Ectodysplasin A signaling in hair follicle development (Mus musculus)

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1Induction/Patterningp50EdarNfkb2ShhCell GrowthEDA-A1 isoformEdaraddRelbRelNfkb1Gli1LtbCell DifferentiationRelap65BMP PathwayEDA-A5 isoformDkk4RelbSostdc1Dkk1PtcWnt Signaling


Description

EDA protein regulation of hair follicle growth and differentiation through activation Nf-kB pathway occurring by binding of p65/p50 complex. The new protein complex of Nf-kB/p65/p50 activates Wnt and Bmp pathway inhibitors stopping induction/patterning. Nf-kB complex then binds with Ltb and Shh to activate pathways for growth and differentiation. This pathway is based on figure 4 from Cui et al.

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Ontology Terms

 

Bibliography

  1. Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D; ''Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129298view22:08, 25 March 2024Khanspersupdated xref
129297view22:04, 25 March 2024KhanspersModified description
129296view22:04, 25 March 2024KhanspersModified title
129295view22:00, 25 March 2024Khanspersupdated outdated xrefs, updated pathway nodes
123392view06:22, 23 July 2022EgonwMade a pathway clickable
116428view09:27, 7 May 2021EweitzModified title
114009view14:52, 17 December 2020LaurentConnected line
97556view15:07, 24 May 2018Mkutmonchanged "Ensembl Mouse" to "Ensembl"
97555view15:06, 24 May 2018Mkutmoncreated complex for nfkb
89222view21:43, 23 August 2016KhanspersOntology Term : 'CL:0000477' removed !
89221view21:43, 23 August 2016KhanspersOntology Term : 'hair follicle cell' added !
89220view21:42, 23 August 2016KhanspersOntology Term : 'follicle cell' added !
88463view22:55, 9 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88462view22:54, 9 August 2016AAR&CoEdited Labels and Interactions
87955view13:08, 25 July 2016SusanOntology Term : 'nuclear factor kappa B signaling pathway' added !
85916view18:06, 21 June 2016AAR&CoModified description
85773view18:58, 12 June 2016AAR&CoModified description
85770view18:53, 12 June 2016AAR&CoEdited interaction
85769view18:52, 12 June 2016AAR&CoAdded new interactions
85768view18:37, 12 June 2016AAR&CoQuick edit to datanode annotation or property
85767view18:34, 12 June 2016AAR&CoAdded Intermediate Protein
85766view18:14, 12 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BMP PathwayPathway
Cell DifferentiationPathwayWP2082 (WikiPathways)
Cell GrowthPathway
Dkk1GeneProduct13380 (Entrez Gene)
Dkk4GeneProduct234130 (Entrez Gene)
EDA-A1 isoformProteinQ3UV69 (Uniprot-TrEMBL)
EDA-A5 isoformProteinQ1L2D9 (Uniprot-TrEMBL)
EdarGeneProduct13608 (Entrez Gene)
EdaraddGeneProduct171211 (Entrez Gene)
Gli1GeneProduct14632 (Entrez Gene)
LtbGeneProduct16994 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
Nfkb2GeneProductENSMUSG00000025225 (Ensembl)
PtcGeneProduct19206 (Entrez Gene)
RelGeneProduct19698 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
RelbGeneProduct19698 (Entrez Gene)
ShhGeneProduct20423 (Entrez Gene)
Sostdc1GeneProduct66042 (Entrez Gene)
Wnt SignalingPathwayWP403 (WikiPathways)
p50GeneProduct18033 (Entrez Gene)
p65GeneProduct19697 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3652"
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