Hepatocyte growth factor receptor signaling (Rattus norvegicus)

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1ActinExtracellularAP-1TranscriptionRAC1pathwayAnoikisTrancriptionCDC42pathwayRHOpathwayTranscriptionof Cox2AKT PathwayCytoplasmChanges in Cytoskeletonand Cell mobilityGab1SrcPIK3CAMap4k1CrklItga1Ptk2Mapk1Pak1MetMapk8Map2k2PxnRap1aRaf1SrcPtpn11Elk1Stat3FosPtenItgb1Ptk2bPtk2bPtk2CrkMap2k1HgfHrasRasa1RAPGEF1Mapk3JunPxnDock1Grb2Rap1bSos1PPP


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 92% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118829view09:00, 2 June 2021DeSlAdded description from WP313
118828view08:59, 2 June 2021DeSlConverted "P" to States
118827view08:58, 2 June 2021DeSlConverted ReceptorSquare to MIM binding with lit. ref.
118826view08:57, 2 June 2021DeSlRemoved textlabel
118825view08:56, 2 June 2021DeSlOntology Term : 'hepatocyte' added !
118824view08:56, 2 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
117011view11:22, 16 May 2021EweitzModified title
109393view16:05, 16 March 2020L DupuisConverted interactions to graphical lines
69363view18:54, 8 July 2013MaintBotUpdated to 2013 gpml schema
67647view11:44, 26 June 2013DdiglesOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
41677view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
34067view19:08, 9 December 2009MaintBotAutomatic update of empty xrefs
33589view09:53, 1 December 2009MaintBotRemoved group label
31612view22:15, 13 August 2009MaintBotFixed text labels
30988view00:55, 30 July 2009MaintBotConverted from Homo sapiens
20879view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:WP94]]: Moved to stable identifier
8388view13:46, 7 January 2008MaintBot[[Pathway:Rat:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:Rattus norvegicus:Signaling of Hepatocyte Growth Factor Receptor Biocarta]]: Renaming species
7811view16:19, 18 December 2007MaintBotfixed category names
7297view12:41, 4 November 2007MaintBotAdded categories to GPML
6593view22:20, 22 May 2007169.230.77.174gpml file for [[Rat:Signaling_of_Hepatocyte_Growth_Factor_Receptor_Biocarta]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CrkGeneProduct54245 (Entrez Gene)
CrklGeneProduct287942 (Entrez Gene)
Dock1GeneProduct309081 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
Elk1GeneProduct314436 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
HgfGeneProduct24446 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
Itga1GeneProduct25118 (Entrez Gene)
Itgb1GeneProduct24511 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Map4k1GeneProduct292763 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
MetGeneProduct24553 (Entrez Gene)
PIK3CAGeneProduct170911 (Entrez Gene)
Pak1GeneProduct29431 (Entrez Gene)
PtenGeneProduct50557 (Entrez Gene)
Ptk2GeneProduct25614 (Entrez Gene)
Ptk2bGeneProduct50646 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene)
RAPGEF1GeneProduct63881 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rap1aGeneProduct295347 (Entrez Gene)
Rap1bGeneProduct171337 (Entrez Gene)
Rasa1GeneProduct25676 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SrcGeneProduct83805 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP94"
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