Hepatitis C and hepatocellular carcinoma (Homo sapiens)

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1Cell migrationCell growth and survivalCell cycle progressionPTGS2VEGFAIL6RSMAD3VAV2BRCA1VEGFAGRB2MYOFCytoskeleton activationCXCR1BIRC5LEF1CASP9PODXLFASLGCDKN1AE2F2NFKB1 signalingCell proliferationSTAT3BIRC3NFKB1MIR744MIR34ADNA repairCell migrationMMP1CCND1IL6UCHL1TP53RAC1COL4A2CCND1ApoptosisCTTNWNT signalingMAPK3HIF1AMYCMAPK signalingRRM2CASP3PTPN11BCL2L1CD44SOS1IL8JAK1FRZBMAPK14TGFB1PI3K signalingAKT1AngiogenesisHNF1AMYCJUNCCND1MYCMAPK signalingMYCCell proliferationCell proliferationAngiogenesisApoptosisCASP9CASP7MIR34AMIR155MIR34AMIR155MIR34AMIR155MIR24-1MIR24-2MIR92A1MIR92A2BIRC3BCL2L1ApoptosisNOS2AngiogenesisMIR34AMAPK signalingMAPK8JUNCCND1IL8MMP1SMAD4CDKN1ATGFBR1MIR24-1MIR24-2MIR744MAPK signalingApoptosisMIR155AngiogenesisTNFSS10Cell proliferationCell proliferation


Description

Pathway model based on hub miRNAs and their putative targets from network analysis.
  • From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/).
  • After topological analysis and network visualization in Cytoscape, the top hub genes were identified.
  • miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network.

Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, Ghavami S, Alavian SE, Rezaei Moghadam A, Amiri M; ''How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.''; Hepat Mon, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135169view00:57, 7 August 2024EweitzClear cache to fix board height
135168view00:55, 7 August 2024EweitzEconomize layout
135167view00:49, 7 August 2024EweitzIncrease font size
128258view00:16, 30 January 2024EweitzStandardize case
116732view10:58, 11 May 2021EweitzModified title
111190view07:11, 23 July 2020EgonwMade a few more pathway nodes clickable
107467view18:45, 10 October 2019KhanspersModified description
106591view19:33, 10 September 2019KhanspersModified description
105615view04:56, 10 August 2019KhanspersModified description
103011view15:22, 31 January 2019Mkutmonupdated outdated Ensembl identifier (MIR34A)
102150view18:57, 4 December 2018Khanspersupdated mirna identifiers
97632view10:53, 31 May 2018AMTanOntology Term : 'hepatocellular carcinoma' added !
88640view14:54, 12 August 2016JmeliusOntology Term : 'disease pathway' added !
85722view23:14, 6 June 2016KhanspersModified description
85720view20:53, 6 June 2016KhanspersAdded one final interaction
85719view20:49, 6 June 2016KhanspersModified description
85718view20:48, 6 June 2016KhanspersModified description
85714view20:39, 6 June 2016KhanspersModified description
85713view20:39, 6 June 2016KhanspersModified description
85700view18:34, 6 June 2016KhanspersOntology Term : 'hepatocyte' added !
85699view18:33, 6 June 2016KhanspersOntology Term : 'carcinoma' added !
85698view18:32, 6 June 2016KhanspersOntology Term : 'hepatitis' added !
85697view18:31, 6 June 2016KhanspersModified description
85696view18:28, 6 June 2016Khanspersupdate
85566view22:54, 31 May 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BIRC5GeneProductENSG00000089685 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
CTTNGeneProductENSG00000085733 (Ensembl)
CXCR1GeneProductENSG00000163464 (Ensembl)
Cell cycle progressionPathwayWP45 (WikiPathways)
Cell migrationPathway
Cell proliferationPathway
Cytoskeleton activationPathway
DNA repairPathwayWP707 (WikiPathways)
E2F2GeneProductENSG00000007968 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FRZBGeneProductENSG00000162998 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HNF1AGeneProductENSG00000135100 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
IL8GeneProductENSG00000169429 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MIR155GeneProductENSG00000283904 (Ensembl)
MIR24-1GeneProductENSG00000284459 (Ensembl)
MIR24-2GeneProductENSG00000284387 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIR744GeneProductENSG00000266297 (Ensembl)
MIR92A1GeneProductMIR92A1 (HGNC)
MIR92A2GeneProductENSG00000284538 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
NFKB1 signalingPathway
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
PI3K signalingPathway
PODXLGeneProductENSG00000128567 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RRM2GeneProductENSG00000171848 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TNFSS10GeneProductENSG00000117560 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCHL1GeneProductENSG00000154277 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
WNT signalingPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions

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