Energy metabolism (Homo sapiens)

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HDACHDACAcMuscular atrophyP= family members of PPARGC1ANUCLEUSP= Key regulatorP+= PPARGC1A induced by external stimuliP+Imported to mitochondriaEncoded Genes+PPARGC1A ++-= PPARGC1A induces expression?+-+= PPARGC1A co-activates nuclear receptors and transcription factorsNUCLEUS+PPre-initiation Complex-+Fatty Acid Oxidation+++= transcription factors for mtDNATranscription Nuclear +-+CYTOPLASMEnzymesGenes of mitochondrial CYTOPLASM= PPARGC1A and muscle control= Double positive feedback loop++= PPARGC1A, PPARs and UCP2, 3+Post-transcriptional modificationMAPK14GABPPPARGC1ATFAMUnknown Transcription FactorsMEF2A,B,C,DUnknown Transcription FactorsESRRAPPARA/PPARDPPARGC1ATFAMPPARA/PPARGNCOA1PPARGC1APRKAA1, PRKAA2, PRKAB1, PRKAB2TFB1MMEF2TFB2MPPARGC1APRKAG1, PRKAG2, PRKAG3Unknown Transcription Factors EP300PPARGC1ANRF1CREB1SIRT1TFB2MMEF2BPPARGTFB1MPPARA/PPARD/PPARGPPARGC1AFOXO3RXRGSK3BSIRT3PPARGC1ACAMK4NRF1PPARGC1APPARGC1AUnknown Transcription FactorsPPARGC1ACAMK2GCREB1UCP3FOXO1Unknown Transcription FactorsMED1TFB1MPPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2PPARGC1AMYBBP1APPARGC1BUnknown Transcription FactorsMEF2DMEF2UCP2GABPUnknown Transcription FactorsNRF1MEF2APPARGC1APRMT1PPARGC1AMEF2CPPRC1TFB2MFOXO3PPARGC1ACAMK4PPARGC1AATF2PPARGC1APPARGC1APPARGC1A


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Bibliography

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History

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CompareRevisionActionTimeUserComment
126394view15:26, 26 April 2023EgonwLicense is CCZero
117711view12:27, 22 May 2021EweitzModified title
106404view21:33, 28 August 2019KhanspersModified description
105585view04:43, 10 August 2019KhanspersModified description
94314view12:10, 1 September 2017Marvin M2Connected unconnected line
94237view12:49, 29 August 2017DeSlChanged ID for acetyl (which was an acetyl leaving group), added ID for CAMK4
94202view14:54, 25 August 2017DeSlAdded ID for acetaldehyde
91584view19:53, 18 March 2017AlexanderPicotweaked interactions
91583view19:49, 18 March 2017MaintBotremoving color and legend to enable general use
89375view06:28, 10 September 2016EgonwConnected lines.
80210view21:02, 22 May 2015KhanspersReverted to version '17:36, 8 July 2013' by Khanspers
80182view20:02, 18 May 2015Khanspersremoved node coloring
80167view22:28, 14 May 2015KhanspersAdded mir219 targeting of CAMK2G, removed node colors, added labels, added states
68947view17:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
45242view18:25, 7 October 2011AlexanderPicoOntology Term : 'energy metabolic pathway' added !
41103view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38811view08:31, 24 September 2010Jildaucompartment
38121view01:34, 13 August 2010AlexanderPicofixed legend
38118view01:00, 13 August 2010AlexanderPicoModified categories
38117view00:59, 13 August 2010AlexanderPicoModified description
38116view00:53, 13 August 2010AlexanderPicofinished connecting datanodes and lines
38115view00:23, 13 August 2010AlexanderPicoPeriodical save, work in progress
38094view00:29, 12 August 2010AlexanderPicofixed arrows and datanodes in top third of pathway
38093view23:58, 11 August 2010AlexanderPicoConnecting genes to database, fixing lines and datanodes
38091view23:49, 11 August 2010AlexanderPicoPeriodical save, work in progress
38089view23:38, 11 August 2010AlexanderPicoadded pathway name
38021view14:06, 30 July 2010MXFKoshoPeriodical save, work in progress
38020view13:59, 30 July 2010MXFKoshoSpecify description
37913view09:34, 16 July 2010MXFKoshoSpecify description
37910view02:35, 16 July 2010MXFKoshoSpecify description
37909view02:32, 16 July 2010MXFKoshoSpecify description
37908view02:26, 16 July 2010MXFKoshoPeriodical save, work in progress
37907view02:24, 16 July 2010MXFKosho
37906view02:16, 16 July 2010MXFKoshoPeriodical save, work in progress
37905view02:04, 16 July 2010MXFKoshoSpecify description
37904view01:59, 16 July 2010MXFKoshoSpecify description
37903view01:54, 16 July 2010MXFKoshoPeriodical save, work in progress
37902view01:45, 16 July 2010MXFKoshoSpecify description
37563view17:12, 11 June 2010MXFKoshoSpecify description
37559view13:51, 11 June 2010MXFKoshoSpecify description
37558view13:46, 11 June 2010MXFKoshoSpecify description
37557view13:38, 11 June 2010MXFKoshoPeriodical save, work in progress
37556view12:57, 11 June 2010MXFKoshoPeriodical save, work in progress
37290view21:21, 24 May 2010MXFKoshoSpecify description
37285view19:20, 24 May 2010MXFKoshoPeriodical save, work in progress
37284view19:01, 24 May 2010MXFKoshoSpecify description
37283view18:01, 24 May 2010MXFKoshoSpecify description
37282view15:01, 24 May 2010MXFKoshoPeriodical save, work in progress
37281view14:49, 24 May 2010MXFKoshoSpecify description
37280view10:44, 24 May 2010MXFKoshoSpecify description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
ATF2GeneProduct
CAMK2GGeneProduct818 (Entrez Gene)
CAMK4GeneProduct
CREB1GeneProduct
CREB1GeneProduct1385 (Entrez Gene)
EP300GeneProduct
ESRRAGeneProduct
FOXO1GeneProduct2308 (Entrez Gene)
FOXO3GeneProduct2309 (Entrez Gene)
GABPGeneProduct
GSK3BGeneProduct2932 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MED1GeneProduct
MEF2GeneProduct
MEF2A,B,C,DGeneProduct
MEF2AGeneProduct4205 (Entrez Gene)
MEF2BGeneProduct100271849 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MEF2DGeneProduct4209 (Entrez Gene)
MYBBP1AGeneProduct10514 (Entrez Gene)
NCOA1
NRF1GeneProduct
PPARA/PPARDGeneProduct
PPARA/PPARD/PPARGGeneProduct
PPARA/PPARGGeneProduct
PPARGGeneProduct
PPARGC1AGeneProduct
PPARGC1AGeneProduct10891 (Entrez Gene)
PPARGC1BGeneProduct
PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2GeneProduct
PPRC1GeneProduct
PRKAA1, PRKAA2, PRKAB1, PRKAB2GeneProduct
PRKAG1, PRKAG2, PRKAG3GeneProduct
PRMT1GeneProduct
RXRGeneProduct
SIRT1GeneProduct
SIRT3GeneProduct23410 (Entrez Gene)
TFAMGeneProduct
TFB1MGeneProduct
TFB2MGeneProduct
UCP2GeneProduct
UCP3GeneProduct
Unknown Transcription FactorsGeneProduct
Unknown Transcription Factors GeneProduct

Annotated Interactions

No annotated interactions

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