Wnt signaling pathway and pluripotency (Bos taurus)

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6473Tcf/Lef-1Ubiquitin Taggedbeta-cateninDifferentiationTRProtein Kinase CPhosphorylated beta-cateninTcf/Lef-1Promotes DifferentiationTR: Transcriptional RegulationPP2ANucleusWnt ReceptorsTRTRFrizzled LigandsTRRecruitment to UnknownUbiquitin Conjugating EnzymePluripotencyTRPromotes Pluripotencybeta-cateninTRbeta-cateninCytoskeletonStabilized beta-cateninLRP5DVL2FOSL1BIOCTBP1PRKCQEP300NANOGLRP6PRKCGCCND2PAFAH1B1RACGAP1PPP2R5CFZD9NKD2GrouchoWNT3PLAUCCND1FZD8CCND3WNT7AWNT5AGSK3BWNT11CREBBPPRKCZPPM1JWNT11TCF7L1CTNND1FZD2FZD5WNT10BMGC155143JUNFZD4SOX2NLKPPP2R2CDVL3RHOAMAPK9FRAT1WNT5BPRKCHPPARDPRKCEWNT16POU5F1MAP3K7FZD6PPP2R3ALDLRPPP2R3BMAPK10PRKD1AXIN2LEF1CTBP2PPP2R1AFZD10PRKCBApoptosisTP53WNT4NKD1PPP2R1BPPP2R2APPP2CAIQ-1PPP2R4TCF7PRKCDPPP2R2BWNT2PRKCAMAP2K4TCFL2MYCWNT6PPP2R5EFZD3WNT3ACD44WNT9BDVL1FBXW2CTNNB1ESRRB26S Proteasome DegradationAXIN1CSNK1EMMP7PRKCIPPP2CBWNT2BFZD7WNT10AFZD1FOXD3WNT7BWNT1APCNFYA1LRRK25PCTNNB1PCTNNB1Ub


Description

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.

A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP399(79474) with a 99.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  3. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC Scholia
  4. Yi F, Pereira L, Merrill BJ; ''Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.''; Stem Cells, 2008 PubMed Europe PMC Scholia
  5. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC Scholia
  6. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,
  7. Zhang X, Zhang J, Wang T, Esteban MA, Pei D; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
120483view09:20, 8 December 2021EgonwMade two pathways clickable
117625view11:44, 21 May 2021EweitzModified title
115729view09:29, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
86915view08:05, 14 July 2016MkutmonOntology Term : 'pluripotent stem cell' added !
86914view08:05, 14 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
86913view08:05, 14 July 2016MkutmonOntology Term : 'Wnt signaling, canonical pathway' added !
86912view08:04, 14 July 2016Mkutmonfix ontology tag issue
80808view15:26, 30 June 2015Mkutmonhomology conversion
72100view21:41, 24 October 2013Mkutmonadded datasource for "Proteasome Degradation" and "Apoptosis"
63388view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
48128view05:47, 9 May 2012MaintBotUpdating from human to fix xref duplication
40561view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33799view00:16, 9 December 2009MaintBotAutomatic update of empty xrefs
32489view12:45, 17 August 2009MaintBotFixed text labels
32184view12:33, 15 August 2009MaintBotFixed text labels
31655view11:37, 14 August 2009MaintBotFixed group labels
31187view19:29, 13 August 2009MaintBotFixed text labels
30579view22:08, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP1079 (WikiPathways)
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
AXIN1GeneProductENSBTAG00000016577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
AXIN2GeneProductENSBTAG00000030162 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8313
ApoptosisPathwayWP254 (WikiPathways)
BIOMetabolite5287844 (PubChem-compound)
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND2GeneProductENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CD44GeneProductENSBTAG00000011578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:960
CREBBPGeneProductENSBTAG00000026403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
CSNK1EGeneProductENSBTAG00000047582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1454
CTBP1GeneProductENSBTAG00000008480 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1487
CTBP2GeneProductENSBTAG00000003397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1488
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
CTNND1GeneProductENSBTAG00000002411 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1500
DVL1GeneProductENSBTAG00000010696 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
DVL2GeneProductENSBTAG00000003075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
DVL3GeneProductENSBTAG00000019336 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
EP300GeneProductENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
ESRRBGeneProductENSBTAG00000012285 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2103
FBXW2GeneProductENSBTAG00000000712 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26190
FOSL1GeneProductENSBTAG00000006194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061
FOXD3GeneProductENSBTAG00000008501 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187140
FRAT1GeneProductENSBTAG00000007956 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10023
FZD10GeneProductENSBTAG00000007047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111432
FZD1GeneProductENSBTAG00000002107 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8321
FZD2GeneProductENSBTAG00000020590 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2535
FZD3GeneProductENSBTAG00000006621 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7976
FZD4GeneProductENSBTAG00000040128 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8322
FZD5GeneProductENSBTAG00000020957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7855
FZD6GeneProductENSBTAG00000010529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8323
FZD7GeneProductENSBTAG00000002283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8324
FZD8GeneProductENSBTAG00000015072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8325
FZD9GeneProductENSBTAG00000020742 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8326
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
GrouchoGeneProduct
IQ-1Metabolite331001-62-8 (CAS)
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
LEF1GeneProductENSBTAG00000006844 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
LRP5GeneProductENSBTAG00000005903 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4041
LRP6GeneProductENSBTAG00000011761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4040
LRRK2GeneProductENSBTAG00000016260 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:120892
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MGC155143GeneProductENSBTAG00000017184 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10009
MMP7GeneProductENSBTAG00000004594 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4316
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NANOGGeneProductENSBTAG00000020916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79923
NFYAGeneProductENSBTAG00000009905 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001167
NKD1GeneProductENSBTAG00000012295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85407
NKD2GeneProductENSBTAG00000034435 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85409
NLKGeneProductENSBTAG00000014825 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51701
PAFAH1B1GeneProductENSBTAG00000016806 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5048
PLAUGeneProductENSBTAG00000005947 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
POU5F1GeneProductENSBTAG00000001873 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5460
PPARDGeneProductENSBTAG00000017542 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5467
PPM1JGeneProductENSBTAG00000006081 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155367
PPP2CAGeneProductENSBTAG00000000469 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5515
PPP2CBGeneProductENSBTAG00000009245 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
PPP2R1AGeneProductENSBTAG00000019851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5518
PPP2R1BGeneProductENSBTAG00000020277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5519
PPP2R2AGeneProductENSBTAG00000018317 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5520
PPP2R2BGeneProductENSBTAG00000001862 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5521
PPP2R2CGeneProductENSBTAG00000020598 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5522
PPP2R3AGeneProductENSBTAG00000023416 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5523
PPP2R3BGeneProductENSBTAG00000046338 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:28227
PPP2R4GeneProductENSBTAG00000001933 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5524
PPP2R5CGeneProductENSBTAG00000020192 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5527
PPP2R5EGeneProductENSBTAG00000019784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5529
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCBGeneProductENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCDGeneProductENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PRKCEGeneProductENSBTAG00000020614 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
PRKCGGeneProductENSBTAG00000013550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
PRKCHGeneProductENSBTAG00000003276 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
PRKCIGeneProductENSBTAG00000001403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
PRKCQGeneProductENSBTAG00000010664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
PRKCZGeneProductENSBTAG00000014119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
PRKD1GeneProductENSBTAG00000012789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
RACGAP1GeneProductENSBTAG00000012784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29127
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
SOX2GeneProductENSBTAG00000011598 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6657
TCF7GeneProductENSBTAG00000001002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081059
TCF7L1GeneProductENSBTAG00000010111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83439
TCFL2GeneProductENSBTAG00000021574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148737
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
WNT10AGeneProductENSBTAG00000009217 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80326
WNT10BGeneProductENSBTAG00000015347 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7480
WNT11GeneProductENSBTAG00000010820 (Ensembl)
  • Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7481
WNT16GeneProductENSBTAG00000002940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51384
WNT1GeneProductENSBTAG00000015364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
WNT2BGeneProductENSBTAG00000014291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
WNT2GeneProductENSBTAG00000008097 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
WNT3GeneProductENSBTAG00000016012 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7473
WNT4GeneProductENSBTAG00000022671 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54361
WNT5AGeneProductENSBTAG00000020221 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
WNT5BGeneProductENSBTAG00000001341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81029
WNT6GeneProductENSBTAG00000013990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7475
WNT7AGeneProductENSBTAG00000001668 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7476
WNT7BGeneProductENSBTAG00000009532 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477
WNT9BGeneProductENSBTAG00000002664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7484

Annotated Interactions

No annotated interactions
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