Chorismate biosynthesis (Saccharomyces cerevisiae)

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Description

Chorismate, an intermediate in the synthesis of the aromatic amino acids and the vitamins, p-aminobenzoate and p-hydroxybenzoate, is synthesized by the shikimate pathway. The shikimate pathway has been found to be common to all eukaryotes and prokaryotes studied thus far (as reported in. In Saccharomyces cerevisiae the initial step is catalyzed by two deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase isoenzymes, one of which (ARO3) is feedback inhibited by phenylalanine, and the other (ARO4) by tyrosine. Both DAHP isoenzymes are derepressed by amino acid starvation (general control of amino acid biosynthesis). The 5 subsequent reactions are catalyzed by the pentafunctional arom enzyme, Aro1p. Aro1p is a mosaic of five monofunctional domains, each of which corresponds to one of five separate monofunctional E. coli enzymes. The last step of chorismate biosynthesis, before the pathway branches to synthesize different terminal products, is catalyzed by Aro2p. Description from YeastPathways.

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Bibliography

  1. Braus GH; ''Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.''; Microbiol Rev, 1991 PubMed Europe PMC Scholia
  2. ''chorismate biosynthesis''; YeastPathways,

History

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CompareRevisionActionTimeUserComment
135465view20:21, 10 September 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135464view20:21, 10 September 2024Khanspersupdated lit ref
135463view20:20, 10 September 2024KhanspersModified description
135462view20:19, 10 September 2024KhanspersReverted to version '20:17, 10 September 2024' by Khanspers
135461view20:19, 10 September 2024KhanspersModified description
135460view20:17, 10 September 2024Khanspersoverhaul, added literature ref
117275view10:45, 20 May 2021EweitzModified title
107263view14:35, 17 September 2019MaintBotChEBI identifier normalization
92978view17:43, 21 July 2017KhanspersModified description
92977view17:43, 21 July 2017Khanspersremoved GenMAPP notes
92917view10:52, 17 July 2017DeSlChanged CAs to ChEBI ID (more stereospecific).
89660view05:03, 24 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
73732view20:00, 19 February 2014EgonwFixed the PubChem-compound DB name.
73731view19:57, 19 February 2014EgonwFigured out the EPSP identifier too.
73730view19:47, 19 February 2014EgonwAdded two more missing metabolite IDs.
73729view19:42, 19 February 2014EgonwAdded a bunch of missing metabolite identifiers.
71337view18:00, 17 October 2013MaintBotAutomated update of data sources
71020view19:59, 22 September 2013EgonwConverted many labels into Metabolite DataNodes.
69883view18:33, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69575view20:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
67778view15:04, 26 June 2013DdiglesOntology Term : 'shikimate metabolic pathway' added !
41795view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
36615view22:31, 9 April 2010MaintBotDescription and bibliography added from SGD
21688view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Chorismate Biosynthesis]] moved to [[Pathway:WP479]]: Moved to stable identifier
12672view07:57, 17 May 2008MaintBotautomated metabolite conversion
8666view14:06, 7 January 2008MaintBotAdded to category $category
8664view14:06, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-dehydro-shikimateMetaboliteCHEBI:16630 (ChEBI)
3-dehydroquinateMetaboliteCHEBI:32364 (ChEBI)
3-deoxy-arabino-heptulosonate-7-phosphateMetabolite5460215 (PubChem-compound)
5-enolypyruvylshikimate-3-phosphateMetaboliteCHEBI:57701 (ChEBI)
ADPMetabolite58-64-0 (CAS)
ARO1GeneProductS000002534 (SGD)
ARO2GeneProductS000003116 (SGD)
ARO3GeneProductS000002442 (SGD)
ARO4GeneProductS000000453 (SGD)
ATPMetabolite1927-31-7 (CAS)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADPMetaboliteCHEBI:18009 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
chorismateMetaboliteCHEBI:17333 (ChEBI)
erythrose-4-phosphateMetabolite585-18-2 (CAS)
phosphateMetabolite14265-44-2 (CAS)
phosphoenolpyruvateMetabolite138-08-9 (CAS)
shikimate-3-phosphateMetaboliteCHEBI:57701 (ChEBI)
shikimateMetaboliteCHEBI:36208 (ChEBI)

Annotated Interactions

No annotated interactions

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