Hypothetical network for drug addiction (Canis familiaris)

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1Gonadotropins gene expression & secretionStrong depolarizationLong-term potentiationNeuroactive ligand-receptorinteractionMAPK signaling pathwayAMPARGnRH Signal pathwayNMDARRegulation of actin cytoskeletonmGluRGap junctionLocal TranslationRegulation of gap junctionGRIN2BconnexinGRM5Cyclic AMPGRIA3MAP2K2GiADCY8D-GlutamatePRKCEGsZHX2MAPK3MAP2K1ADCY1AC1DRD1NISCHGRIA2GRIN2DACTA1Ca++GRIA1PRKACACAMK2GRIN1PPA1GRM1GRIA4KRIT1CREB1TERF2IPCAMK4GRIN2APRKACAconnexinDRD4GRIN2CMAPK1DRD2


Description

Adapted from figure 2 in Li et al..

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 75% conversion rate.

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Ontology Terms

 

Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118083view10:44, 24 May 2021EweitzModified title
107086view14:17, 17 September 2019MaintBotChEBI identifier normalization
102909view11:10, 28 January 2019EgonwFixed the ChEBI identifier for Ca2+
88656view15:14, 12 August 2016JmeliusOntology Term : 'substance dependence disease pathway' added !
68502view21:46, 5 July 2013MaintBotUpdated to 2013 gpml schema
40653view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33946view18:19, 9 December 2009MaintBotAutomatic update of empty xrefs
32548view13:05, 17 August 2009MaintBotFixed text labels
32229view12:49, 15 August 2009MaintBotFixed text labels
31733view11:58, 14 August 2009MaintBotFixed group labels
31246view19:50, 13 August 2009MaintBotFixed text labels
30677view22:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC1GeneProduct
ACTA1GeneProduct403580 (Entrez Gene)
ADCY1GeneProduct
ADCY8GeneProduct482045 (Entrez Gene)
CAMK2GeneProduct
CAMK4GeneProduct
CREB1GeneProduct607922 (Entrez Gene)
Ca++MetaboliteCHEBI:29108 (ChEBI)
Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
D-GlutamateMetaboliteCHEBI:15966 (ChEBI)
DRD1GeneProduct489110 (Entrez Gene)
DRD2GeneProduct403701 (Entrez Gene)
DRD4GeneProduct448805 (Entrez Gene)
GRIA1GeneProduct489168 (Entrez Gene)
GRIA2GeneProduct482667 (Entrez Gene)
GRIA3GeneProduct492110 (Entrez Gene)
GRIA4GeneProduct489427 (Entrez Gene)
GRIN1GeneProduct494007 (Entrez Gene)
GRIN2AGeneProduct490012 (Entrez Gene)
GRIN2BGeneProduct494009 (Entrez Gene)
GRIN2CGeneProduct483302 (Entrez Gene)
GRIN2DGeneProduct484405 (Entrez Gene)
GRM1GeneProduct484024 (Entrez Gene)
GRM5GeneProduct485146 (Entrez Gene)
GiGeneProduct
GsGeneProduct
KRIT1GeneProduct482299 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
NISCHGeneProduct476594 (Entrez Gene)
PPA1GeneProduct479238 (Entrez Gene)
PRKACAGeneProduct403556 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene)
TERF2IPGeneProduct479643 (Entrez Gene)
ZHX2GeneProduct482033 (Entrez Gene)
connexinGeneProduct

Annotated Interactions

No annotated interactions
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