Leptin-insulin signaling overlap (Homo sapiens)

Quality Tags

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Review changes for Approved Revision 137955 of this pathway was approved for data analysis by Kristina Hanspers.

Review changes for Featured Revision 118425 of this pathway was tagged to be featured on the front page of WikiPathways by Martina Kutmon.

Annotate nodes Comment: 1 out of 25 DataNodes have a missing external reference. Check DataNode table at the bottom of the page. Please help improve this pathway by annotating gene, protein and metabolite nodes.

Homology Converted Comment: Inferred from another species Revision {{{tag_revision}}} of this pathway has been inferred from another species (tagged by Maintenance bot). Expression error: Unrecognised punctuation character "{"

Ontology Terms

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Bibliography

1. Banks AS, Davis SM, Bates SH, Myers MG Jr; ''Activation of downstream signals by the long form of the leptin receptor.''; J Biol Chem, 2000 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
AKT1	GeneProduct	ENSG00000142208 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
DGKZ	GeneProduct	ENSG00000149091 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040479
INS	GeneProduct	ENSG00000254647 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
INSR	GeneProduct	ENSG00000171105 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1	GeneProduct	ENSG00000169047 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
IRS2	GeneProduct	ENSG00000185950 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:384783
IRS4	GeneProduct	ENSG00000133124 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16370
Irs3	GeneProduct		No homologues found for original id L:16369
JAK2	GeneProduct	ENSG00000096968 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
LEP	GeneProduct	ENSG00000174697 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P41160
LEPR	GeneProduct	ENSG00000116678 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
PDPK1	GeneProduct	ENSG00000140992 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PIK3CG	GeneProduct	ENSG00000105851 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573
PIK3R3	GeneProduct	ENSG00000117461 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698
PIP2	Metabolite	CHEBI:18348 (ChEBI)
PIP3	Metabolite	CHEBI:16618 (ChEBI)
SOCS1	GeneProduct	ENSG00000185338 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12703
SOCS2	GeneProduct	ENSG00000120833 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216233
SOCS3	GeneProduct	ENSG00000184557 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12702
STAT3	GeneProduct	ENSG00000168610 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848

Annotated Interactions