A network map of RORgt mediated signaling pathway in inflammatory diseases (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none GATA-3Intestinal Inflammatory DiseasesCP and OAS36SchizophreniaFOXP3AsthmaS489LigandFood AllergyRORCIL-5IL-13CCR3COX2IL-17MUC5ACIncreases Inflammation in colorectal cancerMaintainsmucosal immunityPhosphorylationPrevents InflammatoryDiseasesHormone / DrugInhibiting RA-related inflammation and bone deteriorationAlleviates inflammation in antigen induced arthritisIncreased inflammation and the development of psoriatic lesionsCircadian clockregulates cell immunityManaging Inflammation and joint destructionLeads to multiple reactionsBim and caspase-8 leads to apoptosisInhibits Airway hyperresponsiveness(AHR),and airway inflammation in Asthma.IRF-1 SNPs (rs10035166, rs2706384, rs2070721)Increased Risk for childhood Allergic AsthmaRegulation of gene/protein expressionAssociated disease:IBDmodulates the inflammatoryconditions in rheumatoid arthritisMaintains barrier integrity,Limits permeabilityIncreases ColitisCYJQ-1, and 2',FL are usedto alleviate Psoriases like inflammationNucleusDevelopment spontaneousof Autoimmune diseasessuppression of Th17 cell-mediated autoimmune responsesIncreased expressionTranslocationIFNβ ameliorates RR MSTreatment of PsoriasisInhibitionNUIncreases Autophagy markers LC3-11and P62, hence results inEnhancedAutophagyLEGENDDLL4NOTCH4NICDADAM10γ-secretaseNICDNUCSLNICDCSLNICDCSLMAML1RORgtAsthma, airway hyperreactivity,airway inflammation, airway epithelial injury and airway smooth muscle thickening.IRF1 SNPsICAM3XBP-1IRF-8IFN-gRORCTSC2NOD2ILT4Vitamin D [25(OH)D3]IRF-8RORCIL17IL23RCCR6Vitamin D [25(OH)D3] ameliorates inflammationby reducing Th17 cells differentiation in Young AsthmaticsEsculetinRORCAKTERKNFKBIL17IL23IL6IL1BTNFaInhibition of ERK, AKT, RORC,and NFkB reduces inflammation associatedwith Acute Lung Injury (ALI).FOXP3IL2raCTLA4P13K/AKTStage II pulmonary sarcoidosisRORCIL17GM-CSFIL1IL6KCMIPSteroid insensitiveneutrophilic airwayinflammationIL4Ra R576GRB2MAPKC-RafMKK3MKK6ERK1ERK2p38MAPKIL6STAT3RORCIL17Airway inflammation, AHR, AsthmaIAVTLR2TLR9IL23TGFBSTAT3RORCIL17StreptococcuspneumoniaeIL4PAMPsPRRsMyD88RORgtThe increased expression of RORgt and decreased expression ofHelios in iTreg cells protect against Food Allergy (FA).HeliosIL23RORgtIL17Act-1OcculidinTCRCDC42Pak2RORgtIL17ItchS316WntGSK-3B-CateninTCF-1B-CateninTCF-1FOXP3RORgtIL17B-CateninCYNUTCRGSK-3GSK-3SHP-1/2PERK-1/2TSC-1/2mTORC1TNFARORgtRORAIL17AAtg5RORCTBX21Atg5BimmTORC1c-MYCCaspase-8GlycolysisFOXP3Batch2RORgtRORAIL17ATNFALTLTBRIL23RORgtIL22Multiple SclerosisSOCS3RORCSTAT1IFNIL27IL12IL17IL23IL17ACCR6IL23RSTAT3IFNBSTAT1RORCIRF7IFNIL17ACCR6IL23RIL27IL12P35IL10IL1BTGFBIL23RDMFIL2GSHSTAT5ROSP13KFOXP3AKTTBetRORgtIL17FOXO1CD58CD2RORgtIL17PsoriasisS18-000003IL23STAT3RORgtIL17IL23IL23RSTAT3RORgtIL17JQ-12`,FLFOSLLPPARgRORCIL17ASTAT3FOXP3ArthritisNicotinea7nAchMEK1/2ERK1/2RORCIL17AGATA3IL4Cpd1RORgtIL17AIL23GLKIKKBRORgtRORgtPKCQAHRAHRAHRRORgtIL17AT-614IL6ERK1/2RAKLMMP3RORCIL17IL1BIL6IL21IL23TGFBSTAT3RORCIL17AIL17FIL22IL23IL6JAK 1/2STAT3RORgtIL17FOXP3JAK 1/2Inflammatory DiseasesAutophagyMelROSMT1MT2ROR A/B/CLC3-11P62LiClWnt/B-CateninTCF1RORgtIL17TNFAIL17TNFATCF1RORgtDKK1Wnt/B-CateninIL10IL17FIL17ARORgtBMAL1IL22NR1D1PER3CRY1BAXBCL2L11Circadian and ImmunityCIAReceptorProteinmRNAGene/ProteinDecreased expressionProteinPCYERPMCytoplasmEndoplasmic ReticulumPlasma MembraneGene/ProteinDFM ameliorates multiple sclerosisaHSTC modulates immune responses by suppressing Th17 cellsimplication in the development of schizophreniaPathogenic conversion of RORγt+ Tregs in autoimmunity by reduced expression of PTPN2PPPPPPPPPPCYNUCYNUName: A network map of RORgt mediated signaling pathway in inflammatory diseasesOrganism: Anopheles gambiae


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A Network Map of RORgt Signaling Pathway in Inflammatory Diseases

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CompareRevisionActionTimeUserComment
136265view02:46, 16 January 2025HafeezOrganism is corrected
136222view15:54, 10 January 2025Ash iyerOntology Term : 'schizophrenia' added !
136221view15:52, 10 January 2025Ash iyerOntology Term : 'food allergy' added !
136220view15:51, 10 January 2025Ash iyerOntology Term : 'arthritis' added !
136219view15:51, 10 January 2025Ash iyerOntology Term : 'asthma' added !
136218view15:51, 10 January 2025Ash iyerOntology Term : 'psoriasis' added !
136217view15:50, 10 January 2025Ash iyerOntology Term : 'multiple sclerosis' added !
136216view15:49, 10 January 2025Ash iyerOntology Term : 'autoimmune disease' added !
136215view15:49, 10 January 2025Ash iyerOntology Term : 'signaling pathway' added !
136186view16:09, 1 January 2025HafeezNew pathway

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