Arylamine metabolism (Homo sapiens)

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13222222N,O-TransacetylationDNA adductsO-acetylationan N-hydroxyarylamineArylamineSULT1A2DeacetylaseSULT1A1DeacetylaseN-aryl sulfamic acidUGT1A9NAT1UGT1A4N-AcetylarylamineN-hydroxy-N-acetylamineArylamine N,O-sulfateO-acetylarylamineAcetyl-CoAArylamine N-glucuronideNAT2CYP1A2NAT1NAT2Coenzyme A


Description

Simplified scheme of arylamine metabolism pathway. Arylamines are N-acetylated by NAT2 in the liver, transforming them to relatively nonreactive. Alternatively, they may be N-hydroxylated by CYPIA2, transported to the bladder, and undergo O-acetylation by NATI, to form a highly reactive species. [1]

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sim E, Abuhammad A, Ryan A; ''Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery.''; Br J Pharmacol, 2014 PubMed Europe PMC Scholia
  2. Meyer UA; ''Polymorphism of human acetyltransferases.''; Environ Health Perspect, 1994 PubMed Europe PMC Scholia
  3. Chou HC, Lang NP, Kadlubar FF; ''Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).''; Cancer Res, 1995 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134407view20:32, 21 July 2024EweitzModified description
106139view12:03, 16 August 2019MaintBotHMDB identifier normalization
102520view19:21, 3 January 2019Khanspersadded missing xref
102462view05:49, 24 December 2018EgonwFixed a data source.
96691view12:10, 27 March 2018Asios Oliaadded literature reference (Sim et.al.,2014)
96049view16:15, 15 February 2018DeSlRemoved "last modified" item
96048view16:15, 15 February 2018DeSlAdded ID for arylamine
96047view16:11, 15 February 2018DeSlModified description
89536view11:06, 16 September 2016Mkutmonontology tag fix
89473view13:39, 15 September 2016Mkutmonremove space from ontology term id
88582view19:20, 11 August 2016Mkutmonfix unconnected lines
67062view10:01, 26 June 2013Christine ChichesterOntology Term : 'arylamine metabolic pathway' added !
63168view20:25, 8 May 2013MaintBotUpdating GPML version
59094view22:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44963view12:49, 6 October 2011MartijnVanIerselOntology Term : 'metabolic pathway of secondary metabolites' added !
41045view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
33410view14:49, 30 November 2009MaintBotRemoved group label
29878view07:48, 9 June 2009Pieter GiesbertzAdded literature reference
29733view22:26, 1 June 2009KhanspersModified categories
29508view08:12, 11 May 2009Pieter GiesbertzAdded literature references
29266view10:49, 21 April 2009Pieter GiesbertzSpecify description
29265view10:46, 21 April 2009Pieter GiesbertzSpecify description
29264view10:13, 21 April 2009Pieter GiesbertzSpecify description
29240view15:02, 17 April 2009EveloAdded backpage for CoA
29213view11:04, 14 April 2009Pieter GiesbertzSpecify description
29212view10:59, 14 April 2009Stan.gajMinor typo-fix; Added more information to Pathway Properties
29208view09:57, 14 April 2009Pieter GiesbertzPeriodical save, work in progress
29207view09:11, 14 April 2009Pieter GiesbertzSpecify description
29206view09:05, 14 April 2009Pieter GiesbertzSpecify description
29205view09:05, 14 April 2009Pieter GiesbertzPeriodical save, work in progress
29204view08:19, 14 April 2009Pieter GiesbertzSpecify description
29202view07:28, 14 April 2009Pieter GiesbertzSpecify description
29170view13:32, 9 April 2009Pieter GiesbertzSpecify description
29167view12:00, 9 April 2009Pieter GiesbertzPeriodical save, work in progress
29165view09:21, 9 April 2009Pieter GiesbertzPeriodical save, work in progress
29163view07:56, 9 April 2009Pieter GiesbertzPeriodical save, work in progress
29157view13:28, 8 April 2009Pieter GiesbertzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Arylamine N,O-sulfateMetabolite
Arylamine N-glucuronideMetabolite
ArylamineMetaboliteCHEBI:50471 (ChEBI)
CYP1A2GeneProductENSG00000140505 (Ensembl)
Coenzyme AMetaboliteHMDB0001423 (HMDB)
DeacetylaseGeneProduct
N-AcetylarylamineMetaboliteHMDB0001250 (HMDB)
N-aryl sulfamic acidMetabolite
N-hydroxy-N-acetylamineMetabolite
NAT1GeneProductENSG00000171428 (Ensembl)
NAT2GeneProductENSG00000156006 (Ensembl)
O-acetylarylamineMetabolite
SULT1A1GeneProductENSG00000196502 (Ensembl)
SULT1A2GeneProductENSG00000197165 (Ensembl)
UGT1A4GeneProduct54657 (Entrez Gene)
UGT1A9GeneProduct54600 (Entrez Gene)
an N-hydroxyarylamineMetaboliteCHEBI:13792 (ChEBI)

Annotated Interactions

No annotated interactions

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