DNA replication (Drosophila melanogaster)

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1, 2Phosphorylated Orc1DNA polymerase alpha: primase: origin complexMcm7Orc complexOriginCTPMcm 4,6,7 trimer forms and associatesCdt1Orc5Ubiquitinated Orc1Orc complexOrc5Orc3Pre-replicative complexCdc6Phosphorylation of Mcm 2-7 complexOrc3Orc4Degraded by proteasome in cytosolCdc6Orc33. DNA replication initiationGemininOrc5p58Mcm4Cdt1PrimasedUTPMcm2dCTPMcm5Orc2Cdt1GTPPhosphorylated Cdc6Cdt1Orc3Mcm6Orc2ADPRFC Heteropentamer:RNA primer-DNA primerPre-replicative complexCdt1UbiquitinRFC37RNA primer-DNA primerCdc6Mcm4Mcm2Mcm51. Assembly of the pre-replicative complexMcm7Orc4ATPOrc2Mcm3RFC Heteropentamer:RNA primer-DNA primer:ATPATPdATPRNA primer-DNA primer:origin duplex:PCNAADP5. Leading/lagging strand synthesisaDNA PolymeraseUTPCdc6Mcm34. Switching of origins to post-replicative stateRFC140Mcm6RFC36Ubiquitinated Cdc6PCNA homotrimerRFC40RNA primer-DNA primerp49Orc1Ubiquitinp180p70dGTPRFC38Mcm10HOMOLOGY MAPPDegraded by proteasome in cytosolOrc complexOrc ComplexATPwith the replication forkProcessive complex2. Activation of the pre-replicative complexOrc2DNA polymerase alpha: primase: origin complexOrc complexRNA PrimerdpaMcm2RfC40dupMcm10RpA-70CDK2mus209RfC38Orc6Mcm5Mcm6CG12018Mcm7DNAprimDNApol-alpha180DNApol-deltaPOLD3DNApol-epsilonRfC3Gnf1DNApol-alpha50CG8142ASKPole2CG9273POLD4RPA4Orc1CG5971Orc5DNApol-alpha73Orc4CDC45LOrc2latGMNNMcm3l(1)G0148RPA3Ubi-p63ERpL40


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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