DNA replication (Mus musculus)

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Orc5OriginCdt1RFC38Mcm7Mcm10Mcm54. Switching of origins to post-replicative stateDegraded by proteasome in cytosolp58Ubiquitinated Orc1Orc3Orc complexOrc complexUbiquitinated Cdc6Orc complexRFC37Orc3Pre-replicative complexMcm4DNA polymerase alpha:primase: origin complexRNA primer-DNA primerOrc5Mcm 4,6,7 trimer forms andassociates with the replication forkOrc2Orc3DNAPolymerase AMcm5Mcm2p70Orc4RNA PrimerRFC140p180Cdt1Mcm3Mcm6Cdc6Mcm2Orc2Orc3Orc complexProcessive complexOrc4RFC402. Activation of the pre-replicative complexOrc1Cdc6RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerPre-replicative complexPrimaseCdt15. Leading/lagging strand synthesisRNA primer-DNA primerRFC Heteropentamer:RNA primer-DNA primerUbiquitinMcm10RNA primer-DNA primer:origin duplex:PCNAp49Degraded byproteasomein cytosolOrc23. DNA replication initiationOrc5Cdt1Orc complexRFC36GemininCdt1Phosphorylation ofMcm 2-7 complexMcm6Cdc6Orc2Mcm4UbiquitinMcm7Phosphorylated Orc1DNA polymerase alpha:primase: origin complex1. Assembly of the pre-replicative complexMcm3Cdc6Phosphorylated Cdc6Pole2ADPRfc3CTPMcm10dATPPcnaRpa3Mcm6Orc6lRpa1Rfc2Orc1lPola2ATPCdc7Cdt1Orc2lMcm5Pold1dGTPPold3Orc3lMcm7dCTPPold4Rfc5Rfc1Prim1Pola1ATPUTPRfc4ADPMcm3GTPCdk2Uba52Rpa2Orc5lCdc45lDbf4Prim2GmnnOrc4ldUTPUbcPolePold2RPA4ATPMcm4Cdc6ATPMcm2


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 72% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117872view10:19, 23 May 2021EweitzModified title
107197view14:28, 17 September 2019MaintBotChEBI identifier normalization
106854view13:33, 17 September 2019MaintBotHMDB identifier normalization
69148view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67160view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41336view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35196view15:36, 11 February 2010ThomasModified description
35195view15:35, 11 February 2010Thomasadded literature
34403view23:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32866view17:56, 16 September 2009MaintBotAdded xrefs
32350view13:38, 15 August 2009MaintBotFixed text labels
31975view13:09, 14 August 2009MaintBotFixed group labels
31398view20:48, 13 August 2009MaintBotFixed text labels
30825view23:59, 29 July 2009MaintBotConverted from Homo sapiens
20997view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:DNA replication Reactome]] moved to [[Pathway:WP150]]: Moved to stable identifier
7992view13:46, 7 January 2008MaintBot[[Pathway:Mouse:DNA replication Reactome]] moved to [[Pathway:Mus musculus:DNA replication Reactome]]: Renaming species
7620view16:04, 18 December 2007MaintBotfixed category names
7210view12:33, 4 November 2007MaintBotAdded categories to GPML
19418view22:18, 22 May 2007D.Korengpml file for [[Mouse:DNA_replication_Reactome]]
6430view22:18, 22 May 2007Kdahlquistgpml file for [[Mouse:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
ATPMetaboliteHMDB01532 (HMDB)
CTPMetaboliteHMDB00998 (HMDB)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdc6GeneProduct23834 (Entrez Gene)
Cdc7GeneProduct12545 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdt1GeneProduct67177 (Entrez Gene)
Dbf4GeneProduct27214 (Entrez Gene)
GTPMetaboliteHMDB01440 (HMDB)
GmnnGeneProduct57441 (Entrez Gene)
Mcm10GeneProduct70024 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pola1GeneProduct18968 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
Pold1GeneProduct18971 (Entrez Gene)
Pold2GeneProduct18972 (Entrez Gene)
Pold3GeneProduct67967 (Entrez Gene)
Pold4GeneProduct69745 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct19687 (Entrez Gene)
Rfc2GeneProduct19718 (Entrez Gene)
Rfc3GeneProduct69263 (Entrez Gene)
Rfc4GeneProduct106344 (Entrez Gene)
Rfc5GeneProduct72151 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
UTPMetabolite17625 (ChEBI)
Uba52GeneProduct22186 (Entrez Gene)
UbcGeneProduct22190 (Entrez Gene)
dATPMetaboliteHMDB01532 (HMDB)
dCTPMetaboliteHMDB00998 (HMDB)
dGTPMetaboliteHMDB01440 (HMDB)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
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