Hallmark of cancer: sustaining proliferative signaling (Homo sapiens)

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Proliferative signalling in cancer cells

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  1. Mitsutake N, Knauf JA, Mitsutake S, Mesa C Jr, Zhang L, Fagin JA; ''Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.''; Cancer Res, 2005 PubMed Europe PMC Scholia
  2. Esapa CT, Johnson SJ, Kendall-Taylor P, Lennard TW, Harris PE; ''Prevalence of Ras mutations in thyroid neoplasia.''; Clin Endocrinol (Oxf), 1999 PubMed Europe PMC Scholia
  3. Bos JL; ''The ras gene family and human carcinogenesis.''; Mutat Res, 1988 PubMed Europe PMC Scholia
  4. Arighi E, Borrello MG, Sariola H; ''RET tyrosine kinase signaling in development and cancer.''; Cytokine Growth Factor Rev, 2005 PubMed Europe PMC Scholia
  5. Kato S, Tomson BN, Buys TP, Elkin SK, Carter JL, Kurzrock R; ''Genomic Landscape of Malignant Mesotheliomas.''; Mol Cancer Ther, 2016 PubMed Europe PMC Scholia
  6. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE; ''Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations.''; Am J Clin Pathol, 2003 PubMed Europe PMC Scholia
  7. Huleihel M, Goldsborough M, Cleveland J, Gunnell M, Bonner T, Rapp UR; ''Characterization of murine A-raf, a new oncogene related to the v-raf oncogene.''; Mol Cell Biol, 1986 PubMed Europe PMC Scholia
  8. Ritt DA, Monson DM, Specht SI, Morrison DK; ''Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  9. Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J; ''Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.''; Cell, 2007 PubMed Europe PMC Scholia
  10. Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A, Santoro M, Fagin JA, Nikiforov YE; ''BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC Scholia
  11. Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M; ''MEK drives BRAF activation through allosteric control of KSR proteins.''; Nature, 2018 PubMed Europe PMC Scholia
  12. Shaul YD, Seger R; ''The MEK/ERK cascade: from signaling specificity to diverse functions.''; Biochim Biophys Acta, 2007 PubMed Europe PMC Scholia
  13. Mossman BT, Shukla A, Heintz NH, Verschraegen CF, Thomas A, Hassan R; ''New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.''; Am J Pathol, 2013 PubMed Europe PMC Scholia
  14. Walsh AB, Bar-Sagi D; ''Differential activation of the Rac pathway by Ha-Ras and K-Ras.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  15. Krishna M, Narang H; ''The complexity of mitogen-activated protein kinases (MAPKs) made simple.''; Cell Mol Life Sci, 2008 PubMed Europe PMC Scholia
  16. Prior IA, Hancock JF; ''Ras trafficking, localization and compartmentalized signalling.''; Semin Cell Dev Biol, 2012 PubMed Europe PMC Scholia
  17. Marie-Claude Jaurand, Didier Jean; ''Biomolecular Pathways and Malignant Pleural Mesothelioma''; Malignant Pleural Mesothelioma: Present Status and Future Directions, 2015 DOI Scholia
  18. Urso L, Calabrese F, Favaretto A, Conte P, Pasello G; ''Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment.''; Crit Rev Oncol Hematol, 2016 PubMed Europe PMC Scholia
  19. Prior IA, Lewis PD, Mattos C; ''A comprehensive survey of Ras mutations in cancer.''; Cancer Res, 2012 PubMed Europe PMC Scholia
  20. Lavoie H, Therrien M; ''Regulation of RAF protein kinases in ERK signalling.''; Nat Rev Mol Cell Biol, 2015 PubMed Europe PMC Scholia
  21. Benedetti S, Nuvoli B, Catalani S, Galati R; ''Reactive oxygen species a double-edged sword for mesothelioma.''; Oncotarget, 2015 PubMed Europe PMC Scholia
  22. Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ; ''Drugging the undruggable RAS: Mission possible?''; Nat Rev Drug Discov, 2014 PubMed Europe PMC Scholia
  23. Melo M, Gaspar da Rocha A, Batista R, Vinagre J, Martins MJ, Costa G, Ribeiro C, Carrilho F, Leite V, Lobo C, Cameselle-Teijeiro JM, Cavadas B, Pereira L, Sobrinho-Simões M, Soares P; ''TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease.''; J Clin Endocrinol Metab, 2017 PubMed Europe PMC Scholia
  24. Suárez HG, Du Villard JA, Caillou B, Schlumberger M, Tubiana M, Parmentier C, Monier R; ''Detection of activated ras oncogenes in human thyroid carcinomas.''; Oncogene, 1988 PubMed Europe PMC Scholia
  25. Cakiroglu E, Senturk S; ''Genomics and Functional Genomics of Malignant Pleural Mesothelioma.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  26. Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA; ''Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
  27. Saavedra HI, Knauf JA, Shirokawa JM, Wang J, Ouyang B, Elisei R, Stambrook PJ, Fagin JA; ''The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
  28. Yan J, Roy S, Apolloni A, Lane A, Hancock JF; ''Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  29. Bandaru P, Kondo Y, Kuriyan J; ''The Interdependent Activation of Son-of-Sevenless and Ras.''; Cold Spring Harb Perspect Med, 2019 PubMed Europe PMC Scholia
  30. Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, Bueno R, Felley-Bosco E, Galateau-Salle F, Jablons D, Mansfield AS, Minaai M, de Perrot M, Pesavento P, Rusch V, Severson DT, Taioli E, Tsao A, Woodard G, Yang H, Zauderer MG, Pass HI; ''Mesothelioma: Scientific clues for prevention, diagnosis, and therapy.''; CA Cancer J Clin, 2019 PubMed Europe PMC Scholia
  31. Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK; ''Regulation of Raf-1 by direct feedback phosphorylation.''; Mol Cell, 2005 PubMed Europe PMC Scholia
  32. Vitagliano D, Portella G, Troncone G, Francione A, Rossi C, Bruno A, Giorgini A, Coluzzi S, Nappi TC, Rothstein JL, Pasquinelli R, Chiappetta G, Terracciano D, Macchia V, Melillo RM, Fusco A, Santoro M; ''Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.''; Oncogene, 2006 PubMed Europe PMC Scholia
  33. Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K; ''B-raf, a new member of the raf family, is activated by DNA rearrangement.''; Mol Cell Biol, 1988 PubMed Europe PMC Scholia
  34. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA; ''High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.''; Cancer Res, 2003 PubMed Europe PMC Scholia
  35. Hylebos M, Van Camp G, van Meerbeeck JP, Op de Beeck K; ''The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.''; J Thorac Oncol, 2016 PubMed Europe PMC Scholia
  36. Bos JL, Rehmann H, Wittinghofer A; ''GEFs and GAPs: critical elements in the control of small G proteins.''; Cell, 2007 PubMed Europe PMC Scholia
  37. Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH Jr, Stephenson JR; ''Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.''; Proc Natl Acad Sci U S A, 1983 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135759view12:06, 9 November 2024EgonwRemoved template comments
135540view19:30, 23 September 2024KhanspersOntology Term : 'signaling pathway' added !
135539view19:29, 23 September 2024KhanspersOntology Term : 'cancer pathway' added !
134341view13:50, 20 July 2024EweitzModified title
134340view13:49, 20 July 2024EweitzModified title
134337view13:40, 20 July 2024EweitzModified title
133258view09:54, 10 June 2024PhilipErnst
130816view14:05, 30 May 2024PhilipErnstNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

RAS

ProteinENSG00000133703 (Ensembl) RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
AML1GeneProductLRG_482 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
BCL9GeneProductENSG00000116128 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl) IKKa
CK1GeneProductENSG00000113712 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
Catenin beta-1ProteinB4DGU4 (Uniprot-TrEMBL)
DEPTORGeneProductENSG00000155792 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FrizzledProteinE5RGK8 (Uniprot-TrEMBL) Frizzled Not Specified
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GSK3BGeneProductENSG00000082701 (Ensembl)
GTPMetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:37565 (ChEBI)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl) IKKy
IL-11ProteinENSG00000095752 (EMBL)
IL6GeneProduct3569 (Entrez Gene)
IL6RGeneProduct3570 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
JAK2GeneProduct3717 (Entrez Gene)
Junction plakoglobinProteinP14923 (Uniprot-TrEMBL)
KDRGeneProductENSG00000128052 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KSR1GeneProductENSG00000141068 (Ensembl)
LEFGeneProductENSG00000138795 (Ensembl) LEF Not Specified
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl)
  • Also known as ERK
  • Type your comment here
MDM2GeneProductENSG00000135679 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIEGeneProductENSG00000146232 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NTRK1GeneProductENSG00000198400 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
P21GeneProductENSG00000124762 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLZFGeneProductENSG00000109906 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PYGOGeneProductENSG00000171016 (Ensembl) PYGO Not Specified
PhosphateMetaboliteHMDB0001429 (HMDB)
RAFGeneProductENSG00000132155 (Ensembl)
RARAGeneProductENSG00000131759 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl) RelA
RELGeneProductENSG00000162924 (Ensembl) c-Rel
RETNProteinENSG00000104918 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RUNX1T1GeneProductENSG00000079102 (Ensembl)
SALL4GeneProductENSG00000101115 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProduct6774 (Entrez Gene)
TCFGeneProductENSG00000071564 (Ensembl) TCF Not Specified
TEKGeneProductENSG00000120156 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TP53ProteinENSG00000141510 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
WNTGeneProductENSG00000125084 (Ensembl) Wnt Not Specified
c-FOSGeneProductENSG00000170345 (Ensembl)
c-JUNGeneProductENSG00000177606 (Ensembl)
c-MYCGeneProductENSG00000136997 (Ensembl)
cyclin-D1ProteinP24385 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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