Arsenic metabolism and reactive oxygen species generation (Homo sapiens)
From WikiPathways
Description
Arsenic induced ROS formation may lead to carcinogenic effects.
Quality Tags
Ontology Terms
Bibliography
- Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M; ''Arsenic: toxicity, oxidative stress and human disease.''; J Appl Toxicol, 2011 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
AS3MT | GeneProduct | ENSG00000214435 (Ensembl) | |
ATP1A1 | GeneProduct | ENSG00000163399 (Ensembl) | |
Activation of oncogenic pathways | |||
CAT | GeneProduct | ENSG00000121691 (Ensembl) | |
COA3 | GeneProduct | ENSG00000183978 (Ensembl) | |
DMA (III) | Metabolite | 161508 (Chemspider) | |
DMA (V) | Metabolite | 2418 (Chemspider) | |
GSH | Metabolite | CHEBI:16856 (ChEBI) | |
GSSG | Metabolite | CHEBI:17858 (ChEBI) | |
GSTO1 | GeneProduct | ENSG00000148834 (Ensembl) | |
H2O2 | Metabolite | 16240 (ChEBI) | |
H2O | Metabolite | CHEBI:15377 (ChEBI) | |
MMA (III) | Metabolite | 141846 (Chemspider) | |
MMA (V) | Metabolite | 8604 (Chemspider) | |
MT-ND1 | GeneProduct | ENSG00000198888 (Ensembl) | |
Mitochondrial dysfunction | |||
O2·– | Metabolite | 18421 (ChEBI) | |
OXPHOS | Pathway | WP111 (WikiPathways) | |
ROS | Metabolite | 26523 (ChEBI) | |
S-adenosylmethionine | Metabolite | CHEBI:15414 (ChEBI) | |
SAH | Metabolite | CHEBI:16680 (ChEBI) | |
SDHA | GeneProduct | ENSG00000073578 (Ensembl) | |
SOD1 | GeneProduct | ENSG00000142168 (Ensembl) | |
SOD2 | GeneProduct | ENSG00000112096 (Ensembl) | |
UQCRFS1 | GeneProduct | ENSG00000169021 (Ensembl) | |
VDAC1 | GeneProduct | ENSG00000213585 (Ensembl) | |
arsenic(3+) | Metabolite | CHEBI:35828 (ChEBI) | |
arsenic(5+) | Metabolite | CHEBI:35829 (ChEBI) | |
arsenic | Metabolite | CHEBI:27563 (ChEBI) |
Annotated Interactions
No annotated interactions