Butyrate-induced histone acetylation (Bos taurus)
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Egonw
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Butyrate
Acetylated Histone
TCA
cycle
Citrate
Beta oxidation
Lipid
biosynthesis
AKT1
HDACs
Acetyl CoA
Citrate
Butyrate
Acetyl CoA
ACLY
Butyrate
Glucose
Butyrate
Description
Metabolism of butyrate is suggested to be an energy source for histone acetylation.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP2366(73980)
with a 66.0% conversion rate.
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Ontology Terms
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Bibliography
Davie JR; ''Inhibition of histone deacetylase activity by butyrate.''; J Nutr, 2003
PubMed
Europe PMC
Scholia
Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ; ''The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation.''; Mol Cell, 2012
PubMed
Europe PMC
Scholia
History
Compare
Revision
Action
Time
User
Comment
115748
view
11:19, 9 March 2021
Egonw
Replaced the WP id of a human pathways with the matching cow pathway
102130
view
21:15, 1 December 2018
Egonw
Replaced Wikipedia with Wikidata identifiers.
89151
view
03:06, 23 August 2016
Ariutta
Ontology Term : 'classic metabolic pathway' added !
80881
view
15:29, 30 June 2015
Mkutmon
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACLY
Protein
ENSBTAG00000016740 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53396
AKT1
Protein
ENSBTAG00000017636 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31749
Acetyl CoA
Metabolite
CHEBI:15351 (ChEBI)
Acetylated Histone
Complex
Q36293 (Wikidata)
Butyrate
Metabolite
CHEBI:17968 (ChEBI)
Citrate
Metabolite
CHEBI:35808 (ChEBI)
Glucose
Metabolite
CHEBI:17634 (ChEBI)
HDACs
Protein
Lipid biosynthesis
Pathway
WP1020 (WikiPathways)
TCA cycle
Pathway
WP78 (WikiPathways)
Annotated Interactions
No annotated interactions
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