Oxidative stress in pulmonary tissue (Homo sapiens)

Revision as of 11:27, 18 February 2025 by Eweitz (Talk | contribs)

Description

Adverse Outcome Pathway (AOP) for stressor induced increase in ROS production in pulmonary tissue.

View approved pathways at the new wikipathways.org.

Sajal Chakraborti, Narasimham L. Parinandi, Rita Ghosh, Nirmal K. Gangul, Tapati Chakraborti; ''Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases''; Pubmed, 2019 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
139762	view	12:27, 4 July 2025	Ddigles	Modified description and deleted hidden old descriptions.
136622	view	11:28, 18 February 2025	Eweitz	Clear dimension cache
136621	view	11:27, 18 February 2025	Eweitz	Economize layout
135313	view	21:29, 16 August 2024	Khanspers	Ontology Term : 'oxidative stress response pathway' added !
133233	view	07:50, 10 June 2024	Burritaco	Endogenous ROS production was deleted and lipid membrane oxidation was removed.
131847	view	15:11, 4 June 2024	Burritaco	New pathway

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Name	Type	Database reference
AO1: Idophatic pulmonary fibrosis		1458 (Other)
AO2: COPD
AO3: Acute respiratory distress syndrome
AO4: Asthma
Apoptosis	Pathway	WP254 (WikiPathways)
Carbon monoxide
Chemokine signalling pathway	Pathway	WP3929 (WikiPathways)
Cigarette smoke
Emission from biomass fuel and combusiton
Industrial smoke
KE1: Increased oxidative stress		1392 (Other)
KE2: Inflammation and pro-fibrotic state		1497 (Other)
KE3: Cell death and cycle arrest
KE4: Mitrochondrial dysfucntion		177 (Other)
KE5: Collagen production and reduced ECM
KE6: ER stress
MIE1: ROS production upregulation
Nitrogen oxides
Ozone
Particulate matter
Pesticides
Pollen grains
Profibrotic pathway	Pathway	WP3624 (WikiPathways)
ROS damage pathway	Pathway	WP5477 (WikiPathways)
Release of pro-inflammatory cytokines	Pathway	WP530 (WikiPathways)
Senescence	Pathway	WP2902 (WikiPathways)
Sulphur oxides

No annotated interactions