De novo NAD biosynthesis (Saccharomyces cerevisiae)

From WikiPathways

Revision as of 22:21, 5 September 2024 by Khanspers (Talk | contribs)
Jump to: navigation, search


Description

Most organisms synthesize NAD+ from simple components. The specific set of reactions differs among organisms, but a common feature is the generation of quinolinic acid (QA) from an amino acid – either tryptophan (Trp) in animals and some bacteria, or aspartic acid (Asp) in some bacteria and plants. The quinolinic acid is converted to nicotinic acid mononucleotide (NaMN) by transfer of a phosphoribose moiety. An adenylate moiety is then transferred to form nicotinic acid adenine dinucleotide (NaAD). Finally, the nicotinic acid moiety in NaAD is amidated to a nicotinamide (Nam) moiety, forming nicotinamide adenine dinucleotide. Description adapted from Wikipedia.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''NAD de novo biosynthesis II (from tryptophan)''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
135457view22:24, 5 September 2024KhanspersModified description
135456view22:21, 5 September 2024Khansperslit ref
135455view22:20, 5 September 2024Khanspersadded lit ref
135305view23:46, 15 August 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135304view23:45, 15 August 2024Khanspersfix interactions, add metabolite ids, layout
117291view11:03, 20 May 2021EweitzModified title
92995view18:21, 21 July 2017KhanspersModified description
92994view18:21, 21 July 2017Khanspersremoved GenMAPP notes
92894view19:08, 14 July 2017EgonwReplace a CAS number for a totally different compound with the ChEBI ID for L-alanine.
89707view06:57, 27 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69942view20:17, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69623view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67145view10:12, 26 June 2013Christine ChichesterOntology Term : 'de novo nicotinamide adenine dinucleotide biosynthetic pathway' added !
41858view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
21818view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:De Novo NAD Biosynthesis]] moved to [[Pathway:WP541]]: Moved to stable identifier
12688view07:58, 17 May 2008MaintBotautomated metabolite conversion
8693view14:06, 7 January 2008MaintBotAdded to category $category
8691view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-Amino-3-carboxymuconate semialdehydeMetaboliteCHEBI:995 (ChEBI)
3-hydroxy-L-kynurenineMetabolite606-14-4 (CAS)
3-hydroxyanthranilateMetaboliteCHEBI:36559 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetabolite1927-31-7 (CAS)
BNA1GeneProductS000003786 (SGD)
BNA2GeneProductS000003839 (SGD)
BNA3GeneProductS000003596 (SGD)
BNA4GeneProductS000000194 (SGD)
BNA5GeneProductS000004221 (SGD)
BNA6GeneProductS000001943 (SGD)
CO2MetaboliteCHEBI:16526 (ChEBI)
H2OMetaboliteHMDB02111 (HMDB)
L-FormylkynurenineMetabolite1022-31-7 (CAS)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-tryptophanMetabolite73-22-3 (CAS)
NADMetaboliteCHEBI:16908 (ChEBI)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
NMA1GeneProductS000004320 (SGD)
NMA2GeneProductS000003242 (SGD)
O2MetaboliteCHEBI:25805 (ChEBI)
PRPPMetabolite97-55-2 (CAS)
QNS1GeneProductS000001116 (SGD)
deamido-NADMetaboliteQ28529688 (Wikidata)
formateMetaboliteCHEBI:15740 (ChEBI)
kynurenineMetabolite343-65-7 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)
quinolinateMetaboliteCHEBI:29959 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP541"
Personal tools