Steroid hormone precursor biosynthesis (Homo sapiens)

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12AllopregnanoloneCYP21A23alpha-hydroxy-5beta-pregnan-20-one5beta-pregnane-3,20-dioneMineralocorticoidsAKR1D15alpha-pregnane-3,20-dionePregnenediolCYP11A1PregnenetriolIsoprogesteroneProgesteroneSRD5A217alpha-hydroxypregnenolone22R-HydroxycholesterolGlucocorticoids17alpha-hydroxyprogesteroneCholesterolPregnanediol-3-glucuronide11-deoxycorticosteroneSRD5A1Pregnenolone11-deoxycortisol20alpha-HydroxyprogesteroneAKR1C1 20R,22R-dihydroxycholesterolPregnanediolCYP11A1CYP11A1CYP17A1HSD3B2HSD3B1CYP17A1AKR1C1


Description

Biosynthesis of steroid hormone precursors

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chen M, Drury JE, Penning TM; ''Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1).''; Steroids, 2011 PubMed Europe PMC Scholia
  2. J Thomas Sanderson; ''The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals''; Toxicol Sci . , 2006 PubMed Europe PMC Scholia
  3. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128533view18:01, 11 February 2024EweitzClarify pathway names
127620view20:20, 8 November 2023LarsgwRemove punctuation from bp:ID
126879view15:02, 29 June 2023DeSlAdded Rhea ID info in description
125493view10:24, 20 February 2023LinaSchifferModified description
124367view08:50, 20 October 2022DeSlOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
124366view08:49, 20 October 2022DeSlOntology Term : 'steroid hormone biosynthetic pathway' added !
124365view08:48, 20 October 2022DeSlOntology Term : 'steroid biosynthetic pathway' added !
124364view08:46, 20 October 2022DeSlsmall layout changes to position of enzyme nodes
124363view08:45, 20 October 2022DeSlChanged width of reactions missing Rhea IDs slightly for better visualization on website
124361view08:43, 20 October 2022DeSlMade interactions with missing Rhea IDs thicker
124357view08:00, 20 October 2022DeSlUpdate layout, connected unconnected line
124354view07:53, 20 October 2022DeSlUpdated description, added reference
124329view14:04, 14 October 2022Conroy lipidsmove rhea IDs to right place
124328view13:26, 14 October 2022Conroy lipidsadd intermediate between pregnenolone and progesterone
124046view07:54, 15 September 2022DeSlOntology Term : 'classic metabolic pathway' added !
124045view07:54, 15 September 2022DeSlOntology Term : 'cholesterol metabolic pathway' added !
124000view10:49, 11 September 2022EgonwMade two pathways clickable
123946view08:45, 7 September 2022Conroy lipidsadd reactiopn
123942view13:46, 6 September 2022Conroy lipidsfixes
123941view13:42, 6 September 2022Conroy lipids
123938view15:49, 5 September 2022Conroy lipidsmore fixes
123937view14:59, 5 September 2022Conroy lipidsmove annotation from catalysis to covnversion (partial) add master ref
123804view07:31, 16 August 2022Conroy lipids
123803view07:28, 16 August 2022Conroy lipidsfixed typo, missing reaction/metbolite link
123797view11:29, 15 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123796view11:28, 15 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-deoxycorticosteroneMetaboliteLMST02030087 (LIPID MAPS)
11-deoxycortisolMetaboliteLMST02030086 (LIPID MAPS)
17alpha-hydroxypregnenoloneMetaboliteLMST02030089 (LIPID MAPS)
17alpha-hydroxyprogesteroneMetaboliteLMST02030161 (LIPID MAPS)
20R,22R-dihydroxycholesterolMetaboliteLMST01010200 (LIPID MAPS)
20alpha-HydroxyprogesteroneMetaboliteLMST02030169 (LIPID MAPS)
22R-HydroxycholesterolMetaboliteLMST01010086 (LIPID MAPS)
3alpha-hydroxy-5beta-pregnan-20-oneMetaboliteLMST02030175 (LIPID MAPS)
5alpha-pregnane-3,20-dioneMetaboliteLMST02030170 (LIPID MAPS)
5beta-pregnane-3,20-dioneMetaboliteLMST02030146 (LIPID MAPS)
AKR1C1 GeneProductQ04828 (Uniprot-TrEMBL)
AKR1D1GeneProductP51857 (Uniprot-TrEMBL)
AllopregnanoloneMetaboliteLMST02030130 (LIPID MAPS)
CYP11A1GeneProductP05108 (Uniprot-TrEMBL)
CYP17A1GeneProductP05093 (Uniprot-TrEMBL)
CYP21A2GeneProductP08686 (Uniprot-TrEMBL)
CholesterolMetaboliteLMST01010001 (LIPID MAPS)
GlucocorticoidsPathwayWP5280 (WikiPathways)
HSD3B1GeneProductP14060 (Uniprot-TrEMBL)
HSD3B2GeneProductP26439 (Uniprot-TrEMBL)
IsoprogesteroneMetaboliteLMST02030299 (LIPID MAPS)
MineralocorticoidsPathwayWP5279 (WikiPathways)
Pregnanediol-3-glucuronideMetaboliteLMST05010073 (LIPID MAPS)
PregnanediolMetaboliteLMST02030264 (LIPID MAPS)
PregnenediolMetaboliteLMST02030205 (LIPID MAPS)
PregnenetriolMetaboliteLMST02030263 (LIPID MAPS)
PregnenoloneMetaboliteLMST02030088 (LIPID MAPS)
ProgesteroneMetaboliteLMST02030159 (LIPID MAPS)
SRD5A1GeneProductP18405 (Uniprot-TrEMBL)
SRD5A2GeneProductP31213 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
17alpha-hydroxypregnenolone17alpha-hydroxyprogesteronemim-conversion24077 (Rhea) EC:1.1.1.145
17alpha-hydroxyprogesterone11-deoxycortisolmim-conversion50309 (Rhea) EC:1.14.14.16
20R,22R-dihydroxycholesterolPregnenolonemim-conversion34344 (Rhea) EC:1.14.15.6
22R-Hydroxycholesterol20R,22R-dihydroxycholesterolmim-conversion34340 (Rhea) EC:1.14.15.6
5alpha-pregnane-3,20-dioneAllopregnanolonemim-conversion41982 (Rhea)
5beta-pregnane-3,20-dione3alpha-hydroxy-5beta-pregnan-20-onemim-conversion69018 (Rhea)
Cholesterol22R-Hydroxycholesterolmim-conversion34336 (Rhea) EC:1.14.15.6
IsoprogesteroneProgesteronemim-conversion43929 (Rhea)
Pregnenolone17alpha-hydroxypregnenolonemim-conversion50237 (Rhea) EC 1.14.14.19
Pregnenolonemim-conversion43925 (Rhea)
Progesterone11-deoxycorticosteronemim-conversion50305 (Rhea) EC:1.14.14.16
Progesterone17alpha-hydroxyprogesteronemim-conversion46309 (Rhea) EC 1.14.14.19
Progesterone20alpha-Hydroxyprogesteronemim-conversion42114 (Rhea)
Progesterone5alpha-pregnane-3,20-dionemim-conversion21954 (Rhea) EC: 1.3.1.22
Progesterone5beta-pregnane-3,20-dionemim-conversion46661 (Rhea) EC:1.3.1.3
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