Chronic hyperglycemia impairment of neuron function (Homo sapiens)
From WikiPathways
Description
First 20% drawn. No identifiers yet. Work in progress.
Quality Tags
Ontology Terms
Bibliography
- Perrone A, Giovino A, Benny J, Martinelli F; ''Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects.''; Oxid Med Cell Longev, 2020 PubMed Europe PMC Scholia
- Rajchgot T, Thomas SC, Wang JC, Ahmadi M, Balood M, Crosson T, Dias JP, Couture R, Claing A, Talbot S; ''Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.''; Front Neurosci, 2019 PubMed Europe PMC Scholia
- King RH; ''The role of glycation in the pathogenesis of diabetic polyneuropathy.''; Mol Pathol, 2001 PubMed Europe PMC Scholia
- Turner DP; ''Advanced glycation end-products: a biological consequence of lifestyle contributing to cancer disparity.''; Cancer Res, 2015 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ADP | Metabolite | Q185253 (Wikidata) | |
AGE | Protein | ||
ATP | Metabolite | Q80863 (Wikidata) | |
BDNF | GeneProduct | 627 (Entrez Gene) | |
C3 | GeneProduct | 718 (Entrez Gene) | |
Ca2+ | Metabolite | 29108 (ChEBI) | |
DNA | GeneProduct | ||
ETC | Protein | ||
Fructose | Metabolite | Q61738075 (Wikidata) | |
GPCR | Protein | ||
Glut-1 | Protein | 6513 (Entrez Gene) | |
Glut-3 | Protein | 6515 (Entrez Gene) | |
INOS | Protein | Protein? | |
K+ | Metabolite | 29103 (ChEBI) | |
MMP | Protein | ||
MMP10 | GeneProduct | 4319 (Entrez Gene) | |
MMP11 | GeneProduct | 4320 (Entrez Gene) | |
MMP12 | GeneProduct | 4321 (Entrez Gene) | |
MMP13 | GeneProduct | 4322 (Entrez Gene) | |
MMP1 | GeneProduct | 4312 (Entrez Gene) | |
MMP14 | GeneProduct | 4323 (Entrez Gene) | |
MMP15 | GeneProduct | 4324 (Entrez Gene) | |
MMP16 | GeneProduct | 4325 (Entrez Gene) | |
MMP17 | GeneProduct | 4326 (Entrez Gene) | |
MMP19 | GeneProduct | 4327 (Entrez Gene) | |
MMP20 | GeneProduct | 9313 (Entrez Gene) | |
MMP21 | GeneProduct | 118856 (Entrez Gene) | |
MMP23B | GeneProduct | 8510 (Entrez Gene) | |
MMP24 | GeneProduct | 10893 (Entrez Gene) | |
MMP2 | GeneProduct | 4313 (Entrez Gene) | |
MMP25 | GeneProduct | 64386 (Entrez Gene) | |
MMP27 | GeneProduct | 64066 (Entrez Gene) | |
MMP28 | GeneProduct | 79148 (Entrez Gene) | |
MMP3 | GeneProduct | 4314 (Entrez Gene) | |
MMP7 | GeneProduct | 4316 (Entrez Gene) | |
MMP8 | GeneProduct | 4317 (Entrez Gene) | |
MMP9 | GeneProduct | 4318 (Entrez Gene) | |
Microangiopathy | Pathway | ||
NADH | Metabolite | Q26987453 (Wikidata) | |
NADPH oxidase | |||
NADPH | Metabolite | Q26841327 (Wikidata) | |
NADP | Metabolite | Q26987754 | |
NAD | Metabolite | Q12499775 (Wikidata) | |
NMUR1 | GeneProduct | 10316 (Entrez Gene) | |
NO | Metabolite | ||
NRS | Metabolite | ||
Na+ | Metabolite | Q31541104 (Wikidata) | |
O2- radical | Metabolite | ||
PGE2 | Metabolite | Q416554 (Wikidata) | |
PRKCA | GeneProduct | 5578 (Entrez Gene) | |
PRKCB | GeneProduct | 5579 (Entrez Gene) | |
PRKCD | GeneProduct | 5580 (Entrez Gene) | |
PRKCE | GeneProduct | 5581 (Entrez Gene) | |
PRKCG | GeneProduct | 5582 (Entrez Gene) | |
PRKCH | GeneProduct | 5583 (Entrez Gene) | |
PRKCI | GeneProduct | 5584 (Entrez Gene) | |
PRKCQ | GeneProduct | 5588 (Entrez Gene) | |
PRKCZ | GeneProduct | 5590 (Entrez Gene) | |
PRKD3 | GeneProduct | 23683 (Entrez Gene) | |
Protein Kinases | Protein | ||
Protein Synthesis | Pathway | ||
RAGE | Protein | 177 (Entrez Gene) | Also AGER |
ROS | Metabolite | ||
SNAP Proteins | Protein | ||
SNAP25 | GeneProduct | 6616 (Entrez Gene) | |
SPNS1 | GeneProduct | 83985 (Entrez Gene) | |
Sensitization Hyperexcitation | Pathway | ||
Sorbitol | Metabolite | Q245280 (Wikidata) | |
TBK1 | GeneProduct | 29110 (Entrez Gene) | |
TKR | Protein | ENSG00000007350 (Ensembl) | Also known as TKTL1 |
WDTC1 | GeneProduct | 23038 (Entrez Gene) | |
cytokines | |||
e- | Metabolite | 10545 (ChEBI) | |
glucose | Metabolite | ||
glucose | Metabolite | Q37525 (Wikidata) | |
ion imbalance |
Annotated Interactions
No annotated interactions