LDL- influence on CD14 and TLR4 (Homo sapiens)

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nucleusP38 MAPK (14)PP38 MAPK (12)PP38 MAPK (13)PP38 MAPK (11)P1 MonocyteCytoplasmNF-κBCREBi measured in study[PMID:27235719]CytokineReleaseNFKB1TLR4LDL-P38 MAPK (11)PI3KAKTIL10CREB1CD14AP-1P38 MAPK (12)P38 MAPK (13)P38 MAPK (14)MCP1IL6IL1-betaIL10IL6MCP1IL1-betaIL6IL1-betaIL10MCP1Extracellular mediaCREB2CREB3CREB5CREB3L1CREB3L2CREB3L3CREB3L4RELANFKB2RELBREL


Description

Electronegative LDL (LDL(-)) is a plasma LDL subfraction inducing induces cytokine release in monocytes by activating TLR4. The subsequent phosphorylation of p38 MAPK phosphorylation (which is higher compared to native LDL) through TLR4 and PI3k/Akt pathways activates NF-kB, AP-1 and CREB. These last three have a direct effect on four cytokines (IL1beta, IL6, IL10 and MCP1), with bold black letters for the highest level of cytokine induction, gray letters for the lowest level and regular letter for the intermediate induction.

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Bibliography

  1. Montserrat Estruch, Jose Luis Sanchez-Quesada, Jordi Ordoñez-Llanos, Sonia Benitez; ''Inflammatory intracellular pathways activated by electronegative LDL in monocytes''; Biochim Biophys Acta ., 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134931view00:13, 30 July 2024EweitzUpgrade PI3K to gene family
134930view00:02, 30 July 2024EweitzEconomize layout
134927view23:45, 29 July 2024EweitzUse gene symbols
134926view23:38, 29 July 2024EweitzUse more conventional term: extracellular media -> extracellular matrix
134925view23:37, 29 July 2024EweitzEconomize layout
134510view11:53, 22 July 2024EweitzModified description
134509view11:50, 22 July 2024EweitzRefine component label placement, standardize case
127745view11:23, 30 November 2023DeSlConverted elements in nucleus to groups and reconnected them.
127744view11:17, 30 November 2023DeSlChanged last MCP-1 to CCL2
127739view11:15, 30 November 2023DeSlFixed outdated/alias HGNC symbol MCP-1 to CCL2
127738view11:09, 30 November 2023DeSlAdding comments to InterPro IDs
127737view11:03, 30 November 2023DeSlUpdated AKT ID to more general one
127736view10:54, 30 November 2023DeSlConnected unocnnected line to IL10 group
123542view11:47, 3 August 2022DeSlAdded ChEBI ID for LDL-
123478view15:00, 28 July 2022DeSlOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
123477view15:00, 28 July 2022DeSlOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
123476view14:59, 28 July 2022DeSlOntology Term : 'Interleukin-10 signaling pathway' added !
123475view14:59, 28 July 2022DeSlOntology Term : 'interleukin-1 family mediated signaling pathway' added !
123474view14:58, 28 July 2022DeSlOntology Term : 'signaling pathway' added !
123473view14:58, 28 July 2022DeSlOntology Term : 'Interleukin mediated signaling pathway' added !
123472view14:58, 28 July 2022DeSlOntology Term : 'cytokine mediated signaling pathway' added !
123471view14:57, 28 July 2022DeSlOntology Term : 'monocyte' added !
123470view14:57, 28 July 2022DeSlAdded all individual proteins for NFKB complex
123469view14:50, 28 July 2022DeSlAdding individual CREB (like) proteins
123468view14:44, 28 July 2022DeSlAdding phosphorylation of P38 MAPK
123467view14:37, 28 July 2022DeSlAdded Cytokine release visualization
123466view14:36, 28 July 2022DeSlUpdate cytokine visualization
123465view14:35, 28 July 2022DeSlAdded ref and description
123464view14:26, 28 July 2022DeSlAdded MCP1 (aka CCL2) annotation
123463view13:17, 28 July 2022DeSlAdded nucleus, cytoplasm info
123462view13:14, 28 July 2022DeSlAdd monocyte, comment on LDL-
123461view12:38, 28 July 2022DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKTProtein2.7.11 (Enzyme Nomenclature) aka Protein kinase B (PKB); Unknown if AKT1, AKT2, or AKT3 are meant in publication
AP-1ProteinIPR000837 (InterPro) The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families; not specified in paper which one is meant.
CD14ProteinP08571 (Uniprot-TrEMBL)
CREB1ProteinP16220 (Uniprot-TrEMBL)
CREB2ProteinP18848 (Uniprot-TrEMBL) AKA ATF4
CREB3L1ProteinQ96BA8 (Uniprot-TrEMBL)
CREB3L2ProteinQ70SY1 (Uniprot-TrEMBL)
CREB3L3ProteinQ68CJ9 (Uniprot-TrEMBL)
CREB3L4ProteinQ8TEY5 (Uniprot-TrEMBL)
CREB3ProteinO43889 (Uniprot-TrEMBL)
CREB5ProteinQ02930 (Uniprot-TrEMBL)
IL1-betaGeneProductENSG00000125538 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
LDL-MetaboliteCHEBI:192800 (ChEBI) High content in Cer, Sph, NEFA
MCP1GeneProductP13500 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKB2ProteinQ00653 (Uniprot-TrEMBL)
P38 MAPK (11)ProteinQ15759 (Uniprot-TrEMBL)
P38 MAPK (12)ProteinP53778 (Uniprot-TrEMBL)
P38 MAPK (13)ProteinO15264 (Uniprot-TrEMBL)
P38 MAPK (14)ProteinQ16539 (Uniprot-TrEMBL)
PI3KProteinIPR000403 (InterPro) Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes; paper doesn't mention which enzyme specifically is involved
RELAProteinQ04206 (Uniprot-TrEMBL)
RELBProteinQ01201 (Uniprot-TrEMBL)
RELProteinQ04864 (Uniprot-TrEMBL)
TLR4ProteinO00206 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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