GeneProductENSG00000049167 (Ensembl)
EXO1GeneProductENSG00000174371 (Ensembl)
FAAP100GeneProductENSG00000185504 (Ensembl)
FAAP24GeneProductENSG00000131944 (Ensembl)
FAN1GeneProductENSG00000198690 (Ensembl)
FANCAGeneProductENSG00000187741 (Ensembl)
FANCBGeneProductENSG00000181544 (Ensembl)
FANCCGeneProductENSG00000158169 (Ensembl)
FANCD2GeneProductENSG00000144554 (Ensembl)
FANCEGeneProductENSG00000112039 (Ensembl)
FANCFGeneProductENSG00000183161 (Ensembl)
FANCGGeneProductENSG00000221829 (Ensembl)
FANCIGeneProductENSG00000140525 (Ensembl)
FANCJGeneProductENSG00000136492 (Ensembl) BRIP1
FANCLGeneProductENSG00000115392 (Ensembl)
FANCMGeneProductENSG00000187790 (Ensembl)
FANCNGeneProductENSG00000083093 (Ensembl) PALB2
FEN1GeneProductENSG00000168496 (Ensembl)
Fanconi Anemia Pathway (FA)
GTF2H1GeneProductENSG00000110768 (Ensembl)
GTF2H2GeneProductENSG00000145736 (Ensembl)
GTF2H3GeneProductENSG00000111358 (Ensembl)
GTF2H4GeneProductENSG00000213780 (Ensembl)
GTF2H5GeneProductENSG00000272047 (Ensembl)
H2AXGeneProductENSG00000188486 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
Homologous Recombination Repair (HR)Wikipathway reference: WP186
LIG1GeneProductENSG00000105486 (Ensembl)
LIG3GeneProductENSG00000005156 (Ensembl)
LIG4GeneProductENSG00000174405 (Ensembl)
MBD4GeneProductENSG00000129071 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)
MHF1GeneProductENSG00000175279 (Ensembl) CENPS
MHF2GeneProductENSG00000169689 (Ensembl) CENPX
MLH1GeneProductENSG00000076242 (Ensembl)
MNAT1GeneProductENSG00000020426 (Ensembl)
MPGGeneProductENSG00000103152 (Ensembl)
MRE11AGeneProductENSG00000020922 (Ensembl)
MRE11GeneProductENSG00000020922 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MSH3GeneProductENSG00000113318 (Ensembl)
MSH6GeneProductENSG00000116062 (Ensembl)
MUTYHGeneProductENSG00000132781 (Ensembl)
Methyl-Guanine DNA Methyltransferase (MGMT)
Mismatch Repair (MMR)Wikipathway reference: WP531
NBNGeneProductENSG00000104320 (Ensembl)
NEIL2GeneProductENSG00000154328 (Ensembl)
NEIL3GeneProductENSG00000109674 (Ensembl)
NHEJ1GeneProductENSG00000187736 (Ensembl)
NTHL1GeneProductENSG00000065057 (Ensembl)
Non-Homologous End Joining (NHEJ)Wikipathway reference: WP438
Nucleotide Excision Repair (NER)Wikipathway reference: WP4753
OGG1GeneProductENSG00000114026 (Ensembl)
PARP1GeneProductENSG00000143799 (Ensembl)
PARP2GeneProductENSG00000129484 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
PMS2GeneProductENSG00000122512 (Ensembl)
PNKPGeneProductENSG00000039650 (Ensembl)
POLBGeneProductENSG00000070501 (Ensembl)
POLD1GeneProductENSG00000062822 (Ensembl)
POLD2GeneProductENSG00000106628 (Ensembl)
POLD3GeneProductENSG00000077514 (Ensembl)
POLD4GeneProductENSG00000175482 (Ensembl)
POLE2GeneProductENSG00000100479 (Ensembl)
POLE3GeneProductENSG00000148229 (Ensembl)
POLE4GeneProductENSG00000115350 (Ensembl)
POLEGeneProductENSG00000177084 (Ensembl)
POLHGeneProductENSG00000170734 (Ensembl)
POLIGeneProductENSG00000101751 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
POLLGeneProductENSG00000166169 (Ensembl)
POLMGeneProductENSG00000122678 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
RAD23AGeneProductENSG00000179262 (Ensembl)
RAD23BGeneProductENSG00000119318 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
RAD51 GeneProductENSG00000051180 (Ensembl)
RAD51CGeneProductENSG00000108384 (Ensembl)
RAD52GeneProductENSG00000002016 (Ensembl)
RAD54BGeneProductENSG00000197275 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
REV1GeneProductENSG00000135945 (Ensembl)
REV3LGeneProductENSG00000009413 (Ensembl)
RFC1GeneProductENSG00000035928 (Ensembl)
RFC2GeneProductENSG00000049541 (Ensembl)
RFC3GeneProductENSG00000133119 (Ensembl)
RFC4GeneProductENSG00000163918 (Ensembl)
RFC5 GeneProductENSG00000111445 (Ensembl)
RPA1GeneProductENSG00000132383 (Ensembl)
RPA2GeneProductENSG00000117748 (Ensembl)
RPA3GeneProductENSG00000106399 (Ensembl)
SMUG1GeneProductENSG00000123415 (Ensembl)
TDGGeneProductENSG00000139372 (Ensembl)
TERF2GeneProductENSG00000132604 (Ensembl)
Trans-Lesion Synthesis (TLS)
UAF1GeneProductENSG00000114742 (Ensembl) WDR48
UNGGeneProductENSG00000076248 (Ensembl)
USP1GeneProductENSG00000162607 (Ensembl)
WRNGeneProductENSG00000165392 (Ensembl)
XPAGeneProductENSG00000136936 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)
XRCC1GeneProductENSG00000073050 (Ensembl)
XRCC4GeneProductENSG00000152422 (Ensembl)
XRCC5GeneProductENSG00000079246 (Ensembl)
XRCC6GeneProductENSG00000196419 (Ensembl)
XRS2GeneProductYDR369C (Ensembl) S. Cerevisiae

Annotated Interactions

No annotated interactions

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