Glutathione metabolism (Mus musculus)

From WikiPathways

Revision as of 15:56, 5 November 2025 by Egonw (Talk | contribs)
Jump to: navigation, search


Description

Glutathione is a major antioxidant in all forms of life and an indicator of cellular oxidative stress. Reduction by the GSR enzyme utilizes NADPH as an electron donor. In a reduced form, glutathione is metabolized in multiple ways leading to the biosynthesis of mercapturonate, glutamate, glycine, cysteine and other amino acids.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP100(r20893) with a 51% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Ahn E, Lee J, Han J, Lee SM, Kwon KS, Hwang GS; ''Glutathione is an aging-related metabolic signature in the mouse kidney.''; Aging (Albany NY), 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141190view15:55, 6 November 2025DeSlConnected 6.3.1.8
141189view15:47, 6 November 2025DeSlremoved last modified section
141188view15:46, 6 November 2025DeSlAdded more annotations based on lit. ref
141181view11:14, 6 November 2025DeSlAdded litref supporting several reactions, and protein annotation
141180view10:53, 6 November 2025DeSlConverted interactions of enzymes to catalysis MIM.
141169view15:56, 5 November 2025EgonwModified description
106858view13:33, 17 September 2019MaintBotHMDB identifier normalization
104993view04:24, 28 June 2019Khanspersremoved KEGG comments
85644view17:07, 4 June 2016EgonwFixed the KEGG id.
71334view17:19, 17 October 2013MaintBotAutomated update of data sources
69192view18:23, 8 July 2013MaintBotUpdated to 2013 gpml schema
67296view10:33, 26 June 2013Christine ChichesterOntology Term : 'glutathione metabolic pathway' added !
48254view21:41, 17 May 2012KhanspersUpdating PubChem xrefs
41383view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34423view23:18, 9 December 2009MaintBotAutomatic update of empty xrefs
32353view13:39, 15 August 2009MaintBotFixed text labels
31980view13:11, 14 August 2009MaintBotFixed group labels
31402view20:50, 13 August 2009MaintBotFixed text labels
30873view00:14, 30 July 2009MaintBotConverted from Homo sapiens
21025view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Gluthation Metabolism KEGG]] moved to [[Pathway:WP164]]: Moved to stable identifier
8086view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Gluthation Metabolism KEGG]] moved to [[Pathway:Mus musculus:Gluthation Metabolism KEGG]]: Renaming species
7665view16:08, 18 December 2007MaintBotfixed category names
7364view12:42, 4 November 2007MaintBotAdded categories to GPML
6451view22:19, 22 May 2007169.230.77.174gpml file for [[Mouse:Gluthation_Metabolism_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(5-L-Glutamyl)-L-amino acidMetaboliteC03740 (KEGG Compound)
1.1.1.43GeneProduct
1.11.1.12GeneProduct
1.5.4.1GeneProduct
1.8.1.13GeneProduct
1.8.3.3GeneProduct
1.8.4.1GeneProduct
1.8.4.2GeneProduct
1.8.4.3GeneProduct
1.8.4.4GeneProduct
1.8.4.7GeneProduct
1.8.5.1GeneProduct
2.3.1.80GeneProduct
2.3.2.4GeneProduct
2.8.1.3GeneProduct
3.4.11.4GeneProduct
3.5.1.78GeneProduct
5-OxoprolineMetaboliteC01879 (KEGG Compound)
6.3.1.8GeneProduct
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Amino acid metabolismPathway
AnpepGeneProduct16790 (Entrez Gene)
Bis-g-glutamylcystineMetaboliteC03646 (KEGG Compound)
Cysteinyl-glycineMetaboliteC01419 (KEGG Compound)
G6pdxGeneProduct14381 (Entrez Gene)
GSTA1GeneProduct14857 (Entrez Gene)
GSTA5GeneProduct
GSTT2GeneProduct14872 (Entrez Gene)
GclcGeneProduct14629 (Entrez Gene)
GclmGeneProduct14630 (Entrez Gene)
Ggt1GeneProduct14598 (Entrez Gene)
Ggt5GeneProduct23887 (Entrez Gene)
Glutamate metabolismPathway
Glutamylcysteinyl-glycylspermidineMetabolite
Glutathione (reduced)MetaboliteC00051 (KEGG Compound)
GlycineMetaboliteHMDB0000123 (HMDB)
Gpx1GeneProduct14775 (Entrez Gene)
Gpx2GeneProduct14776 (Entrez Gene)
Gpx3GeneProduct14778 (Entrez Gene)
Gpx4GeneProduct625249 (Entrez Gene)
GsrGeneProduct14782 (Entrez Gene)
GssGeneProduct14854 (Entrez Gene)
Gstm2GeneProduct14863 (Entrez Gene)
Gstm7GeneProduct68312 (Entrez Gene)
Gstt1GeneProduct14871 (Entrez Gene)
Idh1GeneProduct15926 (Entrez Gene)
L-Amino acidMetaboliteC00151 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
NADP+MetaboliteHMDB0000217 (HMDB)
NADPHMetaboliteHMDB0000221 (HMDB)
OplahGeneProduct75475 (Entrez Gene)
Oxidized glutathioneMetaboliteC00127 (KEGG Compound)
R-S-AlanineMetaboliteC05726 (KEGG Compound)
R-S-AlanylglycineMetaboliteC05729 (KEGG Compound)
R-S-GlutathioneMetaboliteC02320 (KEGG Compound)
R-S-MercapturonateMetabolite8030 (PubChem-compound)
g-L-Glutamyl-L-cysteineMetaboliteC00669 (KEGG Compound)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP164"
Personal tools