Induction of autophagy and toll-like receptor signaling by graphene oxide (Homo sapiens)

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1IFN-betaGOautophagyGOIFN-gammaTNF-alphaNF-kappaBTRAF6MYD88TLR4TRIFIRF3autophagyNF-kappaBTRAF6MYD88IRF3IFN-betaIFN-gammaTNF-alphaTLR9Beclin1LC3Beclin1LC3


Description

Graphene oxide has been found in the RAW264.7 to trigger a cytokine response and resulting autophagy. It was found to be mediated by activation of TLR4 and TLR9, signalling MyD88, TRAF6, and NF-κB, resulting in cytokine expression. However, TLR signaling did not cause IFN-β expression nor IRF3 activation. The process also shows activation of Beclin 1 and LC3.

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Bibliography

  1. Chen GY, Yang HJ, Lu CH, Chao YC, Hwang SM, Chen CL, Lo KW, Sung LY, Luo WY, Tuan HY, Hu YC; ''Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide.''; Biomaterials, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129743view01:54, 22 May 2024EweitzModified title
126593view08:29, 6 June 2023EgonwMore identifiers
126592view08:04, 6 June 2023EgonwAdded more identifiers
125993view15:22, 24 March 2023EgonwOntology Term : 'classic metabolic pathway' added !
125992view15:22, 24 March 2023EgonwOntology Term : 'cytokine mediated signaling pathway' added !
125679view21:29, 6 March 2023EgonwAdded a number of identifiers
125667view16:18, 6 March 2023EgonwAdded the reference
125663view16:11, 6 March 2023EgonwAdded interactions
125657view16:01, 6 March 2023EgonwModified description
125653view15:53, 6 March 2023EgonwNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Beclin1GeneProductQ14457 (Uniprot-TrEMBL)
GOMetaboliteQ95981922 (Wikidata) graphene oxide
IFN-betaGeneProductP01574 (Uniprot-TrEMBL)
IFN-gammaGeneProductP01579 (Uniprot-TrEMBL)
IRF3GeneProductENSG00000126456 (Ensembl)
LC3GeneProductQ9H492 (Uniprot-TrEMBL) Guess based on Wikipedia, which mentions this LC3 in the context of autophagy.
MYD88GeneProductENSG00000172936 (Ensembl)
NF-kappaBGeneProductP19838 (Uniprot-TrEMBL) ID annotation derived from the label.
TLR4GeneProductENSG00000136869 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TNF-alphaGeneProductP01375 (Uniprot-TrEMBL)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRIFGeneProduct
autophagyPathwayWP4923 (WikiPathways)

Annotated Interactions

No annotated interactions

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