Fatty acid biosynthesis (Drosophila melanogaster)

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1-33-L-Hydroxyacyl-CoAAcetyl-CoATCA Cyclebeta-hydroxybutyrylless than 6 iterationsCytosolPyruvateLong-Chain fatty acidAcetyl-synthase3-ketoacyl-CoAButyryl-ACPFatty acyl CoAMalonyl-CoA6 iterationstrans-delta2-enoyl-CoAAcetyl-ACPCitrateMalonyl-ACPPalmitateAcyl-CoA (n+2)Acetoacetyl-ACPCrotonoyl-ACPOxaloacetateMitochondrionPalmitoyl-ACP4ACSL5CG3523CG6984Triacylglyceride Synthesis MAPPCG6543AcCoASCG3961CG3523ATPCLCG3523DECR1CG16935CG11198HADHSCECHDC1yip2ACSL6CG3523CG3523CG3523CG9577CG3523PECRACSL4l(2)44DEaECHDC2CG3523ACACBSCDCG1516


Description

The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.

Comments

GenMAPP notes 
Updated from original (Kam Dahlquist) by Magali Jaillard, Marijke Vermeer, Michiel Adrieans, Ron Schormans and Chris Evelo
GenMAPP remarks 
http://www.bigcat.unimaas.nl/mapps/

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Quality Tags

Ontology Terms

 

Bibliography

  1. de Renobales M, Blomquist GJ; ''Biosynthesis of medium chain fatty acids in Drosophila melanogaster.''; Arch Biochem Biophys, 1984 PubMed Europe PMC Scholia
  2. Keith AD; ''Fatty acid metabolism in Drosophila melanogaster: interaction between dietary fatty acids and de novo synthesis.''; Comp Biochem Physiol, 1967 PubMed Europe PMC Scholia
  3. Parvy JP, Napal L, Rubin T, Poidevin M, Perrin L, Wicker-Thomas C, Montagne J; ''Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
  4. Lowe PN, Rhodes S; ''Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli.''; Biochem J, 1988 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125349view19:46, 3 February 2023AlexanderPicoremoved old genmapp comments
125348view19:44, 3 February 2023AlexanderPicoModified description
116920view09:39, 16 May 2021EweitzModified title
114463view09:40, 13 January 2021Finterlysmall graphical updates. add link to pathway and biological type to metabolites.
109411view18:26, 16 March 2020L DupuisConverted interactions to graphical lines
107101view14:18, 17 September 2019MaintBotChEBI identifier normalization
106093view12:00, 16 August 2019MaintBotHMDB identifier normalization
93103view16:14, 28 July 2017DeSlChanges pubchem substance ID to chebi
86163view08:36, 3 July 2016EgonwColored metabolites by customs and connected more lines.
84333view09:13, 6 February 2016EgonwFixed data sources of KEGG Compound IDs.
77439view20:27, 8 September 2014MaintBotremoved old homology label
73954view20:33, 10 March 2014EgonwMarked three metabolite like structures as type metabolite.
73678view08:19, 15 February 2014EgonwAdded a few metabolite identifiers.
73400view20:18, 26 January 2014EgonwMarked 'long chain fatty acid' as Metabolite, so that the link out will work.
73323view12:18, 20 January 2014AndraAdded references
73322view12:11, 20 January 2014AndraPeriodical save, work in progress
73321view12:01, 20 January 2014AndraPeriodical save, work in progress
73320view11:51, 20 January 2014AndraPeriodical save, work in progress
73319view11:40, 20 January 2014AndraPeriodical save, work in progress
73318view11:30, 20 January 2014AndraPeriodical save, work in progress
73317view11:09, 20 January 2014MaintBotupdated curation tag
73236view21:17, 12 January 2014EgonwAdded a few metabolite identifiers.
73235view21:14, 12 January 2014EgonwConverted metabolite Label's into DataNode's.
71545view19:25, 17 October 2013MaintBotAutomated update of data sources
68709view21:35, 6 July 2013MaintBotUpdated to 2013 gpml schema
67242view10:25, 26 June 2013Christine ChichesterOntology Term : 'fatty acid biosynthetic pathway' added !
40877view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
34155view21:07, 9 December 2009MaintBotAutomatic update of empty xrefs
21876view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:Fatty Acid Synthesis BiGCaT]] moved to [[Pathway:WP568]]: Moved to stable identifier
8606view14:04, 7 January 2008MaintBotAdded to category $category
19459view14:04, 7 January 2008EveloUploaded new pathway
8604view14:04, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-L-Hydroxyacyl-CoAMetabolite
3-ketoacyl-CoAMetaboliteCHEBI:57347 (ChEBI)
ACACBGeneProduct
ACSL4GeneProduct
ACSL5GeneProduct
ACSL6GeneProduct
ATPCLGeneProduct36760 (Entrez Gene)
AcCoASGeneProduct40348 (Entrez Gene)
Acetoacetyl-ACPMetaboliteCHEBI:2393 (ChEBI)
Acetyl-ACPMetaboliteC03939 (KEGG Compound)
Acetyl-CoAMetabolite392413 (Chemspider)
Acetyl-synthase
Acyl-CoA (n+2)MetaboliteCHEBI:37554 (ChEBI)
Butyryl-ACPMetaboliteCHEBI:3247 (ChEBI)
CG11198GeneProduct35761 (Entrez Gene)
CG1516GeneProduct36020 (Entrez Gene)
CG16935GeneProduct36540 (Entrez Gene)
CG3523GeneProduct33524 (Entrez Gene)
CG3961GeneProduct40056 (Entrez Gene)
CG6543GeneProduct36536 (Entrez Gene)
CG6984GeneProduct36926 (Entrez Gene)
CG9577GeneProduct33016 (Entrez Gene)
CitrateMetabolite29081 (Chemspider)
Crotonoyl-ACPMetabolite
DECR1GeneProduct
ECHDC1GeneProduct
ECHDC2GeneProduct
Fatty acyl CoAMetaboliteCHEBI:37554 (ChEBI)
HADHSCGeneProduct
Long-Chain fatty acidMetaboliteCHEBI:15904 (ChEBI)
Malonyl-ACPMetaboliteC01209 (KEGG Compound)
Malonyl-CoAMetaboliteHMDB0001175 (HMDB)
OxaloacetateMetabolite2509917 (Chemspider)
PECRGeneProduct
PalmitateMetabolite440215 (Chemspider)
Palmitoyl-ACP
PyruvateMetabolite96901 (Chemspider)
SCDGeneProduct252579 (Entrez Gene)
Triacylglyceride Synthesis MAPPPathwayWP279 (WikiPathways)
beta-hydroxybutyrylMetabolite644065 (PubChem-compound)
l(2)44DEaGeneProduct46068 (Entrez Gene)
trans-delta2-enoyl-CoAMetabolite
yip2GeneProduct34313 (Entrez Gene)

Annotated Interactions

No annotated interactions
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