Mitochondrial beta-oxidation (Homo sapiens)

From WikiPathways

Revision as of 08:29, 21 June 2022 by DeSl (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Jump to: navigation, search

Description

Human mitochondrial beta oxidation

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

Bibliography

View all...

Alphey MS, Yu W, Byres E, Li D, Hunter WN; ''Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK; ''The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.''; Acta Crystallogr D Biol Crystallogr, 2014 PubMed Europe PMC Scholia
Yamada K, Aiba K, Kitaura Y, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N; ''Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion.''; J Med Genet, 2015 PubMed Europe PMC Scholia
Rozen R, Vockley J, Zhou L, Milos R, Willard J, Fu K, Vicanek C, Low-Nang L, Torban E, Fournier B; ''Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family.''; Genomics, 1994 PubMed Europe PMC Scholia
He XY, Schulz H, Yang SY; ''A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
Vredendaal PJ, van den Berg IE, Malingré HE, Stroobants AK, Olde Weghuis DE, Berger R; ''Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.''; Biochem Biophys Res Commun, 1996 PubMed Europe PMC Scholia
Takahashi Y, Hirata Y, Burstein Y, Listowsky I; ''Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices.''; Biochem J, 1994 PubMed Europe PMC Scholia

History

View all...

Revision	Action	Time	User	Comment
124023	view	15:56, 13 September 2022	Conroy lipids	rheas
124022	view	15:22, 13 September 2022	Conroy lipids	rheas
124017	view	13:12, 13 September 2022	Conroy lipids
124016	view	11:31, 13 September 2022	Conroy lipids	add more rheas
124015	view	11:21, 13 September 2022	Conroy lipids	more rheas
124014	view	08:52, 13 September 2022	Conroy lipids	add rhea ids to some mim conversions
123984	view	10:48, 9 September 2022	Eweitz	Modified description
123983	view	10:48, 9 September 2022	Eweitz	Modified title
123892	view	09:30, 25 August 2022	Conroy lipids	update some IDs to lipidmaps, start addng rhea ids
123868	view	09:45, 22 August 2022	Conroy lipids	fix anchor
123856	view	17:12, 18 August 2022	Conroy lipids	anchors again
123855	view	15:38, 18 August 2022	Conroy lipids
123854	view	15:35, 18 August 2022	Conroy lipids
123853	view	15:32, 18 August 2022	Conroy lipids
123852	view	15:28, 18 August 2022	Conroy lipids
123851	view	15:10, 18 August 2022	Conroy lipids	add acnchors, links
123850	view	12:27, 18 August 2022	Conroy lipids	fixed some unlinked nodes. still more to go
123052	view	08:39, 21 June 2022	DeSl	Updating Swissprot entries to TrEMBL
123051	view	08:36, 21 June 2022	DeSl	Updating Swissprot entries to TrEMBL
123050	view	08:32, 21 June 2022	DeSl	Updating database ID for 3-oxo-7Z,10Z,13Z,16Z,19Z-docosapentaenoyl-CoA to LIPIDMAPS iso inchikey
123049	view	08:30, 21 June 2022	DeSl	Ontology Term : 'classic metabolic pathway' added !
123048	view	08:30, 21 June 2022	DeSl	Ontology Term : 'lipid metabolic pathway' added !
123047	view	08:29, 21 June 2022	DeSl	Ontology Term : 'fatty acid beta degradation pathway' added !
123046	view	06:59, 21 June 2022	Egonw	LM not KEGG.
123045	view	12:13, 20 June 2022	Conroy lipids	add some fatty-acyl coa ligases
123044	view	09:19, 20 June 2022	Conroy lipids	Modified title
123043	view	09:17, 20 June 2022	Conroy lipids	New pathway

External references

DataNodes

View all...

Name	Type	Database reference
(2E,9Z,12Z)-octadecatrienoyl-CoA	Metabolite	LMFA07050404 (LIPID MAPS)
(9Z,12Z)-3-oxolinoleoyl-CoA	Metabolite	LMFA07050136 (LIPID MAPS)
2E,4E,7Z,10Z,13Z,16Z,19Z-Docosaheptaenoyl-CoA	Metabolite	LMFA07050171 (LIPID MAPS)
2E,4Z,7Z,10Z,13Z-hexadecapentaenoyl-CoA	Metabolite	LMFA07050453 (LIPID MAPS)
2E,4Z,7Z,10Z-hexadecatetraenoyl-CoA	Metabolite	LMFA07050484 (LIPID MAPS)
2E,4Z,7Z-decatrienoyl-CoA	Metabolite	LMFA07050466 (LIPID MAPS)
2E,4Z-decadienoyl-CoA	Metabolite	LMFA07050110 (LIPID MAPS)
2E,5Z,8Z,11Z,14Z,17Z-eicosahexaenoyl-CoA	Metabolite	LMFA07050445 (LIPID MAPS)
2E,5Z,8Z,11Z,14Z-eicosapentaenoyl-CoA	Metabolite	LMFA07050410 (LIPID MAPS)
2E,5Z,8Z,11Z-tetradecatetraenoyl-CoA	Metabolite	LMFA07050458 (LIPID MAPS)
2E,5Z,8Z-tetradecatrienoyl-CoA	Metabolite	LMFA07050468 (LIPID MAPS)
2E,5Z-dodecadienoyl-CoA	Metabolite	LMFA07050375 (LIPID MAPS)
2E,5Z-octadienoyl-CoA	Metabolite	LMFA07050433 (LIPID MAPS)
2E,5Z-tetradecadienoyl-CoA	Metabolite	LMFA07050421 (LIPID MAPS)
2E,6Z,9Z,12Z,15Z-octadecapentaenoyl-CoA	Metabolite	LMFA07050449 (LIPID MAPS)
2E,6Z,9Z,12Z-octadecatetraenoyl-CoA	Metabolite	LMFA07050407 (LIPID MAPS)
2E,6Z,9Z-dodecatrienoyl-CoA	Metabolite	LMFA07050462 (LIPID MAPS)
2E,6Z-dodecadienoyl-CoA	Metabolite	LMFA07050111 (LIPID MAPS)
2E,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl-CoA	Metabolite	LMFA07050443 (LIPID MAPS)
2E,7Z,10Z,13Z-hexadecatetraenoyl-CoA	Metabolite	LMFA07050428 (LIPID MAPS)
2E,7Z,10Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050429 (LIPID MAPS)
2E,7Z-decadienoyl-CoA	Metabolite	LMFA07050437 (LIPID MAPS)
2E,7Z-hexadacadienoyl-CoA	Metabolite	LMFA07050418 (LIPID MAPS)
2E,7Z-tetradecadienoyl-CoA	Metabolite	LMFA07050477 (LIPID MAPS)
2E,9Z,12Z,15Z-octadecatetraenoyl-CoA	Metabolite	LMFA07050424 (LIPID MAPS)
2E,9Z-octadecadienoyl-CoA	Metabolite	LMFA07050414 (LIPID MAPS)
2E-9Z-hexadecadienoyl-CoA	Metabolite	LMFA07050473 (LIPID MAPS)
2E-Decenoyl-CoA	Metabolite	LMFA07050391 (LIPID MAPS)
2E-Dodecenoyl-CoA	Metabolite	LMFA07050176 (LIPID MAPS)
2E-Octadecenoyl-CoA	Metabolite	LMFA07050385 (LIPID MAPS)
2E-butanoyl-CoA	Metabolite	LMFA07050307 (LIPID MAPS)
2E-hexadecenoyl-CoA	Metabolite	LMFA07050144 (LIPID MAPS)
2E-hexenoyl-CoA	Metabolite	LMFA07050393 (LIPID MAPS)
2E-octanoyl-CoA	Metabolite	LMFA07050394 (LIPID MAPS)
2E-tetradecenoyl-CoA	Metabolite	LMFA07050396 (LIPID MAPS)
3-Oxohexanoyl-CoA	Metabolite	LMFA07050242 (LIPID MAPS)
3-oxo-5Z,8Z,11Z-tetradecatrienoyl-CoA	Metabolite	LMFA07050460 (LIPID MAPS)
3-oxo-5Z,8Z-tetradecadienoyl-CoA	Metabolite	LMFA07050470 (LIPID MAPS)
3-oxo-5Z-dodecenoyl-CoA	Metabolite	LMFA07050482 (LIPID MAPS)
3-oxo-5Z-octenoyl-CoA	Metabolite	LMFA07050431 (LIPID MAPS)
3-oxo-5Z-tetradecenoyl-CoA	Metabolite	LMFA07050423 (LIPID MAPS)
3-oxo-6Z,9Z,12Z,15Z-octadecatetraenoyl-CoA	Metabolite	LMFA07050451 (LIPID MAPS)
3-oxo-6Z-dodecenoyl-CoA	Metabolite	LMFA07050472 (LIPID MAPS)
3-oxo-7Z,10Z,13Z,16Z,19Z-docosapentaenoyl-CoA	Metabolite	LMFA07050130 (InChIKey)
3-oxo-7Z,10Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050440 (LIPID MAPS)
3-oxo-7Z-decenoyl-CoA	Metabolite	LMFA07050435 (LIPID MAPS)
3-oxo-7Z-hexadecenoyl-CoA	Metabolite	LMFA07050420 (LIPID MAPS)
3-oxo-7Z-tetradecadienoyl-CoA	Metabolite	LMFA07050479 (LIPID MAPS)
3-oxo-9Z,12Z,15Z-octadecatrienoyl-CoA	Metabolite	LMFA07050426 (LIPID MAPS)
3-oxo-9Z-hexadecenoyl-CoA	Metabolite	LMFA07050475 (LIPID MAPS)
3-oxo-Hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA	Metabolite	LMFA07050447 (LIPID MAPS)
3-oxo-arachidonoyl-CoA	Metabolite	LMFA07050412 (LIPID MAPS)
3-oxo-butanoyl-CoA	Metabolite	LMFA07050030 (LIPID MAPS)
3-oxo-decanoyl-CoA	Metabolite	LMFA07050239 (LIPID MAPS)
3-oxo-dodecadienoyl-CoA	Metabolite	LMFA07050464 (LIPID MAPS)
3-oxo-gamma-linoleoyl-CoA	Metabolite	LMFA07050409 (LIPID MAPS)
3-oxo-lauroyl-CoA	Metabolite	C05263 (KEGG Compound)
3-oxo-myristoyl-CoA	Metabolite	LMFA07050256 (LIPID MAPS)
3-oxo-octanoyl-CoA	Metabolite	LMFA07050249 (LIPID MAPS)
3-oxo-oleoyl-CoA	Metabolite	LMFA07050416 (LIPID MAPS)
3-oxopalmitoyl-CoA	Metabolite	LMFA07050250 (LIPID MAPS)
3-oxostearoyl-CoA	Metabolite	LMFA07050248 (LIPID MAPS)
3E,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl-CoA	Metabolite	LMFA07050442 (LIPID MAPS)
3E,7Z,10Z,13Z-hexadecatetraenoyl-CoA	Metabolite	LMFA07050454 (LIPID MAPS)
3E,7Z,10Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050485 (LIPID MAPS)
3E,7Z-decadienoyl-CoA	Metabolite	LMFA07050467 (LIPID MAPS)
3E-decenoyl-CoA	Metabolite	LMFA07050386 (LIPID MAPS)
3S-Hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA	Metabolite	LMFA07050446 (LIPID MAPS)
3S-Hydroxy-5Z,8Z,11Z-tetradecatrienoyl-CoA	Metabolite	LMFA07050459 (LIPID MAPS)
3S-Hydroxy-5Z-dodecenoyl-CoA	Metabolite	LMFA07050481 (LIPID MAPS)
3S-Hydroxy-5Z-octenoyl-CoA	Metabolite	LMFA07050432 (LIPID MAPS)
3S-Hydroxy-6Z,9Z,12Z,15Z-octadecatetraenoyl-CoA	Metabolite	LMFA07050450 (LIPID MAPS)
3S-Hydroxy-6Z-dodecenoyl-CoA	Metabolite	LMFA07050471 (LIPID MAPS)
3S-Hydroxy-7Z,10Z,13Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050455 (LIPID MAPS)
3S-Hydroxy-7Z-decenoyl-CoA	Metabolite	LMFA07050436 (LIPID MAPS)
3S-Hydroxy-7Z-hexadecenoyl-CoA	Metabolite	LMFA07050419 (LIPID MAPS)
3S-Hydroxy-9Z-hexadecenoyl-CoA	Metabolite	LMFA07050474 (LIPID MAPS)
3S-Hydroxy-arachidonoyl-CoA	Metabolite	LMFA07050411 (LIPID MAPS)
3S-Hydroxy-dodecadienoyl-CoA	Metabolite	LMFA07050463 (LIPID MAPS)
3S-Hydroxy-oleoyl-CoA	Metabolite	LMFA07050415 (LIPID MAPS)
3S-Hydroxymyristoyl-CoA	Metabolite	LMFA07050257 (LIPID MAPS)
3S-hydroxy-5Z,8Z-tetradecadienoyl-CoA	Metabolite	LMFA07050469 (LIPID MAPS)
3S-hydroxy-5Z-tetradecadienoyl-CoA	Metabolite	LMFA07050422 (LIPID MAPS)
3S-hydroxy-7Z,10Z,13Z,16Z,19Z-docosapentaenoyl-CoA	Metabolite	LMFA07050444 (LIPID MAPS)
3S-hydroxy-7Z,10Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050439 (LIPID MAPS)
3S-hydroxy-7Z-tetradecadienoyl-CoA	Metabolite	LMFA07050478 (LIPID MAPS)
3S-hydroxy-9Z,12Z,15Z-octadecatrienoyl-CoA	Metabolite	LMFA07050425 (LIPID MAPS)
3S-hydroxy-9Z,12Z-octadecadienoyl-CoA	Metabolite	LMFA07050405 (LIPID MAPS)
3S-hydroxy-decanoyl-CoA	Metabolite	LMFA07050403 (LIPID MAPS)
3S-hydroxy-gamma-linoleoyl-CoA	Metabolite	JCYIHBAQURWSOM-MVHVANHMSA-N (InChIKey)
3S-hydroxy-octanoyl-CoA	Metabolite	LMFA07050160 (LIPID MAPS)
3S-hydroxybutanoyl-CoA	Metabolite	LMFA07050153 (LIPID MAPS)
3S-hydroxyhexanoyl-CoA	Metabolite	LMFA07050156 (LIPID MAPS)
3S-hydroxylauroyl-CoA	Metabolite	LMFA07050158 (LIPID MAPS)
3S-hydroxypalmitoyl-CoA	Metabolite	LMFA07050161 (LIPID MAPS)
3S-hydroxystearoyl-CoA	Metabolite	LMFA07050159 (LIPID MAPS)
3Z,6Z,9Z,12Z,15Z-octadecapentaenoyl-CoA	Metabolite	LMFA07050448 (LIPID MAPS)
3Z,6Z,9Z,12Z-octadecatetraenoyl-CoA	Metabolite	LMFA07050413 (LIPID MAPS)
3Z,6Z,9Z-dodecatrienoyl-CoA	Metabolite	LMFA07050461 (LIPID MAPS)
3Z,6Z-dodecadienoyl-CoA	Metabolite	LMFA07050295 (LIPID MAPS)
3Z-decenoyl-CoA	Metabolite	LMFA07050483 (LIPID MAPS)
3Z-dodecenoyl-CoA	Metabolite	LMFA07050302 (LIPID MAPS)
3Z-hexenoyl-CoA	Metabolite	LMFA07050430 (LIPID MAPS)
3oxo-7Z,10Z,13Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050456 (LIPID MAPS)
4Z,7Z,10Z,13Z-hexadecatetraenoyl-CoA	Metabolite	LMFA07050452 (LIPID MAPS)
4Z,7Z,10Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050438 (LIPID MAPS)
4Z,7Z-decadienoyl-CoA	Metabolite	LMFA07050465 (LIPID MAPS)
4Z-decenoyl-CoA	Metabolite	LMFA07050301 (LIPID MAPS)
5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid	Metabolite	LMFA01030759 (LIPID MAPS)
5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA	Metabolite	LMFA07050122 (LIPID MAPS)
5Z,8Z,11Z-tetradecatrienoyl-CoA	Metabolite	LMFA07050457 (LIPID MAPS)
5Z,8Z-tetradecadienoyl-CoA	Metabolite	LMFA07050296 (LIPID MAPS)
5Z-dodecenoyl-CoA	Metabolite	LMFA07050480 (LIPID MAPS)
5Z-octenoyl-CoA	Metabolite	LMFA07050434 (LIPID MAPS)
5Z-tetradecenoyl-CoA	Metabolite	LMFA07050305 (LIPID MAPS)
7Z,10Z,13Z-hexadecatrienoyl-CoA	Metabolite	LMFA07050427 (LIPID MAPS)
7Z,10Z-hexadecadienoyl-CoA	Metabolite	LMFA07050406 (LIPID MAPS)
7Z-hexadecenoyl-CoA	Metabolite	LMFA07050417 (LIPID MAPS)
7Z-tetradecenoyl-CoA	Metabolite	LMFA07050476 (LIPID MAPS)
9-palmitoleoyl-CoA	Metabolite	LMFA07050359 (LIPID MAPS)
9Z,12Z,15Z-octadecatrienoyl-CoA	Metabolite	LMFA07050286 (LIPID MAPS)
9Z-palmitoleic acid	Metabolite	LMFA01030056 (LIPID MAPS)
ACAA2	GeneProduct	P42765 (Uniprot-SwissProt)
ACADSB	GeneProduct	P45954 (Uniprot-SwissProt)
Acetyl-CoA	Metabolite	LMFA07050281 (LIPID MAPS)
Arachidonic acid	Metabolite	LMFA01030001 (LIPID MAPS)
Arachidonyl-CoA	Metabolite	LMFA07050288 (LIPID MAPS)
Butyryl-CoA	Metabolite	LMFA07050292 (LIPID MAPS)
DECR1	GeneProduct	Q16698 (Uniprot-SwissProt)
Decanoyl-CoA	Metabolite	LMFA07050313 (LIPID MAPS)
Docosahexaenoic acid	Metabolite	LMFA01030185 (LIPID MAPS)
ECHS1	GeneProduct	P30084 (Uniprot-SwissProt)
ECI1	GeneProduct	P42126 (Uniprot-SwissProt)
HSD17B10	GeneProduct	Q99714 (Uniprot-SwissProt)
Hexanoyl-CoA	Metabolite	LMFA07050328 (LIPID MAPS)
Lauric acid	Metabolite	LMFA01010012 (LIPID MAPS)
Lauroyl-CoA	Metabolite	LMFA07050340 (LIPID MAPS)
Linoleic acid	Metabolite	LMFA01030120 (LIPID MAPS)
Linoleoyl-CoA	Metabolite	LMFA07050343 (LIPID MAPS)
Long-chain-fatty-acid--CoA ligase	Protein	6.2.1.3 (BRENDA)
Myristic acid	Metabolite	LMFA01010014 (LIPID MAPS)
Octanoyl-CoA	Metabolite	LMFA07050355 (LIPID MAPS)
Oleic acid	Metabolite	LMFA01030002 (LIPID MAPS)
Palmitic acid	Metabolite	LMFA01010001 (LIPID MAPS)
Palmitoyl-CoA	Metabolite	LMFA07050360 (LIPID MAPS)
Stearic acid	Metabolite	LMFA01010018 (LIPID MAPS)
Stearoyl-CoA	Metabolite	LMFA07050369 (LIPID MAPS)
alpha-Linolenic acid	Metabolite	LMFA01030152 (LIPID MAPS)
docosahexaenoyl-CoA	Metabolite	LMFA07050121 (LIPID MAPS)
gamma-Linolenic acid	Metabolite	LMFA01030141 (LIPID MAPS)
gamma-linolenoyl-CoA	Metabolite	LMFA07050322 (LIPID MAPS)
myristoyl-CoA	Metabolite	LMFA07050352 (LIPID MAPS)
oleoyl-CoA	Metabolite	LMFA07050356 (LIPID MAPS)

Annotated Interactions

View all...

Source	Type	Database reference
ACADSB	mim-catalysis	1.3.8.5 (BRENDA)
DECR1	mim-catalysis	1.3.1.124 (BRENDA)
ECHS1	mim-catalysis	4.2.1.17 (BRENDA)
ECI1	mim-catalysis	5.3.3.8 (BRENDA)
HSD17B10	mim-catalysis	1.1.1.35 (BRENDA)
	mim-catalysis	1.1.1.35 (BRENDA)
	mim-catalysis	1.3.8.5 (BRENDA)
	mim-catalysis	4.2.1.17 (BRENDA)
	mim-catalysis	5.3.3.8 (BRENDA)

Mitochondrial beta-oxidation (Homo sapiens)

From WikiPathways

Description

Try the New WikiPathways

Quality Tags

Ontology Terms

Bibliography

History

External references

DataNodes

Annotated Interactions

Views

Personal tools

search

Download

Activity

Tools

Community Portals

Toolbox