Host-pathogen interaction of human coronaviruses - MAPK signaling (Homo sapiens)

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21p38 pathwaySARSphos-T573SARSinfectionMAP3K1MAP3K9DDIT3MAP3K11MAPK1MAPK9MAP3K4MAPK13MAP2K2MAP2K1MAPK8MAP3K10BCL2MAPK14MAP2K4FOS3aMAPK10MAPK12MAPK11MAPK3RPS6KA1EIF4ESJUNRAF1RPS6KA2MAP2K6ATF2FOSMAP2K3MAP2K7RPS6KA31phos-S380SARS, MERS, 229Einfection3bVLP7aSARSSARS, MERS, 229E infectionSARS, 229EIBV infectionS3a7aN3b6SARSCell survival and proliferationProteinsynthesisApoptosisInnateimmunityAutophagyIFI271BST2JUNBIFITM2IFITM3IFITM1Effectors to fight virus1IFI271BST2IFITM2IFITM3IFITM11ERK pathwayJNK pathwayAP-1 complex


Description

This pathway describes the activation of the human MAPK signaling system during human coronavirus infection, per Fung and Liu, Figure 7 [10.1146/annurev-micro-020518-115759]. The MAPK signaling system regulates response to different environmental stimuli, e.g. inflammation due to infection. Its downstream effects include regulation of cell cycle, apoptosis, differentiation and immune response. During coronavirus infection, three MAPK signaling pathways were studied and described. The p38 pathway (MAPK11 - MAPK14) leads to stimulation of apoptosis via CHOP (DDIT3) while the ERK pathway (MAPK1 and MAPK3) counteracts apoptosis stimulation and supports cell survival by stimulating ATF2 and FOS. The JNK pathway (MAPK 8 - MAPK10) inhibits cell survival protein BCL2, thus stimulating apoptosis but also stimulating the AP1 complex that leads to the production of effectors to fight the infection. The interplay of apoptosis stimulation and cell survival is not yet fully understood in SARS-CoV-2 infection.

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Ontology Terms

 

Bibliography

  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  2. Lulin Huang, Yi Shi, Bo Gong, Li Jiang, Xiaoqi Liu, Jialiang Yang, Juan Tang, Chunfang You, Qi Jiang, Bo Long, Tao Zeng, Mei Luo, Fanwei Zeng, Fanxin Zeng, Shuqiang Wang, Xingxiang Yang, Zhenglin Yang; ''Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19''; https://doi.org/10.1101/2020.03.15.20033472, 2020 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
128363view22:52, 2 February 2024EweitzIdentified two pathways
124642view12:59, 18 November 2022IsabelWassinkshapes of viral proteins changed and their names changed to official gene names
124044view07:49, 15 September 2022DeSlConverted last PW node to textLabel
124043view07:47, 15 September 2022DeSlOntology Term : 'COVID-19' added !
124042view07:47, 15 September 2022DeSlUpdated PW nodes to TextLabels, since there were no annotations for them.
123972view10:27, 9 September 2022EweitzModified description
119237view19:06, 22 June 2021FinterlyAdded DOI to PublicationXref
116595view19:11, 8 May 2021EweitzModified title
115869view18:23, 18 March 2021EgonwMade a few pathways ready to be clicked
114104view18:37, 22 December 2020EgonwConverted Labels to DataNodes
114077view06:30, 21 December 2020EgonwConverted a few labels reflecting processes to pathway DataNodes.
110827view20:54, 10 June 2020Mkutmonfixed publication xrefs
110824view09:45, 10 June 2020FehrhartModified description
110823view09:41, 10 June 2020Fehrhartadded labels for different MAPK pathways
110822view09:22, 10 June 2020Fehrhartupdated transcription/translation
110322view22:54, 3 May 2020Marvin M2Connected unconnected lines
110252view11:25, 30 April 2020Fehrhartmodified graphics
110210view13:10, 24 April 2020EgonwTyped proteins as Type="Protein"
110043view16:56, 14 April 2020Khanspersfixed unconnected
110040view15:18, 14 April 2020Rex D A BInterferon-MAPK Pathway in Response to SARS-CoV-2 Infection
109978view18:20, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109951view18:29, 7 April 2020EgonwAdded three more identifiers.
109851view11:41, 2 April 2020Fehrhartchanged virus protein visualization
109815view14:47, 1 April 2020Fehrhartadded another virus protein ID
109813view14:45, 1 April 2020Fehrhartadded some virus ID
109810view12:57, 1 April 2020FehrhartOntology Term : 'p38 MAPK signaling pathway' added !
109809view12:57, 1 April 2020FehrhartOntology Term : 'signaling pathway' added !
109808view12:57, 1 April 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
109807view12:56, 1 April 2020FehrhartOntology Term : 'viral infectious disease' added !
109806view12:55, 1 April 2020Fehrhartwork in progress
109805view12:40, 1 April 2020Fehrhartwork in progress
109804view12:26, 1 April 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3aProteinP59632 (Uniprot-TrEMBL)
3bProteinP59633 (Uniprot-TrEMBL)
6ProteinP59634 (Uniprot-TrEMBL)
7aProteinP59635 (Uniprot-TrEMBL)
ATF2GeneProductENSG00000115966 (Ensembl)
ApoptosisPathway
AutophagyPathway
BCL2GeneProductENSG00000171791 (Ensembl)
BST2GeneProduct684 (Entrez Gene)
Cell survival and proliferationPathway
DDIT3GeneProductENSG00000175197 (Ensembl) CHOP
EIF4EGeneProductENSG00000151247 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl) c-FOS
IFI27GeneProduct3429 (Entrez Gene)
IFITM1ProteinENSG00000185885 (Ensembl)
IFITM2ProteinENSG00000185201 (Ensembl)
IFITM3ProteinENSG00000142089 (Ensembl)
Innate immunityPathway
JUNBGeneProduct3726 (Entrez Gene)
JUNGeneProductENSG00000177606 (Ensembl) AP1
MAP2K1GeneProductENSG00000169032 (Ensembl) MKK1
MAP2K2GeneProductENSG00000126934 (Ensembl) MKK2
MAP2K3GeneProductENSG00000034152 (Ensembl) MKK3
MAP2K4GeneProductENSG00000065559 (Ensembl) MKK4
MAP2K6GeneProductENSG00000108984 (Ensembl) MKK6
MAP2K7GeneProductENSG00000076984 (Ensembl) MKK7
MAP3K10GeneProductENSG00000130758 (Ensembl) MLK2
MAP3K11GeneProductENSG00000173327 (Ensembl) MLK3
MAP3K1GeneProductENSG00000095015 (Ensembl) MEKK1
MAP3K4GeneProductENSG00000085511 (Ensembl) MEKK4
MAP3K9GeneProductENSG00000006432 (Ensembl) MLK1
MAPK10GeneProduct5602 (Entrez Gene) JNK
MAPK11GeneProduct5600 (Entrez Gene) p38
MAPK12GeneProduct6300 (Entrez Gene) p38
MAPK13GeneProduct5603 (Entrez Gene) p38
MAPK14GeneProductENSG00000112062 (Ensembl) p38
MAPK1GeneProduct5594 (Entrez Gene) ERK2
MAPK3GeneProduct5595 (Entrez Gene) ERK1
MAPK8GeneProduct5599 (Entrez Gene) JNK
MAPK9GeneProduct5601 (Entrez Gene) JNK
NProteinQ89457519 (Wikidata)
Protein synthesisPathway
RAF1GeneProductENSG00000132155 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl) RSK
RPS6KA2GeneProductENSG00000071242 (Ensembl) RSK
RPS6KA3GeneProductENSG00000177189 (Ensembl) RSK
SARS infectionPathway
SARS, 229E IBV infectionPathway
SARS, MERS, 229E infectionPathway
SARS, MERS, 229E infectionPathway
SProteinQ89458416 (Wikidata)
VLPProtein

Annotated Interactions

No annotated interactions

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