Mitochondrial carrier deficiency associated with shuttle disturbances (Homo sapiens)
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Description
Amino acid metabolism in triple-negative breast cancer cells. The glutamine, serine and glycine metabolic pathways are significantly upregulated. The upregulated expression of key genes within the glutamine, serine and glycine metabolic pathways have also been observed in triple-negative breast cancer cells
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Ontology Terms
Saving...Bibliography
- Bhutia YD, Babu E, Ramachandran S, Ganapathy V; ''Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.''; Cancer Res, 2015 PubMed Europe PMC Scholia
- Kung HN, Marks JR, Chi JT; ''Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.''; PLoS Genet, 2011 PubMed Europe PMC Scholia
- Kim SK, Jung WH, Koo JS; ''Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.''; PLoS One, 2014 PubMed Europe PMC Scholia
- Christiaan F. Labuschagne, Niels J.F. van den Broek, Gillian M. Mackay, Karen H. Vousden, Oliver D.K. Maddocks; ''Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells''; https://doi.org/10.1016/j.celrep.2014.04.045, 2014 DOI Scholia
- Wang Z, Jiang Q, Dong C; ''Metabolic reprogramming in triple-negative breast cancer.''; Cancer Biol Med, 2020 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2-oxoglutarate | Metabolite | HMDB0000208 (HMDB)  | |
| GLUD1 | GeneProduct | ENSG00000148672 (Ensembl) | |
| GOT2 | GeneProduct | ENSG00000125166 (Ensembl) | |
| H+ | Metabolite | CHEBI:24636 (ChEBI) | |
| Oxidative phosphorylation | Pathway | WP111 (WikiPathways) | |
| SLC25A12 | GeneProduct | ENSG00000115840 (Ensembl) | Mitochondrial membrane transporter |
| SLC25A13 | GeneProduct | ENSG00000004864 (Ensembl) | Mitochondrial membrane transporter |
| SLC25A22 | GeneProduct | ENSG00000177542 (Ensembl) | Mitochondrial membrane transporter |
| TCA Cycle | Pathway | WP78 (WikiPathways) | |
| aspartate | Metabolite | CHEBI:29995 (ChEBI) | |
| glutamate | Metabolite | 33032 (PubChem-compound) | |
| oxaloacetate | Metabolite | HMDB0000223 (HMDB) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| 2-oxoglutarate | mim-conversion | 21827 (Rhea) | ||
| H+ | 70958 (Rhea) | |||
| H+ | Arrow | 70958 (Rhea) | ||
| aspartate | 70786 (Rhea) | |||
| aspartate | Arrow | 70786 (Rhea) | ||
| aspartate | oxaloacetate | mim-conversion | 21827 (Rhea) | |
| glutamate | 2-oxoglutarate | mim-conversion | 11613 (Rhea) | Maybe also reversed reaction possible through GLUD1, GLUD1 can use both NAD(H) and NADP(H) which are different RHEA entries |
| glutamate | Arrow | 70786 (Rhea) | ||
| glutamate | glutamate | mim-conversion | 70958 (Rhea) | |
| glutamate | mim-conversion | 21827 (Rhea) |
