Caffeine and theobromine metabolism (Homo sapiens)

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13,7-dimethyluric acid1-methyluric acidXanthinetheobrominecaffeinePurine metabolismAFMUCYP1A2CYP1A2XDHparaxanthineXDHNAT21-methylxanthine1,7-dimethyluric acidCYP1A27-methylxanthineCYP2A67-methyluric acidXDH


Description

Metabolism pathway of two compounds commonly found in human samples: caffeine and theobromine.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Denis M. Grant, Bing K. Tang, Werner Kalow; ''Variability in caffeine metabolism''; Clinical Pharmacology and Therapeutics, 1983 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141028view12:54, 2 November 2025EweitzClear cached dimensions
141027view12:54, 2 November 2025EweitzEconomize layout
123391view06:21, 23 July 2022EgonwMade a pathway clickable
118462view15:03, 27 May 2021Marvin M2added pubmed id
117668view11:58, 22 May 2021EweitzModified title
106746view13:22, 17 September 2019MaintBotHMDB identifier normalization
103686view14:37, 28 March 2019DeSlAdded linkout to Purine PW.
85154view12:02, 21 April 2016MaintBotOntology Term : 'caffeine metabolic pathway' added !
85153view11:55, 21 April 2016MaintBotOntology Term : 'xenobiotic metabolic pathway' added !
85116view10:46, 17 April 2016EgonwAdded an XMetDB interaction ID.
85115view10:38, 17 April 2016EgonwModified description
85114view10:37, 17 April 2016EgonwAdded a reference.
85113view10:18, 17 April 2016EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,7-dimethyluric acidMetaboliteHMDB0011103 (HMDB)
1-methyluric acidMetaboliteHMDB0003099 (HMDB)
1-methylxanthineMetaboliteHMDB0010738 (HMDB)
3,7-dimethyluric acidMetaboliteHMDB0001982 (HMDB)
7-methyluric acidMetaboliteHMDB0011107 (HMDB)
7-methylxanthineMetaboliteHMDB0001991 (HMDB)
AFMUMetaboliteCHEBI:32643 (ChEBI)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
NAT2GeneProductENSG00000156006 (Ensembl)
Purine metabolismPathwayWP4224 (WikiPathways)
XDHGeneProductENSG00000158125 (Ensembl)
XanthineMetaboliteHMDB0000292 (HMDB)
caffeineMetaboliteHMDB0001847 (HMDB)
paraxanthineMetaboliteHMDB0001860 (HMDB)
theobromineMetaboliteHMDB0002825 (HMDB)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
caffeineparaxanthinemim-conversionXMETDB64 (XMetDB)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3633"
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