T-cell activation SARS-CoV-2 (Homo sapiens)

From WikiPathways

Revision as of 03:03, 7 August 2024 by Eweitz (Talk | contribs)
Jump to: navigation, search
Endoplasmatic reticulum244, 31381, 12, 227, 436, 4634, 396, 464, 20, 314, 3126, 35, 41254, 31254, 25, 31, 33326, 4623214, 29, 31, 4523142323404, 20, 31109404, 31, 332, 10, 1517, 4710, 13, 27, 36, 374023LysosomeNucleusAntigen presenting cell (APC)Naive T cellHLA-DRACa2+SARS-CoV-2 SpikeHLA-DRAHLA-DRB1HLA-DRB1TRATRBCD247CD247CD3ECD3DCD3ECD3GLATCD80CD4LCKZAP70CD28PIK3R1PDPK1AKT1mTORGSK3BTSC2NFATC1PLCG1PPP33CGRB2SOS1RASGRP1HRASRAF1MAP2K1MAPK323ITPR1PRKCQNFKB1RHEBmTORTSC1NFATC1ICOSCARD11BCL10MALT1CHUK25IKBKBIKBKGNFKBIAProliferationCell growthGlucose metabolismPTPRCFYNRELANFKB1RELAJUNFOSJUNFOSSARS-CoVSpike proteinFOXO33CTLA4TYK2JAK2IL12RB2STAT45IL23R5STAT4STAT4STAT4STAT4IFNAR1IL12AIL23AIL12BIL12RB1IL12RB1TYK2JAK2IL12BIFNAR2CCND1Cell cycle control8, 18, 19, 30, 44IL2CDKN2A 11CCND1TP53 CDKN1AIRF2BPLMYD8842IFNGTNFIL18R1IL12RB2LCP2GRAP2PIP24, 20, 31NFAT2PIP240PIK3CDPTENIFNGIL4IL17ACCL19CCL28IL12BIL12ATLATNFIFNGIL23AIFNB1MLST8DeptorRaptorCD8616, 2816, 28BAXBCL2L1 IL12BIL12AIL2DEPTORMLST8RICTORCa2+IP3DAGPIP3MAP2K2MAPK1


Description

T-cell activation SARS-CoV-2 (Work in Progress)

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. weiguo Zhang, Joanne Sloan-Lancaster, Jason Kitchen, Ronald P Trible, Lawrence E Samelson; ''LAT: The ZAP-70 Tyrosine Kinase Substrate that Links T Cell Receptor to Cellular Activation''; Cell, 1998 PubMed Europe PMC Scholia
  2. Beurel E, Grieco SF, Jope RS; ''Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.''; Pharmacol Ther, 2015 PubMed Europe PMC Scholia
  3. Rönnblom L; ''The type I interferon system in the etiopathogenesis of autoimmune diseases.''; Ups J Med Sci, 2011 PubMed Europe PMC Scholia
  4. Liu T, Zhang L, Joo D, Sun SC; ''NF-κB signaling in inflammation.''; Signal Transduct Target Ther, 2017 PubMed Europe PMC Scholia
  5. Oh-hora M, Rao A; ''The calcium/NFAT pathway: role in development and function of regulatory T cells.''; Microbes Infect, 2009 PubMed Europe PMC Scholia
  6. Isakov N, Altman A; ''Protein kinase C(theta) in T cell activation.''; Annu Rev Immunol, 2002 PubMed Europe PMC Scholia
  7. Greenfield EA, Nguyen KA, Kuchroo VK; ''CD28/B7 costimulation: a review.''; Crit Rev Immunol, 1998 PubMed Europe PMC Scholia
  8. Ogawa H, Iimura M, Eckmann L, Kagnoff MF; ''Regulated production of the chemokine CCL28 in human colon epithelium.''; Am J Physiol Gastrointest Liver Physiol, 2004 PubMed Europe PMC Scholia
  9. Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A; ''SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19.''; Nature, 2020 PubMed Europe PMC Scholia
  10. Hesterberg RS, Cleveland JL, Epling-Burnette PK; ''Role of Polyamines in Immune Cell Functions.''; Med Sci (Basel), 2018 PubMed Europe PMC Scholia
  11. Oh H, Ghosh S; ''NF-κB: roles and regulation in different CD4(+) T-cell subsets.''; Immunol Rev, 2013 PubMed Europe PMC Scholia
  12. C. Martinez Calejman, S. Trefely, S. W. Entwisle, A. Luciano, S. M. Jung, W. Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villén, K. E. Wellen, D. A. Guertin; ''mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis''; Nature, 2020 PubMed Europe PMC Scholia
  13. Rudd CE, Schneider H; ''Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.''; Nat Rev Immunol, 2003 PubMed Europe PMC Scholia
  14. Vaeth M, Feske S; ''NFAT control of immune function: New Frontiers for an Abiding Trooper.''; F1000Res, 2018 PubMed Europe PMC Scholia
  15. Inoki K, Li Y, Zhu T, Wu J, Guan KL; ''TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.''; Nat Cell Biol, 2002 PubMed Europe PMC Scholia
  16. Xue L, Chiang L, Kang C, Winoto A; ''The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint.''; Eur J Immunol, 2008 PubMed Europe PMC Scholia
  17. Huang J, Manning BD; ''A complex interplay between Akt, TSC2 and the two mTOR complexes.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
  18. Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA; ''Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.''; J Exp Med, 1991 PubMed Europe PMC Scholia
  19. Altin JG, Sloan EK; ''The role of CD45 and CD45-associated molecules in T cell activation.''; Immunol Cell Biol, 1997 PubMed Europe PMC Scholia
  20. Rhee SG; ''Regulation of phosphoinositide-specific phospholipaseC.''; Annu Rev Biochem, 2001 PubMed Europe PMC Scholia
  21. Fabre S, Lang V, Harriague J, Jobart A, Unterman TG, Trautmann A, Bismuth G; ''Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control.''; J Immunol, 2005 PubMed Europe PMC Scholia
  22. Good SR, Thieu VT, Mathur AN, Yu Q, Stritesky GL, Yeh N, O'Malley JT, Perumal NB, Kaplan MH; ''Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming.''; J Immunol, 2009 PubMed Europe PMC Scholia
  23. Walunas TL, Bakker CY, Bluestone JA; ''CTLA-4 ligation blocks CD28-dependent T cell activation.''; J Exp Med, 1996 PubMed Europe PMC Scholia
  24. Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O'Shea JJ; ''Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.''; Immunol Rev, 2004 PubMed Europe PMC Scholia
  25. D'Oro U, Ashwell JD; ''Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.''; J Immunol, 1999 PubMed Europe PMC Scholia
  26. Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A; ''Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.''; Nat Immunol, 2018 PubMed Europe PMC Scholia
  27. Weidinger C, Shaw PJ, Feske S; ''STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells.''; EMBO Mol Med, 2013 PubMed Europe PMC Scholia
  28. Oh-hora M, Rao A; ''Calcium signaling in lymphocytes.''; Curr Opin Immunol, 2008 PubMed Europe PMC Scholia
  29. Rincón M; ''MAP-kinase signaling pathways in T cells.''; Curr Opin Immunol, 2001 PubMed Europe PMC Scholia
  30. Okkenhaug K, Patton DT, Bilancio A, Garçon F, Rowan WC, Vanhaesebroeck B; ''The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells.''; J Immunol, 2006 PubMed Europe PMC Scholia
  31. Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X; ''SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation.''; Diabetes, 2018 PubMed Europe PMC Scholia
  32. Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A; ''Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.''; Nat Immunol, 2019 PubMed Europe PMC Scholia
  33. McNeill L, Salmond RJ, Cooper JC, Carret CK, Cassady-Cain RL, Roche-Molina M, Tandon P, Holmes N, Alexander DR; ''The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.''; Immunity, 2007 PubMed Europe PMC Scholia
  34. Prasad KV, Cai YC, Raab M, Duckworth B, Cantley L, Shoelson SE, Rudd CE; ''T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.''; Proc Natl Acad Sci U S A, 1994 PubMed Europe PMC Scholia
  35. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D; ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; Cell, 2020 PubMed Europe PMC Scholia
  36. Krummel MF, Allison JP; ''CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.''; J Exp Med, 1995 PubMed Europe PMC Scholia
  37. Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R; ''A nucleation barrier spring-loads the CBM signalosome for binary activation.''; Elife, 2022 PubMed Europe PMC Scholia
  38. Shenyuan L. Zhang, Ying Yu, Jack Roos, J. Ashot Kozak, Thomas J. Deerinck, Mark H. Ellisman, Kenneth A. Stauderman, Michael D. Cahalan; ''STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane''; Nature, 2005 PubMed Europe PMC Scholia
  39. Pietilä TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I; ''Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.''; J Immunol, 2007 PubMed Europe PMC Scholia
  40. Andrew C Chan, Makio Iwashima, christoph W Turck, Arthur Weiss; ''ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain''; Cell, 1992 PubMed Europe PMC Scholia
  41. Huber RG, Fan H, Bond PJ; ''The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain.''; PLoS Comput Biol, 2015 PubMed Europe PMC Scholia
  42. Kiani A, García-Cózar FJ, Habermann I, Laforsch S, Aebischer T, Ehninger G, Rao A; ''Regulation of interferon-gamma gene expression by nuclear factor of activated T cells.''; Blood, 2001 PubMed Europe PMC Scholia
  43. Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J; ''Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.''; Mol Cell Biol, 2013 PubMed Europe PMC Scholia
  44. Catz SD, Johnson JL; ''Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer.''; Oncogene, 2001 PubMed Europe PMC Scholia
  45. Shaulian E, Karin M; ''AP-1 in cell proliferation and survival.''; Oncogene, 2001 PubMed Europe PMC Scholia
  46. Au-Yeung BB, Shah NH, Shen L, Weiss A; ''ZAP-70 in Signaling, Biology, and Disease.''; Annu Rev Immunol, 2018 PubMed Europe PMC Scholia
  47. Hermida MA, Dinesh Kumar J, Leslie NR; ''GSK3 and its interactions with the PI3K/AKT/mTOR signalling network.''; Adv Biol Regul, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135185view03:58, 7 August 2024EweitzClear cache to fix board dimensions
135184view03:57, 7 August 2024EweitzEconomize layout
135183view03:11, 7 August 2024EweitzAnchor interaction
135182view03:10, 7 August 2024EweitzEconomize layout
135181view03:03, 7 August 2024EweitzEconomize layout
135180view02:58, 7 August 2024EweitzTailor node heights
135179view02:38, 7 August 2024EweitzStandardize font name, economize layout
135178view02:32, 7 August 2024EweitzEconomize layout
129246view02:40, 16 March 2024EweitzOntology Term : 'naive T cell' added !
129245view02:39, 16 March 2024EweitzOntology Term : 'professional antigen presenting cell' added !
125315view21:43, 31 January 2023LarsgwAdd PMID to reference
124943view15:41, 3 January 2023EgonwAdded a reference for the CARD11-BLC10-MALT1 complex
124801view21:24, 11 December 2022AlexanderPicoOntology Term : 'T cell' added !
124800view21:24, 11 December 2022AlexanderPicoOntology Term : 'COVID-19' added !
124799view21:22, 11 December 2022AlexanderPicofixed citations
119538view21:24, 13 July 2021Mkutmonfix unconnected line
119489view14:24, 2 July 2021ClclassChanged NFAT2 to NFATC1
119483view08:34, 2 July 2021EgonwNot a mim-conversion and correct ID for Ca2+
119480view11:39, 1 July 2021Clclassenlarged data nodes
119479view10:56, 1 July 2021Clclassenlarged data nodes
119478view10:52, 1 July 2021ClclassEnlarged data nodes, changed gene annotations
119476view20:09, 30 June 2021MkutmonOntology Term : 'T cell' added !
119475view20:09, 30 June 2021MkutmonOntology Term : 'COVID-19' added !
119471view06:27, 30 June 2021EgonwNot mim-conversions
119180view14:10, 20 June 2021ClclassAdded literature annotations
119179view12:58, 20 June 2021Clclassadded transcription targets
119178view10:16, 20 June 2021Clclassadded literatur annotations
119177view10:05, 20 June 2021ClclassAdded CD86
119176view10:04, 20 June 2021ClclassAdded data nodes
119175view08:50, 20 June 2021ClclassAdded annotations
119165view12:39, 19 June 2021ClclassAdded data nodes
119158view12:37, 18 June 2021ClclassAdded transcriptional targets and identifiers
119095view08:35, 17 June 2021FinterlyAdded PubMed IDs
119065view08:59, 14 June 2021ClclassAdded literature annotations
119051view12:24, 12 June 2021ClclassAdded literature reference
119050view11:55, 12 June 2021ClclassAdded data nodes
119049view09:57, 12 June 2021ClclassAdded Uniprot identifiers
119048view09:54, 12 June 2021ClclassAdded Uniprot identifiers
119047view09:19, 12 June 2021ClclassAdded Uniprot identifiers
119046view09:01, 12 June 2021ClclassAdded Uniprot identifiers
119032view10:21, 11 June 2021ClclassDeleted a pathway
119031view10:01, 11 June 2021ClclassAdded new pathways and annotations
118982view13:28, 6 June 2021ClclassAdded Data nodes and Literature references
118643view13:22, 31 May 2021ClclassAdded Literature Annotations
118614view07:15, 31 May 2021ClclassAdded Literature Annotations
118556view11:47, 28 May 2021ClclassAdded Literature Annotations
118123view18:24, 24 May 2021ClclassAdded Literature Annotations
118122view18:11, 24 May 2021ClclassAdded Literature Annotations
117102view11:45, 17 May 2021ClclassAdded literature annotations
116776view09:49, 14 May 2021EweitzModified title

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1ProteinP31749 (Uniprot-TrEMBL)
BAXProteinQ07812 (Uniprot-TrEMBL)
BCL10ProteinO95999 (Uniprot-TrEMBL)
BCL2L1 ProteinQ07817 (Uniprot-TrEMBL)
CARD11ProteinQ9BXL7 (Uniprot-TrEMBL)
CCL19ProteinQ99731 (Uniprot-TrEMBL)
CCL28ProteinQ9NRJ3 (Uniprot-TrEMBL)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CD247ProteinP20963 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD3DProteinP04234 (Uniprot-TrEMBL)
CD3EProteinP07766 (Uniprot-TrEMBL)
CD3GProteinP09693 (Uniprot-TrEMBL)
CD4ProteinP01730 (Uniprot-TrEMBL)
CD80ProteinP33681 (Uniprot-TrEMBL)
CD86ProteinP42081 (Uniprot-TrEMBL)
CDKN1AProteinP38936 (Uniprot-TrEMBL)
CDKN2A ProteinP42771 (Uniprot-TrEMBL)
CHUKProteinO15111 (Uniprot-TrEMBL)
CTLA4ProteinP16410 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI compound)
DAGMetabolite84974 (ChEBI)
DEPTORProteinQ8TB45 (Uniprot-TrEMBL)
DeptorProteinQ8TB45 (Uniprot-TrEMBL)
FOSProteinP01100 (Uniprot-TrEMBL)
FOXO3ProteinO43524 (Uniprot-TrEMBL)
FYNProteinP06241 (Uniprot-TrEMBL)
GRAP2ProteinO75791 (Uniprot-TrEMBL)
GRB2ProteinP62993 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
HLA-DRAProteinP01903 (Uniprot-TrEMBL)
HLA-DRB1ProteinP01911 (Uniprot-TrEMBL)
HLA-DRB1ProteinP79483 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
ICOSProteinQ9Y6W8 (Uniprot-TrEMBL)
IFNAR1ProteinP17181 (Uniprot-TrEMBL)
IFNAR2ProteinP48551 (Uniprot-TrEMBL)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
IKBKBProteinO14920 (Uniprot-TrEMBL)
IKBKGProteinQ9Y6K9 (Uniprot-TrEMBL)
IL12AProteinP29459 (Uniprot-TrEMBL)
IL12BProteinP29460 (Uniprot-TrEMBL)
IL12RB1ProteinP42701 (Uniprot-TrEMBL)
IL12RB2ProteinQ99665 (Uniprot-TrEMBL)
IL17AProteinQ16552 (Uniprot-TrEMBL)
IL18R1ProteinQ13478 (Uniprot-TrEMBL)
IL23AProteinQ9NPF7 (Uniprot-TrEMBL)
IL23RProteinQ5VWK5 (Uniprot-TrEMBL)
IL2ProteinP60568 (Uniprot-TrEMBL)
IL4ProteinP05112 (Uniprot-TrEMBL)
IP3Metabolite139109 (ChEBI)
IRF2BPLProteinQ9H1B7 (Uniprot-TrEMBL)
ITPR1ProteinQ14643 (Uniprot-TrEMBL)
JAK2ProteinO60674 (Uniprot-TrEMBL)
JUNProteinP05412 (Uniprot-TrEMBL)
LATProteinO43561 (Uniprot-TrEMBL)
LCKProteinP06239 (Uniprot-TrEMBL)
LCP2ProteinQ13094 (Uniprot-TrEMBL)
MALT1ProteinQ9UDY8 (Uniprot-TrEMBL)
MAP2K1ProteinQ02750 (Uniprot-TrEMBL)
MAP2K2ProteinP36507 (Uniprot-TrEMBL)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MLST8ProteinQ9BVC4 (Uniprot-TrEMBL)
MYD88ProteinQ99836 (Uniprot-TrEMBL)
NFAT2ProteinO95644 (Uniprot-TrEMBL)
NFATC1ProteinO95644 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIAProteinP25963 (Uniprot-TrEMBL)
PDPK1ProteinO15530 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3R1ProteinP27986 (Uniprot-TrEMBL)
PIP2Metabolite145877 (ChEBI)
PIP3Metabolite84238 (ChEBI)
PLCG1ProteinP19174 (Uniprot-TrEMBL)
PPP33CProteinP48454 (Uniprot-TrEMBL)
PRKCQProteinQ04759 (Uniprot-TrEMBL)
PTENProteinP60484 (Uniprot-TrEMBL)
PTPRCProteinP08575 (Uniprot-TrEMBL)
RAF1ProteinP04049 (Uniprot-TrEMBL)
RASGRP1ProteinO95267 (Uniprot-TrEMBL)
RELAProteinQ04206 (Uniprot-TrEMBL)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RICTORProteinQ6R327 (Uniprot-TrEMBL)
RaptorProteinQ8N122 (Uniprot-TrEMBL)
SARS-CoV-2 SpikeProteinP0DTC2 (Uniprot-TrEMBL)
SOS1ProteinQ07889 (Uniprot-TrEMBL)
STAT4ProteinQ14765 (Uniprot-TrEMBL)
TLAProteinP01374 (Uniprot-TrEMBL)
TNFProteinP01375 (Uniprot-TrEMBL)
TP53 ProteinP04637 (Uniprot-TrEMBL)
TRAProteinP0DTU3 (Uniprot-TrEMBL)
TRBProteinP0DTU4 (Uniprot-TrEMBL)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2ProteinP49815 (Uniprot-TrEMBL)
TYK2ProteinP29597 (Uniprot-TrEMBL)
ZAP70ProteinP43403 (Uniprot-TrEMBL)
mTORProteinP42345 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5098"
Personal tools