eIF5A regulation in response to inhibition of the nuclear export system (Homo sapiens)
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Description
Model of eIF5A regulation in response to inhibition of the nuclear export system. Under normal conditions, IGF2BP1 is exported by XPO1 and binds to eIF5A in cytoplasm. The binding with IGF2BP1 prevents eIF5A from accumulating in mitochondria. SINE (Selective Inhibitors of Nuclear Export) inhibits the nuclear export of IGF2BP1, resulting in decreased cytoplasmic IGF2BP1. Unbound eIF5A accumulates in mitochondria and induces apoptosis.
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Ontology Terms
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- Miyake T, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, Gharpure KM, Nagaraja AS, Hu W, Cho MS, Dalton HJ, Previs RA, Taylor ML, Hisamatsu T, Kang Y, Liu T, Shacham S, McCauley D, Hawke DH, Wiktorowicz JE, Coleman RL, Sood AK; ''XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia
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External references
DataNodes
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Apoptosis | Pathway | WP254 (WikiPathways)  | |
| CRM1 | GeneProduct | ENSG00000082898 (Ensembl) | |
| EIF5A | GeneProduct | ENSG00000132507 (Ensembl) | |
| EXP4 | GeneProduct | ENSG00000132953 (Ensembl) | |
| IGF2BP1 | GeneProduct | ENSG00000159217 (Ensembl) |
Annotated Interactions
No annotated interactions
