Mitochondrial beta-oxidation (Homo sapiens)
From WikiPathways
Description
Human mitochondrial beta oxidation
Quality Tags
Ontology Terms
Bibliography
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- Alphey MS, Yu W, Byres E, Li D, Hunter WN; ''Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
- Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK; ''The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.''; Acta Crystallogr D Biol Crystallogr, 2014 PubMed Europe PMC Scholia
- Yamada K, Aiba K, Kitaura Y, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N; ''Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion.''; J Med Genet, 2015 PubMed Europe PMC Scholia
- Rozen R, Vockley J, Zhou L, Milos R, Willard J, Fu K, Vicanek C, Low-Nang L, Torban E, Fournier B; ''Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family.''; Genomics, 1994 PubMed Europe PMC Scholia
- He XY, Schulz H, Yang SY; ''A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
- Vredendaal PJ, van den Berg IE, Malingré HE, Stroobants AK, Olde Weghuis DE, Berger R; ''Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.''; Biochem Biophys Res Commun, 1996 PubMed Europe PMC Scholia
- Takahashi Y, Hirata Y, Burstein Y, Listowsky I; ''Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices.''; Biochem J, 1994 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
(2E,9Z,12Z)-octadecatrienoyl-CoA | Metabolite | LMFA07050404 (LIPID MAPS) | |
(9Z,12Z)-3-oxolinoleoyl-CoA | Metabolite | LMFA07050136 (LIPID MAPS) | |
2E,4E,7Z,10Z,13Z,16Z,19Z-Docosaheptaenoyl-CoA | Metabolite | LMFA07050171 (LIPID MAPS) | |
2E,4Z,7Z,10Z,13Z-hexadecapentaenoyl-CoA | Metabolite | LMFA07050453 (LIPID MAPS) | |
2E,4Z,7Z,10Z-hexadecatetraenoyl-CoA | Metabolite | LMFA07050484 (LIPID MAPS) | |
2E,4Z,7Z-decatrienoyl-CoA | Metabolite | LMFA07050466 (LIPID MAPS) | |
2E,4Z-decadienoyl-CoA | Metabolite | LMFA07050110 (LIPID MAPS) | |
2E,5Z,8Z,11Z,14Z,17Z-eicosahexaenoyl-CoA | Metabolite | LMFA07050445 (LIPID MAPS) | |
2E,5Z,8Z,11Z,14Z-eicosapentaenoyl-CoA | Metabolite | LMFA07050410 (LIPID MAPS) | |
2E,5Z,8Z,11Z-tetradecatetraenoyl-CoA | Metabolite | LMFA07050458 (LIPID MAPS) | |
2E,5Z,8Z-tetradecatrienoyl-CoA | Metabolite | LMFA07050468 (LIPID MAPS) | |
2E,5Z-dodecadienoyl-CoA | Metabolite | LMFA07050375 (LIPID MAPS) | |
2E,5Z-octadienoyl-CoA | Metabolite | LMFA07050433 (LIPID MAPS) | |
2E,5Z-tetradecadienoyl-CoA | Metabolite | LMFA07050421 (LIPID MAPS) | |
2E,6Z,9Z,12Z,15Z-octadecapentaenoyl-CoA | Metabolite | LMFA07050449 (LIPID MAPS) | |
2E,6Z,9Z,12Z-octadecatetraenoyl-CoA | Metabolite | LMFA07050407 (LIPID MAPS) | |
2E,6Z,9Z-dodecatrienoyl-CoA | Metabolite | LMFA07050462 (LIPID MAPS) | |
2E,6Z-dodecadienoyl-CoA | Metabolite | LMFA07050111 (LIPID MAPS) | |
2E,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl-CoA | Metabolite | LMFA07050443 (LIPID MAPS) | |
2E,7Z,10Z,13Z-hexadecatetraenoyl-CoA | Metabolite | LMFA07050428 (LIPID MAPS) | |
2E,7Z,10Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050429 (LIPID MAPS) | |
2E,7Z-decadienoyl-CoA | Metabolite | LMFA07050437 (LIPID MAPS) | |
2E,7Z-hexadacadienoyl-CoA | Metabolite | LMFA07050418 (LIPID MAPS) | |
2E,7Z-tetradecadienoyl-CoA | Metabolite | LMFA07050477 (LIPID MAPS) | |
2E,9Z,12Z,15Z-octadecatetraenoyl-CoA | Metabolite | LMFA07050424 (LIPID MAPS) | |
2E,9Z-octadecadienoyl-CoA | Metabolite | LMFA07050414 (LIPID MAPS) | |
2E-9Z-hexadecadienoyl-CoA | Metabolite | LMFA07050473 (LIPID MAPS) | |
2E-Decenoyl-CoA | Metabolite | LMFA07050391 (LIPID MAPS) | |
2E-Dodecenoyl-CoA | Metabolite | LMFA07050176 (LIPID MAPS) | |
2E-Octadecenoyl-CoA | Metabolite | LMFA07050385 (LIPID MAPS) | |
2E-butanoyl-CoA | Metabolite | LMFA07050307 (LIPID MAPS) | |
2E-hexadecenoyl-CoA | Metabolite | LMFA07050144 (LIPID MAPS) | |
2E-hexenoyl-CoA | Metabolite | LMFA07050393 (LIPID MAPS) | |
2E-octanoyl-CoA | Metabolite | LMFA07050394 (LIPID MAPS) | |
2E-tetradecenoyl-CoA | Metabolite | LMFA07050396 (LIPID MAPS) | |
3-Oxohexanoyl-CoA | Metabolite | LMFA07050242 (LIPID MAPS) | |
3-oxo-5Z,8Z,11Z-tetradecatrienoyl-CoA | Metabolite | LMFA07050460 (LIPID MAPS) | |
3-oxo-5Z,8Z-tetradecadienoyl-CoA | Metabolite | LMFA07050470 (LIPID MAPS) | |
3-oxo-5Z-dodecenoyl-CoA | Metabolite | LMFA07050482 (LIPID MAPS) | |
3-oxo-5Z-octenoyl-CoA | Metabolite | LMFA07050431 (LIPID MAPS) | |
3-oxo-5Z-tetradecenoyl-CoA | Metabolite | LMFA07050423 (LIPID MAPS) | |
3-oxo-6Z,9Z,12Z,15Z-octadecatetraenoyl-CoA | Metabolite | LMFA07050451 (LIPID MAPS) | |
3-oxo-6Z-dodecenoyl-CoA | Metabolite | LMFA07050472 (LIPID MAPS) | |
3-oxo-7Z,10Z,13Z,16Z,19Z-docosapentaenoyl-CoA | Metabolite | LMFA07050130 (LIPID MAPS) | |
3-oxo-7Z,10Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050440 (LIPID MAPS) | |
3-oxo-7Z-decenoyl-CoA | Metabolite | LMFA07050435 (LIPID MAPS) | |
3-oxo-7Z-hexadecenoyl-CoA | Metabolite | LMFA07050420 (LIPID MAPS) | |
3-oxo-7Z-tetradecadienoyl-CoA | Metabolite | LMFA07050479 (LIPID MAPS) | |
3-oxo-9Z,12Z,15Z-octadecatrienoyl-CoA | Metabolite | LMFA07050426 (LIPID MAPS) | |
3-oxo-9Z-hexadecenoyl-CoA | Metabolite | LMFA07050475 (LIPID MAPS) | |
3-oxo-Hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA | Metabolite | LMFA07050447 (LIPID MAPS) | |
3-oxo-arachidonoyl-CoA | Metabolite | LMFA07050412 (LIPID MAPS) | |
3-oxo-butanoyl-CoA | Metabolite | LMFA07050030 (LIPID MAPS) | |
3-oxo-decanoyl-CoA | Metabolite | LMFA07050239 (LIPID MAPS) | |
3-oxo-dodecadienoyl-CoA | Metabolite | LMFA07050464 (LIPID MAPS) | |
3-oxo-gamma-linoleoyl-CoA | Metabolite | LMFA07050409 (LIPID MAPS) | |
3-oxo-lauroyl-CoA | Metabolite | C05263 (KEGG Compound) | |
3-oxo-myristoyl-CoA | Metabolite | LMFA07050256 (LIPID MAPS) | |
3-oxo-octanoyl-CoA | Metabolite | LMFA07050249 (LIPID MAPS) | |
3-oxo-oleoyl-CoA | Metabolite | LMFA07050416 (LIPID MAPS) | |
3-oxopalmitoyl-CoA | Metabolite | LMFA07050250 (LIPID MAPS) | |
3-oxostearoyl-CoA | Metabolite | LMFA07050248 (LIPID MAPS) | |
3E,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl-CoA | Metabolite | LMFA07050442 (LIPID MAPS) | |
3E,7Z,10Z,13Z-hexadecatetraenoyl-CoA | Metabolite | LMFA07050454 (LIPID MAPS) | |
3E,7Z,10Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050485 (LIPID MAPS) | |
3E,7Z-decadienoyl-CoA | Metabolite | LMFA07050467 (LIPID MAPS) | |
3E-decenoyl-CoA | Metabolite | LMFA07050386 (LIPID MAPS) | |
3S-Hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA | Metabolite | LMFA07050446 (LIPID MAPS) | |
3S-Hydroxy-5Z,8Z,11Z-tetradecatrienoyl-CoA | Metabolite | LMFA07050459 (LIPID MAPS) | |
3S-Hydroxy-5Z-dodecenoyl-CoA | Metabolite | LMFA07050481 (LIPID MAPS) | |
3S-Hydroxy-5Z-octenoyl-CoA | Metabolite | LMFA07050432 (LIPID MAPS) | |
3S-Hydroxy-6Z,9Z,12Z,15Z-octadecatetraenoyl-CoA | Metabolite | LMFA07050450 (LIPID MAPS) | |
3S-Hydroxy-6Z-dodecenoyl-CoA | Metabolite | LMFA07050471 (LIPID MAPS) | |
3S-Hydroxy-7Z,10Z,13Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050455 (LIPID MAPS) | |
3S-Hydroxy-7Z-decenoyl-CoA | Metabolite | LMFA07050436 (LIPID MAPS) | |
3S-Hydroxy-7Z-hexadecenoyl-CoA | Metabolite | LMFA07050419 (LIPID MAPS) | |
3S-Hydroxy-9Z-hexadecenoyl-CoA | Metabolite | LMFA07050474 (LIPID MAPS) | |
3S-Hydroxy-arachidonoyl-CoA | Metabolite | LMFA07050411 (LIPID MAPS) | |
3S-Hydroxy-dodecadienoyl-CoA | Metabolite | LMFA07050463 (LIPID MAPS) | |
3S-Hydroxy-oleoyl-CoA | Metabolite | LMFA07050415 (LIPID MAPS) | |
3S-Hydroxymyristoyl-CoA | Metabolite | LMFA07050257 (LIPID MAPS) | |
3S-hydroxy-5Z,8Z-tetradecadienoyl-CoA | Metabolite | LMFA07050469 (LIPID MAPS) | |
3S-hydroxy-5Z-tetradecadienoyl-CoA | Metabolite | LMFA07050422 (LIPID MAPS) | |
3S-hydroxy-7Z,10Z,13Z,16Z,19Z-docosapentaenoyl-CoA | Metabolite | LMFA07050444 (LIPID MAPS) | |
3S-hydroxy-7Z,10Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050439 (LIPID MAPS) | |
3S-hydroxy-7Z-tetradecadienoyl-CoA | Metabolite | LMFA07050478 (LIPID MAPS) | |
3S-hydroxy-9Z,12Z,15Z-octadecatrienoyl-CoA | Metabolite | LMFA07050425 (LIPID MAPS) | |
3S-hydroxy-9Z,12Z-octadecadienoyl-CoA | Metabolite | LMFA07050405 (LIPID MAPS) | |
3S-hydroxy-decanoyl-CoA | Metabolite | LMFA07050403 (LIPID MAPS) | |
3S-hydroxy-gamma-linoleoyl-CoA | Metabolite | JCYIHBAQURWSOM-MVHVANHMSA-N (InChIKey) | |
3S-hydroxy-octanoyl-CoA | Metabolite | LMFA07050160 (LIPID MAPS) | |
3S-hydroxybutanoyl-CoA | Metabolite | LMFA07050153 (LIPID MAPS) | |
3S-hydroxyhexanoyl-CoA | Metabolite | LMFA07050156 (LIPID MAPS) | |
3S-hydroxylauroyl-CoA | Metabolite | LMFA07050158 (LIPID MAPS) | |
3S-hydroxypalmitoyl-CoA | Metabolite | LMFA07050161 (LIPID MAPS) | |
3S-hydroxystearoyl-CoA | Metabolite | LMFA07050159 (LIPID MAPS) | |
3Z,6Z,9Z,12Z,15Z-octadecapentaenoyl-CoA | Metabolite | LMFA07050448 (LIPID MAPS) | |
3Z,6Z,9Z,12Z-octadecatetraenoyl-CoA | Metabolite | LMFA07050413 (LIPID MAPS) | |
3Z,6Z,9Z-dodecatrienoyl-CoA | Metabolite | LMFA07050461 (LIPID MAPS) | |
3Z,6Z-dodecadienoyl-CoA | Metabolite | LMFA07050295 (LIPID MAPS) | |
3Z-decenoyl-CoA | Metabolite | LMFA07050483 (LIPID MAPS) | |
3Z-dodecenoyl-CoA | Metabolite | LMFA07050302 (LIPID MAPS) | |
3Z-hexenoyl-CoA | Metabolite | LMFA07050430 (LIPID MAPS) | |
3oxo-7Z,10Z,13Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050456 (LIPID MAPS) | |
4Z,7Z,10Z,13Z-hexadecatetraenoyl-CoA | Metabolite | LMFA07050452 (LIPID MAPS) | |
4Z,7Z,10Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050438 (LIPID MAPS) | |
4Z,7Z-decadienoyl-CoA | Metabolite | LMFA07050465 (LIPID MAPS) | |
4Z-decenoyl-CoA | Metabolite | LMFA07050301 (LIPID MAPS) | |
5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid | Metabolite | LMFA01030759 (LIPID MAPS) | |
5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA | Metabolite | LMFA07050122 (LIPID MAPS) | |
5Z,8Z,11Z-tetradecatrienoyl-CoA | Metabolite | LMFA07050457 (LIPID MAPS) | |
5Z,8Z-tetradecadienoyl-CoA | Metabolite | LMFA07050296 (LIPID MAPS) | |
5Z-dodecenoyl-CoA | Metabolite | LMFA07050480 (LIPID MAPS) | |
5Z-octenoyl-CoA | Metabolite | LMFA07050434 (LIPID MAPS) | |
5Z-tetradecenoyl-CoA | Metabolite | LMFA07050305 (LIPID MAPS) | |
7Z,10Z,13Z-hexadecatrienoyl-CoA | Metabolite | LMFA07050427 (LIPID MAPS) | |
7Z,10Z-hexadecadienoyl-CoA | Metabolite | LMFA07050406 (LIPID MAPS) | |
7Z-hexadecenoyl-CoA | Metabolite | LMFA07050417 (LIPID MAPS) | |
7Z-tetradecenoyl-CoA | Metabolite | LMFA07050476 (LIPID MAPS) | |
9-palmitoleoyl-CoA | Metabolite | LMFA07050359 (LIPID MAPS) | |
9Z,12Z,15Z-octadecatrienoyl-CoA | Metabolite | LMFA07050286 (LIPID MAPS) | |
9Z-palmitoleic acid | Metabolite | LMFA01030056 (LIPID MAPS) | |
ACAA2 | GeneProduct | P42765 (Uniprot-TrEMBL) | |
ACADSB | GeneProduct | P45954 (Uniprot-TrEMBL) | |
Acetyl-CoA | Metabolite | LMFA07050281 (LIPID MAPS) | |
Arachidonic acid | Metabolite | LMFA01030001 (LIPID MAPS) | |
Arachidonyl-CoA | Metabolite | LMFA07050288 (LIPID MAPS) | |
Butyryl-CoA | Metabolite | LMFA07050292 (LIPID MAPS) | |
DECR1 | GeneProduct | Q16698 (Uniprot-TrEMBL) | |
Decanoyl-CoA | Metabolite | LMFA07050313 (LIPID MAPS) | |
Docosahexaenoic acid | Metabolite | LMFA01030185 (LIPID MAPS) | |
ECHS1 | GeneProduct | P30084 (Uniprot-TrEMBL) | |
ECI1 | GeneProduct | P42126 (Uniprot-TrEMBL) | |
HSD17B10 | GeneProduct | Q99714 (Uniprot-TrEMBL) | |
Hexanoyl-CoA | Metabolite | LMFA07050328 (LIPID MAPS) | |
Lauric acid | Metabolite | LMFA01010012 (LIPID MAPS) | |
Lauroyl-CoA | Metabolite | LMFA07050340 (LIPID MAPS) | |
Linoleic acid | Metabolite | LMFA01030120 (LIPID MAPS) | |
Linoleoyl-CoA | Metabolite | LMFA07050343 (LIPID MAPS) | |
Long-chain-fatty-acid--CoA ligase | Protein | 6.2.1.3 (BRENDA) | |
Myristic acid | Metabolite | LMFA01010014 (LIPID MAPS) | |
Octanoyl-CoA | Metabolite | LMFA07050355 (LIPID MAPS) | |
Oleic acid | Metabolite | LMFA01030002 (LIPID MAPS) | |
Palmitic acid | Metabolite | LMFA01010001 (LIPID MAPS) | |
Palmitoyl-CoA | Metabolite | LMFA07050360 (LIPID MAPS) | |
Stearic acid | Metabolite | LMFA01010018 (LIPID MAPS) | |
Stearoyl-CoA | Metabolite | LMFA07050369 (LIPID MAPS) | |
alpha-Linolenic acid | Metabolite | LMFA01030152 (LIPID MAPS) | |
docosahexaenoyl-CoA | Metabolite | LMFA07050121 (LIPID MAPS) | |
gamma-Linolenic acid | Metabolite | LMFA01030141 (LIPID MAPS) | |
gamma-linolenoyl-CoA | Metabolite | LMFA07050322 (LIPID MAPS) | |
myristoyl-CoA | Metabolite | LMFA07050352 (LIPID MAPS) | |
oleoyl-CoA | Metabolite | LMFA07050356 (LIPID MAPS) |
Annotated Interactions
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Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
ACADSB | mim-catalysis | 1.3.8.5 (BRENDA) | ||
DECR1 | mim-catalysis | 1.3.1.124 (BRENDA) | ||
ECHS1 | mim-catalysis | 4.2.1.17 (BRENDA) | ||
ECI1 | mim-catalysis | 5.3.3.8 (BRENDA) | ||
HSD17B10 | mim-catalysis | 1.1.1.35 (BRENDA) | ||
Long-chain-fatty-acid--CoA ligase | mim-catalysis | 6.2.1.3 (BRENDA) | ||
mim-catalysis | 6.2.1.3 (BRENDA) |