Omega-3-fatty acids in senescence (Homo sapiens)

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57, 58543516, 3045, 4829, 4529, 453529, 4557, 5816, 302735, 54353557, 5857, 5835, 544529, 45Dietary LipidsEnzyme A or Enzyme B is required for the reactionEnzyme ADehydrationALOX15BTetracosapentanoic acid (24:5,n-3)14S-HDHACYP2C8ALOX15BCYP3A414R-HDHAMaR-L27S,17S-diHpDHA15d-PGD3*PGJ34S-HpDHAReductionTxB3CYP2D6CYP2C9MaR-L1UnknownCYP2E1UnknownPGE3CYP1A2Δ12-PGJ36-keto-PGF2α*15d-PGJ3Tetracosahexanoic acid (22:6,n-3)3122, 5224, 52242, 31486, 2448247, 34, 487, 34, 4824, 526, 7, 342425, 32, 5724, 522424, 523, 24, 414, 25, 30, 487, 3431482412246, 7, 34243, 24, 41246, 7, 343124127, 34, 487, 347, 34, 4822, 5224, 524810, 32, 39, 477, 483131486, 7, 34, 4834, 482, 314, 16, 18, 25, 307, 34, 483, 24, 41243148247, 34, 4822, 527, 34, 4852247, 345S,12S,18R-TriHEPE22, 5216S,17S-epoxy-DPAHydrolase*17R-HpDHARvE319-hydroxy-RvE15S,6S-epoxy-18R-HEPEDehydration*CMKLR120-carboxy-RvE1*RvE2Peroxidase*RvD5Hydrolysis*7S,8-epoxy-17S-HDHAPeroxidase*AT-RvD3ALOX5RvD5(n-3 DPA)*PTGS2RvD4Enzymatic dehydrogenationRvD6FPR2 Docosahexaenoic acid (22:6,w3)RvD3PD1(n-3 DPA)5S-hydroxyperoxy-18R-HEPEReduction*5S-hydroxyperoxy-18S-HEPE7S,8-epoxy-17R-HDHA15S-hydroxy-5S-HpEPE*RvE4Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)Irradiation-induced senescence4317S-HDHA17S-HpDPA5S,12R,18R-TriHEPE*10,11,dihydro-12-oxo-RvE118-oxo-RvE1Docosapentaenoic acid (22:5,w3)Enzymatic EpoxidationRvE1LTA4H20-hydroxy-RvE118S-HpEPE*UnknownP4507S,17S-diHpDPAGPR327S-hydroperoxy-17S-HDHA5S,6S,18R-TriHEPE*15S-HpEPE7S,8R-epoxy-17S-HDPA*4S,5-epoxy-17R-HDHAHydrolase*18R-HpEPE5S,6R,18R-TriHEPE*5S,6S-epoxy-18S-HEPE18S-RvE217R-HDHA17S-HpDHA12-oxo-RvE118S-RvE113,14-epoxy-DPA*Mar1(n-3 DPA)4S,5-epoxy-17S-HDHANon-enzymatic hydrolysisRvD2(n-3 DPA)*AT-RvD410,11-dihydro-RvE114-HpDPA4S-hydroperoxy-17S-HDHA18, 508, 33, 38, 541, 18, 50PGH316, 21, 26, 30ELOVL5TXASPGDSPGI3Eicosatetraenoic acid (20:4,w3)PGF3αPGD3PGESProstaglandin F synthaseStearidonic acid (18:4,w3)Phospholipase A2PGISTxA3α-Linolenic acid (18:3,w3)Eicosapentaenoic acid (20:5,w3)PGG3Eicosatrienoic acid (20:3,w3)FADS2FADS18, 33, 38, 5433, 35, 38, 44, 5433, 38, 44, 5433, 35, 38, 44, 5433, 35, 38, 5433, 38, 44, 5416, 18, 21, 26, 30...16, 18, 21, 26, 30...PTGS118, 21, 26, 30, 50PTGS2Δ9-Elongase*40, 49Irradiation-induced Senescence49434914S-HpDHA4913S,14S-epoxy-maresinMaresin 1Maresin 2MCTR1MCTR2MCTR3LGR6 receptorRORalphaALOX12HydrolaseGGT1DPEP1Mitochondrial dysfunction-associated senescenceOncogene-induced senescence(RAS)434940, 4910, 32, 39, 47, 5610, 39, 47, 5610, 39, 47, 5610, 32, 39, 47, 5610, 39, 47, 5610, 39, 4710, 39, 47PeroxidasePTGS2RvD1(n-3 DPA)*6, 7, 34, 4896, 7, 34996, 7, 34, 4896, 7, 34HPGD17-oxo-RvD1RvD2AT-RvD28-oxo-RvD1RvD1AT-RvD116-oxo-RvD27-oxo-RvD223, 363623, 3623, 3623, 363623, 36RvT2UnknownRvT4PTGS27,8-epoxy-13R-HDPA*7-hydroperoxy-13R-HpDPA*13R-HpDPA*RvT3RvT1ELOVL2FADS2Hydrolase*ALOX5ALOX1519, 51, 535353535319, 51, 535319, 51, 53535353535319, 51, 53535319, 51, 5319, 51, 5318-F3-IsoP*12-F3-IsoP*8-F3-IsoP*4611-F3-IsoP*5-F3-IsoP*15-F3-IsoP5-H3-IsoP*5-G3-IsoP*8-G3-IsoP*8-H3-IsoP*11-H3-IsoP*11-G3-IsoP*12-H3-IsoP*12-G3-IsoP*15-H3-IsoP*15-G3-IsoP*18-H3-IsoP*18-G3-IsoP*11, 2611, 13, 42, 5111, 2611, 2611, 2611, 2611, 2611, 2611, 2611, 2611, 2611, 2611, 42, 5111, 2611, 42, 5111, 2611, 2611, 2611, 2611, 261111, 2611, 2611, 2611, 2611, 42, 5111, 2611, 2611, 261111, 2611, 42, 5111, 2611, 2611, 2611, 2611, 2611, 42, 5111, 42, 517-G4-NeuroP*11, 42, 514-E4-NeuroP4-F4-NeuroP4-D4-NeuroP11-F4-NeuroP14-F4-NeuroP7-F4-NeuroP17-F4-NeuroP10-F4-NeuroP13-F4-NeuroP20-F4-NeuroP4-G4-NeuroP*4-H4-NeuroP*7-H4-NeuroP*7-E4-NeuroP7-D4-NeuroP10-E4-NeuroP10-D4-NeuroP10-H4-NeuroP10-G4-NeuroP*11-E4-NeuroP11-D4-NeuroP11-H4-NeuroP11-G4-NeuroP*13-E4-NeuroP13-D4-NeuroP13-H4-NeuroP*13-G4-NeuroP*14-E4-NeuroP14-D4-NeuroP14-H4-NeuroP14-G4-NeuroP*17-D4-NeuroP17-E4-NeuroP17-H4-NeuroP*17-G4-NeuroP*20-D4-NeuroP20-E4-NeuroP20-H4-NeuroP*20-G4-NeuroP*GSTM4LTC4SEPHX2PD2(n-3 DPA)*Mar2(n-3 DPA)*Mar3(n-3 DPA)Irradiation-induced senescenceAc43AcHypothetical reaction AcetylationLegendNo ID foundExcretion via urinePAcPhosphorylationMetaboliteProteinUpregulation/OverexpressionDownregulation/UnderexpressionConversionStimulationCatalysisSenescence phenotypeMetabolite*14, 28, 5514, 28, 5514, 28, 55UnknownRCTR1RCTR2RCTR3GGT1DPEP114, 28, 5514, 28, 5514, 28, 55UnknownPCTR1Hydrolysis (Unknown Hydrolase)1516S,17S-epoxyprotectin10S,17S-dihydroxy-DHA15Δ-trans PD110epi-S15Δ-trans PD116R/S,17S-dihydroxy-DHA10R/S,17S-dihydroxy-DHAPD1PD2*6, 15, 2015, 206, 14, 2015, 20Non-enzymatic Hydrolysis15, 20Non-enzymatic HydrolysisEnzymatic HydrolysisPCTR2PCTR3GGT1DPEP110S,17S-11E,13Z,15E-diHpDHAPDXGPx-415, 20h15-LOX13717, 37371717, 371717, 375(S)-HpEPE17LTA4HLTB5LTC5LTA5*LXA5LTD55,6-epoxy-15(S)-HEPE*ALOX5ALOX15ALOX12Enzyme BPeroxisomal beta-oxidation7S-HpDHA


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
135755view12:00, 9 November 2024EgonwNormalized two Rhea identifiers
135723view22:26, 31 October 2024AlexanderPicoModified description
135722view22:25, 31 October 2024AlexanderPicoModified description
130055view22:05, 24 May 2024Khanspersdecrease board height to remove blank space
129800view21:05, 22 May 2024EweitzFix jettisoned graphics
129102view15:01, 11 March 2024Nikita KrstevskaRearrangement of data nodes
128766view15:06, 21 February 2024Nikita KrstevskaAddition of missing gene product identifiers
128090view16:56, 25 January 2024JuliaUMRHEA IDs for PGs
128088view13:46, 25 January 2024DeSlOntology Term : 'fatty acid omega degradation pathway' added !
128086view13:45, 25 January 2024DeSlOntology Term : 'cellular senescence pathway' added !
128058view15:17, 23 January 2024JuliaUMNew IDs
128057view15:00, 23 January 2024JuliaUMRemovel of MaR rxn
128052view11:57, 23 January 2024JuliaUMID for RvD5
128051view11:39, 23 January 2024JuliaUMModified description
128045view14:30, 22 January 2024JuliaUMMar Rxn were refined
127933view15:52, 18 January 2024JuliaUMreactions were refined + addition of MaRL
127912view09:23, 13 January 2024JuliaUMDemo
127833view15:35, 22 December 2023JuliaUMsmall changes in Rv Rxn
127832view12:53, 22 December 2023JuliaUMsmall changes in reactions
127828view08:03, 22 December 2023JuliaUMChanges in reactions
127798view12:34, 16 December 2023EgonwRemoved the RHEA prefix
127794view15:29, 14 December 2023JuliaUMNew reactions eg LX and new IDs
127790view13:01, 13 December 2023JuliaUMIDs for EPA->DHA
127781view15:10, 7 December 2023JuliaUMNew reactions between eicosapentaenoic acid and docosahexaenoic acid
127780view16:54, 6 December 2023JuliaUMOntology Term : 'lipid metabolic pathway' added !
127779view16:49, 6 December 2023JuliaUMNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10,11,dihydro-12-oxo-RvE1MetaboliteCHEBI:165276 (ChEBI)
10,11-dihydro-RvE1MetaboliteCHEBI:165277 (ChEBI)
10-D4-NeuroPMetaboliteLMFA04010186 (LIPID MAPS)
10-E4-NeuroPMetaboliteLMFA04010314 (LIPID MAPS)
10-F4-NeuroPMetaboliteLMFA04010005 (LIPID MAPS)
10-G4-NeuroP*Metabolite
10-H4-NeuroPMetaboliteCHEBI:185511 (ChEBI)
10R/S,17S-dihydroxy-DHAMetabolite
10S,17S-11E,13Z,15E-diHpDHAMetabolite
10S,17S-dihydroxy-DHAMetaboliteCHEBI:138653 (ChEBI)
10epi-S15Δ-trans PD1Metabolite
11-D4-NeuroPMetaboliteLMFA04010202 (LIPID MAPS)
11-E4-NeuroPMetaboliteLMFA04010330 (LIPID MAPS)
11-F3-IsoP*Metabolite
11-F4-NeuroPMetaboliteLMFA04010006 (LIPID MAPS)
11-G3-IsoP*Metabolite
11-G4-NeuroP*Metabolite
11-H3-IsoP*Metabolite
11-H4-NeuroPMetaboliteCHEBI:187424 (ChEBI)
12-F3-IsoP*Metabolite
12-G3-IsoP*Metabolite
12-H3-IsoP*Metabolite
12-oxo-RvE1MetaboliteCHEBI:165264 (ChEBI)
13,14-epoxy-DPA*Metabolite
13-D4-NeuroPMetaboliteLMFA04010218 (LIPID MAPS)
13-E4-NeuroPMetaboliteLMFA04010346 (LIPID MAPS)
13-F4-NeuroPMetaboliteLMFA04010003 (LIPID MAPS)
13-G4-NeuroP*Metabolite
13-H4-NeuroP*Metabolite
13R-HpDPA*Metabolite
13S,14S-epoxy-maresinMetaboliteCHEBI:131958 (ChEBI) (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
14-D4-NeuroPMetaboliteLMFA04010234 (LIPID MAPS)
14-E4-NeuroPMetaboliteLMFA04010362 (LIPID MAPS)
14-F4-NeuroPMetaboliteLMFA04010004 (LIPID MAPS)
14-G4-NeuroP*Metabolite
14-H4-NeuroPMetaboliteHMDB0062292 (HMDB)
14-HpDPAMetaboliteCHEBI:136353 (ChEBI)
14R-HDHAMetaboliteCHEBI:137346 (ChEBI)
14S-HDHAMetaboliteCHEBI:137347 (ChEBI)
14S-HpDHAMetaboliteCHEBI:136526 (ChEBI)
15-F3-IsoPMetaboliteCHEBI:157746 (ChEBI) = 8-epi PGF3
15-G3-IsoP*Metabolite= 8-epi PGF3
15-H3-IsoP*Metabolite= 8-epi PGF3
15S-HpEPEMetaboliteCHEBI:165266 (ChEBI)
15S-hydroxy-5S-HpEPE*Metabolite
15d-PGD3*Metabolite
15d-PGJ3MetaboliteCHEBI:140223 (ChEBI)
15Δ-trans PD1Metabolite
16-oxo-RvD2MetaboliteCHEBI:138281 (ChEBI)
16R/S,17S-dihydroxy-DHAMetabolite
16S,17S-epoxy-DPAMetaboliteCHEBI:140224 (ChEBI)
16S,17S-epoxyprotectinMetaboliteCHEBI:140225 (ChEBI)
17-D4-NeuroPMetaboliteLMFA04010250 (LIPID MAPS) = 17-F4c-NP
17-E4-NeuroPMetaboliteLMFA04010378 (LIPID MAPS) = 17-F4c-NP
17-F4-NeuroPMetaboliteLMFA04010002 (LIPID MAPS) = 17-F4c-NP
17-G4-NeuroP*Metabolite= 17-F4c-NP
17-H4-NeuroP*Metabolite= 17-F4c-NP
17-oxo-RvD1MetaboliteCHEBI:132800 (ChEBI)
17R-HDHAMetaboliteCHEBI:91137 (ChEBI)
17R-HpDHAMetaboliteCHEBI:138590 (ChEBI)
17S-HDHAMetaboliteCHEBI:138640 (ChEBI)
17S-HpDHAMetaboliteCHEBI:136113 (ChEBI)
17S-HpDPAMetaboliteCHEBI:136118 (ChEBI)
18-F3-IsoP*Metabolite
18-G3-IsoP*Metabolite
18-H3-IsoP*Metabolite
18-oxo-RvE1MetaboliteCHEBI:131617 (ChEBI)
18R-HpEPEMetaboliteCHEBI:138565 (ChEBI)
18S-HpEPE*Metabolite
18S-RvE1MetaboliteCHEBI:137038 (ChEBI)
18S-RvE2MetaboliteCHEBI:137034 (ChEBI)
19-hydroxy-RvE1MetaboliteCHEBI:165268 (ChEBI)
20-D4-NeuroPMetaboliteLMFA04010266 (LIPID MAPS)
20-E4-NeuroPMetaboliteLMFA04010394 (LIPID MAPS)
20-F4-NeuroPMetaboliteLMFA04010001 (LIPID MAPS)
20-G4-NeuroP*Metabolite
20-H4-NeuroP*Metabolite
20-carboxy-RvE1*Metabolite
20-hydroxy-RvE1MetaboliteCHEBI:165269 (ChEBI)
4-D4-NeuroPMetaboliteLMFA04010154 (LIPID MAPS)
4-E4-NeuroPMetaboliteLMFA04010282 (LIPID MAPS)
4-F4-NeuroPMetaboliteLMFA04010008 (LIPID MAPS)
4-G4-NeuroP*Metabolite
4-H4-NeuroP*Metabolite
4S,5-epoxy-17R-HDHAMetaboliteCHEBI:187528 (ChEBI)
4S,5-epoxy-17S-HDHAMetaboliteCHEBI:138647 (ChEBI)
4S-HpDHAMetabolite
4S-hydroperoxy-17S-HDHAMetaboliteCHEBI:138641 (ChEBI)
5(S)-HpEPEMetaboliteCHEBI:165271 (ChEBI)
5,6-epoxy-15(S)-HEPE*Metabolite
5-F3-IsoP*Metabolite
5-G3-IsoP*Metabolite
5-H3-IsoP*Metabolite
5S,12R,18R-TriHEPE*Metabolite
5S,12S,18R-TriHEPEMetaboliteCHEBI:133822 (ChEBI)
5S,6R,18R-TriHEPE*Metabolite
5S,6S,18R-TriHEPE*Metabolite
5S,6S-epoxy-18R-HEPEMetaboliteCHEBI:132219 (ChEBI)
5S,6S-epoxy-18S-HEPEMetaboliteCHEBI:138490 (ChEBI)
5S-hydroxyperoxy-18R-HEPEMetaboliteCHEBI:81562 (ChEBI)
5S-hydroxyperoxy-18S-HEPEMetaboliteCHEBI:91287 (ChEBI)
6-keto-PGF2α*Metabolite
7,8-epoxy-13R-HDPA*Metabolite
7-D4-NeuroPMetaboliteLMFA04010170 (LIPID MAPS)
7-E4-NeuroPMetaboliteLMFA04010298 (LIPID MAPS)
7-F4-NeuroPMetaboliteLMFA04010007 (LIPID MAPS)
7-G4-NeuroP*Metabolite
7-H4-NeuroP*Metabolite
7-hydroperoxy-13R-HpDPA*Metabolite
7-oxo-RvD2MetaboliteCHEBI:138279 (ChEBI)
7S,17S-diHpDHAMetaboliteCHEBI:140245 (ChEBI)
7S,17S-diHpDPAMetaboliteCHEBI:140248 (ChEBI)
7S,8-epoxy-17R-HDHAMetaboliteCHEBI:138613 (ChEBI)
7S,8-epoxy-17S-HDHAMetabolite53477500 (PubChem-compound)
7S,8R-epoxy-17S-HDPA*Metabolite
7S-HpDHAMetaboliteInChIKey=IYPGULUSNSBANC-VPNHEHDPSA-M (InChIKey)
7S-hydroperoxy-17S-HDHAMetaboliteCHEBI:138642 (ChEBI)
8-F3-IsoP*Metabolite
8-G3-IsoP*Metabolite
8-H3-IsoP*Metabolite
8-oxo-RvD1MetaboliteCHEBI:132797 (ChEBI)
ALOX12 GeneProductENSG00000108839 (Ensembl) Enzyme 12LOX
ALOX15BGeneProductENSG00000179593 (Ensembl)
ALOX15GeneProductENSG00000161905 (Ensembl)
ALOX5GeneProductENSG00000012779 (Ensembl)
AT-RvD1MetaboliteCHEBI:138179 (ChEBI)
AT-RvD2 MetaboliteCHEBI:138614 (ChEBI)
AT-RvD3MetaboliteCHEBI:138615 (ChEBI)
AT-RvD4MetaboliteCHEBI:138616 (ChEBI)
CMKLR1ComplexENSG00000174600 (Ensembl) =ChemR23
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP2C8GeneProductENSG00000138115 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP2D6GeneProductENSG00000100197 (Ensembl)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
DPEP1 GeneProductENSG00000015413 (Ensembl) dipeptidase 1
Dehydration
Dehydration*
Docosahexaenoic acid (22:6,w3)MetaboliteCHEBI:36005 (ChEBI)
Docosapentaenoic acid (22:5,w3)MetaboliteCHEBI:53488 (ChEBI)
ELOVL2GeneProductENSG00000197977 (Ensembl)
ELOVL5GeneProductENSG00000012660 (Ensembl) fatty acid elongase 5
EPHX2GeneProductENSG00000120915 (Ensembl)
Eicosapentaenoic acid (20:5,w3)MetaboliteCHEBI:28364 (ChEBI)
Eicosatetraenoic acid (20:4,w3)MetaboliteCHEBI:166893 (ChEBI)
Eicosatrienoic acid (20:3,w3)Metabolite5312529 (PubChem-compound)
Enzymatic Epoxidation
Enzymatic HydrolysisProtein
Enzymatic dehydrogenationGeneProduct
FADS1GeneProductENSG00000149485 (Ensembl) gene=FADS1 Δ5-Desaturase
FADS2GeneProductENSG00000134824 (Ensembl)
FPR2 GeneProductENSG00000171049 (Ensembl) =formyl peptide receptor 2 =ALX
GGT1GeneProductENSG00000100031 (Ensembl) gamma-glutamyltransferase 1
GPR32GeneProductENSG00000142511 (Ensembl) =G protein-coupled receptor 32 =RVDR1
GPx-4ProteinENSG00000167468 (Ensembl) Glutathione Peroxidase 4
GSTM4GeneProductENSG00000168765 (Ensembl) glutathione S-transferase mu 4
HPGDGeneProductENSG00000164120 (Ensembl)
Hydrolase
Hydrolase*GeneProduct
Hydrolysis (Unknown Hydrolase)Protein
Hydrolysis*GeneProduct
Irradiation-induced Senescence
Irradiation-induced senescence
LGR6 receptorMetabolite
LTA4HGeneProductENSG00000111144 (Ensembl)
LTA5*Metabolite
LTB5Metabolite5283125 (PubChem-compound)
LTC4SGeneProductENSG00000213316 (Ensembl)
LTC5MetaboliteCHEBI:172777 (ChEBI)
LTD5MetaboliteCHEBI:175815 (ChEBI)
LXA5Metabolite110657-98-2 (CAS)
MCTR1MetaboliteCHEBI:138202 (ChEBI) (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
MCTR2 MetaboliteCHEBI:138206 (ChEBI) (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
MCTR3 MetaboliteCHEBI:138209 (ChEBI) (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
MaR-L1MetaboliteCHEBI:137349 (ChEBI)
MaR-L2MetaboliteCHEBI:137350 (ChEBI)
Mar1(n-3 DPA)MetaboliteCHEBI:140256 (ChEBI)
Mar2(n-3 DPA)*Metabolite
Mar3(n-3 DPA)MetaboliteCHEBI:140258 (ChEBI)
Maresin 1MetaboliteCHEBI:138249 (ChEBI) 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid
Maresin 2MetaboliteCHEBI:138248 (ChEBI) (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid
Mitochondrial dysfunction-associated senescence Oncogene-induced senescence(RAS)
Mitochondrial dysfunction-associated senescence

Oncogene-induced senescence(RAS)

Irradiation-induced senescence
Non-enzymatic HydrolysisProtein
Non-enzymatic hydrolysis
P450GeneProduct
PCTR1MetaboliteLMFA04040004 (LIPID MAPS)
PCTR2MetaboliteLMFA04040005 (LIPID MAPS)
PCTR3MetaboliteLMFA04040006 (LIPID MAPS)
PD1(n-3 DPA)MetaboliteCHEBI:140265 (ChEBI)
PD1Metabolite195348 (ChEBI)
PD2(n-3 DPA)*Metabolite
PD2*Metabolite
PDXMetabolite138653 (ChEBI) (4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid
PGD3MetaboliteCHEBI:34939 (ChEBI)
PGDSGeneProduct5.3.99.2 (Enzyme Nomenclature)
PGE3MetaboliteCHEBI:28031 (ChEBI)
PGESGeneProduct5.3.99.3 (Enzyme Nomenclature)
PGF3αMetaboliteCHEBI:36075 (ChEBI)
PGG3MetaboliteCHEBI:134406 (ChEBI)
PGH3MetaboliteCHEBI:134407 (ChEBI)
PGI3Metabolite
PGISGeneProduct5.3.99.4 (Enzyme Nomenclature)
PGJ3MetaboliteCHEBI:140267 (ChEBI)
PTGS1GeneProductENSG00000095303 (Ensembl) =Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX)
PTGS2GeneProduct
PTGS2GeneProductENSG00000073756 (Ensembl)
Peroxidase
Peroxidase*GeneProduct
Peroxisomal beta-oxidationPathway/ (WikiPathways)
Phospholipase A2GeneProductP47712 (Uniprot-TrEMBL)
Prostaglandin F synthase
RCTR1MetaboliteLMFA04030014 (LIPID MAPS)
RCTR2MetaboliteLMFA04030015 (LIPID MAPS)
RCTR3MetaboliteLMFA04030016 (LIPID MAPS)
RORalphaMetabolite
Reduction
Reduction*
RvD1(n-3 DPA)*Metabolite
RvD1MetaboliteCHEBI:81564 (ChEBI)
RvD2(n-3 DPA)*Metabolite
RvD2MetaboliteCHEBI:81565 (ChEBI)
RvD3MetaboliteCHEBI:138648 (ChEBI)
RvD4MetaboliteCHEBI:138649 (ChEBI)
RvD5Metabolite
RvD5(n-3 DPA)*Metabolite
RvD6MetaboliteCHEBI:138643 (ChEBI)
RvE1MetaboliteCHEBI:81559 (ChEBI)
RvE2MetaboliteCHEBI:81560 (ChEBI)
RvE3MetaboliteCHEBI:138542 (ChEBI)
RvE4Metabolite1025684-60-9 (CAS)
RvT1MetaboliteCHEBI:137011 (ChEBI)
RvT2MetaboliteCHEBI:137018 (ChEBI)
RvT3MetaboliteCHEBI:137019 (ChEBI)
RvT4MetaboliteCHEBI:137020 (ChEBI)
Stearidonic acid (18:4,w3)MetaboliteCHEBI:32389 (ChEBI)
TXASGeneProduct5.3.99.5 (Enzyme Nomenclature)
Tetracosahexanoic acid (22:6,n-3)Metabolite11792612 (PubChem-compound)
Tetracosapentanoic acid (24:5,n-3)MetaboliteHMDB0006323 (HMDB)
TxA3MetaboliteCHEBI:165349 (ChEBI)
TxB3MetaboliteCHEBI:84444 (ChEBI)
Unknown
h15-LOX1Protein
Δ12-PGJ3MetaboliteCHEBI:140274 (ChEBI)
Δ9-Elongase*
α-Linolenic acid (18:3,w3)MetaboliteCHEBI:27432 (ChEBI) IUPAC Name: (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid

Annotated Interactions

SourceTargetTypeDatabase referenceComment
5S,6S-epoxy-18R-HEPE5S,12S,18R-TriHEPEmim-conversion50868 (Rhea)
5S-hydroxyperoxy-18R-HEPERvE2mim-conversion52020 (Rhea)
5S-hydroxyperoxy-18S-HEPE18S-RvE2mim-conversion52024 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5432"
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