G1 to S cell cycle control (Homo sapiens)

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1, 2Nucleusorigin recognition complexG1/S transition CyclinDependent KinasesCell cycle DNA replication genesDNA replicationCyclin DsG2 Phase-M phaseG1 PhaseS phase progressionG1 CyclinDependant CyclasesDNA polymerasesG1/S transition PhaseG1/S Cell CycleCheckpointCyclin EsTFDP2ORC3LE2F1CREBL1CDKN1BMCM2CDK2PCNACCNE1CDK4CDK6PRIM2ACDK1GADD45AMCM6E2F2CDKN2CCCNE1CCNA1CREB3L4CDK6ORC6LTP53CCND3POLA2CDK7CDKN2BCDC45LTFDP1CDK4CDKN2DTP53MCM7CCNB1MNAT1CCNE2CDKN2ACDKN1CCREB3L3RPA3MCM5MDM2CCNHRB1POLE2CCNG2PRIM1RPA1CCNE1CDKN1AMYT1CDK7MYCMCM4CREB3ORC1LCDK2ORC4LMCM3CDK2CDC2ACREB1CREB3L1CDC25AWEE1CCND1POLECCND2ATME2F3ORC5LRPA2Ubiquitin-mediatedproteasome degradationORC2LPPUbPPCCND1CDK4CDK6CCND1CDK4CDK6RB1E2F2PE2F1E2F3TFDP2TFDP1CDKN1BP


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome

Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134854view19:51, 27 July 2024EweitzEconomize layout
134853view19:50, 27 July 2024EweitzEconomize layout
128014view15:59, 21 January 2024EweitzFix typo (dependant cyclase -> dependent kinase), standardize case
127353view18:38, 20 September 2023Khanspersupdated phospho sites
127256view18:17, 28 August 2023Khanspersadded literature reference and updated description
123406view06:47, 23 July 2022EgonwMade a pathway clickable
106424view22:02, 28 August 2019KhanspersModified description
105450view05:01, 8 August 2019KhanspersModified description
105449view04:59, 8 August 2019KhanspersModified description
105242view22:50, 23 July 2019Khansperswork in progress
105241view22:45, 23 July 2019Khansperswork in progress
105240view22:40, 23 July 2019Khansperswork in progress
105239view20:54, 23 July 2019KhanspersUpdated layout
102300view20:48, 17 December 2018Khanspersremoved GenMAPP comment
97000view22:11, 25 April 2018Khanspersadded phosphosites, general cleanup
95145view03:02, 17 November 2017AlexanderPicoconnected interactions
95124view15:09, 16 November 2017DeSlFixed nested groups
94764view16:01, 5 October 2017Ryanmillerconnected lines
80001view08:36, 30 April 2015Zarichanged Box for CyclinD an CdK , annotated CDC2A gene
80000view08:21, 30 April 2015ZariChanged box for CyclinD and CdK
71377view18:39, 17 October 2013MaintBotAutomated update of data sources
67270view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63189view20:50, 8 May 2013MaintBotUpdating gpml version
45301view19:58, 7 October 2011AlexanderPicoOntology Term : 'cell cycle checkpoint pathway' added !
41128view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38746view22:18, 23 September 2010Mark.scottccna1 link
38745view22:17, 23 September 2010Mark.scottconnect cdk1
35815view19:02, 17 February 2010KhanspersModified description
35814view18:36, 17 February 2010KhanspersAdded lit ref
32435view17:14, 15 August 2009MaintBotFixed text labels
32104view13:46, 14 August 2009MaintBotFixed group labels
20771view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:WP45]]: Moved to stable identifier
15393view22:27, 27 May 2008Khanspersconnectors
14438view22:42, 22 May 2008KhanspersAdded connectors, groups
14433view22:33, 22 May 2008KhanspersPeriodical save, work in progress
14427view22:30, 22 May 2008KhanspersAdded connectors
14423view22:23, 22 May 2008KhanspersPeriodical save, work in progress
14421view22:12, 22 May 2008KhanspersAdded connectors
14407view20:10, 22 May 2008KhanspersAdded connectors
12942view10:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
7944view13:46, 7 January 2008MaintBot[[Pathway:Human:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]]: Renaming species
7597view16:03, 18 December 2007MaintBotfixed category names
7205view12:33, 4 November 2007MaintBotAdded categories to GPML
6300view22:17, 22 May 2007A.C.Zambongpml file for [[Human:Cell_Cycle-G1_to_S_control_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProduct472 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CCNG2GeneProduct901 (Entrez Gene)
CCNHGeneProduct902 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC2AGeneProduct1017 (Entrez Gene)
CDC45LGeneProduct8318 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CDKN1CGeneProduct1028 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2BGeneProduct1030 (Entrez Gene)
CDKN2CGeneProduct1031 (Entrez Gene)
CDKN2DGeneProduct1032 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CREB3GeneProduct10488 (Entrez Gene)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L3GeneProduct84699 (Entrez Gene)
CREB3L4GeneProduct148327 (Entrez Gene)
CREBL1GeneProduct1388 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
MYT1GeneProduct4661 (Entrez Gene)
ORC1LGeneProduct4998 (Entrez Gene)
ORC2LGeneProduct4999 (Entrez Gene)
ORC3LGeneProduct23595 (Entrez Gene)
ORC4LGeneProduct5000 (Entrez Gene)
ORC5LGeneProduct5001 (Entrez Gene)
ORC6LGeneProduct23594 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2AGeneProduct5558 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2GeneProduct6118 (Entrez Gene)
RPA3GeneProduct6119 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
Ubiquitin-mediated proteasome degradationPathwayWP183 (WikiPathways)
WEE1GeneProduct7465 (Entrez Gene)

Annotated Interactions

No annotated interactions

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