Irinotecan pathway (Pan troglodytes)

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1, 2Liver CellModel human liver cell showing blood, bile and intestinal compartments, indicating tissueinvolvment of genes in the irinotecan pathway.IntestineNeutropeniaDiarrheaABCC1UGT1A6SN-38UGT1A9CYP3A5ABCC1ABCG2SN-38IrinotecanCES2CYP3A4CES2UGT1A1CYP3A4SN-38GABCC2ABCC2IrinotecanCES1SN-38APCABCC2CES2CES1BCHEUGT1A10CYP3A5IrinotecanUGT1A1CES1CES1CES2SN-38ABCC1M4NPCCYP3A4UGT1A6


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP229(r26589) with a 65% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Mathijssen RH, Marsh S, Karlsson MO, Xie R, Baker SD, Verweij J, Sparreboom A, McLeod HL; ''Irinotecan pathway genotype analysis to predict pharmacokinetics.''; Clin Cancer Res, 2003 PubMed Europe PMC Scholia
  2. Desai AA, Innocenti F, Ratain MJ; ''UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.''; Pharmacogenetics, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116611view09:42, 9 May 2021EweitzModified title
93193view15:16, 2 August 2017DeSlChanged several gene nodes to metabolite nodes, added IDs for them
69250view18:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
67412view10:58, 26 June 2013DdiglesOntology Term : 'irinotecan drug pathway' added !
57481view21:56, 28 January 2013KhanspersChanged identifier for irinotecan
57180view16:24, 23 January 2013EgonwUsed "PubChem-compound"
41557view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35501view13:12, 12 February 2010ThomasModified description
35500view13:11, 12 February 2010Thomasadded literature, removed genmapp comment
34288view22:00, 9 December 2009MaintBotAutomatic update of empty xrefs
33610view09:59, 1 December 2009MaintBotRemoved group label
31624view22:20, 13 August 2009MaintBotFixed text labels
30530view21:53, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCC1GeneProduct453952 (Entrez Gene)
ABCC2GeneProduct450670 (Entrez Gene)
ABCG2GeneProduct471251 (Entrez Gene)
APCGeneProduct461999 (Entrez Gene)
BCHEGeneProduct460830 (Entrez Gene)
CES1GeneProduct747009 (Entrez Gene)
CES2GeneProduct740768 (Entrez Gene)
CYP3A4GeneProduct463582 (Entrez Gene)
CYP3A5GeneProduct737374 (Entrez Gene)
IrinotecanMetabolite3750 (PubChem)
M4GeneProduct
NPCGeneProduct
SN-38GeneProduct
SN-38GGeneProduct
UGT1A10GeneProduct
UGT1A1GeneProduct449596 (Entrez Gene)
UGT1A6GeneProduct739942 (Entrez Gene)
UGT1A9GeneProduct741990 (Entrez Gene)

Annotated Interactions

No annotated interactions
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