One-carbon metabolism and related pathways (Mus musculus)

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Description

Quality Tags

Ontology Terms

Bibliography

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History

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Compare	Revision	Action	Time	User	Comment
	116575	view	11:06, 8 May 2021	Eweitz	Modified title
	107198	view	14:28, 17 September 2019	MaintBot	ChEBI identifier normalization
	106860	view	13:34, 17 September 2019	MaintBot	HMDB identifier normalization
	98296	view	10:23, 17 August 2018	DeSl	Connected last enzyme nodes properly.
	98284	view	12:41, 16 August 2018	DeSl	Checked for unconnected lines (didn't find any, will remove the Quality tag. Connected all enzymes with MIM-catalysis iso line.
	98239	view	13:53, 14 August 2018	Egonw	Replace two PubChem SIDs with a PubChem CIDs.
	96354	view	17:06, 9 March 2018	Egonw	Converted interactions to regular arrows, which were not mim:conversions.
	96326	view	09:28, 8 March 2018	Mkutmon	update NCBI Protein identifiers to Ensembl identifiers
	96325	view	09:20, 8 March 2018	Mkutmon	remove old WP category
	96233	view	13:29, 1 March 2018	DeSl	Removed licence number and last modified part.
	96232	view	13:28, 1 March 2018	DeSl	Added small side branch to opthalmate conversion.
	94313	view	12:07, 1 September 2017	Marvin M2	Made minor change with connection
	94311	view	12:02, 1 September 2017	Marvin M2	Connected unconnected line, changed line into graphical (no connection)
	94207	view	21:15, 25 August 2017	DeSl	Added ID for phosphocholine
	78414	view	10:25, 7 January 2015	MaintBot	added missing graphIds
	71311	view	17:14, 17 October 2013	MaintBot	Automated update of data sources
	69068	view	18:08, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	48487	view	12:08, 29 May 2012	Evelo	Improved methionine backpage
	48224	view	05:32, 17 May 2012	MaintBot	Automatic update of PubChem xrefs
	45171	view	08:49, 7 October 2011	Thomas	Ontology Term : 'folate mediated one-carbon metabolic pathway' added !
	43787	view	21:31, 27 July 2011	Samuel Sklar	Modified description
	41250	view	00:20, 2 March 2011	MaintBot	Removed redundant pathway information and comments
	39628	view	23:06, 4 January 2011	Khanspers	Modified categories
	39587	view	08:22, 28 December 2010	MaintBot	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
10-formyldihydrofolate	Metabolite	189114 (PubChem)
3-Sulfinoalanine	Metabolite	C00606 (Kegg Compound)
5,10-Methenyltetrahydrofolic acid	Metabolite	C00445 (Kegg Compound)
5-Methyltetrahydrofolic acid	Metabolite	C00440 (Kegg Compound)
5-oxoproline	Metabolite	C01879 (Kegg Compound)
Ahcyl1	GeneProduct	229709 (Entrez Gene)
Baat	GeneProduct	12012 (Entrez Gene)
Betaine	Metabolite	C00719 (Kegg Compound)
Bhmt	GeneProduct	12116 (Entrez Gene)
Bhmt2	GeneProduct	64918 (Entrez Gene)
CDP-Ethanolamine	Metabolite	C00570 (Kegg Compound)
CDP-choline	Metabolite	C00307 (Kegg Compound)
Cbs	GeneProduct	12411 (Entrez Gene)
Cdo1	GeneProduct	12583 (Entrez Gene)
Cept1	GeneProduct	99712 (Entrez Gene)
Chdh	GeneProduct	218865 (Entrez Gene)
Chka	GeneProduct	12660 (Entrez Gene)
Chkb	GeneProduct	12651 (Entrez Gene)
Choline	Metabolite	C00114 (Kegg Compound)
Chpt1	GeneProduct	212862 (Entrez Gene)
Csad	GeneProduct	246277 (Entrez Gene)
Cth	GeneProduct	107869 (Entrez Gene)
Dhfr	GeneProduct	13361 (Entrez Gene)
Dimethylglycine	Metabolite	C01026 (Kegg Compound)
Dmgdh	GeneProduct	74129 (Entrez Gene)
Dnm1	GeneProduct	13429 (Entrez Gene)
Dnmt3a	GeneProduct	13435 (Entrez Gene)
Ethanolamine	Metabolite	C00189 (Kegg Compound)
Etnk1	GeneProduct	75320 (Entrez Gene)
Etnk2	GeneProduct	214253 (Entrez Gene)
Folic acid	Metabolite	C00504 (Kegg Compound)
Gad1	GeneProduct	14415 (Entrez Gene)
Gad2	GeneProduct	14417 (Entrez Gene)
Gclc	GeneProduct	14629 (Entrez Gene)
Gclm	GeneProduct	14630 (Entrez Gene)
Glutamate	Metabolite	C00217 (Kegg Compound)
Glutathione (GSH)	Metabolite	C00051 (Kegg Compound)
Glutathione disulfide (GSSG)	Metabolite	C00127 (Kegg Compound)
Glycine	Metabolite	C00037 (Kegg Compound)
Gnmt	GeneProduct	14711 (Entrez Gene)
Gpx1	GeneProduct	14775 (Entrez Gene)
Gpx2	GeneProduct	14776 (Entrez Gene)
Gpx3	GeneProduct	14778 (Entrez Gene)
Gpx4	GeneProduct	625249 (Entrez Gene)
Gpx5	GeneProduct	14780 (Entrez Gene)
Gpx6	GeneProduct	75512 (Entrez Gene)
Gpx7	GeneProduct	67305 (Entrez Gene)
Gsr	GeneProduct	14782 (Entrez Gene)
Gss	GeneProduct	14854 (Entrez Gene)
Homocysteine	Metabolite	C05330 (Kegg Compound)
Hypotaurine	Metabolite	C00519 (Kegg Compound)
L-Cystathionine	Metabolite	C02291 (Kegg Compound)
L-Cysteine	Metabolite	C00097 (Kegg Compound)
L-Methionine	Metabolite	C01733 (Kegg Compound)
L-Serine	Metabolite	C00065 (Kegg Compound)
Mat1a	GeneProduct	11720 (Entrez Gene)
Mat2a	GeneProduct	232087 (Entrez Gene)
Mthfr	GeneProduct	17769 (Entrez Gene)
Mtr	GeneProduct	238505 (Entrez Gene)
NADP	Metabolite	C00006 (Kegg Compound)
NADPH	Metabolite	C00005 (Kegg Compound)
O-Phosphoethanolamine	Metabolite	C00346 (Kegg Compound)
Pcyt1a	GeneProduct	13026 (Entrez Gene)
Pcyt1b	GeneProduct	236899 (Entrez Gene)
Pcyt2	GeneProduct	68671 (Entrez Gene)
Pemt	GeneProduct	18618 (Entrez Gene)
Phosphatidylcholines	Metabolite	8002-43-5 (CAS)
Phosphatidylethanolamine	Metabolite	C00350 (Kegg Compound)
Phosphocholine	Metabolite
Pld1	GeneProduct	18805 (Entrez Gene)
S-Adenosylhomocysteine	Metabolite	C00021 (Kegg Compound)
S-Adenosylmethionine	Metabolite	C00019 (Kegg Compound)
Sarcosine	Metabolite	C00213 (Kegg Compound)
Sardh	GeneProduct	192166 (Entrez Gene)
Shmt1	GeneProduct	20425 (Entrez Gene)
Shmt2	GeneProduct	108037 (Entrez Gene)
Sod1	GeneProduct	20655 (Entrez Gene)
Sod2	GeneProduct	20656 (Entrez Gene)
Sod3	GeneProduct	20657 (Entrez Gene)
Taurine	Metabolite	C00245 (Kegg Compound)
Taurochenodesoxycholic acid	Metabolite	C05465 (Kegg Compound)
Taurocholic acid	Metabolite	C05122 (Kegg Compound)
Tetrahydrofolic acid	Metabolite	C00101 (Kegg Compound)
Total Phospholipids	Metabolite	16247 (ChEBI)
Tyms	GeneProduct	22171 (Entrez Gene)
gamma-Glutamylcysteine	Metabolite	C00669 (Kegg Compound)

Annotated Interactions

No annotated interactions