Hair follicle development: cytodifferentiation - stage 3 of 3 (Homo sapiens)
From WikiPathways
Description
The hair follicle (HF) is the biological unit responsible for producing a single hair shaft. The follicles are arranged with concentric epithelial progenitor layers surrounding the dermal core, which is the dermal papilla (DP). Classically, the development of the follicle itself can be divided into three stages: Induction, Organogenesis and Cytodifferentiation.
Hair follicle cytodifferentiation is the third main step in hair follicle development and leads to the formation of the bulbous peg. Source: Notch signaling and the developing hair follicle, by Geneviève Aubin-Houzelstein
Quality Tags
Ontology Terms
Bibliography
- Collu GM, Hidalgo-Sastre A, Brennan K; ''Wnt-Notch signalling crosstalk in development and disease.''; Cell Mol Life Sci, 2014 PubMed Europe PMC Scholia
- Fantauzzo KA, Kurban M, Levy B, Christiano AM; ''Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
- Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma'ayan A, Rendl M; ''Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.''; Dev Cell, 2012 PubMed Europe PMC Scholia
- Aubin-Houzelstein G; ''Notch signaling and the developing hair follicle.''; Adv Exp Med Biol, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ADAM17 | GeneProduct | P78536 (Uniprot-TrEMBL) | |
ADAMTS20 | GeneProduct | P59510 (Uniprot-TrEMBL) | |
B-catenin | GeneProduct | P35222 (Uniprot-TrEMBL) | |
BCL11B | GeneProduct | Q9C0K0 (Uniprot-TrEMBL) | |
BMP pathway | Pathway | WP1425 (WikiPathways) | |
BMP6 | Protein | P22004 (Uniprot-TrEMBL) | |
BMPR1A | GeneProduct | P36894 (Uniprot-TrEMBL) | |
Bmp4 | Protein | P12644 (Uniprot-TrEMBL) | |
Bmp6 | Protein | P22004 (Uniprot-TrEMBL) | |
CASP14 | GeneProduct | P31944 (Uniprot-TrEMBL) | |
CD200 | GeneProduct | P41217 (Uniprot-TrEMBL) | |
CD34 | Protein | P28906 (Uniprot-TrEMBL) | |
CTGF | Protein | P29279 (Uniprot-TrEMBL) | |
CUX1 | GeneProduct | P39880 (Uniprot-TrEMBL) | |
DKK1 | GeneProduct | O94907 (Uniprot-TrEMBL) | |
DKK3 | Protein | Q9UBP4 (Uniprot-TrEMBL) | |
DKK4 | Protein | Q9UBT3 (Uniprot-TrEMBL) | |
DLX3 | GeneProduct | O60479 (Uniprot-TrEMBL) | |
DSC2 | Protein | Q02487 (Uniprot-TrEMBL) | |
DSG1 | Protein | Q02413 (Uniprot-TrEMBL) | |
DSG4 | Protein | Q86SJ6 (Uniprot-TrEMBL) | |
EGFR | Protein | P00533 (Uniprot-TrEMBL) | |
EGR2 | Protein | P11161 (Uniprot-TrEMBL) | |
ELANE | GeneProduct | P08246 (Uniprot-TrEMBL) | |
Eda pathway | Pathway | ||
FGF | GeneProduct | ||
FOSB | Protein | P53539 (Uniprot-TrEMBL) | |
FOS | Protein | P01100 (Uniprot-TrEMBL) | |
FOXE1 | Protein | O00358 (Uniprot-TrEMBL) | |
FOXN1 | Protein | O15353 (Uniprot-TrEMBL) | |
FOXQ1 | GeneProduct | Q9C009 (Uniprot-TrEMBL) | |
FST | Protein | P19883 (Uniprot-TrEMBL) | |
FZD1 | Protein | Q9UP38 (Uniprot-TrEMBL) | |
GAS1 | Protein | P54826 (Uniprot-TrEMBL) | |
GATA3 | GeneProduct | P23771 (Uniprot-TrEMBL) | |
GJB6 | GeneProduct | O95452 (Uniprot-TrEMBL) | |
GPRC5D | Protein | Q9NZD1 (Uniprot-TrEMBL) | |
GSDMA | GeneProduct | Q96QA5 (Uniprot-TrEMBL) | |
Gli2 | Protein | P10070 (Uniprot-TrEMBL) | |
HOXC12 | GeneProduct | P31275 (Uniprot-TrEMBL) |
|
HOXC13 | GeneProduct | O60479 (Uniprot-TrEMBL) |
|
HR | GeneProduct | O43593 (Uniprot-TrEMBL) | Mx,Cx,Bulb |
IGFBP5 | GeneProduct | P24593 (Uniprot-TrEMBL) | |
IGF | Protein | P05019 (Uniprot-TrEMBL) | |
Interferon gamma | Protein | P01579 (Uniprot-TrEMBL) | |
JUN | Protein | P05412 (Uniprot-TrEMBL) | |
KITLG | GeneProduct | P21583 (Uniprot-TrEMBL) | |
KLK13 | Protein | Q9UKR3 (Uniprot-TrEMBL) | |
KLK14 | Protein | Q9P0G3 (Uniprot-TrEMBL) | |
KLK4 | Protein | Q9Y5K2 (Uniprot-TrEMBL) | |
KLK5 | Protein | Q9Y337 (Uniprot-TrEMBL) | |
KLK6 | Protein | Q92876 (Uniprot-TrEMBL) | |
KLK7 | Protein | P49862 (Uniprot-TrEMBL) | |
KRT15 | GeneProduct | P19012 (Uniprot-TrEMBL) | |
KRT19 | GeneProduct | P08727 (Uniprot-TrEMBL) | |
KRTAP15 | Protein | Q3LI76 (Uniprot-TrEMBL) | |
KRTAP2-4 | Protein | Q9BYR9 (Uniprot-TrEMBL) | |
KRTAP3-3 | GeneProduct | Q9BYR6 (Uniprot-TrEMBL) | |
KRTAP6-1 | Protein | Q3LI64 (Uniprot-TrEMBL) | |
KRTAP8-1 | Protein | Q8IUC2 (Uniprot-TrEMBL) | |
KRTs | GeneProduct | (1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1 | |
LEF1 | Protein | Q9UJU2 (Uniprot-TrEMBL) | |
LGR5 | Protein | O75473 (Uniprot-TrEMBL) | |
LHX2 | Protein | P50458 (Uniprot-TrEMBL) | |
LRIG1 | Protein | Q96JA1 (Uniprot-TrEMBL) | |
MSX1 | Protein | P28360 (Uniprot-TrEMBL) | Mx,Cx,Bulb |
MSX2 | Protein | P35548 (Uniprot-TrEMBL) | Mx,Cx,Bulb |
NFATC1 | GeneProduct | O95644 (Uniprot-TrEMBL) | |
NFKB1 | Protein | P19838 (Uniprot-TrEMBL) | |
NOTCH1 | GeneProduct | ||
NR3C1 | GeneProduct | P04150 (Uniprot-TrEMBL) | |
Nf-kappaB | Protein | P19838 (Uniprot-TrEMBL) | |
Noggin | Protein | Q9BZE4 (Uniprot-TrEMBL) | |
Notch pathway | Pathway | WP268 (WikiPathways) | |
Notch1 | GeneProduct | P46531 (Uniprot-TrEMBL) | |
Notch2 | GeneProduct | Q04721 (Uniprot-TrEMBL) | |
PERP | Protein | Q96FX8 (Uniprot-TrEMBL) | |
PHLDA1 | GeneProduct | Q8WV24 (Uniprot-TrEMBL) | |
PROM1 | Protein | O43490 (Uniprot-TrEMBL) | |
RBPJ | GeneProduct | Q06330 (Uniprot-TrEMBL) | |
RUNX3 | Protein | Q13761 (Uniprot-TrEMBL) | |
S100A4 | GeneProduct | P26447 (Uniprot-TrEMBL) | |
SCF/c-kit signaling | Pathway | ||
SFRP1 | Protein | Q8N474 (Uniprot-TrEMBL) | |
SOSTDC1 | GeneProduct | Q6X4U4 (Uniprot-TrEMBL) | |
SOX2 | Protein | P48431 (Uniprot-TrEMBL) | |
SOX9 | GeneProduct | P48436 (Uniprot-TrEMBL) | |
SPINK5 | GeneProduct | Q9NQ38 (Uniprot-TrEMBL) | |
SPINK6 | GeneProduct | Q6UWN8 (Uniprot-TrEMBL) | |
Shh Pathway | Pathway | WP4249 (WikiPathways) | |
Shh pathway | Pathway | WP4249 (WikiPathways) | |
Smad1 | Protein | Q15797 (Uniprot-TrEMBL) | |
Smad4 | Protein | Q13485 (Uniprot-TrEMBL) | |
Stem cell compartment | |||
TCF3 | GeneProduct | P15923 (Uniprot-TrEMBL) | |
TCF4 | GeneProduct | P15884 (Uniprot-TrEMBL) | |
TGFB | Protein | P01137 (Uniprot-TrEMBL) | |
TP63 | Protein | Q9H3D4 (Uniprot-TrEMBL) | |
WIF1 | Protein | Q9Y5W5 (Uniprot-TrEMBL) | |
WNT5A | Protein | P41221 (Uniprot-TrEMBL) | |
Wnt pathway | Pathway | WP428 (WikiPathways) | |
Wnt5a | Protein | P41221 (Uniprot-TrEMBL) | |
ZBRB16 | GeneProduct | ENSG00000109906 (Ensembl) | Name of GeneProduct (ZFP145) is only know for Rattus norv.; found ortholog through Ensemble (1-to-1 mapping, name is ZBRB16 for Homo sap. ) |
Annotated Interactions
No annotated interactions