Toll-like receptor signaling (Homo sapiens)

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+LipoarabinomannanInflammatory cytokinesChemotacticdsRNANK cell)Specific pathwayin pDCsCpG DNA+p+p+pAutocrine / Paracrine+peffectsssRNAPeptidoglycan(G+)Inflammatory cytokines+pCostimulatory moleculesT cell stimulation+p(Neutrophil, immature DC,+p++pZymosan (Yeast)+pLPS(G-)IKK(T cell)+pAntiviral effectsChemotacticEndosomeUnmethylated+pProinflammatory+pDegradation(anti-viral compounds)DNA+peffectsApoptosisMAPK signaling pathwayImidazoquinolinLipoprotein+peffectsFlagellin+p(Mycobacteria)Cytokine-receptor interactionTRAF6AKT3IFNA17PIK3R3TRAF3MyD88-independent pathwayCD86MAP3K7IP1TLR8IFNA10FOSIRAK1CD14JUNMYD88MAP2K6MAPK11IFNB1SPP1MAP2K2TLR7MAP2K1TLR2IFNA7IL6IFNA16MYD88IFNA14AKT1TICAM2TOLLIPIL8CD40CXCL9STAT1IFNAR2MYD88IRAK4IRF5PIK3R5MAPK1TLR1IL12BCCL3IFNB1MAP3K7CD80MAP3K8Complement and coagulation cascadesRAC1MAPK8Ubiquitin mediated proteolysisMAPK14IKBKGCCL5CXCL11IKBKEMAP3K7IP2NFKB1TIRAPCCL4MAPK13IL1BPIK3CGCXCL10MAP2K4Flagellar assemblyIRAK4IL12AIFNB1MyD88-dependent pathwayPIK3CBNFKB2IRF7CHUKAKT2IFNA6TIRAPTLR9TNFLBPIFNA4IKBKBIFNA5TBK1TRAF6MAPK9PIK3CDPIK3R1MAPK10RELAFADDIRAK1CHUKIFNA2TLR6TRAF6LipopolysaccharidebiosynthesisPIK3R2IFNAR1MAP2K7IRF3IFNA1IFNA8TLR3NFKB1CASP8TLR4TLR2PIK3CAIFNA21MAPK12Jak-STAT signaling pathwayLY96MAPK3RIPK1MAP2K3TICAM1MYD88IFNA13TLR5NFKBIA


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Takeda K, Akira S; ''TLR signaling pathways.''; Semin Immunol, 2004 PubMed Europe PMC Scholia
  2. Kawai T, Akira S; ''Toll-like receptor and RIG-I-like receptor signaling.''; Ann N Y Acad Sci, 2008 PubMed Europe PMC Scholia
  3. ''KEGG Toll-like receptor signaling''; https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa04620,

History

View all...
CompareRevisionActionTimeUserComment
135009view11:27, 31 July 2024EweitzOntology Term : 'mast cell' added !
135008view11:26, 31 July 2024EweitzLabel cell types
135007view11:19, 31 July 2024EweitzOntology Term : 'dendritic cell' added !
135006view11:19, 31 July 2024EweitzOntology Term : 'macrophage' added !
135000view07:25, 31 July 2024EgonwAdded to articles
134999view03:49, 31 July 2024EweitzFix waypoint on segmented line
134998view03:36, 31 July 2024EweitzEconomize layout
134997view03:28, 31 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134996view03:27, 31 July 2024EweitzEconomize layout
134995view02:56, 31 July 2024EweitzCondense PI3K gene family
134994view02:25, 31 July 2024EweitzAvoid colliding interaction, enlarge font on overlooked node
134993view02:21, 31 July 2024EweitzFix membrane left
134992view02:19, 31 July 2024EweitzTweak positions of state icons; interaction anchors, line types
134991view02:07, 31 July 2024EweitzRefine alignment, line types, mitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134990view02:01, 31 July 2024EweitzIncrease font size, for readability
134989view01:48, 31 July 2024EweitzEconomize layout
134988view01:22, 31 July 2024EweitzMove interaction nexus closer to interacting nodes
134987view01:19, 31 July 2024EweitzEconomize layout
134986view01:11, 31 July 2024EweitzAvoid stacking state indicators
134985view00:01, 31 July 2024EweitzRefine interactions
134984view23:58, 30 July 2024EweitzEconomize layout
134983view23:53, 30 July 2024EweitzTweak interaction waypoint
134982view23:51, 30 July 2024EweitzRefine interaction arrangement, economize layout
134981view23:48, 30 July 2024EweitzEconomize layout
134980view23:42, 30 July 2024EweitzEconomize layout
129709view01:30, 22 May 2024EweitzModified title
128034view17:21, 21 January 2024EweitzStack nodes, standardize case
127384view21:44, 26 September 2023Khanspersupdated phosphosites
119233view19:02, 22 June 2021Finterlyadded KEGG pathway info to publicationXref
118981view10:45, 6 June 2021EweitzUpdate WP619 title, straighten arrow
118980view10:40, 6 June 2021EweitzGroup clustered genes, connect interactions to it
117849view15:18, 22 May 2021EweitzModified title
111250view11:10, 27 July 2020EgonwMade a few more pathways clickable
105842view23:12, 15 August 2019KhanspersModified description
105228view07:41, 23 July 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
105219view00:12, 22 July 2019KhanspersModified description
105218view00:07, 22 July 2019Khanspersadded KEGG reference
105217view00:06, 22 July 2019KhanspersOntology Term : 'signaling pathway pertinent to immunity' added !
105216view00:04, 22 July 2019Khanspersadded phospho sites
105215view23:59, 21 July 2019Khanspersadded phospho sites
105214view23:44, 21 July 2019Khanspersupdate node size and layout
105213view23:19, 21 July 2019Khansperscleaned up MAPK
105212view22:56, 21 July 2019Khanspersupdated metabolites, added cellular components
102773view00:27, 24 January 2019AlexanderPicoremoved extra copy of IRAK4 and added TAB3
96020view15:22, 15 February 2018DeSlRemoved licence number
94908view23:52, 12 October 2017Khanspersconnected interactions
94760view15:49, 5 October 2017JmeliusConnect lines
83867view00:46, 18 December 2015AlexanderPicoModified title
72133view07:59, 25 October 2013Mkutmonadded datasource to pathway datanode
70634view09:40, 20 August 2013EgonwConverted a IUPAC-named Label into a Chemspider-backed Metabolite DataNode.

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct208 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct10000 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CASP8GeneProduct841 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProduct6348 (Entrez Gene) Original kegg element: gene;44;hsa:6348
CCL4GeneProduct6351 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct6352 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct929 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD40GeneProduct958 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct941 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct942 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct1147 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CXCL10GeneProduct3627 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProduct6373 (Entrez Gene) Original kegg element: gene;23;hsa:6373
CXCL9GeneProduct4283 (Entrez Gene) Original kegg element: gene;24;hsa:4283
Complement and coagulation cascadesPathwayWP558 (WikiPathways)
Cytokine-receptor interactionPathwayWP530 (WikiPathways)
FADDGeneProduct8772 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FOSGeneProduct2353 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
Flagellar assemblyPathway
IFNA10GeneProduct3446 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct3447 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct3439 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProduct3448 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProduct3449 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProduct3451 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProduct3452 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct3440 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct3441 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct3442 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct3443 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct3444 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProduct3445 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct3454 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct3455 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProduct3456 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IKBKBGeneProduct3551 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct9641 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct8517 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProduct3592 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct3593 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct3553 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct3569 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct3576 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct3654 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct51135 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct3661 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct3663 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProduct3665 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JUNGeneProduct3725 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
Jak-STAT signaling pathwayPathwayWP619 (WikiPathways)
LBPGeneProduct3929 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LY96GeneProduct23643 (Entrez Gene) Original kegg element: gene;71;hsa:23643
Lipopolysaccharide biosynthesisPathway
MAP2K1GeneProduct5604 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct5605 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct5606 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct6416 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct5608 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct5609 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct6885 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct10454 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProduct23118 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct1326 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct5602 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct5600 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct6300 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK13GeneProduct5603 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct1432 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct5594 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK3GeneProduct5595 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct5599 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct5601 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MYD88GeneProduct4615 (Entrez Gene) Original kegg element: gene;47;hsa:4615
MyD88-dependent pathwayPathway
MyD88-independent pathwayPathway
NFKB1GeneProduct4790 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct4791 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct4792 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct5290 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct5291 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct5293 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct5294 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct5295 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct5296 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct8503 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct23533 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
RAC1GeneProduct5879 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RELAGeneProduct5970 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct8737 (Entrez Gene) Original kegg element: gene;17;hsa:8737
SPP1GeneProduct6696 (Entrez Gene) Original kegg element: gene;15;hsa:6696
STAT1GeneProduct6772 (Entrez Gene) Original kegg element: gene;62;hsa:6772
TBK1GeneProduct29110 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct148022 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2GeneProduct353376 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TIRAPGeneProduct114609 (Entrez Gene) Original kegg element: gene;83;hsa:114609
TLR1GeneProduct7096 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct7097 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR3GeneProduct7098 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct7099 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR5GeneProduct7100 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct10333 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct51284 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProduct51311 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct54106 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct7124 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TOLLIPGeneProduct54472 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct7187 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct7189 (Entrez Gene) Original kegg element: gene;53;hsa:7189
Ubiquitin mediated proteolysisPathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP75"
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