SREBP signaling (Bos taurus)

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ERNucleus4423, 35213026Golgi COPII coated vesicleLipogenic enzymes11Up regulationSREExact mechanism unknownInhibitionCholesterol effluxstimulationCofactorLegendPositive effectNegative effectCholesterol synthesisCatalysisAMPKTranscription-Translation Cleavage17CholesterolRBP4MBTPS1MTORPRKAG2PRKAB2INSIG1bta-mir-33aPIK3CASIRT1NR1H2SREBF2OxysterolsUFAsPRKAA1GSK3APRKAG1AMFRAKT1PRKAB1SREBF1FGF21NFYAGlutamineHMGCRPRKAG3LPIN1Glucosebta-mir-33bPRKAA2InsulinCDK8KPNB1CATHL3SCAPPRKACAPUFAsRNF139ATF6279168SCAP36, 374013, 391, 38420, 2219332, 28, 32151635242510454134SCAPINSIG2INSIG1INSIG2SREBF112, 31SREBF2SREBF1SREBF2SREBF1SAR1ASCAPSREBF2SREBF1SAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBF1SAR1BSEC31ASEC31BMBTPS242SCAPSREBF2SREBF1SREBF1GeneSRESREBF2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREB1SP118NFYACREB1SP1YY16, 14YY1PPARGC1BMED1543MED157LSSHMGCS1MVDIDI1FDPSFDFT1SQLECYP51A1LPLLDLRSCARB1ACACAGPAMFASNDBIACLYMDH1PPARGACSS1SCDFatty aciddegradationFatty acid synthesisSIRT129INSIG1INSIG2SREBF2SREBF1


Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1982(79943) with a 99.0% conversion rate.

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Bibliography

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  4. Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I; ''SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.''; Genes Dev, 2001 PubMed Europe PMC Scholia
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  45. Nagoshi E, Imamoto N, Sato R, Yoneda Y; ''Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.''; Mol Biol Cell, 1999 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
116414view09:07, 7 May 2021EweitzModified title
106015view11:54, 16 August 2019MaintBotHMDB identifier normalization
80779view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSBTAG00000017567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000278540
ACLYGeneProductENSBTAG00000016740 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131473
ACSS1GeneProductENSBTAG00000004281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154930
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
AMFRGeneProductENSBTAG00000003798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159461
ATF6GeneProductENSBTAG00000005227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118217
CATHL3GeneProductENSBTAG00000031599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164047
CDK8GeneProductENSBTAG00000016737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132964
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118260
CYP51A1GeneProductENSBTAG00000001992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630
CholesterolMetaboliteHMDB0000067 (HMDB)
DBIGeneProductENSBTAG00000009517 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155368
FASNGeneProductENSBTAG00000015980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169710
FDFT1GeneProductENSBTAG00000012432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079459
FDPSGeneProductENSBTAG00000003948 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160752
FGF21GeneProductENSBTAG00000011624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105550
GPAMGeneProductENSBTAG00000011917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927
GSK3AGeneProductENSBTAG00000020756 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105723
GlucoseMetaboliteHMDB0000122 (HMDB)
GlutamineMetaboliteHMDB0000641 (HMDB)
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
HMGCS1GeneProductENSBTAG00000011839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
IDI1GeneProductENSBTAG00000004075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067064
INSIG1GeneProductENSBTAG00000001592 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186480
INSIG2GeneProductENSBTAG00000002112 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125629
InsulinProtein
KPNB1GeneProductENSBTAG00000006586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108424
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
LPIN1GeneProductENSBTAG00000007689 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134324
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175445
LSSGeneProductENSBTAG00000018936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160285
MBTPS1GeneProductENSBTAG00000010170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140943
MBTPS2GeneProductENSBTAG00000008183 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000012174
MDH1GeneProductENSBTAG00000019295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000014641
MED15GeneProductENSBTAG00000018048 (Ensembl)
  • activator recruited cofactor (ARC)-mediator activator complex
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
MVDGeneProductENSBTAG00000012059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167508
NFYAGeneProductENSBTAG00000009905 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001167
NR1H2GeneProductENSBTAG00000003264 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131408
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121879
PPARGC1BGeneProductENSBTAG00000012943 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155846
PPARGGeneProductENSBTAG00000001333 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132170
PRKAA1GeneProductENSBTAG00000000013 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132356
PRKAA2GeneProductENSBTAG00000018747 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162409
PRKAB1GeneProductENSBTAG00000005940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111725
PRKAB2GeneProductENSBTAG00000014387 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131791
PRKACAGeneProductENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072062
PRKAG1GeneProductENSBTAG00000014426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181929
PRKAG2GeneProductENSBTAG00000002917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
PRKAG3GeneProductENSBTAG00000013492 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115592
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
RBP4GeneProductENSBTAG00000000442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138207
RNF139GeneProductENSBTAG00000020399 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170881
SAR1AGeneProductENSBTAG00000016858 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079332
SAR1BGeneProductENSBTAG00000021226 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152700
SCAPGeneProductENSBTAG00000015782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114650
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073060
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099194
SEC13GeneProductENSBTAG00000017825 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157020
SEC23AGeneProductENSBTAG00000003708 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100934
SEC23BGeneProductENSBTAG00000018295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101310
SEC24AGeneProductENSBTAG00000018322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113615
SEC24BGeneProductENSBTAG00000010945 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138802
SEC24CGeneProductENSBTAG00000002791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176986
SEC24DGeneProductENSBTAG00000003619 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150961
SEC31AGeneProductENSBTAG00000020525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138674
SEC31BGeneProductENSBTAG00000000090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075826
SIRT1GeneProductENSBTAG00000014023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591
SQLEGeneProductENSBTAG00000005498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104549
SREBF1GeneProductENSBTAG00000007884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
SREBF2GeneProductENSBTAG00000014265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
UFAsMetaboliteCHEBI:26208 (ChEBI)
YY1GeneProductENSBTAG00000020819 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100811
bta-mir-33aRnaENSBTAG00000029975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Mb:MI0000091
bta-mir-33bRnaENSBTAG00000036437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Mb:MI0003646

Annotated Interactions

No annotated interactions
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