Hallmark of cancer: sustaining proliferative signaling (Homo sapiens)
From WikiPathways
Description
Proliferative signalling in cancer cells
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Ontology Terms
Pathway Ontology : cancer pathway signaling pathway
Bibliography
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- Mitsutake N, Knauf JA, Mitsutake S, Mesa C Jr, Zhang L, Fagin JA; ''Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.''; Cancer Res, 2005 PubMed Europe PMC Scholia
- Esapa CT, Johnson SJ, Kendall-Taylor P, Lennard TW, Harris PE; ''Prevalence of Ras mutations in thyroid neoplasia.''; Clin Endocrinol (Oxf), 1999 PubMed Europe PMC Scholia
- Bos JL; ''The ras gene family and human carcinogenesis.''; Mutat Res, 1988 PubMed Europe PMC Scholia
- Arighi E, Borrello MG, Sariola H; ''RET tyrosine kinase signaling in development and cancer.''; Cytokine Growth Factor Rev, 2005 PubMed Europe PMC Scholia
- Kato S, Tomson BN, Buys TP, Elkin SK, Carter JL, Kurzrock R; ''Genomic Landscape of Malignant Mesotheliomas.''; Mol Cancer Ther, 2016 PubMed Europe PMC Scholia
- Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE; ''Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations.''; Am J Clin Pathol, 2003 PubMed Europe PMC Scholia
- Huleihel M, Goldsborough M, Cleveland J, Gunnell M, Bonner T, Rapp UR; ''Characterization of murine A-raf, a new oncogene related to the v-raf oncogene.''; Mol Cell Biol, 1986 PubMed Europe PMC Scholia
- Ritt DA, Monson DM, Specht SI, Morrison DK; ''Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
- Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J; ''Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.''; Cell, 2007 PubMed Europe PMC Scholia
- Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A, Santoro M, Fagin JA, Nikiforov YE; ''BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC Scholia
- Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M; ''MEK drives BRAF activation through allosteric control of KSR proteins.''; Nature, 2018 PubMed Europe PMC Scholia
- Shaul YD, Seger R; ''The MEK/ERK cascade: from signaling specificity to diverse functions.''; Biochim Biophys Acta, 2007 PubMed Europe PMC Scholia
- Mossman BT, Shukla A, Heintz NH, Verschraegen CF, Thomas A, Hassan R; ''New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.''; Am J Pathol, 2013 PubMed Europe PMC Scholia
- Walsh AB, Bar-Sagi D; ''Differential activation of the Rac pathway by Ha-Ras and K-Ras.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
- Krishna M, Narang H; ''The complexity of mitogen-activated protein kinases (MAPKs) made simple.''; Cell Mol Life Sci, 2008 PubMed Europe PMC Scholia
- Prior IA, Hancock JF; ''Ras trafficking, localization and compartmentalized signalling.''; Semin Cell Dev Biol, 2012 PubMed Europe PMC Scholia
- Marie-Claude Jaurand, Didier Jean; ''Biomolecular Pathways and Malignant Pleural Mesothelioma''; Malignant Pleural Mesothelioma: Present Status and Future Directions, 2015 DOI Scholia
- Urso L, Calabrese F, Favaretto A, Conte P, Pasello G; ''Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment.''; Crit Rev Oncol Hematol, 2016 PubMed Europe PMC Scholia
- Prior IA, Lewis PD, Mattos C; ''A comprehensive survey of Ras mutations in cancer.''; Cancer Res, 2012 PubMed Europe PMC Scholia
- Lavoie H, Therrien M; ''Regulation of RAF protein kinases in ERK signalling.''; Nat Rev Mol Cell Biol, 2015 PubMed Europe PMC Scholia
- Benedetti S, Nuvoli B, Catalani S, Galati R; ''Reactive oxygen species a double-edged sword for mesothelioma.''; Oncotarget, 2015 PubMed Europe PMC Scholia
- Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ; ''Drugging the undruggable RAS: Mission possible?''; Nat Rev Drug Discov, 2014 PubMed Europe PMC Scholia
- Melo M, Gaspar da Rocha A, Batista R, Vinagre J, Martins MJ, Costa G, Ribeiro C, Carrilho F, Leite V, Lobo C, Cameselle-Teijeiro JM, Cavadas B, Pereira L, Sobrinho-Simões M, Soares P; ''TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease.''; J Clin Endocrinol Metab, 2017 PubMed Europe PMC Scholia
- Suárez HG, Du Villard JA, Caillou B, Schlumberger M, Tubiana M, Parmentier C, Monier R; ''Detection of activated ras oncogenes in human thyroid carcinomas.''; Oncogene, 1988 PubMed Europe PMC Scholia
- Cakiroglu E, Senturk S; ''Genomics and Functional Genomics of Malignant Pleural Mesothelioma.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
- Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA; ''Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
- Saavedra HI, Knauf JA, Shirokawa JM, Wang J, Ouyang B, Elisei R, Stambrook PJ, Fagin JA; ''The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
- Yan J, Roy S, Apolloni A, Lane A, Hancock JF; ''Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
- Bandaru P, Kondo Y, Kuriyan J; ''The Interdependent Activation of Son-of-Sevenless and Ras.''; Cold Spring Harb Perspect Med, 2019 PubMed Europe PMC Scholia
- Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, Bueno R, Felley-Bosco E, Galateau-Salle F, Jablons D, Mansfield AS, Minaai M, de Perrot M, Pesavento P, Rusch V, Severson DT, Taioli E, Tsao A, Woodard G, Yang H, Zauderer MG, Pass HI; ''Mesothelioma: Scientific clues for prevention, diagnosis, and therapy.''; CA Cancer J Clin, 2019 PubMed Europe PMC Scholia
- Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK; ''Regulation of Raf-1 by direct feedback phosphorylation.''; Mol Cell, 2005 PubMed Europe PMC Scholia
- Vitagliano D, Portella G, Troncone G, Francione A, Rossi C, Bruno A, Giorgini A, Coluzzi S, Nappi TC, Rothstein JL, Pasquinelli R, Chiappetta G, Terracciano D, Macchia V, Melillo RM, Fusco A, Santoro M; ''Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.''; Oncogene, 2006 PubMed Europe PMC Scholia
- Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K; ''B-raf, a new member of the raf family, is activated by DNA rearrangement.''; Mol Cell Biol, 1988 PubMed Europe PMC Scholia
- Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA; ''High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.''; Cancer Res, 2003 PubMed Europe PMC Scholia
- Hylebos M, Van Camp G, van Meerbeeck JP, Op de Beeck K; ''The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.''; J Thorac Oncol, 2016 PubMed Europe PMC Scholia
- Bos JL, Rehmann H, Wittinghofer A; ''GEFs and GAPs: critical elements in the control of small G proteins.''; Cell, 2007 PubMed Europe PMC Scholia
- Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH Jr, Stephenson JR; ''Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.''; Proc Natl Acad Sci U S A, 1983 PubMed Europe PMC Scholia
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