ADHD and autism (ASD) pathways (Homo sapiens)

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116251111161161411257611611956, 125MitochondriaNucleusAdrenal MedullaSynapticVesicleAdrenal VesicleSynapticVesicle2-arachidonyl glyceryl ether = 2-AGE = Noladin etherCannabinoid receptor 1 = CB1 = CRN1Cannabinoid receptor 2 = CB2 = CRN2Alex Madsen2023copyright (c) 2023CC0 1.0 Universal (CC0 1.0)Public Domain DedicationROSReactive OxygenStresshydroxylationSerotoninSynthesis(5-HT)GABA-B-receptorIntestinOpioid ReceptorMethionineCycleMelatoninSynthesiscytosol (intracellular)CatecholamineSynthesisIntercellularFolateCycleSynaptophysinSynaptobrevinComplexKynurenine Pathway (KP)n.e.Synaptic CleftBH4Synthase45rs3785157SLC25A13rs3027407deamido-NAD+rs151257822SCN2AAOC1O2L-histidineBHMTrs1979277rs1923886CNTN2RENGLULS-adenosyl-L-homocysteiners740601rs37338903-MTrs2279709SOD2glycineDHFRrs6318rs265981rs4130047rs2129575rs3027400SCN1BMAOBPCBD2TDCrs79970125-10MeTHFrs2254298NOX1SCN1ASCN8ANASrs2056202CDO1SAHAlpha-dystroglycanMethylphenidate(Ritalin)formateRS4818MetanephrineKYAT3rs1137070serineGABRA510-formyl-THFTYQDPRCNTN5H4gtpGPTrs1023159rs165599N-METHYL-HISTAMINECNTNAP2AGTR1alkylglycerolstaurineglycerol 3-phosphateDOPLrs36017rs3813034QPRTPDXKrs2236225MG2+acetaters2242446OPRM1SULT1A3CNTN4SLC52A2rs12843268FLAD1glycine betaineMAOArs16976358SYPDOPETAANATCNTN1L-phenylalanineMTRRXanthurenic acidrs5906883 PNMTBiopterinimidazole-4-acetaldehydeSLC52A14-aminobutanoaters53576rs2550936rs737865MoCors237889NMN-SONOX3PPH4MN-SO4(4aS,6R)-4a-hydroxy - BH4SLC18A1AKRrs4570625CTHrs11178997SCN9AhemiacetalsNMNAT1pyridoxaminers4446909PCBD1rs13189021TPH2MTRImidazole-4-acetateDHFrs7794745NADSYN1NMrs2292813L-arginineSCN4BALDHAdoCblH2O2FOLH1MeCblCBSO2−rs35062132serotoninSPR5-MTHFSCN2Brs4680SHMT2FOLR1rs6189ALDH21-O-(1,2-saturated-alkyl)-sn-glycerolMOCOSrs62805, 10-MTHFPGrs2071010MTHFD2Lhypotauriners6746030GABRB3melatoninB2rs6269rs237902rs3782025SCN3BALDH1L1MOPGALrs1801198PAHL-tyrosinenoladin ether2-AGEGKTYMSMN2+rs6561333HISN8L-dopaPTSCNTN6AGMOrs10521432CPLX1angiotensin IDHNTPOH-GABRDrs1672717rs779867pyridoxalrs1950902THF-polyglutamateDerived From WP4271DOPGALGCH1GTPCHFe2+rs602618rs590551SCN4ACSADGABRA4rs3785143rs7632287DDCB9dopamineDerived From WP4159rs2088102RIT2rs63231′-OXPH4ALDH9A1rs2934966GABRQSCN3Ars4570625NCAM1DOPEGDOPAC2-oxoglutaraters237897nicotinate D-ribonucleotide(2−)SLC6A2SLC6A2rs4291rs1487275Metanephrineq-BH2DBHSLC19A1FMNGABRA1CNTNAP4moco sulfide NOsepiapterinASMTL-alanine6R-BH4SCN5AALDH5A1rs4633NM Aldehyde cystathionineGABRB2HCFC1 (cblX)rs5949028TCN2DAG1adrenalineMHPGMOPEGSCN7AFMO1rs22984445-HialL-cysteiners1051266AHCYL1a 1-(1-hydroxyalkyl)-sn-glycerolGABRB1N-Methylhistaminetyraminers12843533GLSrs1465107rs5989681L-glutamineSAMRFKACESLC46A1L-cysteateNOS3SIRT3rs5905512rs2270637STXBP1rs1800544HDCrs4532rs1799836NOX4CBCollybistinrs3746544rs3622042′-OXPH4rs237887rs2710102L-histidinolAHCYrs2270641NOS14a-HydroxytetrahydrobiopterinGABRA2rs174696THFGPHNglycerolL-citrullineCNTNAP1rs1805087rs13522505-MTmixed amphetamine salts(Adderall)rs686SLC25A123-MT SOrs1051312SLC6A4CNTN3rs651646 rs165774cysteine sulfinateSLC25A32AngiotensinogenMTHFD2CNTNAP3rs5569rs1667627rs594445NOX5L-tryptophanGCATRS6267SCN10ADHPGGABRG1rs1406946fatty aldehydesHNMTMTHFRSLC52A3DHMApyridoxine 5'-phosphaters6651806ALDH1L2ADGRL3GPCRsPNPOCYP2D6SOD1B6pyridoxiners2268491histaminers10879352rs3758653SLC6A3DAT1GABRA3NA Aldehyders1390938rs1799971rs4343rs65820715-hydroxy-L-tryptophanDNMT1SCN11AGABRG2ADAM10TAAR1rs28386840HVALADHTPH1q-H2BPTAKR1B1rs251915MetFAD1515, 1069499771067570910612, 849, 42125993896155145112, 15512744, 54106753415114012105106112, 14556, 125103758615131151499966010615172, 1061569, 28, 92, 1299619, 809964, 1257512, 27, 60, 84, 113...13815187, 106, 10968, 1037536, 70, 11015638, 108111157145, 155157971511119310617, 64, 74, 1252228236, 1181571650, 9510611075106252, 106101767760125129552222, 7038, 108863446, 7077, 14015196251519729107106147991255355, 83129156, 1585753, 12582121, 998110610656, 1259712, 8442, 44, 87, 13520753410634135229915115156, 12510620, 37, 6530, 133861568649, 11210528, 129, 1542515197840, 4716, 8615, 90106151104342516944, 1433482, 12115614515, 9049, 1127575homocysteine86MAT1AMAT2BBH4BH27,8-dihydrofolateAKR1A1AKR1C375CBR175AKR1C1B386B95, 10-MTHFPG34SHMT110-formyl-THFMTHFD134MTHFD1LTHF34NADPrs87665742135NOS2NADPNADPHONOO-serotoninDopamineReceptorsdrd3drd5drd4drd2drd1htr4htr5bhtr6htr1dhtr1ehtr7htr2ahtr1fhtr5ahtr2bhtr1aahtr1bhtr2cadra2cadra1aadrb3aadra1badra2aadrb1adra2badra1dadrb2SerotoninReceptorsAdrenergicReceptorsserotoninNorepinephrinedopaminers1801131rs180113378, 106rs484604978, 10678rs1801394117rs1532268rs3819331rs2518352rs121913223rs70991108NANorepinephriners167771dopamine128serotonindopamineVMAHVA77, 140COMT775-HIAANorepinephrineadrenalineClonidine120GuanfacinePrazosin120Atomoxetine(Strattera)19SNRIEscitalopram (Lexapro)Fluoxetine (Prozac)Paroxetine (Paxil, Pexeva)Sertraline(Zoloft)142L-GluL-AspL-Asprs90867090Ca2+SNAP25VAMP2SYT1STX1ACa2+GluRAMPAAMPARPSDGluNNMDANMDARmGluGRM8KCNA2KCNA1DLG3GRM6GRM5GRM3KCNA3GRIN2CDLG5DLGAP5GRM438GRIN2BDLGAP3GRIA138GRIN1GRM2GRIN2ADLGAP438KCNA4KCNA5DLG2KCNA6CNR1GRIA2111GRM7DLGAP2OXTR38111MC4RSHANK1111GRIA4141F-actin116NLGN138S-SCAM116NRXN238GRIN3BABL1116HOMER2CTNNB1116GRIN3ASHANKDLG4PSD95116116SAPAP116NLGN238DLGAP138KCNA7HOMER116CBL116SRBS2Cortactin132116GRIN2DNLGN4XNRXN338APP38SHANK3116GRIA389, 111GRIP2HOMER3116nArgBP2116, 132DLG1NRXN1NLGN3383, 38, 111PTK2BP116116HOMER1116SHANK2GRM1141GRIP1CACNG2PSD9511632, 38, 48, 144CTTNF-actin116SAPAP116116SHANK116CortactinF-actin116116F-actin116SHANKSAPAP116116Cortactin116PSD95ABL232, 38, 48, 144SHANK116116SAPAPHOMER116PSD95116GKAP132, 38, 48, 144116PP116116S-SCAMBeta-dystroglycan38, 116Potassium(k)channel38NeuroreceptorsPresynapticPostsynapticMetabotropicGlutamateReceptorsNMDAReceptorsAMPARReceptorsGABRAReceptors5-MTHFFOLR2HTR3AHTR3BHTR3CHTR3DHTR3Ers154333485CACNG6CACNG7CACNG3CACNG4CACNG8CACNG5CACNG1GNAQPLCB8888oxytocinOXTCACNA1C88angiotensin II25SOD2SOD38181NADPHMAOIsB95-MTHF5-10MeTHFrs619899rs6296994141414141, 676767676741, 67676741, 67676741, 6767Glucocorticoid stimuli41Pro-inflammatorycytokines3-Hydroxykynurenine52, 53Kynurenic AcidPicolinic Acid53IFNG52KYNU3-Hydroxyanthranilic AcidKAT152, 53, 138Quinolinic AcidQUIN39, 53, 76, 97, 134...Anthranilic AcidKynurenine52, 53NAD+52, 53, 138INFA97KMOIDO1IDO2T23OKAT3AADATAATMTNFAQUINNitric Oxide (NO) SynthaseSynaptic CleftSynaptic CleftadrenalineadrenalineNorepinephrineSynaptic VesicleadrenalineNeurotransmitter Catabolism (Breakdown) Synaptic vesiclegamma-hydroxybutyrate L-glutamateGABA105GABBR1SLC32A1succinate citrate cycleGAD2succinic semialdehydeALDH9A1ABATGAD1GABASLC6A1GABAGLS21052A-3OBUL-threonineFMO3HistamineSynthase &CatabolismCysteine Synthase &CatabolismPLPpyridoxal 5'-phosphateFADFADB2riboflavin16, 86PLPPLPPLPFMNLysosome16911006959cblJABCD4Succinyl-CoAMMUTCblCD320R-cob(III)alamincob(II)alamin13cob(I)alamincbLAMMAAMethylmalonyl-CoAMMADHCcblFLMBRD1cbLCMMACHCcbLCMMACHCFADFMNMMABcblB100PLPPLPPLPPLPPLPPLPR-cob(III)alaminCblD-1MMADHCCblD-2MMADHCCblDMMADHCCYP3A4CYP2C1924Relevant MAPK subtypesendogenous cannabinoidsPKACBD catabolismNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)inactiveInhibition of Glutamate or GABA release in synaptic cleftHepG2 cellsMAPK11MAPK9MAPK10MAPK14MAPK8MAPK12ADCY1MAPK3MAPK1MAPK13CNR1CB1CYP2C911-OH-THCMAPK PhosphatidylethanolamineDAGLBcAMP AHRNAPEPLD14ADCY7NAPE1DAGLA14Arachidonic acidTHC1''-hydroxycannabidiol2-arachidonoylglycerol24protein tyrosine kinasesFAAH14GlutamateADORA2ACNR2CB273CalciumGABA ATPAEAAnti-inflammatory pathwaysCOOH-THCCYP1A113758CBD2''-hydroxycannabidiol 3''-hydroxycannabidiol 24244''-hydroxycannabidiol 5''-hydroxycannabidiol 246a-hydroxycannabidiol 24246b-hydroxycannabidiol 7-hydroxycannabidiol 2424endogeneous cannabinoid synthesisPRKACBPRKACAPRKAR1APRKAR2BPRKAR1BPRKACGPRKAR2APKA regulatory subunit type IPKAcatalytic subunitPKA regulatory subunit type II


Description

Endogenous cannabinoid receptors belong to the endocannabinoid system and are located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. The endocannabinoid system is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis. Two primary endocannabinoid receptors have been identified: CNR1 and CNR2. CNR1 is found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC (tetrahydrocannabinol). One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD (cannabidiol). 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.

Source: https://en.wikipedia.org/wiki/Endocannabinoid_system

Not all MAPK subtypes are relevant for this pathway. The relevant types have been separately added on the right side of the pathway.

Source: Howlett A.C. Cannabinoid Receptor Signaling. In: Pertwee R.G. (eds) Cannabinoids. Handbook of Experimental Pharmacology, vol 168. Springer, Berlin, Heidelberg, 2005

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  1. https://magazine.medlineplus.gov/pdf/Common-antidepressants.PDF_.Final_.09012023.pdf; ''''; ,
  2. Yip CK, Murata K, Walz T, Sabatini DM, Kang SA; ''Structure of the human mTOR complex I and its implications for rapamycin inhibition.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  3. DOI: 10.1093/nar/gkab1016 RHEA:15889 RHEA:36683; ''''; , DOI Scholia
  4. 10.1097/YPG.0000000000000010; ''''; , DOI Scholia
  5. DOI: 10.3390/ijms19082439; ''''; , DOI Scholia
  6. Gerber SH, Südhof TC.; ''Molecular determinants of regulated exocytosis.''; PubMed Europe PMC Scholia
  7. DOI: 10.3390/nu13093207; ''''; , DOI Scholia
  8. Huang J, Manning BD; ''The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.''; Biochem J, 2008 PubMed Europe PMC Scholia
  9. DOI: 10.1101/cshperspect.a036780; ''''; , DOI Scholia
  10. Lang J, Nishimoto I, Okamoto T, Regazzi R, Kiraly C, Weller U, Wollheim CB.; ''Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.''; PubMed Europe PMC Scholia
  11. https://www.pharmgkb.org/pathway/PA166181140; ''''; ,
  12. DOI: 10.1016/j.gene.2017.05.003; ''''; , DOI Scholia
  13. DOI: 10.1016/j.psychres.2016.10.044; ''''; , DOI Scholia
  14. ''Assessment of Methylphenidate and Propranolol Combination Treatment in Comparison with Methylphenidate and Placebo Among Children with Attention Deficit Hyperactivity Disorder (ADHD)''; Scientific Medical Journal, 2011
  15. DOI: 10.3390/genes12091407; ''''; , DOI Scholia
  16. Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbe S, Clague MJ, Tooze SA; ''Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.''; Autophagy, 2010 PubMed Europe PMC Scholia
  17. DOI: 10.1176/appi.ajp.161.4.662; ''Circadian variations of hormonal content in the nervous system of the crayfish.''; Comp Biochem Physiol A Comp Physiol, 1975 DOI Scholia
  18. https://imfar.confex.com/imfar/2008/webprogram/Paper2290.html; ''''; ,
  19. DOI: 10.1186/s12993-015-0080-x; ''''; , DOI Scholia
  20. DOI 10.3390/nu8020068; ''''; , DOI Scholia
  21. https://www.genome.jp/pathway/map04921+K04229; ''''; ,
  22. https://www.pharmgkb.org/pathway/PA166181002; ''''; ,
  23. Cochrane, L., Conroy, Judith, Tansey, Katherine, Gill, Michael, Anney, R., Gallagher, Louise, https://imfar.confex.com/imfar/2008/webprogram/Paper2290.html; ''Genes Analysed for Association with Autism and DBH Level''; Conference: International Meeting for Autism Research 2008, 2008/05/16
  24. doi: 10.1080/10409238.2021.1979459; ''''; , DOI Scholia
  25. DOI: 10.1038/ng1136; ''''; , DOI Scholia
  26. ; ''''; http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2,
  27. 10.1161/hc3801.095585; ''''; , DOI Scholia
  28. https://psychscenehub.com/psychinsights/guanfacine-and-clonidine-for-adhd/; ''''; ,
  29. DOI: 10.1016/j.pnpbp.2018.01.016; ''''; , DOI Scholia
  30. Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg Y, Siu VM, Ang LC, Sabourin-Felix M, Moss T, Rastegar M; ''MECP2 Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients.''; Front Genet, 2018 PubMed Europe PMC Scholia
  31. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK; ''Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.''; J Proteome Res, 2021 PubMed Europe PMC Scholia
  32. DOI: 10.3389/fnmol.2022.922840; ''''; , DOI Scholia
  33. DOI: 10.1038/s41398-020-0755-4; ''''; , DOI Scholia
  34. Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
  35. DOI: 10.1093/ijnp/pyw013; ''''; , DOI Scholia
  36. DOI: 10.1186/2040-2392-3-10; ''''; , DOI Scholia
  37. Catena V, Fanciulli M; ''Deptor: not only a mTOR inhibitor.''; J Exp Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  38. DOI: 10.1161/01.ATV.0000243924.00970.cb; ''''; , DOI Scholia
  39. DOI: 10.1186/2040-2392-2-8; ''''; , DOI Scholia
  40. Yang SN, Berggren PO.; ''Beta-cell CaV channel regulation in physiology and pathophysiology.''; PubMed Europe PMC Scholia
  41. Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, Li Y; ''Targeting the IDO1 pathway in cancer: from bench to bedside.''; J Hematol Oncol, 2018 PubMed Europe PMC Scholia
  42. 10.3109/08039488.2015.1089321; ''''; , DOI Scholia
  43. DOI: 10.1016/j.biopha.2020.110496; ''''; , DOI Scholia
  44. Jung CH, Ro SH, Cao J, Otto NM, Kim DH; ''mTOR regulation of autophagy.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  45. DOI: 10.1038/s41430-022-01110-9.; ''''; , DOI Scholia
  46. Zhao Y, Fang Q, Straub SG, Sharp GW.; ''Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.''; PubMed Europe PMC Scholia
  47. doi: 10.1159/000142363; ''''; , DOI Scholia
  48. DOI: 10.1038/s41531-021-00161-2; ''''; , DOI Scholia
  49. DOI: 10.1186/1471-2105-9-S12-S23; ''''; , DOI Scholia
  50. DOI: 10.1016/j.cell.2010.05.024; ''''; , DOI Scholia
  51. https://www.omim.org/entry/612100; ''''; ,
  52. DOI: 10.1111/cge.13243; ''''; , DOI Scholia
  53. DOI: 10.1038/nn.4352; ''''; , DOI Scholia
  54. DOI: 10.3389/fphar.2021.740996; ''''; , DOI Scholia
  55. doi: 10.3390/antiox12051037; ''''; , DOI Scholia
  56. Yajima H, Komatsu M, Sato Y, Yamada S, Yamauchi K, Sharp GW, Aizawa T, Hashizume K.; ''Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase.''; , PubMed Europe PMC Scholia
  57. Raux E, Schubert HL, Warren MJ; ''Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.''; Cell Mol Life Sci, 2000 PubMed Europe PMC Scholia
  58. 10.1371/journal.pone.0053727; ''''; , DOI Scholia
  59. DOI: https://doi.org/10.3390/children10101639; ''''; , DOI Scholia
  60. https://hmdb.ca/proteins/HMDBP00295; ''''; ,
  61. DOI: 10.1073/pnas.1002404107; ''''; , DOI Scholia
  62. doi: 10.1073/pnas.1002404107; ''''; , DOI Scholia
  63. Vignali S, Leiss V, Karl R, Hofmann F, Welling A.; ''Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.''; PubMed Europe PMC Scholia
  64. doi: 10.1002/jimd.12060; ''''; , DOI Scholia
  65. Lang J.; ''Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.''; PubMed Europe PMC Scholia
  66. Anderson GD, Chan LN; ''Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.''; Clin Pharmacokinet, 2016 PubMed Europe PMC Scholia
  67. MacDonald PE, Wang G, Tsuk S, Dodo C, Kang Y, Tang L, Wheeler MB, Cattral MS, Lakey JR, Salapatek AM, Lotan I, Gaisano HY.; ''Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.''; PubMed Europe PMC Scholia
  68. Carrier EJ, Auchampach JA, Hillard CJ; ''Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  69. http://autism.mindspec.org/GeneDetail/NLGN4X; ''''; ,
  70. DOI: 10.3389/fpsyt.2021.788779; ''''; , DOI Scholia
  71. Ross D, Joyner WL.; ''Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells.''; PubMed Europe PMC Scholia
  72. Grabsch H, Pereverzev A, Weiergräber M, Schramm M, Henry M, Vajna R, Beattie RE, Volsen SG, Klöckner U, Hescheler J, Schneider T.; ''Immunohistochemical detection of alpha1E voltage-gated Ca(2+) channel isoforms in cerebellum, INS-1 cells, and neuroendocrine cells of the digestive system.''; PubMed Europe PMC Scholia
  73. DOI: 10.1186/s40246-021-00319-2; ''''; , DOI Scholia
  74. DOI: 10.1016/j.neures.2008.11.007; ''''; , DOI Scholia
  75. DOI: https://doi.org/10.3390/ijms21228870; ''''; , DOI Scholia
  76. Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW.; ''Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.''; PubMed Europe PMC Scholia
  77. DOI: 10.3389/fphar.2018.00279; ''''; , DOI Scholia
  78. Froese DS, Gravel RA; ''Genetic disorders of vitamin B12 metabolism: eight complementation groups--eight genes.''; Expert Rev Mol Med, 2010 PubMed Europe PMC Scholia
  79. DOI: 10.1038/mp.2013.140; ''''; , DOI Scholia
  80. 10.1038/sj.mp.4002016; ''''; , DOI Scholia
  81. DOI: 10.1590/2326-4594-jiems-2019-0007; ''''; , DOI Scholia
  82. doi: 10.1007/s13311-021-01043-4; ''''; , DOI Scholia
  83. Watkins D, Rosenblatt DS; ''Inborn errors of cobalamin absorption and metabolism.''; Am J Med Genet C Semin Med Genet, 2011 PubMed Europe PMC Scholia
  84. ''''; , PubMed Europe PMC Scholia
  85. https://my.clevelandclinic.org/health/treatments/24797-snri; ''''; ,
  86. DOI: 10.3389/fphar.2019.00452; ''''; , DOI Scholia
  87. Roach PJ; ''AMPK -> ULK1 -> autophagy.''; Mol Cell Biol, 2011 PubMed Europe PMC Scholia
  88. Cheng H, Straub SG, Sharp GW.; ''Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.''; PubMed Europe PMC Scholia
  89. 10.1093/jncics/pkad039; ''''; , DOI Scholia
  90. ''''; , PubMed Europe PMC Scholia
  91. DOI: 10.3389/fpls.2021.668819; ''''; , DOI Scholia
  92. ''''; , PubMed Europe PMC Scholia
  93. Henquin JC, Ishiyama N, Nenquin M, Ravier MA, Jonas JC.; ''Signals and pools underlying biphasic insulin secretion.''; PubMed Europe PMC Scholia
  94. Bakula D, Muller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T; ''WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.''; Nat Commun, 2017 PubMed Europe PMC Scholia
  95. doi: 10.1371/journal.pone.0085164; ''''; , DOI Scholia
  96. DOI: 10.17116/jnevro2021121041151; ''''; , DOI Scholia
  97. Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM; ''Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.''; Br J Pharmacol, 2015 PubMed Europe PMC Scholia
  98. Ostenson CG, Gaisano H, Sheu L, Tibell A, Bartfai T.; ''Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients.''; PubMed Europe PMC Scholia
  99. Froese DS, Zhang J, Healy S, Gravel RA; ''Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria.''; Mol Genet Metab, 2009 PubMed Europe PMC Scholia
  100. 10.1136/jmedgenet-2011-100386; ''''; , DOI Scholia
  101. ''''; , PubMed Europe PMC Scholia
  102. Barg S, Eliasson L, Renström E, Rorsman P.; ''A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.''; PubMed Europe PMC Scholia
  103. https://doi.org/10.1177/1362361319868633; ''''; , DOI Scholia
  104. Barg S, Rorsman P.; ''Insulin secretion: a high-affinity Ca2+ sensor after all?''; PubMed Europe PMC Scholia
  105. DOI: 10.1016/j.nbd.2020.105061; ''''; , PubMed Europe PMC Scholia
  106. DOI: 10.1016/S1075-6280(01)27007-4; ''''; , DOI Scholia
  107. Luvisetto S, Fellin T, Spagnolo M, Hivert B, Brust PF, Harpold MM, Stauderman KA, Williams ME, Pietrobon D.; ''Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.''; PubMed Europe PMC Scholia
  108. DOI: 10.1038/s41598-017-06782-z; ''''; , DOI Scholia
  109. DOI: 10.3390/genes12050782; ''''; , DOI Scholia
  110. DOI: 10.3389/fpsyt.2022.904091; ''''; , DOI Scholia
  111. http://autism.mindspec.org/GeneDetail/SHANK2; ''''; ,
  112. PMID: 10.1016/j.biopsych.2013.03.027; ''''; , DOI Scholia
  113. DOI: 10.3390/cells12071087; ''''; , DOI Scholia
  114. DOI: 10.1084/jem.20181965; ''''; , DOI Scholia
  115. Yang SN, Berggren PO.; ''The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.''; PubMed Europe PMC Scholia
  116. DOI: 10.3390/cells10051081; ''''; , DOI Scholia
  117. 10.1016/j.euroneuro.2012.07.003; ''''; , DOI Scholia
  118. Raybaud A, Baspinar EE, Dionne F, Dodier Y, Sauvé R, Parent L.; ''The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.''; PubMed Europe PMC Scholia
  119. doi: 10.1038/s41398-019-0588-1; ''''; , DOI Scholia
  120. Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K; ''Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.''; Life Sci, 2011 PubMed Europe PMC Scholia
  121. DOI: 10.1016/j.biopsych.2013.03.027; ''''; , DOI Scholia
  122. Zachari M, Ganley IG; ''The mammalian ULK1 complex and autophagy initiation.''; Essays Biochem, 2017 PubMed Europe PMC Scholia
  123. DOI: 10.3390/ijms23073861; ''''; , DOI Scholia
  124. DOI: 10.1111/pcn.12606; ''''; , DOI Scholia
  125. DOI: 10.1089/gtmb.2014.0066; ''''; , DOI Scholia
  126. DOI: 10.3390/ijms23031910; ''''; , DOI Scholia
  127. Memmott RM, Dennis PA; ''Akt-dependent and -independent mechanisms of mTOR regulation in cancer.''; Cell Signal, 2009 PubMed Europe PMC Scholia
  128. http://autism.mindspec.org/GeneDetail/NLGN3; ''''; ,
  129. ''''; , DOI Scholia
  130. DOI: 10.1089/ars.2012.4641; ''''; , PubMed Europe PMC Scholia
  131. 10.3389/fnmol.2022.919773; ''''; , DOI Scholia
  132. DOI: 10.1039/C4RA09872B; ''''; , DOI Scholia
  133. DOI: 10.3390/ijms21155310; ''''; , DOI Scholia
  134. Sher E, Giovannini F, Codignola A, Passafaro M, Giorgi-Rossi P, Volsen S, Craig P, Davalli A, Carrera P.; ''Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.''; PubMed Europe PMC Scholia
  135. 10.1097/MD.0000000000027858; ''''; , DOI Scholia
  136. DOI: 10.1371/journal.pone.0051330; ''''; , DOI Scholia
  137. DOI: 10.1007/s00702-009-0281-2; ''''; , DOI Scholia
  138. 10.1007/s00213-009-1628-y; ''''; , DOI Scholia
  139. ''''; , PubMed Europe PMC Scholia
  140. DOI: 10.1038/tp.2012.7; ''''; , DOI Scholia
  141. DOI 10.3390/nu8020068; ''Defects of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in Neurospora and their pleiotropic effects.''; Curr Top Cell Regul, 1976 DOI Scholia
  142. ''''; , PubMed Europe PMC Scholia
  143. DOI: 10.3389/fneur.2021.683275; ''''; , DOI Scholia
  144. DOI: 10.3389/fpsyt.2021.780921; ''''; , DOI Scholia
  145. http://autism.mindspec.org/GeneDetail/PTEN; ''''; ,
  146. Rutter GA, Hill EV.; ''Insulin vesicle release: walk, kiss, pause ... then run.''; PubMed Europe PMC Scholia
  147. DOI: 10.1038/mp.2017.255; ''''; , DOI Scholia
  148. Sharp GW.; ''Mechanisms of inhibition of insulin release.''; PubMed Europe PMC Scholia
  149. DOI: 10.1016/j.pneurobio.2020.101906; ''''; , DOI Scholia
  150. https://www.potomacpsychiatry.com/blog/adra2a-gene-test-adhd-genetic-testing; ''''; ,
  151. Tsuboi T, Rutter GA.; ''Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells.''; PubMed Europe PMC Scholia
  152. ''Serum microRNA-501-3p is a potential diagnostic tool for detecting mild cognitive impairment: Ehime genome study.''; J Neurochem, 2023 PubMed Europe PMC Scholia
  153. DOI: https://doi.org/10.1002/iub.114; ''''; , DOI Scholia
  154. DOI 10.3390/cells10051081; ''''; , DOI Scholia
  155. Wolthers KR, Lou X, Toogood HS, Leys D, Scrutton NS; ''Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry.''; Biochemistry, 2007 PubMed Europe PMC Scholia
  156. 10.1016/j.pnpbp.2018.01.013; ''''; , DOI Scholia
  157. https://tmedweb.tulane.edu/pharmwiki/doku.php/amphetamines; ''''; ,
  158. DOI: 10.1038/s41598-021-03885-6; ''''; , DOI Scholia
  159. DOI: 10.1038/s12276-017-0018-5; ''''; , DOI Scholia
  160. 10.1002/ajmg.b.30872; ''''; , DOI Scholia
  161. 10.3389/fmicb.2019.02305; ''''; , DOI Scholia
  162. DOI: 10.1515/cclm-2012-0673; ''''; , DOI Scholia
  163. DOI: 10.1016/j.psychres.2016.10.044; ''''; , DOI Scholia
  164. https://www.genome.jp/pathway/hsa04150; ''''; ,
  165. doi: 10.20517/jtgg.2020.34; ''''; , DOI Scholia
  166. DOI: 10.1016/j.neubiorev.2017.01.013; ''''; , DOI Scholia
  167. doi: 10.1093/scan/nsp049; ''''; , DOI Scholia
  168. DOI: 10.1016/j.molmet.2018.01.007; ''''; , DOI Scholia
  169. 10.31887/DCNS.2012.14.3/jneul; ''''; , DOI Scholia
  170. doi: 10.1016/j.bbadis.2016.10.016; ''''; , DOI Scholia
  171. DOI: 10.3390/cells11233815; ''''; , DOI Scholia
  172. https://medlineplus.gov/genetics/gene/hcfc1/#synonyms; ''''; ,
  173. 10.1111/j.1601-183X.2007.00384.x; ''''; , DOI Scholia
  174. DOI: 10.3389/fendo.2019.00249; ''''; , DOI Scholia
  175. Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI.; ''Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.''; PubMed Europe PMC Scholia
  176. DOI: 10.1016/j.psychres.2012.08.016; ''''; , DOI Scholia
  177. DOI: 10.1016/j.jphs.2022.08.00; ''A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus Pneumoniae.''; Biochem Biophys Res Commun, 1975 DOI Scholia
  178. 10.DOI: 10.1080/1028415X.2019.1570442; ''''; , DOI Scholia
  179. DOI: 10.1111/j.1600-079X.2011.00902.x; ''''; , DOI Scholia
  180. 10.1038/sj.mp.4002090; ''''; , DOI Scholia
  181. ''''; , PubMed Europe PMC Scholia
  182. rs1801394; ''''; ,
  183. doi: 10.1002/jimd.12060.; ''''; , DOI Scholia
  184. DOi: 10.3390/ijms23073861; ''''; , DOI Scholia
  185. DOI: 10.1016/j.phrs.2022.106340; ''''; , DOI Scholia
  186. DOI: 10.1038/nature12630; ''''; , DOI Scholia
  187. DOI: 10.1016/j.euroneuro.2012.07.003; ''''; , DOI Scholia
  188. doi: 10.1016/B978-0-12-801238-3.64985-1; ''''; , DOI Scholia
  189. DOI: 10.1016/j.tips.2017.04.001; ''''; , DOI Scholia
  190. Yamada K, Gherasim C, Banerjee R, Koutmos M; ''Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.''; J Biol Chem, 2015 PubMed Europe PMC Scholia
  191. DOI: 10.3389/fgene.2018.00635; ''''; , DOI Scholia
  192. DOI: 10.1007/s12519-023-00702-0; ''''; , DOI Scholia
  193. Doi: 10.3390/antiox12051037; ''''; , DOI Scholia
  194. 10.DOI: 10.1080/23312025.2019.1606555; ''''; , DOI Scholia
  195. 10.4088/JCP.14l09346; ''''; , DOI Scholia
  196. DOI: 10.4137/IJTR.S8158; ''''; , DOI Scholia
  197. doi: 10.1515/jpem-2012-0293; ''''; , DOI Scholia
  198. DOI: 10.15586/codonpublications.parkinsonsdisease.2018.ch7; ''''; , DOI Scholia
  199. doi: 10.1590/2326-4594-jiems-2019-0007; ''''; , DOI Scholia
  200. Winzell MS, Ahrén B.; ''G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.''; PubMed Europe PMC Scholia
  201. 10.1007/7854_2011_187; ''''; , DOI Scholia
  202. Funderburk SF, Wang QJ, Yue Z; ''The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.''; Trends Cell Biol, 2010 PubMed Europe PMC Scholia
  203. DOI: 10.1038/s41430-020-0657-9; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, DOI Scholia
  204. DOI: 10.1093/nar/gkab1016 RHEA:15889; ''''; , DOI Scholia
  205. https://en.wikipedia.org/wiki/DLG4; ''''; ,
  206. ; ''''; , DOI Scholia
  207. DOI: 10.1038/s41392-022-01081-0; ''''; , DOI Scholia
  208. DOI: 10.1016/S0003-9861(03)00295-9; ''''; , DOI Scholia
  209. Díaz-Alonso J, Guzmán M, Galve-Roperh I; ''Endocannabinoids via CB� receptors act as neurogenic niche cues during cortical development.''; Philos Trans R Soc Lond B Biol Sci, 2012 PubMed Europe PMC Scholia
  210. DOI: 10.1172/JCI121277; ''''; , DOI Scholia
  211. Aylett CH, Sauer E, Imseng S, Boehringer D, Hall MN, Ban N, Maier T; ''Architecture of human mTOR complex 1.''; Science, 2016 PubMed Europe PMC Scholia
  212. doi: 10.1124/jpet.105.085282.; ''''; , DOI Scholia
  213. Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S.; ''Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.''; PubMed Europe PMC Scholia
  214. Jeon SM; ''Regulation and function of AMPK in physiology and diseases.''; Exp Mol Med, 2016 PubMed Europe PMC Scholia
  215. https://doi.org/10.3390/ijms21228870; ''''; , DOI Scholia
  216. DOI: 10.1021/BI992997S; ''''; , DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
134491view05:19, 22 July 2024EgonwImproved the semantics of the references
134489view04:58, 22 July 2024EgonwRemoved template comments
134394view19:39, 21 July 2024EweitzRemove template comments
130790view09:07, 30 May 2024DeSlAll pathway models in WikiPathways are CC0, other licences are not valid.
129619view16:06, 19 May 2024Alexmadsen1
129618view15:55, 19 May 2024Alexmadsen1split Adderall into Dextroamphetamine
129599view17:29, 17 May 2024Alexmadsen1add beta blockers and connect adrenaline
129450view23:43, 22 April 2024EweitzModified title
128702view21:57, 20 February 2024EgonwFixed two datasources
128690view20:04, 19 February 2024EgonwRemoved redundant RHEA: prefix in two interaction identifiers
128491view01:18, 7 February 2024Alexmadsen1update
128483view04:10, 6 February 2024Alexmadsen1add Purine Synthesis cycle and connection and I connected in ADSL that is #22 on ASD/ADHD list.
128459view19:53, 4 February 2024Alexmadsen1updat PNMT SAD
128458view19:48, 4 February 2024Alexmadsen1add SNP
128312view19:35, 31 January 2024Khanspersupdate with latest changes from Alex Madsen
128112view19:42, 26 January 2024KhanspersReverted to version '19:33, 26 January 2024' by Khanspers
128111view19:39, 26 January 2024KhanspersLatest edits from Alex Madsen
128110view19:33, 26 January 2024KhanspersReverted to version '02:04, 6 January 2024' by Khanspers
128109view19:29, 26 January 2024KhanspersIncorporating latest changes from Alex Madsen
127881view02:04, 6 January 2024EweitzModified description
127879view23:55, 5 January 2024Alexmadsen1uodate TSC1/2 <-->AMPK <-> NOS
127878view23:13, 5 January 2024Alexmadsen1add GPT The linkage between AMPK, NOS, MECP2, PTEN, PRKCB, mTORC1, mTORC2, and their relationship to Autism Spectrum Disorder (ASD) represents a complex network of interactions critical for neuronal function and development.
127877view03:54, 5 January 2024Alexmadsen1added linkage between NOS and 5-MTH per https://doi.org/10.1159/000142363
127876view02:56, 5 January 2024Alexmadsen1added refrences for Cbl / b12 pathway and added methionine synthase interactome
127875view04:15, 4 January 2024Alexmadsen1final check in
127874view03:26, 4 January 2024Alexmadsen1add glycine > guanidinoacetate > creatine and several DOI refrences
127873view01:42, 4 January 2024Alexmadsen1
127869view03:20, 3 January 2024Alexmadsen1general cleanup
127868view03:16, 3 January 2024Alexmadsen1add mTORC1 and mTORC 2 complex and MAPK3 MAPK1
127867view01:01, 3 January 2024Alexmadsen1add PI3K/Akt/mTOR intracellular signaling pathway
127855view03:24, 2 January 2024Alexmadsen1reorganise gudimate recptors
127854view01:19, 2 January 2024Alexmadsen1
127850view18:45, 31 December 2023Alexmadsen1added DRD4 SNP and RD4 VNTR exon III-7 repeat (7R), rs916455, rs1800955
127849view02:16, 30 December 2023Alexmadsen1cleanup
127848view21:43, 28 December 2023Alexmadsen1removed incorrect linkage between DHF to THF and BH2 to BH4
127733view04:05, 30 November 2023Alexmadsen1add Risperidone
127724view04:16, 29 November 2023Alexmadsen1add SAMe to COMT Neurotransmitter Catabolism (Breakdown). Linked COMT SNP to PNMT.
127718view04:44, 28 November 2023Alexmadsen1add NDRI Bupropion (Wellbutrin), fix Guanfacine and Clonidine and other cleanup
127682view23:20, 21 November 2023EweitzModified description
127680view23:14, 21 November 2023EweitzModified title
127675view22:42, 19 November 2023Alexmadsen1clanup
127674view22:24, 19 November 2023Alexmadsen1general cleanup
127672view17:10, 18 November 2023Alexmadsen1add SAME to NA to NM with COMT
127671view05:38, 18 November 2023Alexmadsen1add SAM to SAH conversion for PNMT when convering Norepinephran to Epinephran
127665view02:51, 16 November 2023Alexmadsen1fix floating connections
127664view02:47, 16 November 2023Alexmadsen1add PEA,NMPEA,2-phenylacetaldehyde
127638view14:02, 11 November 2023EgonwFixed more reference identifiers
127637view13:33, 11 November 2023EgonwFixed a few references (removed a few duplicates) and added a missing slash is a DOI
127597view02:09, 3 November 2023Alexmadsen1clean up methods of action in synaptic gap
127596view01:46, 3 November 2023Alexmadsen1

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(4aS,6R)-4a-hydroxy - BH4MetaboliteCHEBI:15642 (ChEBI)
1''-hydroxycannabidiolMetaboliteCHEBI:133056 (ChEBI)
1-O-(1,2-saturated-alkyl)-sn-glycerolMetaboliteCHEBI:83957 (ChEBI)
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
11-OH-THCMetaboliteHMDB0060906 (HMDB)
1′-OXPH4Metabolite
2''-hydroxycannabidiol MetaboliteCHEBI:133058 (ChEBI)
2-arachidonoylglycerolMetaboliteHMDB0004666 (HMDB)
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
2A-3OBUMetaboliteCHEBI:78948 (ChEBI)
2′-OXPH4Metabolite
3''-hydroxycannabidiol MetaboliteCHEBI:133059 (ChEBI)
3-Hydroxyanthranilic AcidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
3-MT SOMetaboliteCHEBI:133708 (ChEBI)
3-MTMetaboliteCHEBI:1582 (ChEBI)
4''-hydroxycannabidiol MetaboliteCHEBI:133055 (ChEBI)
4-aminobutanoateMetaboliteCHEBI:30566 (ChEBI)
4a-HydroxytetrahydrobiopterinMetaboliteCHEBI:15642 (ChEBI)
5''-hydroxycannabidiol MetaboliteCHEBI:133062 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-HIAAMetaboliteCHEBI:27823 (ChEBI) AKA 5-HIAA
5-HialMetaboliteCHEBI:50157 (ChEBI)
5-MTMetaboliteCHEBI:2089 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
5-hydroxy-L-tryptophanMetaboliteCHEBI:58266 (ChEBI)
6R-BH4MetaboliteCHEBI:59560 (ChEBI)
6a-hydroxycannabidiol MetaboliteCHEBI:133049 (ChEBI)
6b-hydroxycannabidiol MetaboliteCHEBI:133052 (ChEBI)
7-hydroxycannabidiol MetaboliteCHEBI:133053 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AANATProteinQ16613 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABL1ProteinP00519 (Uniprot-TrEMBL)
ABL2ProteinP42684 (Uniprot-TrEMBL)
ACEGeneProductP12821 (Uniprot-TrEMBL)
ADAM10ProteinO14672 (Uniprot-TrEMBL)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADGRL3 GPCRsProteinQ9HAR2 (Uniprot-TrEMBL)
ADHProtein
ADORA2AGeneProductENSG00000128271 (Ensembl)
AEAMetaboliteHMDB0004080 (HMDB)
AGMOProteinQ6ZNB7 (Uniprot-TrEMBL)
AGTR1ProteinP30556 (Uniprot-TrEMBL)
AHCYL1ProteinO43865 (Uniprot-TrEMBL)
AHCYProteinP23526 (Uniprot-TrEMBL)
AHRGeneProductENSG00000106546 (Ensembl)
AKRProtein
AKR1A1ProteinP14550 (Uniprot-TrEMBL)
AKR1B1ProteinP15121 (Uniprot-TrEMBL)
AKR1C1ProteinQ04828 (Uniprot-TrEMBL)
AKR1C3ProteinP42330 (Uniprot-TrEMBL)
ALDHProtein
ALDH1L1ProteinO75891 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALDH2ProteinP05091 (Uniprot-TrEMBL)
ALDH5A1ProteinCHEBI:57706 (Uniprot-TrEMBL)
ALDH9A1ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
AOC1GeneProductP19801 (Uniprot-TrEMBL)
APPProteinP05067 (Uniprot-TrEMBL)
ASMTProteinP46597 (Uniprot-TrEMBL)
ATPMetaboliteHMDB0000538 (HMDB)
AdoCblMetaboliteCHEBI:18408 (ChEBI)
Alpha-dystroglycanProtein
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
Anthranilic AcidMetaboliteCHEBI:16567 (ChEBI)
Anti-inflammatory pathwaysPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Atomoxetine (Strattera)MetaboliteHMDB14434 (HMDB)
B2 riboflavinMetaboliteCHEBI:17015 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B3MetaboliteCHEBI:17154 (ChEBI)
B6 pyridoxineMetaboliteCHEBI:16709 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BH2 7,8-dihydrofolateMetaboliteCHEBI:64240 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
Beta-dystroglycanProtein
BiopterinMetaboliteCHEBI:15373 (ChEBI)
CACNA1CProteinQ13936 (Uniprot-TrEMBL)
CACNG1ProteinQ06432 (UniGene)
CACNG2ProteinQ9Y698 (Uniprot-TrEMBL)
CACNG3ProteinO60359 (UniGene)
CACNG4ProteinQ9UBN1 (UniGene)
CACNG5ProteinQ9UF02 (UniGene)
CACNG6ProteinQ9BXT2 (UniGene)
CACNG7ProteinP62955 (UniGene)
CACNG8ProteinQ8WXS5 (UniGene)
CB CollybistinProtein
CBDMetaboliteCHEBI:69478 (ChEBI)
CBLProteinP22681 (Uniprot-TrEMBL)
CBR1ProteinP16152 (Uniprot-TrEMBL)
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CDO1GeneProductQ16878 (Uniprot-TrEMBL)
CNR1 CB1GeneProductP21554 (Uniprot-TrEMBL)
CNR1ProteinP21554 (Uniprot-TrEMBL)
CNR2 CB2GeneProductP34972 (Uniprot-TrEMBL)
CNTN1GeneProductQ9UQ52 (Uniprot-TrEMBL)
CNTN2GeneProductO94779 (Uniprot-TrEMBL)
CNTN3GeneProductQ8IWV2 (Uniprot-TrEMBL)
CNTN4GeneProductQ9P232 (Uniprot-TrEMBL)
CNTN5GeneProductQ02246 (Uniprot-TrEMBL)
CNTN6GeneProductQ12860 (Uniprot-TrEMBL)
CNTNAP1GeneProductP78357 (Uniprot-TrEMBL)
CNTNAP2GeneProductQ9UHC6 (Uniprot-TrEMBL)
CNTNAP3GeneProductQ9BZ76 (Uniprot-TrEMBL)
CNTNAP4GeneProductQ9C0A0 (Uniprot-TrEMBL)
COMTProteinP21964 (Uniprot-TrEMBL) AKA Catechol-O- metyltransferase
COOH-THCMetaboliteCHEBI:77273 (ChEBI)
CPLX1ProteinO14810 (Uniprot-TrEMBL)
CSADProteinQ9Y600 (Uniprot-TrEMBL)
CTHProteinP32929 (Uniprot-TrEMBL)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTTNProteinQ14247 (UniGene)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP2D6ProteinP10635 (Uniprot-TrEMBL)
CYP3A4GeneProductENSG00000160868 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CalciumMetaboliteHMDB0000464 (HMDB)
CblD MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-1 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-2 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblMetaboliteQ3329800 (Wikidata)
ClonidineMetaboliteCHEBI:46631 (ChEBI)
CortactinGeneProductENSG00000085733 (Ensembl)
DAG1GeneProductQ14118 (Uniprot-TrEMBL)
DAGLAGeneProductENSG00000134780 (Ensembl)
DAGLBGeneProductENSG00000164535 (Ensembl)
DBHProteinP09172 (Uniprot-TrEMBL)
DDCProteinP20711 (Uniprot-TrEMBL)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DHMAMetaboliteCHEBI:27637 (ChEBI)
DHNTPMetaboliteCHEBI:18372 (ChEBI)
DHPGMetaboliteCHEBI:1387 (ChEBI)
DLG1ProteinQ12959 (Uniprot-TrEMBL)
DLG2ProteinQ15700 (Uniprot-TrEMBL)
DLG3ProteinQ92796 (Uniprot-TrEMBL)
DLG4 PSD95ProteinP78352 (Uniprot-TrEMBL)
DLG5ProteinQ8TDM6 (Uniprot-TrEMBL)
DLGAP1GeneProductO14490 (Uniprot-TrEMBL)
DLGAP2GeneProductQ9P1A6 (Uniprot-TrEMBL)
DLGAP3GeneProductO95886 (Uniprot-TrEMBL)
DLGAP4GeneProductQ9Y2H0 (Uniprot-TrEMBL)
DLGAP5GeneProductQ15398 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DOPEGMetaboliteCHEBI:1387 (ChEBI)
DOPETMetaboliteCHEBI:68889 (ChEBI)
DOPGAL MetaboliteCHEBI:180943 (ChEBI)
DOPLMetaboliteCHEBI:27978 (ChEBI)
Derived From WP4159PathwayWP4159 (WikiPathways)
Derived From WP4271Pathway
F-actinGeneProduct
FAAHGeneProductENSG00000117480 (Ensembl)
FADMetaboliteCHEBI:16238 (ChEBI) cofactor
FADMetaboliteCHEBI:57692 (ChEBI)
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetaboliteCHEBI:17621 (ChEBI) cofactor
FMNMetabolitecHEBI:58210 (ChEBI)
FMO1GeneProductQ01740 (Uniprot-TrEMBL)
FMO3GeneProductQ01740 (Uniprot-TrEMBL)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
GABA MetaboliteHMDB0000112 (HMDB)
GABAMetaboliteCHEBI:59888 (ChEBI)
GABBR1ProteinQ9UBS5 (Uniprot-TrEMBL)
GABRA1ProteinP14867 (Uniprot-TrEMBL)
GABRA2ProteinP47869 (Uniprot-TrEMBL)
GABRA3ProteinP34903 (Uniprot-TrEMBL)
GABRA4ProteinP48169 (Uniprot-TrEMBL)
GABRA5ProteinP31644 (Uniprot-TrEMBL)
GABRB1ProteinP18505 (Uniprot-TrEMBL)
GABRB2ProteinP47870 (Uniprot-TrEMBL)
GABRB3ProteinP28472 (Uniprot-TrEMBL)
GABRDProteinO14764 (Uniprot-TrEMBL)
GABRG1ProteinQ8N1C3 (Uniprot-TrEMBL)
GABRG2ProteinP18507 (Uniprot-TrEMBL)
GABRQProteinQ9UN88 (Uniprot-TrEMBL)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GCATGeneProductO75600 (Uniprot-TrEMBL)
GCH1 GTPCHProteinP30793 (Uniprot-TrEMBL)
GKAP1GeneProductQ5VSY0 (Uniprot-TrEMBL)
GKGeneProductP32189 (Uniprot-TrEMBL)
GLS2ProteinQ9UI32 (Uniprot-TrEMBL)
GLSProteinO94925 (Uniprot-TrEMBL)
GLULGeneProductP15104 (Uniprot-TrEMBL)
GNAQProteinP50148 (Uniprot-TrEMBL)
GPHNProteinQ9NQX3 (Uniprot-TrEMBL)
GRIA1ProteinP42261 (Uniprot-TrEMBL)
GRIA2ProteinP42262 (Uniprot-TrEMBL)
GRIA3ProteinP42263 (Uniprot-TrEMBL)
GRIA4ProteinP48058 (Uniprot-TrEMBL)
GRIN1ProteinQ05586 (Uniprot-TrEMBL)
GRIN2AProteinQ12879 (Uniprot-TrEMBL)
GRIN2BProteinQ13224 (Uniprot-TrEMBL)
GRIN2CProteinQ14957 (Uniprot-TrEMBL)
GRIN2DProteinO15399 (Uniprot-TrEMBL)
GRIN3AProteinQ8TCU5 (Uniprot-TrEMBL)
GRIN3BProteinO60391 (Uniprot-TrEMBL)
GRIP1ProteinQ9Y3R0 (Uniprot-TrEMBL)
GRIP2ProteinQ9C0E4 (Uniprot-TrEMBL)
GRM1ProteinQ13255 (Uniprot-TrEMBL)
GRM2ProteinQ14416 (Uniprot-TrEMBL)
GRM3ProteinQ14832 (Uniprot-TrEMBL)
GRM4ProteinQ14833 (Uniprot-TrEMBL)
GRM5ProteinP41594 (Uniprot-TrEMBL)
GRM6ProteinO15303 (Uniprot-TrEMBL)
GRM7ProteinQ14831 (Uniprot-TrEMBL)
GRM8ProteinO00222 (Uniprot-TrEMBL)
GlutamateMetaboliteHMDB0000148 (HMDB)
GuanfacineMetaboliteHMDB15153 (HMDB)
H2O2Metabolite16240 (ChEBI)
H4gtp GPTMetaboliteCHEBI:15996 (ChEBI)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
HDCGeneProductP19113 (Uniprot-TrEMBL)
HISN8ProteinQ9C5U8 (Uniprot-TrEMBL)
HNMTGeneProductP50135 (Uniprot-TrEMBL)
HOMERGeneProduct
HOMER1ProteinQ86YM7 (Uniprot-TrEMBL)
HOMER2ProteinQ9NSB8 (Uniprot-TrEMBL)
HOMER3ProteinQ9NSC5 (Uniprot-TrEMBL)
HTR3AProteinP40227 (Uniprot-TrEMBL)
HTR3BProteinO95264 (Uniprot-TrEMBL)
HTR3CProteinQ8WXA8 (Uniprot-TrEMBL)
HTR3DProteinQ70Z44 (Uniprot-TrEMBL)
HTR3EProteinA5X5Y0 (Uniprot-TrEMBL)
HVAMetaboliteCHEBI:545959 (ChEBI) AKA HVA
HVALMetabolite
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
INFAProtein
Imidazole-4-acetateMetaboliteCHEBI:16974 (ChEBI)
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KCNA1ProteinQ09470 (Uniprot-TrEMBL)
KCNA2ProteinP16389 (Uniprot-TrEMBL)
KCNA3ProteinP22001 (Uniprot-TrEMBL)
KCNA4ProteinP22459 (Uniprot-TrEMBL)
KCNA5ProteinP22460 (Uniprot-TrEMBL)
KCNA6ProteinP17658 (Uniprot-TrEMBL)
KCNA7ProteinQ96RP8 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KYAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Kynurenic AcidMetaboliteCHEBI:58454 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-GluMetaboliteCHEBI:29985 (ChEBI)
L-alanineMetabolite57972 (ChEBI)
L-arginineMetaboliteCHEBI:32682 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
L-cysteateMetaboliteCHEBI:58090 (ChEBI)
L-cysteineMetaboliteCHEBI:35235 (ChEBI)
L-dopaMetaboliteCHEBI:57504 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
L-glutamineMetaboliteCHEBI:58359 (ChEBI)
L-histidineMetaboliteCHEBI:57595 (ChEBI)
L-histidinolMetaboliteCHEBI:57699 (ChEBI)
L-phenylalanineMetaboliteCHEBI:58095 (ChEBI)
L-threonineMetaboliteCHEBI:57926 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
MAOAProteinP21397 (Uniprot-TrEMBL)
MAOBProteinP27338 (Uniprot-TrEMBL)
MAOIsMetabolite
MAPK GeneProduct2.7.11.24 (Enzyme Nomenclature)
MAPK10GeneProductP53779 (Uniprot-TrEMBL)
MAPK11GeneProductQ15759 (Uniprot-TrEMBL)
MAPK12GeneProductP53778 (Uniprot-TrEMBL)
MAPK13GeneProductO15264 (Uniprot-TrEMBL)
MAPK14GeneProductQ16539 (Uniprot-TrEMBL)
MAPK1GeneProductP28482 (Uniprot-TrEMBL)
MAPK3GeneProductP27361 (Uniprot-TrEMBL)
MAPK8GeneProductP45983 (Uniprot-TrEMBL)
MAPK9GeneProductP45984 (Uniprot-TrEMBL)
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MC4RProteinP32245 (Uniprot-TrEMBL)
MG2+MetaboliteCHEBI:18420 (ChEBI)
MHPG MOPEGMetaboliteCHEBI:1576 (ChEBI)
MMAB cblBProtein60488 (Uniprot-TrEMBL) gene: MMAB
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MN-SO4MetaboliteHMDB0240719 (HMDB)
MN2+Metabolite
MOCOSProteinQ96EN8 (Uniprot-TrEMBL)
MOPGALMetabolite27932 (ChEBI)
MTHFD1LProteinQ6UB35 (Uniprot-TrEMBL)
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFD2LProteinQ9H903 (Uniprot-TrEMBL)
MTHFD2ProteinP13995 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCblMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
MetanephrineMetaboliteCHEBI:89633 (ChEBI)
MetanephrineMetaboliteHMDB04063 (HMDB)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Methylphenidate (Ritalin)MetaboliteHMDB14566 (HMDB)
MoCoMetabolite71302 (ChEBI)
N-METHYL-HISTAMINEMetaboliteCHEBI:58600 (ChEBI)
N-MethylhistamineMetaboliteCHEBI:29009 (ChEBI)
NA NorepinephrineMetaboliteCHEBI:72587 (ChEBI)
NA AldehydeMetabolite
NAD+MetaboliteCHEBI:13389 (ChEBI)
NADPMetaboliteCHEBI:58349 (ChEBI)
NADPHMetaboliteCHEBI:57783 (ChEBI)
NADSYN1ProteinQ6IA69 (Uniprot-TrEMBL)
NAPEMetaboliteCHEBI:61232 (ChEBI)
NAPEPLDGeneProductENSG00000161048 (Ensembl)
NASMetaboliteCHEBI:17697 (ChEBI)
NCAM1ProteinP13591 (Uniprot-TrEMBL)
NLGN1ProteinQ8N2Q7 (Uniprot-TrEMBL)
NLGN2ProteinQ8NFZ4 (Uniprot-TrEMBL)
NLGN3ProteinQ9NZ94 (Uniprot-TrEMBL)
NLGN4XProteinQ8N0W4 (Uniprot-TrEMBL)
NM Aldehyde Metabolite
NMMetaboliteHMDB00819 (HMDB)
NMN-SOMetaboliteHMDB0240719 (HMDB)
NMNAT1ProteinQ9HAN9 (Uniprot-TrEMBL)
NOMetabolite16480 (ChEBI)
NOS1ProteinP29475 (Uniprot-TrEMBL)
NOS2ProteinP35228 (Uniprot-TrEMBL)
NOS3ProteinP29474 (Uniprot-TrEMBL)
NOX1ProteinQ9Y5S8 (Uniprot-TrEMBL)
NOX3ProteinQ9HBY0 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
NOX5ProteinQ96PH1 (Uniprot-TrEMBL)
NRXN1ProteinQ9ULB1 (Uniprot-TrEMBL)
NRXN2ProteinP58401 (Uniprot-TrEMBL)
NRXN3ProteinQ9HDB5 (Uniprot-TrEMBL)
NorepinephrineMetaboliteCHEBI:72587 (ChEBI)
O2MetaboliteCHEBI:5379 (ChEBI)
O2−MetaboliteCHEBI:18421 (ChEBI)
OH-MetaboliteCHEBI:16234 (ChEBI)
ONOO-MetaboliteCHEBI:25941 (ChEBI)
OPRM1ProteinP35372 (UniGene)
OXTProteinP01178 (Uniprot-TrEMBL)
OXTRProteinP30559 (Uniprot-TrEMBL)
P
PAHProteinP00439 (Uniprot-TrEMBL)
PCBD1ProteinP61457 (Uniprot-TrEMBL)
PCBD2ProteinQ9H0N5 (Uniprot-TrEMBL)
PDXKProteinO00764 (Uniprot-TrEMBL)
PLCBGeneProductP50148 (Uniprot-TrEMBL)
PLP pyridoxal 5'-phosphateMetaboliteCHEBI:597326 (ChEBI)
PLPMetaboliteCHEBI:597326 (ChEBI)
PNMTProteinP11086 (Uniprot-TrEMBL)
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
PPH4MetaboliteCHEBI:17804 (ChEBI)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (EMBL)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
PSD95GeneProductP78352 (Uniprot-TrEMBL)
PTK2BProteinQ14289 (Uniprot-TrEMBL)
PTSProteinQ03393 (Uniprot-TrEMBL)
PhosphatidylethanolamineMetaboliteHMDB0060501 (HMDB)
Picolinic AcidMetaboliteCHEBI:28747 (ChEBI)
PrazosinMetaboliteHMDB14600 (HMDB)
QDPRProteinP09417 (Uniprot-TrEMBL)
QPRTProteinQ15274 (Uniprot-TrEMBL)
QUINMetaboliteCHEBI:16675 (ChEBI)
Quinolinic Acid QUINMetaboliteCHEBI:16675 (ChEBI)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RENProteinP00797 (Uniprot-TrEMBL)
RFKProteinQ969G6 (Uniprot-TrEMBL)
RIT2ProteinQ99578 (Uniprot-TrEMBL)
RS4818Rna
RS6267Rna
S-SCAMGeneProduct
S-adenosyl-L-homocysteineMetaboliteCHEBI:57856 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAM MetaboliteCHEBI:59789 (ChEBI)
SAPAPGeneProduct
SCN10AGeneProductQ9Y5Y9
SCN11AGeneProductQ9UI33
SCN1AGeneProductP35498
SCN1BGeneProductQ07699
SCN2AGeneProductQ99250
SCN2BGeneProductO60939
SCN3AGeneProductQ9NY46
SCN3BGeneProductQ9NY72
SCN4AGeneProductP35499
SCN4BGeneProductQ8IWT1
SCN5AGeneProductQ14524
SCN7AGeneProductQ01118
SCN8AGeneProductQ9UQD0
SCN9AGeneProductQ15858
SHANKGeneProduct
SHANK1ProteinQ9Y566 (Uniprot-TrEMBL)
SHANK2ProteinQ9UPX8 (Uniprot-TrEMBL)
SHANK3ProteinQ9BYB0 (Uniprot-TrEMBL)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SHMT2ProteinP34897 (Uniprot-TrEMBL)
SIRT3GeneProductQ9NTG7 (Uniprot-TrEMBL)
SLC18A1ProteinP54219 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC25A12ProteinO75746 (Uniprot-TrEMBL)
SLC25A13ProteinQ9UJS0 (Uniprot-TrEMBL)
SLC25A32ProteinQ9H2D1 (Uniprot-TrEMBL)
SLC32A1ProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC6A1GeneProductP30531 (Uniprot-TrEMBL)
SLC6A2Protein
SLC6A2ProteinP23975 (Uniprot-TrEMBL)
SLC6A3 DAT1Protein
SLC6A4ProteinP31645 (Uniprot-TrEMBL)
SNAP25ProteinP60880 (Uniprot-TrEMBL)
SNRI

Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil, Pexeva)

Sertraline(Zoloft)		MetaboliteHMDB14600 (HMDB)
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2ProteinP04179 (Uniprot-TrEMBL)
SOD3ProteinP08294 (Uniprot-TrEMBL)
SPRProteinP35270 (Uniprot-TrEMBL)
SRBS2GeneProductO94875 (Uniprot-TrEMBL)
STX1AProteinQ16623 (Uniprot-TrEMBL)
STXBP1ProteinP61764 (Uniprot-TrEMBL)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYPProteinP08247 (Uniprot-TrEMBL)
SYT1ProteinP21579 (Uniprot-TrEMBL)
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
T23OProteinP48775 (Uniprot-TrEMBL)
TAAR1ProteinQ96RJ0 (Uniprot-TrEMBL)
TCN2ProteinP20062 (Uniprot-TrEMBL)
TDC Protein
THCMetaboliteHMDB0041865 (HMDB)
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TNFAProteinP01375 (Uniprot-TrEMBL)
TPH1ProteinP17752 (Uniprot-TrEMBL)
TPH2ProteinQ8IWU9 (Uniprot-TrEMBL)
TYMSProteinP04818 (Uniprot-TrEMBL)
TYProteinP07101 (Uniprot-TrEMBL)
VAMP2ProteinP63027 (Uniprot-TrEMBL)
VMAMetaboliteCHEBI:27622 (ChEBI)
Xanthurenic acidMetaboliteCHEBI:10072 (ChEBI)
a 1-(1-hydroxyalkyl)-sn-glycerolMetaboliteCHEBI:73418 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
adra1aGeneProductENSDARG00000028725 (Ensembl)
adra1bGeneProductENSDARG00000011317 (Ensembl)
adra1dGeneProductENSDARG00000024101 (Ensembl)
adra2aGeneProduct266750 (Entrez Gene)
adra2bGeneProduct266751 (Entrez Gene)
adra2cGeneProduct266752 (Entrez Gene)
adrb1GeneProduct557194 (Entrez Gene)
adrb2GeneProduct
adrb3aGeneProduct558248 (Entrez Gene)
adrenalineMetaboliteCHEBI:28918 (ChEBI)
alkylglycerolsMetaboliteCHEBI:52575 (ChEBI)
angiotensin IMetaboliteCHEBI:147350 (ChEBI)
angiotensin IIMetaboliteCHEBI:58506 (ChEBI)
cAMP MetaboliteHMDB0000058 (HMDB)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cbLC MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) Gene is called MMAC
cblF LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL)
cblJ ABCD4ProteinO14678 (Uniprot-TrEMBL)
citrate cyclePathwayWP78 (WikiPathways)
cob(I)alaminMetabolitecob(I)alamin (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
cystathionineMetaboliteCHEBI:58161 (ChEBI)
cysteine sulfinateMetaboliteCHEBI:61085 (ChEBI)
deamido-NAD+MetaboliteCHEBI:58437 (ChEBI)
dopamineMetaboliteCHEBI:59905 (ChEBI)
drd1GeneProduct568126 (Entrez Gene)
drd2GeneProduct
drd3GeneProduct282554 (Entrez Gene)
drd4GeneProduct
drd5GeneProductENSDARG00000090669 (Ensembl)
fatty aldehydesMetaboliteCHEBI:35746 (ChEBI)
formateMetaboliteCHEBI:15740 (ChEBI)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
glycerol 3-phosphateMetaboliteCHEBI:57597 (ChEBI)
glycerolMetaboliteCHEBI:17754 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
hemiacetalsMetabolite5653 (ChEBI)
histamineMetaboliteCHEBI:58432 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
htr1aaGeneProduct100001828 (Entrez Gene)
htr1bGeneProduct561647 (Entrez Gene)
htr1dGeneProductENSDARG00000054124 (Ensembl)
htr1eGeneProductENSDARG00000011468 (Ensembl)
htr1fGeneProductENSDARG00000002773 (Ensembl)
htr2aGeneProductENSDARG00000057029 (Ensembl)
htr2bGeneProductENSDARG00000070940 (Ensembl)
htr2cGeneProduct
htr4GeneProductENSDARG00000061940 (Ensembl)
htr5aGeneProduct100038775 (Entrez Gene)
htr5bGeneProduct
htr6GeneProductENSDARG00000016095 (Ensembl)
htr7GeneProductENSDARG00000056949 (Ensembl)
hypotaurineMetaboliteCHEBI:57853 (ChEBI)
imidazole-4-acetaldehydeMetaboliteCHEBI:27398 (ChEBI)
melatoninMetaboliteCHEBI:16796 (ChEBI)
mixed amphetamine salts (Adderall)Metabolite
moco sulfide Metabolite82685 (ChEBI)
nArgBP2Protein
nicotinate D-ribonucleotide(2−)MetaboliteCHEBI:57502 (ChEBI)
noladin ether 2-AGEMetaboliteCHEBI:75913 (ChEBI)
oxytocinMetaboliteCHEBI:7872 (ChEBI)
protein tyrosine kinasesPathway
pyridoxalMetaboliteCHEBI:17310 (ChEBI)
pyridoxamineMetaboliteCHEBI:57761 (ChEBI)
pyridoxine 5'-phosphateMetaboliteCHEBI:58589 (ChEBI)
q-BH2MetaboliteCHEBI:43029 (ChEBI)
q-H2BPTMetaboliteCHEBI:43120 (ChEBI)
rs1023159Rna
rs1051266Rna
rs1051312Rna
rs10521432Rna
rs10879352Rna
rs11178997Rna
rs1137070Rna
rs121913223Rna
rs12843268Rna
rs12843533Rna
rs13189021Rna
rs1352250Rna
rs1390938Rna
rs1406946Rna
rs1465107Rna
rs1487275Rna
rs151257822GeneProduct
rs1532268Rna
rs1543334Rna
rs165599Rna
rs165774Rna
rs1667627Rna
rs1672717Rna
rs167771Rna
rs16976358Rna
rs174696Rna
rs1799836Rna
rs1799971Rna
rs1800544Rna
rs1801131Rna
rs1801133Rna
rs1801198Rna
rs1801394Rna
rs1805087Rna
rs1923886Rna
rs1950902Rna
rs1979277Rna
rs2056202Rna
rs2071010Rna
rs2088102Rna
rs2129575Rnars2129575
rs2236225Rna
rs2242446Rna
rs2254298GeneProduct
rs2268491GeneProduct
rs2270637Rna
rs2270641Rna
rs2279709Rna
rs2292813Rna
rs2298444Rna
rs237887GeneProduct
rs237889GeneProduct
rs237897GeneProduct
rs237902GeneProduct
rs2518352Rna
rs251915Rna
rs2550936Rna
rs265981Rna
rs2710102Rna
rs28386840Rna
rs2934966Rna
rs3027400Rna
rs3027407Rna
rs35062132GeneProduct
rs36017Rna
rs362204Rna
rs3733890Rna
rs3746544Rna
rs3758653Rna
rs3782025Rna
rs3785143Rna
rs3785157Rna
rs3813034Rna
rs3819331Rna
rs4130047Rna
rs4291Rna
rs4343Rna
rs4446909Rna
rs4532Rna
rs4570625Rna
rs4633Rna
rs4680Rna
rs4846049Rna
rs53576GeneProduct
rs5569Rna
rs590551Rna
rs5905512Rna
rs5906883 Rna
rs594445Rna
rs5949028Rna
rs5989681Rna
rs602618Rna
rs6189Rna
rs6198Rna
rs6269Rna
rs6280Rna
rs6296Rna
rs6318Rna
rs6323Rna
rs651646 Rna
rs6561333Rna
rs6582071Rna
rs6651806Rna
rs6746030Rna
rs686Rna
rs70991108Rna
rs737865Rna
rs740601Rna
rs7632287GeneProduct
rs7794745Rna
rs779867Rna
rs7997012Rna
rs876657421Rna
rs908670Rna
sepiapterinMetaboliteCHEBI:16095 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
serotoninMetaboliteCHEBI:350546 (ChEBI)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteCHEBI:57706 (ChEBI)
taurineMetaboliteCHEBI:507393 (ChEBI)
tyramineMetaboliteCHEBI:327995 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5420"
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