ADHD and autism (ASD) pathways (Homo sapiens)

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1281281286112135128189177, 135126NucleusAdrenal MedullaMitochondriaSynapticVesicleAdrenal VesicleSynapticVesicleSynaptophysinSynaptobrevinComplexn.e.ROSReactive OxygenStressIntercellularcytosol (intracellular)FolateCycleSerotoninSynthesis(5-HT)Opioid ReceptorAlex Madsen2023copyright (c) 2023CC0 1.0 Universal (CC0 1.0)Public Domain DedicationKynurenine Pathway (KP)Synaptic CleftMelatoninSynthesishydroxylationGABA-B-receptorCatecholamineSynthesisMethionineCycleIntestinBH4Synthase87rs265981formate2′-OXPH4DDCAngiotensinogenSTXBP1B9TPH1GLULBHMTrs2934966NOS1SPRCNTNAP25, 10-MTHFPGTPH2GABRB3ALDH1L1NOX3MG2+rs151257822CPLX1PAHDHMAL-histidineL-dopaL-phenylalaniners2550936ADAM10L-tyrosineCNTN3rs4130047FMNMN-SO4rs2254298SCN1Bmixed amphetamine salts(Adderall)rs2270641GCH1GTPCHADHmethylcob(III)alaminAGTR1MMAA3-MTNMNAT1SLC52A2FOLR1melatoninRFKrs6651806CNTN4CBSHDCMethylphenidate(Ritalin)rs1979277SLC52A3CBCollybistinSLC52A1HISN8MMADHCCblDDHNTPrs2071010rs3733890rs1051266L-glutamineNOS3L-alaniners2279709MeCblOPRM1rs602618nicotinate D-ribonucleotide(2−)Metanephriners237897SCN4AserotoninMTRcysteine sulfinateTAAR1NCAM1SIRT3rs362204rs4532rs779867rs740601q-BH2RS4818rs4633NM Aldehyde MAOASLC25A32glycine betaineFLAD1rs3758653HVALTCN2rs1799836SCN2Ars6582071rs2129575rs237887Metrs16976358rs651646 N-METHYL-HISTAMINErs5906883 DHFMOPGALrs11178997FOLH1SLC25A12L-cysteatePNPOALDH9A1pyridoxine 5'-phosphateGABRB1GLSCNTN5rs2298444TYCNTN6DOPEGGABRB2MTHFD2NMFe2+GPHNGABRA2rs590551GABRQSLC18A1rs5949028SCN11AN-MethylhistamineSCN3BMoCoACEALDH5A1rs3813034AHCYSLC46A1rs165599DOPLALDH2tyramineNOX5rs36017rs13909381′-OXPH4rs12843533rs3785143SCN7ASOD2rs2268491SCN5ASCN1AMetanephriners6189histamineCDO1CSAD4-aminobutanoateangiotensin IhypotaurineB12THF-polyglutamaters237902rs2242446DOPETrs4570625DBHrs4291NOX12-oxoglutaraters2292813rs6323NA AldehydeMTHFRGABRA5rs594445RS6267ADGRL3GPCRsSCN2Brs4680serineSCN10AMMACHCCblC5-hydroxy-L-tryptophanDerived From WP4159rs1801198GABRA4rs1023159rs4570625QDPRSULT1A3adrenalinePCBD1rs3027407MMABcblB4a-Hydroxytetrahydrobiopterinmoco sulfide CNTN2ALDH1L2FMO1rs6318rs1923886DNMT1dopaminers12843268rs13189021L-histidinolrs4446909CNTNAP3rs3746544PPH4rs7794745rs174696rs28386840O2Alpha-dystroglycanrs3027400rs53576PCBD2GABRA3DOPACAHCYL1L-tryptophanSYPMOCOSSAH(4aS,6R)-4a-hydroxy - BH4CNTNAP4NOX4rs1800544GABRA1RIT2SLC6A2NADSYN1pyridoxalImidazole-4-acetaters7997012sepiapterinGABRDrs2056202BiopterinCNTNAP1SHMT2SCN4BRENpyridoxaminers6269GABRG1TDCDHPGSCN8APNMTrs2088102rs6746030rs4343SOD1rs737865B6pyridoxiners1672717DHFRS-adenosyl-L-homocysteiners7632287PTSCYP2D6rs2710102H2O2rs6561333rs1051312GABRG2SLC18A2rs1465107Xanthurenic acidL-citrulliners1406946DOPGALrs5569SLC6A4MHPGMOPEGMetaboliters1805087SCN3ANASFADNOdeamido-NAD+rs2236225H4gtpGPTASMTMTRRSLC6A3DAT1CNTN1cystathionineNMN-SOB2rs1487275SAM5-MTHFSLC19A1GCAT3-MT SOAOC1MN2+rs686AANAT5-10MeTHFL-arginine5-MTSCN9AacetatePDXKrs10879352rs1950902imidazole-4-acetaldehydeDAG15-Hialrs3782025rs13522506R-BH4rs6280rs35062132rs2270637rs10521432QPRTSLC25A13rs251915O2−OH-tauriners165774MTHFD2LAKR1B1THFAKRCTHglycineMAOBALDHrs1799971rs378515710-formyl-THFrs1137070rs5989681HNMTrs1667627TYMSrs5905512L-cysteineKYAT3rs23788941, 124117961116, 32, 70, 1015478, 135117111463029, 89831046110535614059, 13327, 4411743113, 1196314309913, 464312213520, 329612043130963047993059265813655, 10511315, 82, 105136106404336, 934345, 10319, 101, 111113, 11922, 10913977, 13511126111139133104139303042135, 1381044313561111117961813077, 13561105, 13086, 1119631, 38, 79111, 1211115012227, 4412283, 12470, 11814026, 40, 6433, 1111391221113057, 11011826, 40, 118, 12911191963, 94111656032, 6211111142, 9630104614377, 1359253583078, 80, 95, 135139124, 1363868130122139, 1405113712211113810211841, 1244343431111113643135431334383, 13610, 16, 23, 47, 49...82471836, 9321, 35homocysteine139MAT1AMAT2BBH4BH27,8-dihydrofolateAKR1A1AKR1C330CBR130AKR1C1B3B91395, 10-MTHFPGSHMT112210-formyl-THFMTHFD1122MTHFD1LTHF122NADPrs87665742174NOS2NADPNADPHONOO-serotoninDopamineReceptorsdrd3drd5drd4drd2drd1htr4htr5bhtr6htr1dhtr1ehtr7htr2ahtr1fhtr5ahtr2bhtr1aahtr1bhtr2cadra2cadra1aadrb3aadra1badra2aadrb1adra2badra1dadrb2SerotoninReceptorsAdrenergicReceptorsserotoninNorepinephrinedopaminers180113148, 111rs180113348, 111rs4846049rs18013944811rs1532268rs3819331rs2518352rs121913223rs70991108B12139NANorepinephriners167771dopamine125serotonindopamineVMAHVA59, 133COMT1335-HIAANorepinephrineadrenalineClonidine39GuanfacinePrazosin39Atomoxetine(Strattera)10317SNRIEscitalopram (Lexapro)Fluoxetine (Prozac)Paroxetine (Paxil, Pexeva)Sertraline(Zoloft)L-GluL-AspL-Asprs90867044Ca2+SNAP25VAMP2SYT1STX1ACa2+GluRAMPAAMPARPSDGluNNMDANMDARmGluGRM8KCNA2KCNA1DLG3GRM6GRM5GRM3KCNA3GRIN2CDLG5DLGAP536GRM4GRIN2BDLGAP336GRIA1GRIN1GRM2GRIN2ADLGAP4KCNA436KCNA5DLG2KCNA6CNR1GRIA218GRM7DLGAP236OXTRMC4R1818SHANK1GRIA412F-actin128NLGN136S-SCAM128NRXN236GRIN3BABL1HOMER2128B-Catenin128GRIN3ASHANK128DLG4PSD95128SAPAPNLGN2128DLGAP13636KCNA7HOMER128CBL128SRBS2Cortactin76GRIN2D128NLGN4X36NRXN336APPSHANK3128GRIA318, 88GRIP2HOMER3128nArgBP276, 128DLG1NRXN1NLGN33618, 36, 52PTK2BP128128HOMER1128SHANK212GRM1GRIP1CACNG2PSD951289, 36, 37, 90CTTNF-actin128SAPAP128128SHANKCortactin128F-actin128F-actin128SHANK128SAPAP128128CortactinPSD95128ABL29, 36, 37, 90SHANK128SAPAP128128HOMER128PSD959, 36, 37, 90GKAP1128PP128128S-SCAM36, 128Beta-dystroglycanPotassium(k)channel36NeuroreceptorsPresynapticPostsynapticMetabotropicGlutamateReceptorsNMDAReceptorsAMPARReceptorsGABRAReceptors5-MTHFFOLR2HTR3AHTR3BHTR3CHTR3DHTR3Ers15433344CACNG6CACNG7CACNG3CACNG4CACNG8CACNG5CACNG1GNAQPLCB81oxytocin81OXTCACNA1C81angiotensin II61SOD2SOD368NADPH68MAOIsB95-MTHF5-10MeTHFrs6198rs6296969612712712712767, 1276767676767, 127676767, 127676767, 12767Glucocorticoid stimuli127Pro-inflammatorycytokines3-HydroxykynurenineKynurenic Acid97, 138138Picolinic Acid97IFNGKYNU3-Hydroxyanthranilic Acid97, 102, 138KAT1Quinolinic AcidQUIN24, 91, 102, 107, 117...Anthranilic Acid97, 138KynurenineNAD+97, 102, 138INFA117KMOIDO1IDO2T23OKAT3AADATAATMTNFAQUINNitric Oxide (NO) SynthaseSynaptic CleftSynaptic CleftadrenalineadrenalineNorepinephrineSynaptic VesicleadrenalineNeurotransmitter Catabolism (Breakdown) Synaptic vesiclegamma-hydroxybutyrate L-glutamateGABA99GABBR1SLC32A1succinate citrate cycleGAD2succinic semialdehydeALDH9A1ABATGAD1GABASLC6A1GABAGLS22A-3OBU99L-threonineHRSP12FMO3HistamineSynthase &CatabolismCysteine Synthase &CatabolismPLPpyridoxal 5'-phosphateFADFADFADB2riboflavin139, 140PLPPLPPLPFMN140


Description

Pathways associated with ADHD (Attention-Deficit/Hyperactivity Disorder) and Autism Spectrum Disorder (ASD):

One-Carbon (1C) Metabolism Folate Cycle Methionine Cycle Tetrahydrobiopterin (BH4) Pathway Neurotransmitter Synthesis, Reuptake, and Breakdown

Neuroreceptor Dynamics in the Synaptic Cleft

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Alex Madsen

9/11/2023
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History

View all...
CompareRevisionActionTimeUserComment
134491view05:19, 22 July 2024EgonwImproved the semantics of the references
134489view04:58, 22 July 2024EgonwRemoved template comments
134394view19:39, 21 July 2024EweitzRemove template comments
130790view09:07, 30 May 2024DeSlAll pathway models in WikiPathways are CC0, other licences are not valid.
129619view16:06, 19 May 2024Alexmadsen1
129618view15:55, 19 May 2024Alexmadsen1split Adderall into Dextroamphetamine
129599view17:29, 17 May 2024Alexmadsen1add beta blockers and connect adrenaline
129450view23:43, 22 April 2024EweitzModified title
128702view21:57, 20 February 2024EgonwFixed two datasources
128690view20:04, 19 February 2024EgonwRemoved redundant RHEA: prefix in two interaction identifiers
128491view01:18, 7 February 2024Alexmadsen1update
128483view04:10, 6 February 2024Alexmadsen1add Purine Synthesis cycle and connection and I connected in ADSL that is #22 on ASD/ADHD list.
128459view19:53, 4 February 2024Alexmadsen1updat PNMT SAD
128458view19:48, 4 February 2024Alexmadsen1add SNP
128312view19:35, 31 January 2024Khanspersupdate with latest changes from Alex Madsen
128112view19:42, 26 January 2024KhanspersReverted to version '19:33, 26 January 2024' by Khanspers
128111view19:39, 26 January 2024KhanspersLatest edits from Alex Madsen
128110view19:33, 26 January 2024KhanspersReverted to version '02:04, 6 January 2024' by Khanspers
128109view19:29, 26 January 2024KhanspersIncorporating latest changes from Alex Madsen
127881view02:04, 6 January 2024EweitzModified description
127879view23:55, 5 January 2024Alexmadsen1uodate TSC1/2 <-->AMPK <-> NOS
127878view23:13, 5 January 2024Alexmadsen1add GPT The linkage between AMPK, NOS, MECP2, PTEN, PRKCB, mTORC1, mTORC2, and their relationship to Autism Spectrum Disorder (ASD) represents a complex network of interactions critical for neuronal function and development.
127877view03:54, 5 January 2024Alexmadsen1added linkage between NOS and 5-MTH per https://doi.org/10.1159/000142363
127876view02:56, 5 January 2024Alexmadsen1added refrences for Cbl / b12 pathway and added methionine synthase interactome
127875view04:15, 4 January 2024Alexmadsen1final check in
127874view03:26, 4 January 2024Alexmadsen1add glycine > guanidinoacetate > creatine and several DOI refrences
127873view01:42, 4 January 2024Alexmadsen1
127869view03:20, 3 January 2024Alexmadsen1general cleanup
127868view03:16, 3 January 2024Alexmadsen1add mTORC1 and mTORC 2 complex and MAPK3 MAPK1
127867view01:01, 3 January 2024Alexmadsen1add PI3K/Akt/mTOR intracellular signaling pathway
127855view03:24, 2 January 2024Alexmadsen1reorganise gudimate recptors
127854view01:19, 2 January 2024Alexmadsen1
127850view18:45, 31 December 2023Alexmadsen1added DRD4 SNP and RD4 VNTR exon III-7 repeat (7R), rs916455, rs1800955
127849view02:16, 30 December 2023Alexmadsen1cleanup
127848view21:43, 28 December 2023Alexmadsen1removed incorrect linkage between DHF to THF and BH2 to BH4
127733view04:05, 30 November 2023Alexmadsen1add Risperidone
127724view04:16, 29 November 2023Alexmadsen1add SAMe to COMT Neurotransmitter Catabolism (Breakdown). Linked COMT SNP to PNMT.
127718view04:44, 28 November 2023Alexmadsen1add NDRI Bupropion (Wellbutrin), fix Guanfacine and Clonidine and other cleanup
127682view23:20, 21 November 2023EweitzModified description
127680view23:14, 21 November 2023EweitzModified title
127675view22:42, 19 November 2023Alexmadsen1clanup
127674view22:24, 19 November 2023Alexmadsen1general cleanup
127672view17:10, 18 November 2023Alexmadsen1add SAME to NA to NM with COMT
127671view05:38, 18 November 2023Alexmadsen1add SAM to SAH conversion for PNMT when convering Norepinephran to Epinephran
127665view02:51, 16 November 2023Alexmadsen1fix floating connections
127664view02:47, 16 November 2023Alexmadsen1add PEA,NMPEA,2-phenylacetaldehyde
127638view14:02, 11 November 2023EgonwFixed more reference identifiers
127637view13:33, 11 November 2023EgonwFixed a few references (removed a few duplicates) and added a missing slash is a DOI
127597view02:09, 3 November 2023Alexmadsen1clean up methods of action in synaptic gap
127596view01:46, 3 November 2023Alexmadsen1

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(4aS,6R)-4a-hydroxy - BH4MetaboliteCHEBI:15642 (ChEBI)
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
1′-OXPH4Metabolite
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
2A-3OBUMetaboliteCHEBI:78948 (ChEBI)
2′-OXPH4Metabolite
3-Hydroxyanthranilic AcidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
3-MT SOMetaboliteCHEBI:133708 (ChEBI)
3-MTMetaboliteCHEBI:1582 (ChEBI)
4-aminobutanoateMetabolite
4a-HydroxytetrahydrobiopterinMetaboliteCHEBI:15642 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-HIAAMetaboliteCHEBI:27823 (ChEBI) AKA 5-HIAA
5-HialMetaboliteCHEBI:50157 (ChEBI)
5-MTMetaboliteCHEBI:2089 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
5-hydroxy-L-tryptophanMetaboliteCHEBI:58266 (ChEBI)
6R-BH4MetaboliteCHEBI:59560 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AANATProteinQ16613 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABL1ProteinP00519 (Uniprot-TrEMBL)
ABL2ProteinP42684 (Uniprot-TrEMBL)
ACEGeneProductP12821 (Uniprot-TrEMBL)
ADAM10ProteinO14672 (Uniprot-TrEMBL)
ADGRL3 GPCRsProteinQ9HAR2 (Uniprot-TrEMBL)
ADHProtein
AGTR1ProteinP30556 (Uniprot-TrEMBL)
AHCYL1ProteinO43865 (Uniprot-TrEMBL)
AHCYProteinP23526 (Uniprot-TrEMBL)
AKRProtein
AKR1A1ProteinP14550 (Uniprot-TrEMBL)
AKR1B1ProteinP15121 (Uniprot-TrEMBL)
AKR1C1ProteinQ04828 (Uniprot-TrEMBL)
AKR1C3ProteinP42330 (Uniprot-TrEMBL)
ALDHProtein
ALDH1L1ProteinO75891 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALDH2ProteinP05091 (Uniprot-TrEMBL)
ALDH5A1ProteinCHEBI:57706 (Uniprot-TrEMBL)
ALDH9A1ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
AOC1GeneProductP19801 (Uniprot-TrEMBL)
APPProteinP05067 (Uniprot-TrEMBL)
ASMTProteinP46597 (Uniprot-TrEMBL)
Alpha-dystroglycanProtein
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
Anthranilic AcidMetaboliteCHEBI:16567 (ChEBI)
Atomoxetine (Strattera)MetaboliteHMDB14434 (HMDB)
B-CateninGeneProduct
B12MetaboliteCHEBI:17439 (ChEBI)
B2 riboflavinMetaboliteCHEBI:17015 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B3MetaboliteCHEBI:17154 (ChEBI)
B6 pyridoxineMetaboliteCHEBI:16709 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BH2 7,8-dihydrofolateMetaboliteCHEBI:64240 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
Beta-dystroglycanProtein
BiopterinMetaboliteCHEBI:15373 (ChEBI)
CACNA1CProteinQ13936 (Uniprot-TrEMBL)
CACNG1ProteinQ06432 (UniGene)
CACNG2ProteinQ9Y698 (Uniprot-TrEMBL)
CACNG3ProteinO60359 (UniGene)
CACNG4ProteinQ9UBN1 (UniGene)
CACNG5ProteinQ9UF02 (UniGene)
CACNG6ProteinQ9BXT2 (UniGene)
CACNG7ProteinP62955 (UniGene)
CACNG8ProteinQ8WXS5 (UniGene)
CB CollybistinProtein
CBLProteinP22681 (Uniprot-TrEMBL)
CBR1ProteinP16152 (Uniprot-TrEMBL)
CBSProteinP35520 (Uniprot-TrEMBL)
CDO1GeneProductQ16878 (Uniprot-TrEMBL)
CNR1ProteinP21554 (Uniprot-TrEMBL)
CNTN1GeneProductQ9UQ52 (Uniprot-TrEMBL)
CNTN2GeneProductO94779 (Uniprot-TrEMBL)
CNTN3GeneProductQ8IWV2 (Uniprot-TrEMBL)
CNTN4GeneProductQ9P232 (Uniprot-TrEMBL)
CNTN5GeneProductQ02246 (Uniprot-TrEMBL)
CNTN6GeneProductQ12860 (Uniprot-TrEMBL)
CNTNAP1GeneProductP78357 (Uniprot-TrEMBL)
CNTNAP2GeneProductQ9UHC6 (Uniprot-TrEMBL)
CNTNAP3GeneProductQ9BZ76 (Uniprot-TrEMBL)
CNTNAP4GeneProductQ9C0A0 (Uniprot-TrEMBL)
COMTProteinP21964 (Uniprot-TrEMBL) AKA Catechol-O- metyltransferase
CPLX1ProteinO14810 (Uniprot-TrEMBL)
CSADProteinQ9Y600 (Uniprot-TrEMBL)
CTHProteinP32929 (Uniprot-TrEMBL)
CTTNProteinQ14247 (UniGene)
CYP2D6ProteinP10635 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
ClonidineMetaboliteCHEBI:46631 (ChEBI)
CortactinGeneProduct
DAG1GeneProductQ14118 (Uniprot-TrEMBL)
DBHProteinP09172 (Uniprot-TrEMBL)
DDCProteinP20711 (Uniprot-TrEMBL)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DHMAMetaboliteCHEBI:27637 (ChEBI)
DHNTPMetaboliteCHEBI:18372 (ChEBI)
DHPGMetaboliteCHEBI:1387 (ChEBI)
DLG1ProteinQ12959 (Uniprot-TrEMBL)
DLG2ProteinQ15700 (Uniprot-TrEMBL)
DLG3ProteinQ92796 (Uniprot-TrEMBL)
DLG4 PSD95ProteinP78352 (Uniprot-TrEMBL)
DLG5ProteinQ8TDM6 (Uniprot-TrEMBL)
DLGAP1GeneProductO14490 (Uniprot-TrEMBL)
DLGAP2GeneProductQ9P1A6 (Uniprot-TrEMBL)
DLGAP3GeneProductO95886 (Uniprot-TrEMBL)
DLGAP4GeneProductQ9Y2H0 (Uniprot-TrEMBL)
DLGAP5GeneProductQ15398 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DOPEGMetaboliteCHEBI:1387 (ChEBI)
DOPETMetaboliteCHEBI:68889 (ChEBI)
DOPGAL MetaboliteCHEBI:180943 (ChEBI)
DOPLMetaboliteCHEBI:27978 (ChEBI)
Derived From WP4159PathwayWP4159 (WikiPathways)
F-actinGeneProduct
FADMetaboliteCHEBI:57692 (ChEBI)
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI)
FMO1GeneProductQ01740 (Uniprot-TrEMBL)
FMO3GeneProductQ01740 (Uniprot-TrEMBL)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
Fe2+Metabolite
GABAMetaboliteCHEBI:59888 (ChEBI)
GABBR1ProteinQ9UBS5 (Uniprot-TrEMBL)
GABRA1ProteinP14867 (Uniprot-TrEMBL)
GABRA2ProteinP47869 (Uniprot-TrEMBL)
GABRA3ProteinP34903 (Uniprot-TrEMBL)
GABRA4ProteinP48169 (Uniprot-TrEMBL)
GABRA5ProteinP31644 (Uniprot-TrEMBL)
GABRB1ProteinP18505 (Uniprot-TrEMBL)
GABRB2ProteinP47870 (Uniprot-TrEMBL)
GABRB3ProteinP28472 (Uniprot-TrEMBL)
GABRDProteinO14764 (Uniprot-TrEMBL)
GABRG1ProteinQ8N1C3 (Uniprot-TrEMBL)
GABRG2ProteinP18507 (Uniprot-TrEMBL)
GABRQProteinQ9UN88 (Uniprot-TrEMBL)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GCATGeneProductO75600 (Uniprot-TrEMBL)
GCH1 GTPCHProteinP30793 (Uniprot-TrEMBL)
GKAP1GeneProductQ5VSY0 (Uniprot-TrEMBL)
GLS2ProteinQ9UI32 (Uniprot-TrEMBL)
GLSProteinO94925 (Uniprot-TrEMBL)
GLULGeneProductP15104 (Uniprot-TrEMBL)
GNAQProteinP50148 (Uniprot-TrEMBL)
GPHNProteinQ9NQX3 (Uniprot-TrEMBL)
GRIA1ProteinP42261 (Uniprot-TrEMBL)
GRIA2ProteinP42262 (Uniprot-TrEMBL)
GRIA3ProteinP42263 (Uniprot-TrEMBL)
GRIA4ProteinP48058 (Uniprot-TrEMBL)
GRIN1ProteinQ05586 (Uniprot-TrEMBL)
GRIN2AProteinQ12879 (Uniprot-TrEMBL)
GRIN2BProteinQ13224 (Uniprot-TrEMBL)
GRIN2CProteinQ14957 (Uniprot-TrEMBL)
GRIN2DProteinO15399 (Uniprot-TrEMBL)
GRIN3AProteinQ8TCU5 (Uniprot-TrEMBL)
GRIN3BProteinO60391 (Uniprot-TrEMBL)
GRIP1ProteinQ9Y3R0 (Uniprot-TrEMBL)
GRIP2ProteinQ9C0E4 (Uniprot-TrEMBL)
GRM1ProteinQ13255 (Uniprot-TrEMBL)
GRM2ProteinQ14416 (Uniprot-TrEMBL)
GRM3ProteinQ14832 (Uniprot-TrEMBL)
GRM4ProteinQ14833 (Uniprot-TrEMBL)
GRM5ProteinP41594 (Uniprot-TrEMBL)
GRM6ProteinO15303 (Uniprot-TrEMBL)
GRM7ProteinQ14831 (Uniprot-TrEMBL)
GRM8ProteinO00222 (Uniprot-TrEMBL)
GuanfacineMetaboliteHMDB15153 (HMDB)
H2O2Metabolite16240 (ChEBI)
H4gtp GPTMetaboliteCHEBI:15996 (ChEBI)
HDCGeneProductP19113 (Uniprot-TrEMBL)
HISN8ProteinQ9C5U8 (Uniprot-TrEMBL)
HNMTGeneProductP50135 (Uniprot-TrEMBL)
HOMERGeneProduct
HOMER1ProteinQ86YM7 (Uniprot-TrEMBL)
HOMER2ProteinQ9NSB8 (Uniprot-TrEMBL)
HOMER3ProteinQ9NSC5 (Uniprot-TrEMBL)
HRSP12ProteinP52758 (Uniprot-TrEMBL)
HTR3AProteinP40227 (Uniprot-TrEMBL)
HTR3BProteinO95264 (Uniprot-TrEMBL)
HTR3CProteinQ8WXA8 (Uniprot-TrEMBL)
HTR3DProteinQ70Z44 (Uniprot-TrEMBL)
HTR3EProteinA5X5Y0 (Uniprot-TrEMBL)
HVAMetaboliteCHEBI:545959 (ChEBI) AKA HVA
HVALMetabolite
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
INFAProtein
Imidazole-4-acetateMetaboliteCHEBI:16974 (ChEBI)
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KCNA1ProteinQ09470 (Uniprot-TrEMBL)
KCNA2ProteinP16389 (Uniprot-TrEMBL)
KCNA3ProteinP22001 (Uniprot-TrEMBL)
KCNA4ProteinP22459 (Uniprot-TrEMBL)
KCNA5ProteinP22460 (Uniprot-TrEMBL)
KCNA6ProteinP17658 (Uniprot-TrEMBL)
KCNA7ProteinQ96RP8 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KYAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Kynurenic AcidMetaboliteCHEBI:58454 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
L-alanineMetabolite57972 (ChEBI)
L-arginineMetaboliteCHEBI:32682 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
L-cysteateMetaboliteCHEBI:58090 (ChEBI)
L-cysteineMetaboliteCHEBI:35235 (ChEBI)
L-dopaMetaboliteCHEBI:57504 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
L-glutamineMetaboliteCHEBI:58359 (ChEBI)
L-histidineMetaboliteCHEBI:57595 (ChEBI)
L-histidinolMetaboliteCHEBI:57699 (ChEBI)
L-phenylalanineMetaboliteCHEBI:58095 (ChEBI)
L-threonineMetaboliteCHEBI:57926 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
MAOAProteinP21397 (Uniprot-TrEMBL)
MAOBProteinP27338 (Uniprot-TrEMBL)
MAOIsMetabolite
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MC4RProteinP32245 (Uniprot-TrEMBL)
MG2+MetaboliteCHEBI:18420 (ChEBI)
MHPG MOPEGMetaboliteCHEBI:1576 (ChEBI)
MMAAGeneProductQ8IVH4 (dbSNP)
MMAB cblBProteinQ96EY8 (Uniprot-TrEMBL)
MMACHC

CblC

GeneProductQ9Y4U1 (Uniprot-TrEMBL)
MMADHC CblDGeneProductQ9H3L0 (Uniprot-TrEMBL)
MN-SO4MetaboliteHMDB0240719 (HMDB)
MN2+Metabolite
MOCOSProteinQ96EN8 (Uniprot-TrEMBL)
MOPGALMetabolite27932 (ChEBI)
MTHFD1LProteinQ6UB35 (Uniprot-TrEMBL)
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFD2LProteinQ9H903 (Uniprot-TrEMBL)
MTHFD2ProteinP13995 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCblMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
MetaboliteMetabolite
MetanephrineMetaboliteCHEBI:89633 (ChEBI)
MetanephrineMetaboliteHMDB04063 (HMDB)
Methylphenidate (Ritalin)MetaboliteHMDB14566 (HMDB)
MoCoMetabolite71302 (ChEBI)
N-METHYL-HISTAMINEMetaboliteCHEBI:58600 (ChEBI)
N-MethylhistamineMetaboliteCHEBI:29009 (ChEBI)
NA NorepinephrineMetaboliteCHEBI:72587 (ChEBI)
NA AldehydeMetabolite
NAD+MetaboliteCHEBI:13389 (ChEBI)
NADPMetaboliteCHEBI:58349 (ChEBI)
NADPHMetaboliteCHEBI:57783 (ChEBI)
NADSYN1ProteinQ6IA69 (Uniprot-TrEMBL)
NASMetaboliteCHEBI:17697 (ChEBI)
NCAM1ProteinP13591 (Uniprot-TrEMBL)
NLGN1ProteinQ8N2Q7 (Uniprot-TrEMBL)
NLGN2ProteinQ8NFZ4 (Uniprot-TrEMBL)
NLGN3ProteinQ9NZ94 (Uniprot-TrEMBL)
NLGN4XProteinQ8N0W4 (Uniprot-TrEMBL)
NM Aldehyde Metabolite
NMMetaboliteHMDB00819 (HMDB)
NMN-SOMetaboliteHMDB0240719 (HMDB)
NMNAT1ProteinQ9HAN9 (Uniprot-TrEMBL)
NOMetabolite16480 (ChEBI)
NOS1ProteinP29475 (Uniprot-TrEMBL)
NOS2ProteinP35228 (Uniprot-TrEMBL)
NOS3ProteinP29474 (Uniprot-TrEMBL)
NOX1ProteinQ9Y5S8 (Uniprot-TrEMBL)
NOX3ProteinQ9HBY0 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
NOX5ProteinQ96PH1 (Uniprot-TrEMBL)
NRXN1ProteinQ9ULB1 (Uniprot-TrEMBL)
NRXN2ProteinP58401 (Uniprot-TrEMBL)
NRXN3ProteinQ9HDB5 (Uniprot-TrEMBL)
NorepinephrineMetaboliteCHEBI:72587 (ChEBI)
O2MetaboliteCHEBI:5379 (ChEBI)
O2−MetaboliteCHEBI:18421 (ChEBI)
OH-Metabolite
ONOO-MetaboliteCHEBI:25941 (ChEBI)
OPRM1ProteinP35372 (UniGene)
OXTProteinP01178 (Uniprot-TrEMBL)
OXTRProteinP30559 (Uniprot-TrEMBL)
P
PAHProteinP00439 (Uniprot-TrEMBL)
PCBD1ProteinP61457 (Uniprot-TrEMBL)
PCBD2ProteinQ9H0N5 (Uniprot-TrEMBL)
PDXKProteinO00764 (Uniprot-TrEMBL)
PLCBGeneProductP50148 (Uniprot-TrEMBL)
PLP pyridoxal 5'-phosphateMetaboliteCHEBI:597326 (ChEBI)
PLPMetaboliteCHEBI:597326 (ChEBI)
PNMTProteinP11086 (Uniprot-TrEMBL)
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
PPH4MetaboliteCHEBI:17804 (ChEBI)
PSD95GeneProductP78352 (Uniprot-TrEMBL)
PTK2BProteinQ14289 (Uniprot-TrEMBL)
PTSProteinQ03393 (Uniprot-TrEMBL)
Picolinic AcidMetaboliteCHEBI:28747 (ChEBI)
PrazosinMetaboliteHMDB14600 (HMDB)
QDPRProteinP09417 (Uniprot-TrEMBL)
QPRTProteinQ15274 (Uniprot-TrEMBL)
QUINMetaboliteCHEBI:16675 (ChEBI)
Quinolinic Acid QUINMetaboliteCHEBI:16675 (ChEBI)
RENProteinP00797 (Uniprot-TrEMBL)
RFKProteinQ969G6 (Uniprot-TrEMBL)
RIT2ProteinQ99578 (Uniprot-TrEMBL)
RS4818Rna
RS6267Rna
S-SCAMGeneProduct
S-adenosyl-L-homocysteineMetaboliteCHEBI:57856 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAM MetaboliteCHEBI:59789 (ChEBI)
SAPAPGeneProduct
SCN10AGeneProductQ9Y5Y9
SCN11AGeneProductQ9UI33
SCN1AGeneProductP35498
SCN1BGeneProductQ07699
SCN2AGeneProductQ99250
SCN2BGeneProductO60939
SCN3AGeneProductQ9NY46
SCN3BGeneProductQ9NY72
SCN4AGeneProductP35499
SCN4BGeneProductQ8IWT1
SCN5AGeneProductQ14524
SCN7AGeneProductQ01118
SCN8AGeneProductQ9UQD0
SCN9AGeneProductQ15858
SHANKGeneProduct
SHANK1ProteinQ9Y566 (Uniprot-TrEMBL)
SHANK2ProteinQ9UPX8 (Uniprot-TrEMBL)
SHANK3ProteinQ9BYB0 (Uniprot-TrEMBL)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SHMT2ProteinP34897 (Uniprot-TrEMBL)
SIRT3GeneProductQ9NTG7 (Uniprot-TrEMBL)
SLC18A1ProteinP54219 (Uniprot-TrEMBL)
SLC18A2Protein
SLC19A1Protein
SLC25A12ProteinO75746 (Uniprot-TrEMBL)
SLC25A13ProteinQ9UJS0 (Uniprot-TrEMBL)
SLC25A32ProteinQ9H2D1 (Uniprot-TrEMBL)
SLC32A1ProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC6A1GeneProductP30531 (Uniprot-TrEMBL)
SLC6A2Protein
SLC6A3 DAT1Protein
SLC6A4ProteinP31645 (Uniprot-TrEMBL)
SNAP25ProteinP60880 (Uniprot-TrEMBL)
SNRI

Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil, Pexeva)

Sertraline(Zoloft)		MetaboliteHMDB14600 (HMDB)
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2ProteinP04179 (Uniprot-TrEMBL)
SOD3ProteinP08294 (Uniprot-TrEMBL)
SPRProteinP35270 (Uniprot-TrEMBL)
SRBS2GeneProductO94875 (Uniprot-TrEMBL)
STX1AProteinQ16623 (Uniprot-TrEMBL)
STXBP1ProteinP61764 (Uniprot-TrEMBL)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYPProteinP08247 (Uniprot-TrEMBL)
SYT1ProteinP21579 (Uniprot-TrEMBL)
T23OProteinP48775 (Uniprot-TrEMBL)
TAAR1ProteinQ96RJ0 (Uniprot-TrEMBL)
TCN2Protein
TDC Protein
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TNFAProteinP01375 (Uniprot-TrEMBL)
TPH1ProteinP17752 (Uniprot-TrEMBL)
TPH2ProteinQ8IWU9 (Uniprot-TrEMBL)
TYMSProteinP04818 (Uniprot-TrEMBL)
TYProteinP07101 (Uniprot-TrEMBL)
VAMP2ProteinP63027 (Uniprot-TrEMBL)
VMAMetaboliteCHEBI:27622 (ChEBI)
Xanthurenic acidMetaboliteCHEBI:10072 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
adra1aGeneProductENSDARG00000028725 (Ensembl)
adra1bGeneProductENSDARG00000011317 (Ensembl)
adra1dGeneProductENSDARG00000024101 (Ensembl)
adra2aGeneProduct266750 (Entrez Gene)
adra2bGeneProduct266751 (Entrez Gene)
adra2cGeneProduct266752 (Entrez Gene)
adrb1GeneProduct557194 (Entrez Gene)
adrb2GeneProduct
adrb3aGeneProduct558248 (Entrez Gene)
adrenalineMetaboliteCHEBI:28918 (ChEBI)
angiotensin IMetaboliteCHEBI:147350 (ChEBI)
angiotensin IIMetaboliteCHEBI:58506 (ChEBI)
citrate cyclePathwayWP78 (WikiPathways)
cystathionineMetaboliteCHEBI:58161 (ChEBI)
cysteine sulfinateMetaboliteCHEBI:61085 (ChEBI)
deamido-NAD+MetaboliteCHEBI:58437 (ChEBI)
dopamineMetaboliteCHEBI:59905 (ChEBI)
drd1GeneProduct568126 (Entrez Gene)
drd2GeneProduct
drd3GeneProduct282554 (Entrez Gene)
drd4GeneProduct
drd5GeneProductENSDARG00000090669 (Ensembl)
formateMetaboliteCHEBI:15740 (ChEBI)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
histamineMetaboliteCHEBI:58432 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
htr1aaGeneProduct100001828 (Entrez Gene)
htr1bGeneProduct561647 (Entrez Gene)
htr1dGeneProductENSDARG00000054124 (Ensembl)
htr1eGeneProductENSDARG00000011468 (Ensembl)
htr1fGeneProductENSDARG00000002773 (Ensembl)
htr2aGeneProductENSDARG00000057029 (Ensembl)
htr2bGeneProductENSDARG00000070940 (Ensembl)
htr2cGeneProduct
htr4GeneProductENSDARG00000061940 (Ensembl)
htr5aGeneProduct100038775 (Entrez Gene)
htr5bGeneProduct
htr6GeneProductENSDARG00000016095 (Ensembl)
htr7GeneProductENSDARG00000056949 (Ensembl)
hypotaurineMetaboliteCHEBI:57853 (ChEBI)
imidazole-4-acetaldehydeMetaboliteCHEBI:27398 (ChEBI)
melatoninMetaboliteCHEBI:16796 (ChEBI)
methylcob(III)alaminMetaboliteCHEBI:28115 (ChEBI)
mixed amphetamine salts (Adderall)Metabolite
moco sulfide Metabolite82685 (ChEBI)
nArgBP2Protein
nicotinate D-ribonucleotide(2−)MetaboliteCHEBI:57502 (ChEBI)
oxytocinMetaboliteCHEBI:7872 (ChEBI)
pyridoxalMetaboliteCHEBI:17310 (ChEBI)
pyridoxamineMetaboliteCHEBI:57761 (ChEBI)
pyridoxine 5'-phosphateMetaboliteCHEBI:58589 (ChEBI)
q-BH2MetaboliteCHEBI:43029 (ChEBI)
rs1023159Rna
rs1051266Rna
rs1051312Rna
rs10521432Rna
rs10879352Rna
rs11178997Rna
rs1137070Rna
rs121913223Rna
rs12843268Rna
rs12843533Rna
rs13189021Rna
rs1352250Rna
rs1390938Rna
rs1406946Rna
rs1465107Rna
rs1487275Rna
rs151257822GeneProduct
rs1532268Rna
rs1543334Rna
rs165599Rna
rs165774Rna
rs1667627Rna
rs1672717Rna
rs167771Rna
rs16976358Rna
rs174696Rna
rs1799836Rna
rs1799971Rna
rs1800544Rna
rs1801131Rna
rs1801133Rna
rs1801198Rna
rs1801394Rna
rs1805087Rna
rs1923886Rna
rs1950902Rna
rs1979277Rna
rs2056202Rna
rs2071010Rna
rs2088102Rna
rs2129575Rnars2129575
rs2236225Rna
rs2242446Rna
rs2254298GeneProduct
rs2268491GeneProduct
rs2270637Rna
rs2270641Rna
rs2279709Rna
rs2292813Rna
rs2298444Rna
rs237887GeneProduct
rs237889GeneProduct
rs237897GeneProduct
rs237902GeneProduct
rs2518352Rna
rs251915Rna
rs2550936Rna
rs265981Rna
rs2710102Rna
rs28386840Rna
rs2934966Rna
rs3027400Rna
rs3027407Rna
rs35062132GeneProduct
rs36017Rna
rs362204Rna
rs3733890Rna
rs3746544Rna
rs3758653Rna
rs3782025Rna
rs3785143Rna
rs3785157Rna
rs3813034Rna
rs3819331Rna
rs4130047Rna
rs4291Rna
rs4343Rna
rs4446909Rna
rs4532Rna
rs4570625Rna
rs4633Rna
rs4680Rna
rs4846049Rna
rs53576GeneProduct
rs5569Rna
rs590551Rna
rs5905512Rna
rs5906883 Rna
rs594445Rna
rs5949028Rna
rs5989681Rna
rs602618Rna
rs6189Rna
rs6198Rna
rs6269Rna
rs6280Rna
rs6296Rna
rs6318Rna
rs6323Rna
rs651646 Rna
rs6561333Rna
rs6582071Rna
rs6651806Rna
rs6746030Rna
rs686Rna
rs70991108Rna
rs737865Rna
rs740601Rna
rs7632287GeneProduct
rs7794745Rna
rs779867Rna
rs7997012Rna
rs876657421Rna
rs908670Rna
sepiapterinMetaboliteCHEBI:16095 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
serotoninMetaboliteCHEBI:350546 (ChEBI)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteCHEBI:57706 (ChEBI)
taurineMetaboliteCHEBI:507393 (ChEBI)
tyramineMetaboliteCHEBI:327995 (ChEBI)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5420"
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