Sickle cell disease (Homo sapiens)

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Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sundd P, Gladwin MT, Novelli EM; ''Pathophysiology of Sickle Cell Disease.''; Annu Rev Pathol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142382view16:34, 30 January 2026DeSlOntology Term : 'cardiovascular system disease pathway' added !
142381view16:33, 30 January 2026DeSlOntology Term : 'disease pathway' added !
142380view16:32, 30 January 2026DeSlAdded ID for IL18
142334view09:43, 23 January 2026DdiglesDNA damage incorrectly linked to wikidata ischemia/reperfusion injury. Updated to link to DNA damage instead.
142198view01:56, 13 December 2025KhanspersOntology Term : 'DOID:0081445' removed !
141502view08:33, 16 November 2025EgonwAdded two more identifiers
141501view08:30, 16 November 2025EgonwMore unicode
141474view13:04, 15 November 2025EweitzRefine state position
141473view13:03, 15 November 2025EweitzRefine label position
141472view13:01, 15 November 2025EweitzOntology Term : 'platelet' added !
141471view13:01, 15 November 2025EweitzOntology Term : 'endothelial cell' added !
141470view13:01, 15 November 2025EweitzOntology Term : 'neutrophil' added !
141469view13:00, 15 November 2025EweitzOntology Term : 'erythrocyte' added !
141468view13:00, 15 November 2025EweitzModified description
141467view12:59, 15 November 2025EweitzModified description
141466view12:55, 15 November 2025EweitzAdd section IDs
141465view12:42, 15 November 2025EweitzClear cached dimensions
141464view12:41, 15 November 2025EweitzEconomize layout
141462view12:38, 15 November 2025EweitzRefine state position
141461view12:37, 15 November 2025EweitzRefine node type, align
141460view12:32, 15 November 2025EweitzAdd literature reference
141459view12:30, 15 November 2025EweitzEconomize layout
141458view12:27, 15 November 2025EweitzAdd more background containers
141457view12:15, 15 November 2025EweitzSimplify interactions
141456view12:14, 15 November 2025EweitzRefine low- and high-oxygen effects
141455view12:09, 15 November 2025EweitzRemove legend, add container for vaso-occlusion
141454view11:57, 15 November 2025EweitzAdd gene identifiers
141453view11:45, 15 November 2025EweitzAdd gene identifiers
141452view00:10, 15 November 2025EweitzConnect vaso-occlusion and sterile inflammation
141450view16:52, 14 November 2025EweitzRefine big labels to pathways, add inflammasome
141449view16:29, 14 November 2025EweitzStart "Sterile inflammation" section
141448view15:55, 14 November 2025EweitzRefine orientation of heme, iron, oxygen relative to globin
141447view15:46, 14 November 2025EweitzBind heme to globin
141446view15:26, 14 November 2025EweitzDetail endothelial dysfunction
141439view12:27, 14 November 2025EweitzRefine endothelial dysfunction nodes, overall graphics
141429view01:59, 14 November 2025EweitzAdd iron, oxygen, bonds
141428view01:35, 14 November 2025EweitzAdd heme, refine graphics
141427view01:23, 14 November 2025EweitzRefine graphics
141426view01:09, 14 November 2025EweitzRefine graphics
141425view00:55, 14 November 2025EweitzAdd hemolysis graphic
141419view13:07, 13 November 2025EweitzLabel erythrocyte
141418view12:56, 13 November 2025EweitzColor cell types
141417view12:01, 13 November 2025Ash iyerOntology Term : 'sickle cell disease' added !
141416view12:01, 13 November 2025Ash iyerOntology Term : 'sickle cell anemia' added !
141415view04:10, 13 November 2025EweitzAdd neutrophils, platelets
141414view03:53, 13 November 2025EweitzAdd sickle cell prototype, endothelial cells
141413view03:28, 13 November 2025EweitzAdd headings
141412view03:24, 13 November 2025EweitzAdd Hb polymer bundles, hemolysis, sickling
141411view01:38, 13 November 2025EweitzAdd legend with other hemoglobins
141410view12:30, 12 November 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNA damageQ100611440 (Wikidata)
Damage-associated

molecular patterns

(DAMPs)		Pathway
Endothelial dysfunctionPathway
Fe2+MetaboliteCHEBI:29033 (ChEBI)
Fe3+MetaboliteCHEBI:29034 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
HBA1GeneProductENSG00000206172 (Ensembl)
HBA2GeneProductENSG00000188536 (Ensembl)
HBBGeneProductENSG00000244734 (Ensembl)
Hb polymer bundlesGeneProductENSG00000244734 (Ensembl)
HbS polymerizationPathway
HemeMetaboliteCHEBI:30413 (ChEBI)
HemolysisQ471706 (Wikidata)
IL18GeneProduct
IL1BGeneProductENSG00000125538 (Ensembl)
Ischemia-reperfusion injuryQ100611440 (Wikidata)
NOMetabolite
NO3-Metabolite
Neutrophil

extracellular

traps (NETs)		Pathway
O2MetaboliteCHEBI:15379 (ChEBI)
OHMetaboliteCHEBI:29191 (ChEBI)
ROSMetaboliteCHEBI:26523 (ChEBI)
Sterile inflammationPathway
TLR4GeneProductENSG00000136869 (Ensembl)
Vaso-occlusionPathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5604"
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