ATM signaling in development and disease (Homo sapiens)

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1PPP activationATM substrateLegendHypotonic Stress V(D)JDNA Damage AutophagyOxidative StressCSRMRE11APPP2R4CDKRNF8Rad50RNF20NF-KBCdc25p38CTIPATMINCDK5CHK2Cell CycleBub1RIF1CHK1RNF40uH2BLamin-BCEP63KAP1RNF168ATF2WIP1HMGN1mTORC153BP1MRE11BuH2ANEMOLKB1G6PDAurora BTSC2AMPKHDAC4XLFNbs1ATMHMGN1SMC1Reactive Oxygen Species DNAPKcsATRArtemisp38MAPKPPP2R4PP5ATMMDC1HSP27TIP60H2AXATMATMATMMRE11ARad50Nbs1ATMNbs1MRE11ARad50ATMATMchromatin relaxationImmunityDNA repairNeuronal survivaltranscriptionalsilencingchromatin retentioncheckpointactivationG1/Sintra-SG2/MSACMRE11BMRE11Bcell cycle checkpointcellular process or ATM function


Description

This pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage through the appropriate cellular programs such as transcription, translation, etc etc. The ataxia-telangiectasia mutated (ATM) kinase acts as the main core of this pathway acting upon or receiving a lot of the reactions towards other gene products. ATM substrates use several different cell cycle checkpoints to determine the health of the DNA, and determine different types of disease/damage done to the DNA. The p38MAPK which is a reaction by ATM later leads to HSP27 which inhibits oxidative stress within the cell. DDR and ATM both work to help the cell recover from any damage it has received and understanding how ATM works will help increase doctors and scientists understanding of diseases, and their treatment. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

  1. Stracker TH, Roig I, Knobel PA, Marjanović M; ''The ATM signaling network in development and disease.''; Front Genet, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128977view18:05, 26 February 2024Khanspersclarify connection to checkpoint activation
128958view14:50, 25 February 2024EgonwFixed a datasource
128600view02:05, 15 February 2024EweitzTweak placement
128599view02:04, 15 February 2024EweitzTuck straggling node
128598view02:01, 15 February 2024EweitzEconomize layout, standardize case
127927view19:35, 17 January 2024Khanspersupdated xrefs, lables
127911view07:10, 13 January 2024Khanspersupdated and xrefs and cleaned up pathway nodes
127910view06:34, 13 January 2024Khanspersupdated xrefs
123399view06:26, 23 July 2022EgonwMade a pathway clickable
117656view11:51, 22 May 2021EweitzModified title
106756view13:23, 17 September 2019MaintBotHMDB identifier normalization
105871view04:47, 16 August 2019KhanspersModified description
105432view04:33, 8 August 2019KhanspersModified description
89745view23:52, 29 September 2016KhanspersModified title
89623view19:41, 21 September 2016Khanspersupdated labels, some xrefs, added legend and coloring
88965view22:23, 17 August 2016AAR&CoModified description
88964view22:20, 17 August 2016AAR&CoModified description
88962view22:15, 17 August 2016AAR&CoModified description
88856view15:59, 16 August 2016AAR&CoModified description
88849view22:17, 15 August 2016AAR&CoOntology Term : 'G1 phase pathway' added !
88848view22:16, 15 August 2016AAR&CoOntology Term : 'DNA repair pathway' added !
88847view22:15, 15 August 2016AAR&CoAdded Literature Reference
88846view22:13, 15 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
53BP1GeneProductENSG00000067369 (Ensembl)
AMPKGeneProductENSG00000132356 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATMINGeneProductENSG00000166454 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
ArtemisGeneProductENSG00000152457 (Ensembl)
Aurora BGeneProductENSG00000178999 (Ensembl)
Bub1GeneProductENSG00000169679 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDKGeneProductENSG00000170312 (Ensembl)
CEP63GeneProductENSG00000182923 (Ensembl)
CHK1GeneProductENSG00000149554 (Ensembl)
CHK2GeneProductENSG00000183765 (Ensembl)
CTIPGeneProductENSG00000101773 (Ensembl)
Cdc25GeneProductENSG00000058335 (Ensembl)
Cell CyclePathwayWP45 (WikiPathways)
DNAPKcsGeneProductENSG00000253729 (Ensembl)
G6PDGeneProductENSG00000160211 (Ensembl)
H2AXGeneProductENSG00000188486 (Ensembl)
HDAC4GeneProductENSG00000068024 (Ensembl)
HMGN1GeneProductENSG00000205581 (Ensembl)
HSP27GeneProductENSG00000106211 (Ensembl)
KAP1GeneProductENSG00000130726 (Ensembl)
LKB1GeneProductENSG00000118046 (Ensembl)
Lamin-BGeneProductENSG00000143815 (Ensembl)
MDC1GeneProductENSG00000137337 (Ensembl)
MRE11AGeneProductENSG00000020922 (Ensembl)
MRE11BGeneProductENSG00000242537 (Ensembl)
NEMOGeneProductENSG00000269335 (Ensembl)
NF-KBGeneProductENSG00000109320 (Ensembl)
Nbs1GeneProductENSG00000104320 (Ensembl)
PP5GeneProductENSG00000011485 (Ensembl)
PPP2R4GeneProductENSG00000119383 (Ensembl)
RIF1GeneProductENSG00000080345 (Ensembl)
RNF168GeneProductENSG00000163961 (Ensembl)
RNF20GeneProductENSG00000155827 (Ensembl)
RNF40GeneProductENSG00000103549 (Ensembl)
RNF8GeneProductENSG00000112130 (Ensembl)
Rad50GeneProductENSG00000113522 (Ensembl)
Reactive Oxygen Species MetaboliteHMDB0003125 (HMDB)
SMC1GeneProductENSG00000072501 (Ensembl)
TIP60GeneProductENSG00000172977 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
WIP1GeneProductENSG00000170836 (Ensembl)
XLFGeneProductENSG00000152457 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)
p38GeneProductENSG00000176749 (Ensembl)
p38MAPKGeneProductENSG00000197442 (Ensembl)
uH2AGeneProductIdentifier not Found
uH2BGeneProductIdentifier not Found

Annotated Interactions

No annotated interactions

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