Pentose phosphate metabolism (Homo sapiens)

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1Phosphogluconate Pathway++++G6PDSedoheptulose-7-PhosphateFructose-6-PhosphateXylulose-5-PhosphateGlyceraldehyde-3-phosphateNucleotide BiosynthesisHexose Monophosphosphate ShuntD-Ribose-5-Phosphate6-PhosphogluconatePGLSRPEErythrose-4-PhosphateRibulose-5-PhosphateGlucose-6-PhosphateTALDO1RPIATKTGlyceraldehyde-3-phosphate6-Phosphonoglucono-delta-lactonePGDTKTFructose-6-PhosphateGlycolysis/Gluconeogenesis


Description

Pentose phosphate, phosphogluconate, or hexose monophsphate pathway oxidizes glucose-6-phosphate to fructose-6-phosphate and glyceraldehyde-3-P. NADP+ is the electron acceptor. The pathways yields NADPH as well as 5, 4, and 7 carbon intermediaries for synthesis of nucleotides.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. D. Voet, J.G. Voet; ''Biochemistry''; 0307-4412(90)90145-E, 1990 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
135344view20:19, 27 August 2024Khanspersupdate lit ref
135338view18:47, 26 August 2024Khansperstypo
135336view20:47, 23 August 2024Khanspersupdated lit ref
126271view16:19, 19 April 2023EgonwLicense is CCZero
118339view13:21, 27 May 2021Marvin M2correcting isbn
118338view13:15, 27 May 2021Marvin M2added ref link
117816view14:48, 22 May 2021EweitzModified title
114260view13:56, 2 January 2021EgonwTwo more pathways clickable
106687view12:58, 17 September 2019MaintBotHMDB identifier normalization
106545view00:09, 6 September 2019KhanspersModified description
105782view19:44, 15 August 2019KhanspersModified description
102320view08:15, 20 December 2018FehrhartChanged title due to overlap with other pathway
94935view16:25, 15 October 2017Khanspersconnected line
94922view10:59, 13 October 2017DeSlConnected lines, changed complexes for metabolites to groups, changed textlabel to 2 PW nodes
94920view09:28, 13 October 2017DeSlModified description
94659view11:22, 4 October 2017DeSlchanged label of ribose-5-phosphate to D-ribose-5-phosphate
88600view20:02, 11 August 2016Mkutmonfix unconnected lines
82700view18:54, 22 October 2015EgonwFixed the CAS number; the one that was given was for Glu-1-phosphate.
68931view17:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67579view11:28, 26 June 2013DdiglesOntology Term : 'pentose phosphate pathway' added !
45148view01:20, 7 October 2011AlexanderPico
45147view01:19, 7 October 2011AlexanderPicoadded pub ref
45146view01:18, 7 October 2011AlexanderPicofixed reactions and pathway ref
43479view08:22, 23 June 2011AdrienDefayadd wikiPathways for the database of Glycolysis/Gluconeogenesis
41079view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
38860view18:14, 24 September 2010Khanspers
38773view23:47, 23 September 2010KhanspersAdded pathway links
32324view13:26, 15 August 2009MaintBotFixed text labels
31929view12:55, 14 August 2009MaintBotFixed group labels
30180view20:53, 7 July 2009KhanspersAdded metabolite xrefs
20963view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Pentose Phosphate Pathway]] moved to [[Pathway:WP134]]: Moved to stable identifier
14088view11:35, 21 May 2008MartijnVanIerselLinked up, added metabolites
13102view11:15, 17 May 2008MaintBotautomated metabolite conversion
8330view13:46, 7 January 2008MaintBot[[Pathway:Human:Pentose Phosphate Pathway]] moved to [[Pathway:Homo sapiens:Pentose Phosphate Pathway]]: Renaming species
7783view16:17, 18 December 2007MaintBotfixed category names
7389view12:42, 4 November 2007MaintBotAdded categories to GPML
6361view22:18, 22 May 2007Kdahlquistgpml file for [[Human:Pentose_Phosphate_Pathway]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-PhosphogluconateMetaboliteHMDB0001316 (HMDB)
6-Phosphonoglucono-delta-lactoneMetaboliteHMDB0001127 (HMDB)
D-Ribose-5-PhosphateMetabolite3615-55-2 (CAS)
Erythrose-4-PhosphateMetaboliteHMDB0001321 (HMDB)
Fructose-6-PhosphateMetabolite643-13-0 (CAS)
Fructose-6-PhosphateMetaboliteHMDB0000124 (HMDB)
G6PDGeneProduct2539 (Entrez Gene)
Glucose-6-PhosphateMetabolite56-73-5 (CAS)
Glyceraldehyde-3-phosphateMetaboliteHMDB0001112 (HMDB)
Glycolysis/GluconeogenesisPathwayWP534 (WikiPathways)
Hexose Monophosphosphate ShuntPathway
Nucleotide BiosynthesisPathwayWP404 (WikiPathways)
PGDGeneProduct5226 (Entrez Gene)
PGLSGeneProduct25796 (Entrez Gene)
Phosphogluconate PathwayPathway
RPEGeneProduct6120 (Entrez Gene)
RPIAGeneProduct22934 (Entrez Gene)
Ribulose-5-PhosphateMetabolite4151-19-3 (CAS)
Sedoheptulose-7-PhosphateMetabolite2646-35-7 (CAS)
TALDO1GeneProduct6888 (Entrez Gene)
TKTGeneProduct7086 (Entrez Gene)
Xylulose-5-PhosphateMetabolite60802-29-1 (CAS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP134"
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