Metabolic pathways of fibroblasts (Homo sapiens)

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FibroblastGlycolysisMitochondrionP5CSProcollagenProlineP5CRSHMTP5CPSAT1PSPHASCT2GLUT4SerineCollagenGlycineGLS2Nucleotide BiosynthesisPHGDHLDHGlutamateHKG6PPentose Phosphate PathwayFatty Acid MetabolismTCA cycleGLSAcetyl-CoAPyruvateGlutamineαKGGlucose3PGF6PLactic acidGlycosaminoglycan SynthesisGolgi ApparatusGlutamineASCT2GlutamateGlutamineGlucoseEndoplasmic ReticulumSerine biosynthesisGlutaminolysis


Description

Metabolic pathways of fibroblasts: basis

Comments

 
Para, R. et al. (2019) “Metabolic reprogramming as a driver of fibroblast activation in pulmonaryfibrosis,” The American Journal of the Medical Sciences, 357(5), pp. 394–398. Available at: https://doi.org/10.1016/j.amjms.2019.02.003.


Wang, S., Liang, Y. and Dai, C. (2022) “Metabolic regulation of fibroblast activation and proliferation during organ fibrosis,” Kidney Diseases, 8(2), pp. 115–125. Available at: https://doi.org/10.1159/000522417.

 
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Bibliography

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  13. Timothy D. Hewitson, Edward R. Smith; ''A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How? ''; Frontiers in Physiology , 2021 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
125794view11:24, 10 March 2023DeSlChanged DataNodes in legend to textLabels
125756view10:33, 9 March 2023DeSlChanged MIMconversion to Arrow for Fatty Acid to PW node interaction
125744view08:43, 9 March 2023DeSlRemoved empty comment beneath description
125743view08:41, 9 March 2023DeSlConverted MIM-conversion arrow for FA Beta ox to Acetyl-CoA to arrow; converted interactions in legend to graphical lines, converted pathway ndoes to current standard color.
125567view22:42, 27 February 2023AlexanderPicoSetting all missing PublicationXref IDs to NA
125541view21:07, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125540view21:06, 26 February 2023AndraOntology Term : 'pulmonary fibrosis' added !
125535view08:04, 26 February 2023EgonwUpdated the UniProt data sources
125530view06:16, 26 February 2023EgonwMarked a data node with a ChEBI identifier as "Metabolite"
125250view17:39, 30 January 2023Mariamierzejewskalayout
125249view17:38, 30 January 2023Mariamierzejewskalayout
125248view17:37, 30 January 2023Mariamierzejewskalayout
125247view17:35, 30 January 2023Mariamierzejewskalayout
125245view17:17, 30 January 2023JgumbaragyteModified description
125244view16:34, 30 January 2023JgumbaragyteModified description
125239view15:48, 30 January 2023Mariamierzejewskalayout
125238view15:47, 30 January 2023Mariamierzejewskalayout adjustment
125237view15:44, 30 January 2023Mariamierzejewskalayout adjustment
125236view15:43, 30 January 2023Mariamierzejewskalayout adjustment
125235view15:42, 30 January 2023Mariamierzejewskalayout update
125234view15:41, 30 January 2023Mariamierzejewskavisual adjustment
125233view15:40, 30 January 2023Mariamierzejewskalayout change
125232view15:35, 30 January 2023JgumbaragyteAdjustment
125229view13:25, 30 January 2023MatejKrivulkaGLUT1 relocation
125224view11:20, 30 January 2023Alippifedtitle change
125223view11:11, 30 January 2023Mariamierzejewskatitle adjustment
125222view11:00, 30 January 2023JgumbaragyteGlycosaminoglycan synthesis pathway expanded
125221view10:40, 30 January 2023AliHbdladaptation of the legend
125215view20:50, 29 January 2023AliHbdlconversion arrow changed to activation in the signaling pathways
125214view20:48, 29 January 2023AliHbdlAdding source to fgfr signaling
125213view20:43, 29 January 2023AliHbdlAddition of legend and modification of glycosamidoglycan synthesis
125212view19:41, 29 January 2023AliHbdlMore citations, modification of the collagen and proline pathways
125211view16:56, 29 January 2023AliHbdlAddition of citations and gene names
125206view16:02, 29 January 2023AliHbdlCorrection of references

Addition of comments with gene name

Correction of the glycosaminoglycan synthesis pathway and adaptation of the signalling pathways
125203view13:20, 29 January 2023AliHbdlFix citation 10
125196view14:02, 28 January 2023JgumbaragyteLPAR1 signaling modified
125193view12:04, 28 January 2023JgumbaragyteLiterature added
125168view11:56, 26 January 2023AliHbdlAddition of litterature
125162view16:23, 25 January 2023AliHbdlAddition of proteins for collagen synthesis
125134view17:27, 24 January 2023JgumbaragytePI3K-Akt signaling pathway expanded
125133view17:05, 24 January 2023JgumbaragyteFGFR signaling pathways added
125128view16:13, 24 January 2023JgumbaragyteChanged arrows to show activation; expanded LPAR1 pathway; expanded and fixed glycosaminoglycan synthesis pathway
125099view00:39, 23 January 2023EweitzModified title
125095view13:39, 22 January 2023AliHbdladdition of the lactate transporter
125093view07:03, 22 January 2023JgumbaragyteLPAR1 signaling added
125086view14:45, 20 January 2023AliHbdlAddition of proteins + fixing colors
125085view14:15, 20 January 2023AliHbdlcorrection colors
125084view14:14, 20 January 2023AliHbdlAddition of serine biosynthesis and graphic changes
125073view13:57, 19 January 2023AliHbdladdition of catalysts
125071view13:33, 19 January 2023AliHbdlphysical changes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3PGMetaboliteHMDB00807 (HMDB)
ASCT2GeneProductQ15758 (Uniprot-SwissProt)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
CollagenGeneProductCHEBI:3815 (ChEBI) Hewitson, Timothy D., and Edward R. Smith. “A Metabolic Reprogramming of Glycolysis and Glutamine Metabolism Is a Requisite for Renal Fibrogenesis—Why and How?” Frontiers in Physiology, vol. 12, 2021, https://doi.org/10.3389/fphys.2021.645857.
F6PMetaboliteCHEBI:15946 (ChEBI)
Fatty Acid MetabolismPathwayWP143 (WikiPathways)
G6PMetaboliteHMDB01401 (HMDB)
GLS2ProteinENSG00000135423 (Ensembl Human) Gene: GLS
GLSGeneProductENSG00000115419 (Ensembl)
GLUT4ProteinP14672 (Uniprot-SwissProt) Gene: SLC2A4 Longo N, Bell GI, Shuster RC, Griffin LD, Langley SD, Elsas LJ. Human fibroblasts express the insulin-responsive glucose transporter (GLUT4). Trans Assoc Am Physicians. 1990;103:202-13. PMID: 2132532.
GlucoseMetaboliteHMDB00122 (HMDB)
GlutamateMetaboliteCHEBI:29985 (ChEBI)
GlutamineMetaboliteCHEBI:18050 (ChEBI)
GlycineMetabolite15428 (ChEBI)
Glycosaminoglycan SynthesisPathwayWP2743 (WikiPathways)
HKGeneProduct3098 (Entrez Gene)
LDHGeneProductENSG00000134333 (Ensembl)
Lactic acidMetaboliteHMDB00190 (HMDB)
Nucleotide BiosynthesisPathwayWP404 (WikiPathways)
P5CMetaboliteCHEBI:15893 (ChEBI)
P5CRProteinP32322 (Uniprot-SwissProt) Gene: PYCR1
P5CSProteinP54886 (Uniprot-SwissProt) Gene: ALDH18A1
PHGDHGeneProductENSG00000092621 (Ensembl Human)
PSAT1GeneProductENSG00000135069 (Ensembl Human)
PSPHGeneProductENSG00000146733 (Ensembl Human)
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
ProcollagenGeneProductP02452 (Uniprot-SwissProt)
ProlineMetaboliteCHEBI:26271 (ChEBI)
PyruvateMetaboliteHMDB00243 (HMDB)
SHMTProteinO62585 (Uniprot-SwissProt) Gene: SHMT-1; SHMT-2 National Center for Biotechnology Information (2023). PubChem Pathway Summary for PathwayBlob SMP0000004, Glycine and Serine Metabolism, Source: PathBank. Retrieved January 19, 2023 from https://pubchem.ncbi.nlm.nih.gov/pathway/PathBank:SMP0000004.
SerineMetaboliteCHEBI:17822 (ChEBI)
TCA cyclePathwayWP78 (WikiPathways)
αKGMetaboliteHMDB00208 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5312"
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