Sebaleic acid formation and metabolism (Homo sapiens)

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232122Unidentified5S-18-DiODEFADS1ACSL1et al5S-HODESebaleoyl CoA5-KODEPalmitoyl CoA8Z-octadecenoyl-CoA5-oxo-18-ODECYP4F3Sebaleic acidFADS2Palmitic AcidSapienic acidSapienoyl-CoAALOX5


Description

Formation of sebaleic acid and its related octadecanoids

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Quality Tags

Ontology Terms

 

Bibliography

  1. Cossette C, Patel P, Anumolu JR, Sivendran S, Lee GJ, Gravel S, Graham FD, Lesimple A, Mamer OA, Rokach J, Powell WS; ''Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  2. Küçüksayan E, Sansone A, Chatgilialoglu C, Ozben T, Tekeli D, Talibova G, Ferreri C; ''Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines.''; Cells, 2022 PubMed Europe PMC Scholia
  3. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM; ''Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.''; J Invest Dermatol, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134474view00:52, 22 July 2024EweitzFix graphical truncation in node, improve node alignment
125120view10:08, 24 January 2023Conroy lipidsadd ECs
125089view22:47, 20 January 2023AlexanderPicofixed uniprot ref
125051view12:19, 17 January 2023Conroy lipidsOntology Term : 'classic metabolic pathway' added !
125050view12:18, 17 January 2023Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
125049view12:18, 17 January 2023Conroy lipidsOntology Term : 'fatty acid biosynthetic pathway' added !
125045view12:06, 17 January 2023Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
5-KODEMetaboliteLMFA02000395 (LIPID MAPS)
5-oxo-18-ODEMetaboliteLMFA02000396 (LIPID MAPS)
5S-18-DiODEMetaboliteLMFA02000397 (LIPID MAPS)
5S-HODEMetaboliteLMFA02000394 (LIPID MAPS)
8Z-octadecenoyl-CoAMetaboliteLMFA07050489 (LIPID MAPS)
ACSL1 et alGeneProductP33121 (Uniprot-TrEMBL)
ALOX5GeneProductP09917 (Uniprot-SwissProt)
CYP4F3GeneProductQ08477 (Uniprot-TrEMBL)
FADS1GeneProductO60427 (Uniprot-TrEMBL)
FADS2GeneProductO95864 (Uniprot-TrEMBL)
Palmitic AcidMetaboliteLMFA01010001 (LIPID MAPS)
Palmitoyl CoAMetaboliteLMFA07050360 (LIPID MAPS)
Sapienic acidMetaboliteLMFA01030267 (LIPID MAPS)
Sapienoyl-CoAMetaboliteLMFA07050488 (LIPID MAPS)
Sebaleic acidMetaboliteLMFA01030323 (LIPID MAPS)
Sebaleoyl CoAMetaboliteLMFA07050490 (LIPID MAPS)
UnidentifiedGeneProduct

Annotated Interactions

SourceTargetTypeDatabase referenceComment
Palmitic AcidPalmitoyl CoAmim-conversion30752 (Rhea)
Palmitoyl CoASapienoyl-CoAmim-conversion37024 (Rhea)
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